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The map label for this gene is obg

Identifier: 134300371

GI number: 134300371

Start: 2755778

End: 2757046

Strand: Reverse

Name: obg

Synonym: Dred_2532

Alternate gene names: 134300371

Gene position: 2757046-2755778 (Counterclockwise)

Preceding gene: 134300372

Following gene: 134300370

Centisome position: 76.41

GC content: 46.57

Gene sequence:

>1269_bases
ATGTTTTATGATAGGGCAAAAATTTACGTCAAGGGTGGAGACGGTGGCAATGGTTGTATCGCCATGCGTCGTGAAAAATA
TGTACCCTTTGGCGGCCCATGGGGCGGAGATGGCGGCCACGGTGGGGATGTAACCTTTATAGCCGACGAAGGACTGAATA
CACTACAGGATTTCCGTTACAAGAAGCACTTTAAGGCAGAGCGTGGCGGTCACGGAATGGGTAAAAATATGAATGGCCCG
GCAGGCGAGGATTTACTGGTTAAAGTCCCCACAGGTACCGTGGTTCGTGAAGCTGAAACAGGTAGACTAATTGCAGATCT
GCTGGAAAATGGGCAGCAGGTTGTTATTGCTAAAGGGGGCCGAGGCGGTCGGGGTAATGTCCATTTTGCTTCAAGTAGCA
ACAAAGCACCTCGTATTGCAGAAAAAGGTGAGCCAGGGGAAGAATTGTGGTTAGAGTTGGAGTTAAAAGTTATTGCGGAT
GTTGGTCTCATTGGTTTTCCCAATGCCGGTAAGTCCACCTTTATTTCTATGGTCTCCGCTGCTAAACCGAAAATTGCTGA
TTACCCCTTTACTACTCTGGTTCCCAATTTGGGAGTTGTGTCAGCCGGAGAAGAAGGAAGTTTCGTGTTGGCAGATATAC
CAGGCTTAGTTGAGGGTGCTTCCCAGGGGGTTGGCCTTGGGCATGAATTTTTACGTCATACCGAGCGCACTCGGTTGTTG
ATTCACGTGGTGGATACCGCTGGCACCGAGGGGCGGGACCCCGTGGAAGATATTAAAATTATTAATCGCGAATTAGAACT
CTATGATCCACGGTTGTCAACAAGACCCCAAATTATTGCGGCTAATAAAATGGATATTATCCCTCTGGCAGAGGAAAATT
TAGCACGTCTTAGAGAAGAGTTTGGAGAGCAATTCGAAATTTATCCCATATCCGCTGCCACCAACCAGGGATTGGATAAA
GTTATCCATCGGGTGGCTGAACTATTGGCACAATTACCCAAAATCGAGCCAGAACAACCCGAAGAGGATGTAATGTTTGA
ACCAGAAGAAAGGTTTAACATTAAGAGGGATATCGACGGTAACTGGCGTGTCACCGGCAAAGAAATTGAGCGTCATGTGG
CCATGACCTATCTGGAAGAAGATCAGTCACTTGAACGGTTGCAAAGAATTATGAAAATGATGGGATTAGAGAATGGGCTT
GTTGAGGCTGGAGTTAAAGTAGGCGATATTGTTCGAATTGGAGACTGGGAATTTGAATGGTCTGAATAA

Upstream 100 bases:

>100_bases
GCTGTAACAGAAAAAGAAGCAGAAATCTATATGATATTTCCAAAGAAATAGGCTTAGGAAAATTAAGGCGGTAAATAATA
GTATTGGGTGATGAATAACA

Downstream 100 bases:

>100_bases
CCATGCCTCTAACATAGAAATTGTATTACCTGAACTGATTGAGGCAGTATTTGTGGAAAGAGTAAATCGTTTTGTAGGGA
TGGTTCAAGTGGCGGGGCAT

Product: GTP1/OBG domain-containing protein

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MFYDRAKIYVKGGDGGNGCIAMRREKYVPFGGPWGGDGGHGGDVTFIADEGLNTLQDFRYKKHFKAERGGHGMGKNMNGP
AGEDLLVKVPTGTVVREAETGRLIADLLENGQQVVIAKGGRGGRGNVHFASSSNKAPRIAEKGEPGEELWLELELKVIAD
VGLIGFPNAGKSTFISMVSAAKPKIADYPFTTLVPNLGVVSAGEEGSFVLADIPGLVEGASQGVGLGHEFLRHTERTRLL
IHVVDTAGTEGRDPVEDIKIINRELELYDPRLSTRPQIIAANKMDIIPLAEENLARLREEFGEQFEIYPISAATNQGLDK
VIHRVAELLAQLPKIEPEQPEEDVMFEPEERFNIKRDIDGNWRVTGKEIERHVAMTYLEEDQSLERLQRIMKMMGLENGL
VEAGVKVGDIVRIGDWEFEWSE

Sequences:

>Translated_422_residues
MFYDRAKIYVKGGDGGNGCIAMRREKYVPFGGPWGGDGGHGGDVTFIADEGLNTLQDFRYKKHFKAERGGHGMGKNMNGP
AGEDLLVKVPTGTVVREAETGRLIADLLENGQQVVIAKGGRGGRGNVHFASSSNKAPRIAEKGEPGEELWLELELKVIAD
VGLIGFPNAGKSTFISMVSAAKPKIADYPFTTLVPNLGVVSAGEEGSFVLADIPGLVEGASQGVGLGHEFLRHTERTRLL
IHVVDTAGTEGRDPVEDIKIINRELELYDPRLSTRPQIIAANKMDIIPLAEENLARLREEFGEQFEIYPISAATNQGLDK
VIHRVAELLAQLPKIEPEQPEEDVMFEPEERFNIKRDIDGNWRVTGKEIERHVAMTYLEEDQSLERLQRIMKMMGLENGL
VEAGVKVGDIVRIGDWEFEWSE
>Mature_422_residues
MFYDRAKIYVKGGDGGNGCIAMRREKYVPFGGPWGGDGGHGGDVTFIADEGLNTLQDFRYKKHFKAERGGHGMGKNMNGP
AGEDLLVKVPTGTVVREAETGRLIADLLENGQQVVIAKGGRGGRGNVHFASSSNKAPRIAEKGEPGEELWLELELKVIAD
VGLIGFPNAGKSTFISMVSAAKPKIADYPFTTLVPNLGVVSAGEEGSFVLADIPGLVEGASQGVGLGHEFLRHTERTRLL
IHVVDTAGTEGRDPVEDIKIINRELELYDPRLSTRPQIIAANKMDIIPLAEENLARLREEFGEQFEIYPISAATNQGLDK
VIHRVAELLAQLPKIEPEQPEEDVMFEPEERFNIKRDIDGNWRVTGKEIERHVAMTYLEEDQSLERLQRIMKMMGLENGL
VEAGVKVGDIVRIGDWEFEWSE

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=323, Percent_Identity=43.0340557275542, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI111955139, Length=347, Percent_Identity=36.0230547550432, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI111955063, Length=247, Percent_Identity=37.246963562753, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI58761500, Length=132, Percent_Identity=34.0909090909091, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4557537, Length=144, Percent_Identity=31.9444444444444, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4758796, Length=127, Percent_Identity=34.6456692913386, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1789574, Length=346, Percent_Identity=50.5780346820809, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI1787454, Length=132, Percent_Identity=34.8484848484849, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1790615, Length=199, Percent_Identity=25.1256281407035, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=329, Percent_Identity=37.6899696048632, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17552324, Length=321, Percent_Identity=31.7757009345794, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17509631, Length=128, Percent_Identity=35.9375, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71981008, Length=118, Percent_Identity=33.8983050847458, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17555344, Length=118, Percent_Identity=32.2033898305085, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=192, Percent_Identity=40.1041666666667, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321649, Length=141, Percent_Identity=31.9148936170213, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321612, Length=92, Percent_Identity=35.8695652173913, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24585318, Length=359, Percent_Identity=37.6044568245125, Blast_Score=178, Evalue=5e-45,
Organism=Drosophila melanogaster, GI20129375, Length=325, Percent_Identity=39.0769230769231, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24640873, Length=132, Percent_Identity=35.6060606060606, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24640877, Length=132, Percent_Identity=35.6060606060606, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24640875, Length=132, Percent_Identity=35.6060606060606, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356473, Length=126, Percent_Identity=34.9206349206349, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17981711, Length=127, Percent_Identity=32.2834645669291, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_DESRM (A4J7I9)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113867.1
- ProteinModelPortal:   A4J7I9
- SMR:   A4J7I9
- STRING:   A4J7I9
- GeneID:   4955761
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_2532
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   HFTTLVP
- PhylomeDB:   A4J7I9
- BioCyc:   DRED349161:DRED_2532-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR03595

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF102741 GTP-bd_prot_GTP1/OBG_C; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 46483; Mature: 46483

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00905 GTP1_OBG; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYDRAKIYVKGGDGGNGCIAMRREKYVPFGGPWGGDGGHGGDVTFIADEGLNTLQDFRY
CCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHH
KKHFKAERGGHGMGKNMNGPAGEDLLVKVPTGTVVREAETGRLIADLLENGQQVVIAKGG
HHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCHHHHHHHHCCCEEEEEECC
RGGRGNVHFASSSNKAPRIAEKGEPGEELWLELELKVIADVGLIGFPNAGKSTFISMVSA
CCCCCCEEEECCCCCCCCCCCCCCCHHHEEEEEEEEEEEEECEEECCCCCHHHHHHHHHH
AKPKIADYPFTTLVPNLGVVSAGEEGSFVLADIPGLVEGASQGVGLGHEFLRHTERTRLL
CCCCCCCCCHHHHCCCCCEEECCCCCCEEEEECCHHHHCCCCCCCCCHHHHHHHCCCEEE
IHVVDTAGTEGRDPVEDIKIINRELELYDPRLSTRPQIIAANKMDIIPLAEENLARLREE
EEEEECCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCEEEECCEEEEECCHHHHHHHHHH
FGEQFEIYPISAATNQGLDKVIHRVAELLAQLPKIEPEQPEEDVMFEPEERFNIKRDIDG
HCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCHHHCCEEECCCC
NWRVTGKEIERHVAMTYLEEDQSLERLQRIMKMMGLENGLVEAGVKVGDIVRIGDWEFEW
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEECCEEEEC
SE
CC
>Mature Secondary Structure
MFYDRAKIYVKGGDGGNGCIAMRREKYVPFGGPWGGDGGHGGDVTFIADEGLNTLQDFRY
CCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHH
KKHFKAERGGHGMGKNMNGPAGEDLLVKVPTGTVVREAETGRLIADLLENGQQVVIAKGG
HHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCCCHHHHHHHHCCCEEEEEECC
RGGRGNVHFASSSNKAPRIAEKGEPGEELWLELELKVIADVGLIGFPNAGKSTFISMVSA
CCCCCCEEEECCCCCCCCCCCCCCCHHHEEEEEEEEEEEEECEEECCCCCHHHHHHHHHH
AKPKIADYPFTTLVPNLGVVSAGEEGSFVLADIPGLVEGASQGVGLGHEFLRHTERTRLL
CCCCCCCCCHHHHCCCCCEEECCCCCCEEEEECCHHHHCCCCCCCCCHHHHHHHCCCEEE
IHVVDTAGTEGRDPVEDIKIINRELELYDPRLSTRPQIIAANKMDIIPLAEENLARLREE
EEEEECCCCCCCCHHHHHHHHHHHHHEECCCCCCCCCEEEECCEEEEECCHHHHHHHHHH
FGEQFEIYPISAATNQGLDKVIHRVAELLAQLPKIEPEQPEEDVMFEPEERFNIKRDIDG
HCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCHHHCCEEECCCC
NWRVTGKEIERHVAMTYLEEDQSLERLQRIMKMMGLENGLVEAGVKVGDIVRIGDWEFEW
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEEECCEEEEC
SE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA