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The map label for this gene is lon

Identifier: 134300398

GI number: 134300398

Start: 2784808

End: 2787240

Strand: Reverse

Name: lon

Synonym: Dred_2559

Alternate gene names: 134300398

Gene position: 2787240-2784808 (Counterclockwise)

Preceding gene: 134300399

Following gene: 134300397

Centisome position: 77.25

GC content: 44.55

Gene sequence:

>2433_bases
GTGAATTCCGAAATTAAATCTTTACCCCTGCTCCCATTACGGGGTATTTTGGTATTTCCTTATATGGTCATACACCTAGA
CGTTGGAAGAGAAAAATCAATTCAAGCCATAGAAGAAGCAATGGTTCAGGATAGAATGATTTTCCTAGCAACTCAAAGAG
AGGCTCAGACCGATGAGCCCACAGTGGATGACATTTATAATATTGGAACAGTGGCAGAAGTAAAGCAACTGTTAAAACTT
CCGGGTGGCACAATTAGAGTGCTGGTGGAAGGCATTGCTCGGGCCAAAATTGAAAAATATGAACATCAAGATCCTTATTT
TAGAGTAGAAGTTCAGCAGTATTCGGAAGAATTTGAGAAAGGTGCAGAAGTAGAAGCTCTAATGAGGAGTTTGGTCTATC
AATTTGAGCAATATGTAAAACTTTCTAAAAGAATTCCTCCAGAAACGGTGGTCTCTGTAGTAAATTTAGAAGAACCTGGC
CGTCTGGCTGATATTATTGCCTCTCATTTGGCCCTAAAAATTGAAGATAAGCAAAACGTGCTTGAATCTGTTGAGATAGT
AGATCGCTTGGAAAAACTTTGTGGTATCGTGGCTAAAGAGTTGGAAATTGTTGAATTAGAGCGTAAGATCAACATTCGAG
TTCGCAAGCAAATGGAAAAAACACAAAAAGAGTACTATTTAAGGGAACAAATGAAAGCCATCCAAAAAGAATTAGGTGAA
AAGGATGAGCGGGTGGCTGAATGCGAAGAATTTAGAGAGAAAATTTCTAAGGCTAAGTTCCCAAAAGAAGCTGAAGAAAA
GGCTTTAAAGGAAGTGGAGCGCCTGGAAAAAATGCCCCCAATGGCAGCGGAGGCAGCTGTTGTACGCAACTATCTCGATT
GGATGTTAAGTTTGCCTTGGAGCAAGAGTACTAAAGACCGCATTGATATCAATGCGGCGGAAGAAGTTTTAGAAGCCGAC
CACTACGGATTAAAGGATCCCAAAGAAAGAATCACCGAATATTTAGCTATTCGTAAATTGGCCAAGAAAATGAAAGGTCC
TATACTCTGCTTAGTTGGGCCTCCAGGTGTTGGTAAAACCTCCCTAGGGCGTTCTGTTGCCAGGGCCCTAGATCGCAAGT
TTGTAAGGATTTCCTTGGGAGGTGTACGGGACGAGGCAGAAATACGTGGTCACCGTAGAACCTATGTAGGGGCTATGCCC
GGACGGGTTATCCAAGGAATGAGAACCGCCGGGTCTAAGAATCCGGTATTCCTACTGGATGAAATTGATAAAATGGCCAG
CGATTTCAGAGGAGACCCGTCTTCTGCGTTGCTGGAAGTACTGGATCCTGAGCAAAATAGTACCTTCAGTGACCATTACA
TCGAAACACCCTTTGATCTGTCCAATGTTATGTTTATTACCACAGCTAACAATATGTATTCCATTCCCCGGCCCTTGCTG
GATCGCATGGAAGTTATTCAAATTTCTGGGTATACTGAAGAAGAGAAACTACAAATAGCTAAGCGTCACCTGATGCCTAA
ACAAATTAAAGACCATGGGCTGACCGAAGAAATGATCCAGATTTCCGAAAATACCATTCTGAAAGTGATTCGGGAGTATA
CTCGGGAATCCGGGGTAAGGAATTTGGAGCGCAAGATTGCATCCATCTGCCGTAAAACTGCCAAAAAAATTGTGGCTGGG
CAAGCGGAAAAAGTGAAGGTTACTACCCAGAATCTGGAACAGTTCTTAGGAATTCCCCGTTATCGTTACGGAGTAGCGGA
GCAAAATGATGAAGTGGGTACAGTGACTGGCATGGCCTGGACCGAAGTGGGTGGTGATACCCTGGTCATCGAAGTAACCA
CCTATAAAGGAACCGGTCGTATGACCCTTACAGGTAAACTGGGCGATGTCATGAAAGAATCTGCCCAGGCTGGCTATAGC
TTTATTCGCAGCCGTGCCCAGGAACTTGGTATTGATCAGGAAATGTTTGAGAAGTGGGATTTGCATATTCATATCCCCGA
AGGGGCTATTCCCAAGGACGGTCCCTCTGCCGGTATAACAATGGCTACAGCGATGGCTTCGGTGCTTACGGGACGTAAGG
TGCGACATGATATTGCTATGACCGGTGAAATTACCCTGCGTGGTCGCGTCTTGCCCGTAGGTGGAATTAAAGAGAAGGTC
ATGGCAGCCCACCGGGCAGGTATTAAATTGATCATTCTGCCCAACGATAACAAAAAAGACTTGGAGGATATCCCAGTCAA
CATTAAAAAGCAGCTAGAATTTAAGCTGGTGGATCACATCGATCAGGTGTTGGCCATTGCCCTGCTGGAAAAAGAAGTGG
TAGACACGACCACAGTTTTAGAACCAGAAGCAGCAGTAATGGATAATCCGCACTTTTCGGCGGTGGATTCCCAGGAGGTT
CAGCAGCAAGGAGGAACCCAGTTACCGTCGTGA

