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The map label for this gene is accD

Identifier: 134300154

GI number: 134300154

Start: 2533084

End: 2533950

Strand: Reverse

Name: accD

Synonym: Dred_2315

Alternate gene names: 134300154

Gene position: 2533950-2533084 (Counterclockwise)

Preceding gene: 134300155

Following gene: 134300153

Centisome position: 70.23

GC content: 41.06

Gene sequence:

>867_bases
TTGGTCCTAGAAATATTTCGCAAACCTAAATATGTAACTGTACGTCCCGAAAAAACAGAAACGACTCAAGGCAACGAAAG
AAGAGACATTCCAGAAGGTTTATGGGTAAAATGTTCTCGCTGCAATGAAATTCTTTATACAAAGGAATTGGATAAAAATT
TTAAGGTATGTCATAAGTGCAATTTTCATTTTAGGTTAAATGCGCAAGAGCGTATTCATATGACCCTAGATGAAGGTTCT
TTTCAGGAACGTGACAATGAGTTAATTACATTGAATCCATTGAATTTTCCAGATTATCAGGAAAAAATACAGTCTGCTCA
AAAAGCAACTGAATTGAAGGAAGCCGTAGTAACCGGCGAAGGTACCATAGGCGGAAATCCTGTGGTCATTGGTGTTATGG
ACTCGCATTTTATTATGGGTAGTATGGGATCTGTGGTTGGAGAAAAAATTGCCCGTGCCATTGAAAGAGCCATTGAAAAG
AAATTACCGGTGGTTCTGTTTTCTACTTCCGGTGGTGCCAGGATGCAGGAGGGAATTTTATCTCTTATGCAAATGGCAAA
AACTGCTGCAGCTTTGGCTAAATTAGATGAAGCGGGATTATTGTATGTTGCTGTCCTTACTGACCCCACAACCGGCGGAG
TAACAGCCAGCTTTGCCTCTCTGGGAGATATTATTATAGCAGAACCCGGAGCTTTAATTGGTTTTACCGGCCCTAGGGTT
ATTGAGCAAACCATTCGGCAAAAGTTACCCGAGGGCTTCCAAAGGGCTGAGTTTTTGCGAAAGCATGGTATGGTCGATAT
GATTGTGAATCGTCCACAGCTTAAAGATACCCTGGCTAACATTCTTTCACTTCATGGGACGAATTAA

Upstream 100 bases:

>100_bases
TGGATCGGTAGAAATCTTAGTACCGGAATCAGAGCTGGATGAGGCATTGGAAATTATCAATACAGTATAAAGCTACGGGG
AACTAAGGGAGAGGTGAGTT

Downstream 100 bases:

>100_bases
AGGAGGCCAGTATGGCGTTAGATTTTGAAAGGCCAATATTGGAGTTAGAGGCTAAAATTGAAGAGCTAAAGAGATTTACC
AATGAAAAGGGGATTGACTT

Product: acetyl-CoA carboxylase, carboxyl transferase subunit beta

Products: NA

Alternate protein names: ACCase subunit beta; Acetyl-CoA carboxylase carboxyltransferase subunit beta

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MVLEIFRKPKYVTVRPEKTETTQGNERRDIPEGLWVKCSRCNEILYTKELDKNFKVCHKCNFHFRLNAQERIHMTLDEGS
FQERDNELITLNPLNFPDYQEKIQSAQKATELKEAVVTGEGTIGGNPVVIGVMDSHFIMGSMGSVVGEKIARAIERAIEK
KLPVVLFSTSGGARMQEGILSLMQMAKTAAALAKLDEAGLLYVAVLTDPTTGGVTASFASLGDIIIAEPGALIGFTGPRV
IEQTIRQKLPEGFQRAEFLRKHGMVDMIVNRPQLKDTLANILSLHGTN

Sequences:

>Translated_288_residues
MVLEIFRKPKYVTVRPEKTETTQGNERRDIPEGLWVKCSRCNEILYTKELDKNFKVCHKCNFHFRLNAQERIHMTLDEGS
FQERDNELITLNPLNFPDYQEKIQSAQKATELKEAVVTGEGTIGGNPVVIGVMDSHFIMGSMGSVVGEKIARAIERAIEK
KLPVVLFSTSGGARMQEGILSLMQMAKTAAALAKLDEAGLLYVAVLTDPTTGGVTASFASLGDIIIAEPGALIGFTGPRV
IEQTIRQKLPEGFQRAEFLRKHGMVDMIVNRPQLKDTLANILSLHGTN
>Mature_288_residues
MVLEIFRKPKYVTVRPEKTETTQGNERRDIPEGLWVKCSRCNEILYTKELDKNFKVCHKCNFHFRLNAQERIHMTLDEGS
FQERDNELITLNPLNFPDYQEKIQSAQKATELKEAVVTGEGTIGGNPVVIGVMDSHFIMGSMGSVVGEKIARAIERAIEK
KLPVVLFSTSGGARMQEGILSLMQMAKTAAALAKLDEAGLLYVAVLTDPTTGGVTASFASLGDIIIAEPGALIGFTGPRV
IEQTIRQKLPEGFQRAEFLRKHGMVDMIVNRPQLKDTLANILSLHGTN

Specific function: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA

COG id: COG0777

COG function: function code I; Acetyl-CoA carboxylase beta subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AccD/PCCB family

Homologues:

Organism=Homo sapiens, GI119943100, Length=188, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1788655, Length=260, Percent_Identity=55.7692307692308, Blast_Score=302, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI25147359, Length=188, Percent_Identity=27.1276595744681, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147362, Length=188, Percent_Identity=27.1276595744681, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACCD_DESRM (A4J6X2)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113650.1
- ProteinModelPortal:   A4J6X2
- SMR:   A4J6X2
- STRING:   A4J6X2
- GeneID:   4958441
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_2315
- eggNOG:   COG0777
- HOGENOM:   HBG285696
- OMA:   LEHGMVD
- PhylomeDB:   A4J6X2
- ProtClustDB:   CLSK853682
- BioCyc:   DRED349161:DRED_2315-MONOMER
- HAMAP:   MF_01395
- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011762
- PRINTS:   PR01070
- TIGRFAMs:   TIGR00515

Pfam domain/function: PF01039 Carboxyl_trans

EC number: =6.4.1.2

Molecular weight: Translated: 31885; Mature: 31885

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS50980 COA_CT_NTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLEIFRKPKYVTVRPEKTETTQGNERRDIPEGLWVKCSRCNEILYTKELDKNFKVCHKC
CEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEHHHHCCCHHHHHCC
NFHFRLNAQERIHMTLDEGSFQERDNELITLNPLNFPDYQEKIQSAQKATELKEAVVTGE
CCEEEECCCCEEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
GTIGGNPVVIGVMDSHFIMGSMGSVVGEKIARAIERAIEKKLPVVLFSTSGGARMQEGIL
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHH
SLMQMAKTAAALAKLDEAGLLYVAVLTDPTTGGVTASFASLGDIIIAEPGALIGFTGPRV
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHCCEEEECCCCEEECCCHHH
IEQTIRQKLPEGFQRAEFLRKHGMVDMIVNRPQLKDTLANILSLHGTN
HHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVLEIFRKPKYVTVRPEKTETTQGNERRDIPEGLWVKCSRCNEILYTKELDKNFKVCHKC
CEEEEECCCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEHHHHCCCHHHHHCC
NFHFRLNAQERIHMTLDEGSFQERDNELITLNPLNFPDYQEKIQSAQKATELKEAVVTGE
CCEEEECCCCEEEEEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCC
GTIGGNPVVIGVMDSHFIMGSMGSVVGEKIARAIERAIEKKLPVVLFSTSGGARMQEGIL
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHH
SLMQMAKTAAALAKLDEAGLLYVAVLTDPTTGGVTASFASLGDIIIAEPGALIGFTGPRV
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHCCEEEECCCCEEECCCHHH
IEQTIRQKLPEGFQRAEFLRKHGMVDMIVNRPQLKDTLANILSLHGTN
HHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA