Click here to switch to the map view.

The map label for this gene is lon2 [H]

Identifier: 134300399

GI number: 134300399

Start: 2787453

End: 2789168

Strand: Reverse

Name: lon2 [H]

Synonym: Dred_2560

Alternate gene names: 134300399

Gene position: 2789168-2787453 (Counterclockwise)

Preceding gene: 134300400

Following gene: 134300398

Centisome position: 77.3

GC content: 46.5

Gene sequence:

>1716_bases
ATGGGGGAACTTACCAGTCTTGGGGGTTTTCTCACCTTCATACAGGTATTTTTTGCGGTGGTAATTGGTCTGTACTTCTG
GAATTTATTAAAGCAACAACAAGGCAATAAAACTGCCGTAGAAAAGGAATCCCGTAAAGAGATGGAGAAATTGCAACGGC
TTAGGGCTATTTCCCTAACAGAACCGTTGGCAGAGAAAACAAGACCCAAAAAGTTTAGTGAGATCATAGGGCAGGAAGAG
GGTTTAAAATCCCTGAGGGCTGCTCTATGTGGACCCAACCCACAGCATGTTATTGTCTATGGCCCTCCTGGTGTCGGTAA
AACTGCAGCAGCCAGACTGGTATTGGAAGAGGCAAAAAAGGTACCTAGCTCACCCTTTAAGGAAAATGCAAAATTCATCG
AGTTGGATGCCACCACGGCCCGCTTTGATGAAAGGGGTATTGCAGACCCATTAATCGGTTCGGTGCATGACCCCATCTAC
CAGGGAGCAGGCCCAATGGGCATGGCAGGAATCCCACAACCCAAGCCTGGGGCTGTCACAAAGGCCCATGGAGGATTGCT
TTTCATTGATGAAATTGGGGAACTTCACCCTATTCAGATGAACAAATTATTAAAGGTTTTGGAAGATCGCAAGGTCTTTT
TGGAAAGTGCCTACTACAGCACCGAAGACAGTAACATACCGACTCATATTCATGATATTTTCCAGAATGGATTGCCGGCG
GATTTCCGTATGGTCGGTGCAACCACCCGAACACCAGATGAAATTCCGCCGGCCATACGTTCCCGCTGCTTGGAAATTTT
CTTCCGTCCGCTGCAACAGGATGAGATAGAGAAGATTGCAGATAATGCAGCACAAAAGATTGGTTTTCCCCTAGAGAAAG
GGGCCTTAGATGTCATTAAACGGTATGCCACAAATGGCAGGGAATCTGTAAATATTATTCAGATCGCTGGTGGTATTGCC
CTTACGGAAGGTAGGAAAGAAATTCTAGTAAGGGATATAGAGTGGGTTATCCATAGCGGTCAATACTCACCACGACCCGA
GCGGAAAATTAATCCTCAACCCCAGATTGGTGTGGTGAACGGACTGGCAGTGTATGGTCCCAATATGGGGATTGTCTCAG
AAGTGGAAGCAACGGTTATCCCCAATGTTGCGGGAACTGGGAAAATCACTGTTACTGGAGTAGTTGAAGAAGAAGAGATT
GGTGGCAACGGGAAAAAAGTACGGCGCAAAAGTATGGCTCGTAGTTCAGTAGAAAATGTAGTTACTGTACTGCGGCGGGT
TATGGATGTAAATCCACAAAATTATGATATCCATGTAAATTTCCTGGGCAGTGGTTTAGTGGATGGTCCCTCTGCTGGCG
TTACCATAGCCACAGCCATTTATTCAGCTATCAAAGGGATTGCTGTTGACAATACCGTAGCCATGACCGGGGAGATATCC
ATTCGTGGCTTAGTAAAGCCCATTGGCGGCGTTGTGGCAAAGGTAGACGCGGCACGTCAGGCCGGGGTTAAAAAGGTTCT
CATCCCTAGGGAGAATTACCAAGAAATGTTTAAAAACATGGAAGGTATTGAGGTAATCCCTGTGGATACCTTGGGAGATG
TGATTACAGGGTCACTTATGGGACAGTCAGAGAAAGAGCAACAGTGGGAGCCATTAACTTCCAATCTAGAGCTTCCCGCT
GCAGCTTTTTTAGCACAGGAATCTGCCAAATCCTGA

Upstream 100 bases:

>100_bases
CAGCTATAATCCAAAGAATTACCCTAAATTAGGGTGTAAAATCTGGTCCTTTTAGCAATAATACAAAAAGAAATGTTAGC
TAAAAGGAGGCGTCGGATTA

Downstream 100 bases:

>100_bases
TAATTAAAAAAATATCTGTGAATAATAGGTATTCTTGTTACTTAAAATTTTAGATTTCCTTCATCAAACTTCCAAAACCC
AGCTATTGCTGGGTTTTTTC

Product: ATPase central domain-containing protein

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 571; Mature: 570

Protein sequence:

>571_residues
MGELTSLGGFLTFIQVFFAVVIGLYFWNLLKQQQGNKTAVEKESRKEMEKLQRLRAISLTEPLAEKTRPKKFSEIIGQEE
GLKSLRAALCGPNPQHVIVYGPPGVGKTAAARLVLEEAKKVPSSPFKENAKFIELDATTARFDERGIADPLIGSVHDPIY
QGAGPMGMAGIPQPKPGAVTKAHGGLLFIDEIGELHPIQMNKLLKVLEDRKVFLESAYYSTEDSNIPTHIHDIFQNGLPA
DFRMVGATTRTPDEIPPAIRSRCLEIFFRPLQQDEIEKIADNAAQKIGFPLEKGALDVIKRYATNGRESVNIIQIAGGIA
LTEGRKEILVRDIEWVIHSGQYSPRPERKINPQPQIGVVNGLAVYGPNMGIVSEVEATVIPNVAGTGKITVTGVVEEEEI
GGNGKKVRRKSMARSSVENVVTVLRRVMDVNPQNYDIHVNFLGSGLVDGPSAGVTIATAIYSAIKGIAVDNTVAMTGEIS
IRGLVKPIGGVVAKVDAARQAGVKKVLIPRENYQEMFKNMEGIEVIPVDTLGDVITGSLMGQSEKEQQWEPLTSNLELPA
AAFLAQESAKS

Sequences:

>Translated_571_residues
MGELTSLGGFLTFIQVFFAVVIGLYFWNLLKQQQGNKTAVEKESRKEMEKLQRLRAISLTEPLAEKTRPKKFSEIIGQEE
GLKSLRAALCGPNPQHVIVYGPPGVGKTAAARLVLEEAKKVPSSPFKENAKFIELDATTARFDERGIADPLIGSVHDPIY
QGAGPMGMAGIPQPKPGAVTKAHGGLLFIDEIGELHPIQMNKLLKVLEDRKVFLESAYYSTEDSNIPTHIHDIFQNGLPA
DFRMVGATTRTPDEIPPAIRSRCLEIFFRPLQQDEIEKIADNAAQKIGFPLEKGALDVIKRYATNGRESVNIIQIAGGIA
LTEGRKEILVRDIEWVIHSGQYSPRPERKINPQPQIGVVNGLAVYGPNMGIVSEVEATVIPNVAGTGKITVTGVVEEEEI
GGNGKKVRRKSMARSSVENVVTVLRRVMDVNPQNYDIHVNFLGSGLVDGPSAGVTIATAIYSAIKGIAVDNTVAMTGEIS
IRGLVKPIGGVVAKVDAARQAGVKKVLIPRENYQEMFKNMEGIEVIPVDTLGDVITGSLMGQSEKEQQWEPLTSNLELPA
AAFLAQESAKS
>Mature_570_residues
GELTSLGGFLTFIQVFFAVVIGLYFWNLLKQQQGNKTAVEKESRKEMEKLQRLRAISLTEPLAEKTRPKKFSEIIGQEEG
LKSLRAALCGPNPQHVIVYGPPGVGKTAAARLVLEEAKKVPSSPFKENAKFIELDATTARFDERGIADPLIGSVHDPIYQ
GAGPMGMAGIPQPKPGAVTKAHGGLLFIDEIGELHPIQMNKLLKVLEDRKVFLESAYYSTEDSNIPTHIHDIFQNGLPAD
FRMVGATTRTPDEIPPAIRSRCLEIFFRPLQQDEIEKIADNAAQKIGFPLEKGALDVIKRYATNGRESVNIIQIAGGIAL
TEGRKEILVRDIEWVIHSGQYSPRPERKINPQPQIGVVNGLAVYGPNMGIVSEVEATVIPNVAGTGKITVTGVVEEEEIG
GNGKKVRRKSMARSSVENVVTVLRRVMDVNPQNYDIHVNFLGSGLVDGPSAGVTIATAIYSAIKGIAVDNTVAMTGEISI
RGLVKPIGGVVAKVDAARQAGVKKVLIPRENYQEMFKNMEGIEVIPVDTLGDVITGSLMGQSEKEQQWEPLTSNLELPAA
AFLAQESAKS

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=172, Percent_Identity=40.1162790697674, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI21396489, Length=475, Percent_Identity=26.1052631578947, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1786643, Length=187, Percent_Identity=35.8288770053476, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17556486, Length=495, Percent_Identity=25.4545454545455, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17505831, Length=483, Percent_Identity=24.6376811594203, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319449, Length=97, Percent_Identity=40.2061855670103, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221513036, Length=530, Percent_Identity=25.2830188679245, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24666867, Length=530, Percent_Identity=25.2830188679245, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 62035; Mature: 61904

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGELTSLGGFLTFIQVFFAVVIGLYFWNLLKQQQGNKTAVEKESRKEMEKLQRLRAISLT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EPLAEKTRPKKFSEIIGQEEGLKSLRAALCGPNPQHVIVYGPPGVGKTAAARLVLEEAKK
HHHHHHCCCHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHC
VPSSPFKENAKFIELDATTARFDERGIADPLIGSVHDPIYQGAGPMGMAGIPQPKPGAVT
CCCCCCCCCCCEEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
KAHGGLLFIDEIGELHPIQMNKLLKVLEDRKVFLESAYYSTEDSNIPTHIHDIFQNGLPA
ECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCC
DFRMVGATTRTPDEIPPAIRSRCLEIFFRPLQQDEIEKIADNAAQKIGFPLEKGALDVIK
CEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHCCHHHHHH
RYATNGRESVNIIQIAGGIALTEGRKEILVRDIEWVIHSGQYSPRPERKINPQPQIGVVN
HHHCCCCCCEEEEEEECCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEC
GLAVYGPNMGIVSEVEATVIPNVAGTGKITVTGVVEEEEIGGNGKKVRRKSMARSSVENV
CEEEECCCCCCHHHHHHHCCCCCCCCCCEEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHH
VTVLRRVMDVNPQNYDIHVNFLGSGLVDGPSAGVTIATAIYSAIKGIAVDNTVAMTGEIS
HHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEECCEEEEECCEE
IRGLVKPIGGVVAKVDAARQAGVKKVLIPRENYQEMFKNMEGIEVIPVDTLGDVITGSLM
EHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHC
GQSEKEQQWEPLTSNLELPAAAFLAQESAKS
CCCHHHHHCCCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
GELTSLGGFLTFIQVFFAVVIGLYFWNLLKQQQGNKTAVEKESRKEMEKLQRLRAISLT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
EPLAEKTRPKKFSEIIGQEEGLKSLRAALCGPNPQHVIVYGPPGVGKTAAARLVLEEAKK
HHHHHHCCCHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHC
VPSSPFKENAKFIELDATTARFDERGIADPLIGSVHDPIYQGAGPMGMAGIPQPKPGAVT
CCCCCCCCCCCEEEECCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
KAHGGLLFIDEIGELHPIQMNKLLKVLEDRKVFLESAYYSTEDSNIPTHIHDIFQNGLPA
ECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCC
DFRMVGATTRTPDEIPPAIRSRCLEIFFRPLQQDEIEKIADNAAQKIGFPLEKGALDVIK
CEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHCCHHHHHH
RYATNGRESVNIIQIAGGIALTEGRKEILVRDIEWVIHSGQYSPRPERKINPQPQIGVVN
HHHCCCCCCEEEEEEECCEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEC
GLAVYGPNMGIVSEVEATVIPNVAGTGKITVTGVVEEEEIGGNGKKVRRKSMARSSVENV
CEEEECCCCCCHHHHHHHCCCCCCCCCCEEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHH
VTVLRRVMDVNPQNYDIHVNFLGSGLVDGPSAGVTIATAIYSAIKGIAVDNTVAMTGEIS
HHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEECCEEEEECCEE
IRGLVKPIGGVVAKVDAARQAGVKKVLIPRENYQEMFKNMEGIEVIPVDTLGDVITGSLM
EHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEECCHHHHHHHHHHC
GQSEKEQQWEPLTSNLELPAAAFLAQESAKS
CCCHHHHHCCCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]