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The map label for this gene is 134300359

Identifier: 134300359

GI number: 134300359

Start: 2739895

End: 2740404

Strand: Reverse

Name: 134300359

Synonym: Dred_2520

Alternate gene names: NA

Gene position: 2740404-2739895 (Counterclockwise)

Preceding gene: 134300361

Following gene: 134300358

Centisome position: 75.95

GC content: 43.53

Gene sequence:

>510_bases
ATGGAAAATTTGTGGGCCCCCTGGCGATCTATTTATATCGGAAAACCCCAAACAGGGTGCATCTTTTGTGAAAAGCTAAA
CTCGGATCAGGACGAAGAAAATCTTGTGATTTACCGGGGAGATAAGACCTTTGTTATTATGAATTTGTACCCTTATAATA
ACGGACACCTCCTGATTGCCCCCAAAAGACATGTGGGAGATATTACAGAGCTTACTGATGAAGAATTGCTCGAATTACAT
AAAATGACACAATTCATGGTGCAAGCCCTTCGGAGAGCCTTTGGTAACCCACATGGTTTTAATATTGGCATCAATCTTGG
TAAGGTAGCCGGGGCTGGGATACCCGGGCATCTTCATGTTCACATTGTACCTCGCTGGGACGGGGATGCTAATTTCATGG
CTGTCATTGGAGATACACGGGTTATTTCTGAGGGGTTGCAGCGTACCTATGAAAAAATAACCAGAGCCATTACGGCATTA
AAAAGCGAAGGATCGACCAATGGTAATTAA

Upstream 100 bases:

>100_bases
AACAGAATAATCCTTAATAGAACAAGATCTTTTTATTTAGAAGGTATTTAACAAATAAAAAAGAAAAATATGTTTTAAAG
AAGAAACGGGAGATGATAGT

Downstream 100 bases:

>100_bases
TATTTAGTAAAGCTATTTATCATGTCTGGTTGCTTTTTGATAAAATTACCATTAAAATGACGTTAGTTAAAGGTGAAAGG
ATATTACACATGCAAGAAAT

Product: histidine triad (HIT) protein

Products: NA

Alternate protein names: ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase [H]

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MENLWAPWRSIYIGKPQTGCIFCEKLNSDQDEENLVIYRGDKTFVIMNLYPYNNGHLLIAPKRHVGDITELTDEELLELH
KMTQFMVQALRRAFGNPHGFNIGINLGKVAGAGIPGHLHVHIVPRWDGDANFMAVIGDTRVISEGLQRTYEKITRAITAL
KSEGSTNGN

Sequences:

>Translated_169_residues
MENLWAPWRSIYIGKPQTGCIFCEKLNSDQDEENLVIYRGDKTFVIMNLYPYNNGHLLIAPKRHVGDITELTDEELLELH
KMTQFMVQALRRAFGNPHGFNIGINLGKVAGAGIPGHLHVHIVPRWDGDANFMAVIGDTRVISEGLQRTYEKITRAITAL
KSEGSTNGN
>Mature_169_residues
MENLWAPWRSIYIGKPQTGCIFCEKLNSDQDEENLVIYRGDKTFVIMNLYPYNNGHLLIAPKRHVGDITELTDEELLELH
KMTQFMVQALRRAFGNPHGFNIGINLGKVAGAGIPGHLHVHIVPRWDGDANFMAVIGDTRVISEGLQRTYEKITRAITAL
KSEGSTNGN

Specific function: Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues [H]

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17556280, Length=94, Percent_Identity=39.3617021276596, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: =2.7.7.53 [H]

Molecular weight: Translated: 18974; Mature: 18974

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENLWAPWRSIYIGKPQTGCIFCEKLNSDQDEENLVIYRGDKTFVIMNLYPYNNGHLLIA
CCCCCCCCCEEEECCCCCCEEEEECCCCCCCCCCEEEEECCCEEEEEEEEECCCCEEEEE
PKRHVGDITELTDEELLELHKMTQFMVQALRRAFGNPHGFNIGINLGKVAGAGIPGHLHV
CCHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEEEE
HIVPRWDGDANFMAVIGDTRVISEGLQRTYEKITRAITALKSEGSTNGN
EEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MENLWAPWRSIYIGKPQTGCIFCEKLNSDQDEENLVIYRGDKTFVIMNLYPYNNGHLLIA
CCCCCCCCCEEEECCCCCCEEEEECCCCCCCCCCEEEEECCCEEEEEEEEECCCCEEEEE
PKRHVGDITELTDEELLELHKMTQFMVQALRRAFGNPHGFNIGINLGKVAGAGIPGHLHV
CCHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCEEEE
HIVPRWDGDANFMAVIGDTRVISEGLQRTYEKITRAITALKSEGSTNGN
EEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036 [H]