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The map label for this gene is atoS [H]

Identifier: 134300114

GI number: 134300114

Start: 2487074

End: 2488747

Strand: Reverse

Name: atoS [H]

Synonym: Dred_2275

Alternate gene names: 134300114

Gene position: 2488747-2487074 (Counterclockwise)

Preceding gene: 134300115

Following gene: 134300113

Centisome position: 68.98

GC content: 41.46

Gene sequence:

>1674_bases
ATGTTTGACGATAAACTAACCATCATACAAAATTTAACTGGTGTTAACTCTTCAAAATTAAATTATTACTTGGCAGCCCA
ACGGTCCAATGAACAAATTAAGATTCAAATGAATCGCATGGAAATTTTACACCAGATCATTAAAGATATTAATATTGATA
TGTCTTTGGCTGATATAGTAGGACGGGTTTACAATAAACTTCCCAAGGCTATACCTTGCTGTTTTTTAGGATTGGCACTG
GCGGAAAATGATAAGTTAATTATGACCGCTGCAACACCTGTCAGTGATTGTGTGGGACAACCGGTTCCATCGCTATCGGT
TATTTGGCAATCCTACAGTCAGTGCAAGCGAATTTTGTATGACCTAGGCAGTCAATCGAAACAACTGTGTCCCTTGATGA
ATGGGAAGGACCCGGTAGAAAGTTTGGGCCTGAAATCGACGGCCATTGTTCCTTTATTGGTTCGCAGCCAAGTGATTGGG
GTTCTCATAGTGGGAGATAATCATATTTCGGCCTATGGTAATTCAGAAGTAACATTTATTGAACAGATGGCTGACCAGTT
GGCCATCTGCATTGAGAATGCCCGCTTATATAAAGAGGTCTCAAAGGGGAAGCAGCAGTGGGAAGATACCTTTAAGGCTG
TGCCAGATCCCATTATCCTTATTGATAAGAACTACAAAGTTTTAAGGCATAATCTGCGAGAGGCTCAATCCCTTACTATG
AACCTAGGGGATGGAGTCAACCCCCAATGTTACCAGGCTCTCTGGCAAAGAGAAATTCCCTGTGAACATTGTCCACTGGC
TAAAGTGTATCAAACGGGCAGGGGTGTTTACCTGCAAGTCCAAAATGAAGGGACTATTTTTGATTCCTTTTATTATCCCA
TGGTGGATACAAATGGAGAAATATATGCAGTGATATTGCATATGAAAGATGTAACCGAAAAGGTAAAGATGGAAGCACAG
TTAATGCACTCGGCAAAGTTGGTTGCCATAGGAGAGATGGCTGCCGGGGTTGCCCATGAACTAAACAGCCCTATGACCGT
AATTATTGGTACTGCTCAGATGATGCAGAGGGATATGGGGCCGGAAGACCCTCGGTCTGAATGGCTGGACGATATTATTG
GGTGCGGTATGCGATGCAAAAAGATTATTCAAAACTTATTATCTTTCTCCAGACAAGGTCAGTTTGCCCTTAACGAAACT
GATATTAATCAGCAGGTTGAAAAAGTATTAAGCTTGATCCATTATCAAATAAACCGGAACAATATTAATATTATTAAAAA
TTTGGACCTGAATGTTCCTTATATTATGGCTAACGGTCACCAGATACAACAAGTATTAATTAATTTACTGTTAAATGCCA
GGGATGCCCTGGAGGAAATAGAGGGTGAAAAGAGTATTTGGATTTCAACCACCGTTGAAAGTGATCAGGAAACCCAATGG
GTGGTGTTAACAGTTCGGGATAATGGCTGTGGTATTCATCCAGAGGGGTTAAATAAGATATTTAACCCCTTCTACACCAG
TAAAGAAGCAAGCAAAGGAACAGGACTGGGGCTTTCAGTAAGTTTGGGAATTGCCCAGTCCCACGGTGGAACCATTAAGG
TCGAAAGTCAGCAAGGATTCGGCAGTTCTTTTCATTTTATGCTGCCATTAAAGCAAACAGGGGGTGAGGCCTAG

Upstream 100 bases:

>100_bases
CCAACGCTGTTAAAGATGCCTGTCTGGTAACAAATCCCCGGGATTGCAGTGTCGAGCAAATTGAAGCACTTTATCGAAAA
GCCCTCTAGGAGGGATACCT

Downstream 100 bases:

>100_bases
TGGTAAATGCACCAGGTGTTTTAATTATTGATGATGAGCAATCCGTTGGAACTTTCTTTAGCCGCCTGTTAAAACCTAAG
GGTTATCGAGTTGGTGTAGC

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MFDDKLTIIQNLTGVNSSKLNYYLAAQRSNEQIKIQMNRMEILHQIIKDINIDMSLADIVGRVYNKLPKAIPCCFLGLAL
AENDKLIMTAATPVSDCVGQPVPSLSVIWQSYSQCKRILYDLGSQSKQLCPLMNGKDPVESLGLKSTAIVPLLVRSQVIG
VLIVGDNHISAYGNSEVTFIEQMADQLAICIENARLYKEVSKGKQQWEDTFKAVPDPIILIDKNYKVLRHNLREAQSLTM
NLGDGVNPQCYQALWQREIPCEHCPLAKVYQTGRGVYLQVQNEGTIFDSFYYPMVDTNGEIYAVILHMKDVTEKVKMEAQ
LMHSAKLVAIGEMAAGVAHELNSPMTVIIGTAQMMQRDMGPEDPRSEWLDDIIGCGMRCKKIIQNLLSFSRQGQFALNET
DINQQVEKVLSLIHYQINRNNINIIKNLDLNVPYIMANGHQIQQVLINLLLNARDALEEIEGEKSIWISTTVESDQETQW
VVLTVRDNGCGIHPEGLNKIFNPFYTSKEASKGTGLGLSVSLGIAQSHGGTIKVESQQGFGSSFHFMLPLKQTGGEA

Sequences:

>Translated_557_residues
MFDDKLTIIQNLTGVNSSKLNYYLAAQRSNEQIKIQMNRMEILHQIIKDINIDMSLADIVGRVYNKLPKAIPCCFLGLAL
AENDKLIMTAATPVSDCVGQPVPSLSVIWQSYSQCKRILYDLGSQSKQLCPLMNGKDPVESLGLKSTAIVPLLVRSQVIG
VLIVGDNHISAYGNSEVTFIEQMADQLAICIENARLYKEVSKGKQQWEDTFKAVPDPIILIDKNYKVLRHNLREAQSLTM
NLGDGVNPQCYQALWQREIPCEHCPLAKVYQTGRGVYLQVQNEGTIFDSFYYPMVDTNGEIYAVILHMKDVTEKVKMEAQ
LMHSAKLVAIGEMAAGVAHELNSPMTVIIGTAQMMQRDMGPEDPRSEWLDDIIGCGMRCKKIIQNLLSFSRQGQFALNET
DINQQVEKVLSLIHYQINRNNINIIKNLDLNVPYIMANGHQIQQVLINLLLNARDALEEIEGEKSIWISTTVESDQETQW
VVLTVRDNGCGIHPEGLNKIFNPFYTSKEASKGTGLGLSVSLGIAQSHGGTIKVESQQGFGSSFHFMLPLKQTGGEA
>Mature_557_residues
MFDDKLTIIQNLTGVNSSKLNYYLAAQRSNEQIKIQMNRMEILHQIIKDINIDMSLADIVGRVYNKLPKAIPCCFLGLAL
AENDKLIMTAATPVSDCVGQPVPSLSVIWQSYSQCKRILYDLGSQSKQLCPLMNGKDPVESLGLKSTAIVPLLVRSQVIG
VLIVGDNHISAYGNSEVTFIEQMADQLAICIENARLYKEVSKGKQQWEDTFKAVPDPIILIDKNYKVLRHNLREAQSLTM
NLGDGVNPQCYQALWQREIPCEHCPLAKVYQTGRGVYLQVQNEGTIFDSFYYPMVDTNGEIYAVILHMKDVTEKVKMEAQ
LMHSAKLVAIGEMAAGVAHELNSPMTVIIGTAQMMQRDMGPEDPRSEWLDDIIGCGMRCKKIIQNLLSFSRQGQFALNET
DINQQVEKVLSLIHYQINRNNINIIKNLDLNVPYIMANGHQIQQVLINLLLNARDALEEIEGEKSIWISTTVESDQETQW
VVLTVRDNGCGIHPEGLNKIFNPFYTSKEASKGTGLGLSVSLGIAQSHGGTIKVESQQGFGSSFHFMLPLKQTGGEA

Specific function: Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=262, Percent_Identity=32.824427480916, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1790436, Length=238, Percent_Identity=33.6134453781513, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1790300, Length=253, Percent_Identity=26.8774703557312, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI87081816, Length=245, Percent_Identity=29.3877551020408, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=29.8701298701299, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI48994928, Length=268, Percent_Identity=23.8805970149254, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790346, Length=231, Percent_Identity=30.3030303030303, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI145693157, Length=260, Percent_Identity=26.9230769230769, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790861, Length=212, Percent_Identity=28.7735849056604, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789149, Length=251, Percent_Identity=24.7011952191235, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 62093; Mature: 62093

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDDKLTIIQNLTGVNSSKLNYYLAAQRSNEQIKIQMNRMEILHQIIKDINIDMSLADIV
CCCCHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHHHCCCCCHHHHHH
GRVYNKLPKAIPCCFLGLALAENDKLIMTAATPVSDCVGQPVPSLSVIWQSYSQCKRILY
HHHHHHCCHHHHHHHHHHHEECCCCEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHH
DLGSQSKQLCPLMNGKDPVESLGLKSTAIVPLLVRSQVIGVLIVGDNHISAYGNSEVTFI
HCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCEEEEEEECCCEEEECCCCCHHHH
EQMADQLAICIENARLYKEVSKGKQQWEDTFKAVPDPIILIDKNYKVLRHNLREAQSLTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHEE
NLGDGVNPQCYQALWQREIPCEHCPLAKVYQTGRGVYLQVQNEGTIFDSFYYPMVDTNGE
ECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEEECCCCCEEECEECCEECCCCC
IYAVILHMKDVTEKVKMEAQLMHSAKLVAIGEMAAGVAHELNSPMTVIIGTAQMMQRDMG
EEEEEEEHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHCCCCEEEEEECHHHHHHCCC
PEDPRSEWLDDIIGCGMRCKKIIQNLLSFSRQGQFALNETDINQQVEKVLSLIHYQINRN
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHCCCC
NINIIKNLDLNVPYIMANGHQIQQVLINLLLNARDALEEIEGEKSIWISTTVESDQETQW
CEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEE
VVLTVRDNGCGIHPEGLNKIFNPFYTSKEASKGTGLGLSVSLGIAQSHGGTIKVESQQGF
EEEEEECCCCCCCHHHHHHHHCHHHCCCCCCCCCCCEEEEEEEEEECCCCEEEEECCCCC
GSSFHFMLPLKQTGGEA
CCCEEEEEEEHHCCCCC
>Mature Secondary Structure
MFDDKLTIIQNLTGVNSSKLNYYLAAQRSNEQIKIQMNRMEILHQIIKDINIDMSLADIV
CCCCHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHHHCCCCCHHHHHH
GRVYNKLPKAIPCCFLGLALAENDKLIMTAATPVSDCVGQPVPSLSVIWQSYSQCKRILY
HHHHHHCCHHHHHHHHHHHEECCCCEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHH
DLGSQSKQLCPLMNGKDPVESLGLKSTAIVPLLVRSQVIGVLIVGDNHISAYGNSEVTFI
HCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHCCEEEEEEECCCEEEECCCCCHHHH
EQMADQLAICIENARLYKEVSKGKQQWEDTFKAVPDPIILIDKNYKVLRHNLREAQSLTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHEE
NLGDGVNPQCYQALWQREIPCEHCPLAKVYQTGRGVYLQVQNEGTIFDSFYYPMVDTNGE
ECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCEEEEECCCCCEEECEECCEECCCCC
IYAVILHMKDVTEKVKMEAQLMHSAKLVAIGEMAAGVAHELNSPMTVIIGTAQMMQRDMG
EEEEEEEHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHCCCCEEEEEECHHHHHHCCC
PEDPRSEWLDDIIGCGMRCKKIIQNLLSFSRQGQFALNETDINQQVEKVLSLIHYQINRN
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHHHCCCC
NINIIKNLDLNVPYIMANGHQIQQVLINLLLNARDALEEIEGEKSIWISTTVESDQETQW
CEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCEE
VVLTVRDNGCGIHPEGLNKIFNPFYTSKEASKGTGLGLSVSLGIAQSHGGTIKVESQQGF
EEEEEECCCCCCCHHHHHHHHCHHHCCCCCCCCCCCEEEEEEEEEECCCCEEEEECCCCC
GSSFHFMLPLKQTGGEA
CCCEEEEEEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8346225; 9097040; 9278503 [H]