Upstream 100 bases:

>100_bases
TTATTGTTATAGCAGTATTAAGAACTTTTATGTTATGATAACTTTATTCTTAGTAACTAATTACTCAACATATGTTTAGA
ATATACAAGGAGGTGCGGCA

Downstream 100 bases:

>100_bases
AAATAGTAGCCGCAGAATTTGTAACAAGTGCAGTTAACCCCGGGGGGTATCCCCCGGGGAATTTACCCGAGGTGGCCTTT
GTGGGACGTTCTAATGTTGG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 810; Mature: 810

Protein sequence:

>810_residues
MNSEIKSLPLLPLRGILVFPYMVIHLDVGREKSIQAIEEAMVQDRMIFLATQREAQTDEPTVDDIYNIGTVAEVKQLLKL
PGGTIRVLVEGIARAKIEKYEHQDPYFRVEVQQYSEEFEKGAEVEALMRSLVYQFEQYVKLSKRIPPETVVSVVNLEEPG
RLADIIASHLALKIEDKQNVLESVEIVDRLEKLCGIVAKELEIVELERKINIRVRKQMEKTQKEYYLREQMKAIQKELGE
KDERVAECEEFREKISKAKFPKEAEEKALKEVERLEKMPPMAAEAAVVRNYLDWMLSLPWSKSTKDRIDINAAEEVLEAD
HYGLKDPKERITEYLAIRKLAKKMKGPILCLVGPPGVGKTSLGRSVARALDRKFVRISLGGVRDEAEIRGHRRTYVGAMP
GRVIQGMRTAGSKNPVFLLDEIDKMASDFRGDPSSALLEVLDPEQNSTFSDHYIETPFDLSNVMFITTANNMYSIPRPLL
DRMEVIQISGYTEEEKLQIAKRHLMPKQIKDHGLTEEMIQISENTILKVIREYTRESGVRNLERKIASICRKTAKKIVAG
QAEKVKVTTQNLEQFLGIPRYRYGVAEQNDEVGTVTGMAWTEVGGDTLVIEVTTYKGTGRMTLTGKLGDVMKESAQAGYS
FIRSRAQELGIDQEMFEKWDLHIHIPEGAIPKDGPSAGITMATAMASVLTGRKVRHDIAMTGEITLRGRVLPVGGIKEKV
MAAHRAGIKLIILPNDNKKDLEDIPVNIKKQLEFKLVDHIDQVLAIALLEKEVVDTTTVLEPEAAVMDNPHFSAVDSQEV
QQQGGTQLPS

Sequences:

>Translated_810_residues
MNSEIKSLPLLPLRGILVFPYMVIHLDVGREKSIQAIEEAMVQDRMIFLATQREAQTDEPTVDDIYNIGTVAEVKQLLKL
PGGTIRVLVEGIARAKIEKYEHQDPYFRVEVQQYSEEFEKGAEVEALMRSLVYQFEQYVKLSKRIPPETVVSVVNLEEPG
RLADIIASHLALKIEDKQNVLESVEIVDRLEKLCGIVAKELEIVELERKINIRVRKQMEKTQKEYYLREQMKAIQKELGE
KDERVAECEEFREKISKAKFPKEAEEKALKEVERLEKMPPMAAEAAVVRNYLDWMLSLPWSKSTKDRIDINAAEEVLEAD
HYGLKDPKERITEYLAIRKLAKKMKGPILCLVGPPGVGKTSLGRSVARALDRKFVRISLGGVRDEAEIRGHRRTYVGAMP
GRVIQGMRTAGSKNPVFLLDEIDKMASDFRGDPSSALLEVLDPEQNSTFSDHYIETPFDLSNVMFITTANNMYSIPRPLL
DRMEVIQISGYTEEEKLQIAKRHLMPKQIKDHGLTEEMIQISENTILKVIREYTRESGVRNLERKIASICRKTAKKIVAG
QAEKVKVTTQNLEQFLGIPRYRYGVAEQNDEVGTVTGMAWTEVGGDTLVIEVTTYKGTGRMTLTGKLGDVMKESAQAGYS
FIRSRAQELGIDQEMFEKWDLHIHIPEGAIPKDGPSAGITMATAMASVLTGRKVRHDIAMTGEITLRGRVLPVGGIKEKV
MAAHRAGIKLIILPNDNKKDLEDIPVNIKKQLEFKLVDHIDQVLAIALLEKEVVDTTTVLEPEAAVMDNPHFSAVDSQEV
QQQGGTQLPS
>Mature_810_residues
MNSEIKSLPLLPLRGILVFPYMVIHLDVGREKSIQAIEEAMVQDRMIFLATQREAQTDEPTVDDIYNIGTVAEVKQLLKL
PGGTIRVLVEGIARAKIEKYEHQDPYFRVEVQQYSEEFEKGAEVEALMRSLVYQFEQYVKLSKRIPPETVVSVVNLEEPG
RLADIIASHLALKIEDKQNVLESVEIVDRLEKLCGIVAKELEIVELERKINIRVRKQMEKTQKEYYLREQMKAIQKELGE
KDERVAECEEFREKISKAKFPKEAEEKALKEVERLEKMPPMAAEAAVVRNYLDWMLSLPWSKSTKDRIDINAAEEVLEAD
HYGLKDPKERITEYLAIRKLAKKMKGPILCLVGPPGVGKTSLGRSVARALDRKFVRISLGGVRDEAEIRGHRRTYVGAMP
GRVIQGMRTAGSKNPVFLLDEIDKMASDFRGDPSSALLEVLDPEQNSTFSDHYIETPFDLSNVMFITTANNMYSIPRPLL
DRMEVIQISGYTEEEKLQIAKRHLMPKQIKDHGLTEEMIQISENTILKVIREYTRESGVRNLERKIASICRKTAKKIVAG
QAEKVKVTTQNLEQFLGIPRYRYGVAEQNDEVGTVTGMAWTEVGGDTLVIEVTTYKGTGRMTLTGKLGDVMKESAQAGYS
FIRSRAQELGIDQEMFEKWDLHIHIPEGAIPKDGPSAGITMATAMASVLTGRKVRHDIAMTGEITLRGRVLPVGGIKEKV
MAAHRAGIKLIILPNDNKKDLEDIPVNIKKQLEFKLVDHIDQVLAIALLEKEVVDTTTVLEPEAAVMDNPHFSAVDSQEV
QQQGGTQLPS

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=827, Percent_Identity=39.782345828295, Blast_Score=606, Evalue=1e-173,
Organism=Homo sapiens, GI21396489, Length=829, Percent_Identity=39.2038600723764, Blast_Score=580, Evalue=1e-165,
Organism=Escherichia coli, GI1786643, Length=767, Percent_Identity=55.2803129074316, Blast_Score=885, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=703, Percent_Identity=39.5448079658606, Blast_Score=526, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17556486, Length=801, Percent_Identity=33.083645443196, Blast_Score=459, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319449, Length=693, Percent_Identity=40.6926406926407, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI221513036, Length=692, Percent_Identity=43.4971098265896, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24666867, Length=692, Percent_Identity=43.4971098265896, Blast_Score=558, Evalue=1e-159,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_DESRM (A4J7L6)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113894.1
- ProteinModelPortal:   A4J7L6
- STRING:   A4J7L6
- MEROPS:   S16.001
- GeneID:   4957999
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_2559
- eggNOG:   COG0466
- HOGENOM:   HBG566281
- OMA:   IDPDFHE
- PhylomeDB:   A4J7L6
- ProtClustDB:   CLSK928788
- BioCyc:   DRED349161:DRED_2559-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 91334; Mature: 91334

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 676-676 ACT_SITE 719-719

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSEIKSLPLLPLRGILVFPYMVIHLDVGREKSIQAIEEAMVQDRMIFLATQREAQTDEP
CCCCCCCCCCCHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCC
TVDDIYNIGTVAEVKQLLKLPGGTIRVLVEGIARAKIEKYEHQDPYFRVEVQQYSEEFEK
CHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHC
GAEVEALMRSLVYQFEQYVKLSKRIPPETVVSVVNLEEPGRLADIIASHLALKIEDKQNV
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHEEEECHHHHH
LESVEIVDRLEKLCGIVAKELEIVELERKINIRVRKQMEKTQKEYYLREQMKAIQKELGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KDERVAECEEFREKISKAKFPKEAEEKALKEVERLEKMPPMAAEAAVVRNYLDWMLSLPW
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
SKSTKDRIDINAAEEVLEADHYGLKDPKERITEYLAIRKLAKKMKGPILCLVGPPGVGKT
CCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHH
SLGRSVARALDRKFVRISLGGVRDEAEIRGHRRTYVGAMPGRVIQGMRTAGSKNPVFLLD
HHHHHHHHHHHHHEEEEEECCCCCHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCEEEHH
EIDKMASDFRGDPSSALLEVLDPEQNSTFSDHYIETPFDLSNVMFITTANNMYSIPRPLL
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHH
DRMEVIQISGYTEEEKLQIAKRHLMPKQIKDHGLTEEMIQISENTILKVIREYTRESGVR
HHHHEEEECCCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NLERKIASICRKTAKKIVAGQAEKVKVTTQNLEQFLGIPRYRYGVAEQNDEVGTVTGMAW
HHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCCEEEECCEE
TEVGGDTLVIEVTTYKGTGRMTLTGKLGDVMKESAQAGYSFIRSRAQELGIDQEMFEKWD
EECCCCEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
LHIHIPEGAIPKDGPSAGITMATAMASVLTGRKVRHDIAMTGEITLRGRVLPVGGIKEKV
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHEEECEEEEEEEEEECCCHHHHH
MAAHRAGIKLIILPNDNKKDLEDIPVNIKKQLEFKLVDHIDQVLAIALLEKEVVDTTTVL
HHHHHCCEEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
EPEAAVMDNPHFSAVDSQEVQQQGGTQLPS
CCCHHHCCCCCCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure
MNSEIKSLPLLPLRGILVFPYMVIHLDVGREKSIQAIEEAMVQDRMIFLATQREAQTDEP
CCCCCCCCCCCHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCC
TVDDIYNIGTVAEVKQLLKLPGGTIRVLVEGIARAKIEKYEHQDPYFRVEVQQYSEEFEK
CHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHC
GAEVEALMRSLVYQFEQYVKLSKRIPPETVVSVVNLEEPGRLADIIASHLALKIEDKQNV
CCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHEEEECHHHHH
LESVEIVDRLEKLCGIVAKELEIVELERKINIRVRKQMEKTQKEYYLREQMKAIQKELGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KDERVAECEEFREKISKAKFPKEAEEKALKEVERLEKMPPMAAEAAVVRNYLDWMLSLPW
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
SKSTKDRIDINAAEEVLEADHYGLKDPKERITEYLAIRKLAKKMKGPILCLVGPPGVGKT
CCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHH
SLGRSVARALDRKFVRISLGGVRDEAEIRGHRRTYVGAMPGRVIQGMRTAGSKNPVFLLD
HHHHHHHHHHHHHEEEEEECCCCCHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCEEEHH
EIDKMASDFRGDPSSALLEVLDPEQNSTFSDHYIETPFDLSNVMFITTANNMYSIPRPLL
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHH
DRMEVIQISGYTEEEKLQIAKRHLMPKQIKDHGLTEEMIQISENTILKVIREYTRESGVR
HHHHEEEECCCCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NLERKIASICRKTAKKIVAGQAEKVKVTTQNLEQFLGIPRYRYGVAEQNDEVGTVTGMAW
HHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCCCCCCCCCCCEEEECCEE
TEVGGDTLVIEVTTYKGTGRMTLTGKLGDVMKESAQAGYSFIRSRAQELGIDQEMFEKWD
EECCCCEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCC
LHIHIPEGAIPKDGPSAGITMATAMASVLTGRKVRHDIAMTGEITLRGRVLPVGGIKEKV
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHEEECEEEEEEEEEECCCHHHHH
MAAHRAGIKLIILPNDNKKDLEDIPVNIKKQLEFKLVDHIDQVLAIALLEKEVVDTTTVL
HHHHHCCEEEEEECCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
EPEAAVMDNPHFSAVDSQEVQQQGGTQLPS
CCCHHHCCCCCCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA