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The map label for this gene is atoC [H]

Identifier: 134300113

GI number: 134300113

Start: 2485536

End: 2487074

Strand: Reverse

Name: atoC [H]

Synonym: Dred_2274

Alternate gene names: 134300113

Gene position: 2487074-2485536 (Counterclockwise)

Preceding gene: 134300114

Following gene: 134300112

Centisome position: 68.93

GC content: 42.88

Gene sequence:

>1539_bases
GTGGTAAATGCACCAGGTGTTTTAATTATTGATGATGAGCAATCCGTTGGAACTTTCTTTAGCCGCCTGTTAAAACCTAA
GGGTTATCGAGTTGGTGTAGCCTGTTCAGGGGTCCAGGCCCACGAACTGGTGGCAAAGGATCATTACGATGTGGCAATGG
TGGATTTAAAACTGCCAGATGCCGATGGTTTAAGTTTGTTACAGCATATCAAAAATGTACAACCCCAGTGCGAAGTTATT
ATTATGACAGGCTACAGTACAACTCGAACCGCAGTTAAGGCCATTCAATATGGGGCCTTCGACTATATTGAAAAGCCCTT
TGATGATATCTTATTAATTGAAAAGTTAATTGAAAAGGCTCTAAACTTTGGTATGACAGATGGGCAAATGGATAAAGAAA
CTTTCAGTTGGAGCAAGGTAGCCGAAAAGATCGGTTTTCAAGTGGGCAGAACCCCTCAAATGATTAAACTGGTTTCCATA
GCAGAACGGATTGCAGCAAAGGATATAAACGTCTTAATTCAAGGTGAAACTGGTACAGGTAAAGAAGTACTGGCCCGCTT
TGTTCACGCAGCCAGCCAGCGAAGTGATAAGCCTTTTCTGGCCATAAACTGCGGTGCATTGCCGGAAAACCTGTTGGAAA
GTGAACTTTTTGGACATGAAAGGGGTTCCTTTACTGGAGCCAGTGTCCAGCGCAAAGGAATTTTTGAATTAGCTAACAAT
GGTACACTTTTTCTGGATGAAATTGGGGAAGCCAGTTTGGCCATTCAAGTAAAACTATTAAGGGTTTTGGAAACAGGAGA
GTTTCTCAGGGTAGGTGGAGAAAAACCTGTTAAAACAAACGTTCGTATAATTGCTGCTACCAACGTGGATTTGGAAGAGG
CAGTAAAACAAAAACAATTTCGGGAGGACTTGTTCTATCGCTTGGATGTAATCCGCCTGGTTCTACCGCCCCTGAAGGAA
AGATTAGAAGATATCCCACAGTTTGTAGAACACTTTGTCAATCGCTTTTGGGAAAGAAATGATGGTCCTGTGCCCGCTTT
TGCGCCATCCTGCATAGAAGCCATGTTAAACTATCATTGGCCGGGAAATATTCGGGAATTGGCCAACTCTGTGGAACAAG
CACTGGCCCTATGTGATGGAAATGCCGTACTGCCAGAGCATTTATCCGGGAAAATTAATGGGCAGTTTTTAAATGATGAG
CGAACCGATAAAAAAGCTTTGAGTTATCATCCAGGGCTGAGTGATGCAACCAGTGTTTTAAATGTTAAGCCGGAGGATTT
AGATCAACTTGATCAACAAGCATTACTGGACCTCTATCATAAGGTGGACGGTCTTTACCGGGCGATTCACCGAACCATGG
GAAAGAAGGGAATTACTACGGTTTTTCCCTTAACGATACAGGAACTGGAAGCTAGGGCCATTGAAGAAACCTTAGAATTT
TTCAATGGTAATGTCAGTATGAGTGCCCGGGCCTTGGGTATTGGACGGAACACATTATACCGTAAGGCCAAGGAATATAA
CATAAATATTTCCGGTTAA

Upstream 100 bases:

>100_bases
CCCAGTCCCACGGTGGAACCATTAAGGTCGAAAGTCAGCAAGGATTCGGCAGTTCTTTTCATTTTATGCTGCCATTAAAG
CAAACAGGGGGTGAGGCCTA

Downstream 100 bases:

>100_bases
GACAAATGCGACAAGGGGGAAGGTTCTCGTTGTCGCATGTTTCTTTATGATACGAATGTTCGCATTTGAAACAATAAGTT
GTGCTATATTGGTTCATTTT

Product: two component sigma-54 specific Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MVNAPGVLIIDDEQSVGTFFSRLLKPKGYRVGVACSGVQAHELVAKDHYDVAMVDLKLPDADGLSLLQHIKNVQPQCEVI
IMTGYSTTRTAVKAIQYGAFDYIEKPFDDILLIEKLIEKALNFGMTDGQMDKETFSWSKVAEKIGFQVGRTPQMIKLVSI
AERIAAKDINVLIQGETGTGKEVLARFVHAASQRSDKPFLAINCGALPENLLESELFGHERGSFTGASVQRKGIFELANN
GTLFLDEIGEASLAIQVKLLRVLETGEFLRVGGEKPVKTNVRIIAATNVDLEEAVKQKQFREDLFYRLDVIRLVLPPLKE
RLEDIPQFVEHFVNRFWERNDGPVPAFAPSCIEAMLNYHWPGNIRELANSVEQALALCDGNAVLPEHLSGKINGQFLNDE
RTDKKALSYHPGLSDATSVLNVKPEDLDQLDQQALLDLYHKVDGLYRAIHRTMGKKGITTVFPLTIQELEARAIEETLEF
FNGNVSMSARALGIGRNTLYRKAKEYNINISG

Sequences:

>Translated_512_residues
MVNAPGVLIIDDEQSVGTFFSRLLKPKGYRVGVACSGVQAHELVAKDHYDVAMVDLKLPDADGLSLLQHIKNVQPQCEVI
IMTGYSTTRTAVKAIQYGAFDYIEKPFDDILLIEKLIEKALNFGMTDGQMDKETFSWSKVAEKIGFQVGRTPQMIKLVSI
AERIAAKDINVLIQGETGTGKEVLARFVHAASQRSDKPFLAINCGALPENLLESELFGHERGSFTGASVQRKGIFELANN
GTLFLDEIGEASLAIQVKLLRVLETGEFLRVGGEKPVKTNVRIIAATNVDLEEAVKQKQFREDLFYRLDVIRLVLPPLKE
RLEDIPQFVEHFVNRFWERNDGPVPAFAPSCIEAMLNYHWPGNIRELANSVEQALALCDGNAVLPEHLSGKINGQFLNDE
RTDKKALSYHPGLSDATSVLNVKPEDLDQLDQQALLDLYHKVDGLYRAIHRTMGKKGITTVFPLTIQELEARAIEETLEF
FNGNVSMSARALGIGRNTLYRKAKEYNINISG
>Mature_512_residues
MVNAPGVLIIDDEQSVGTFFSRLLKPKGYRVGVACSGVQAHELVAKDHYDVAMVDLKLPDADGLSLLQHIKNVQPQCEVI
IMTGYSTTRTAVKAIQYGAFDYIEKPFDDILLIEKLIEKALNFGMTDGQMDKETFSWSKVAEKIGFQVGRTPQMIKLVSI
AERIAAKDINVLIQGETGTGKEVLARFVHAASQRSDKPFLAINCGALPENLLESELFGHERGSFTGASVQRKGIFELANN
GTLFLDEIGEASLAIQVKLLRVLETGEFLRVGGEKPVKTNVRIIAATNVDLEEAVKQKQFREDLFYRLDVIRLVLPPLKE
RLEDIPQFVEHFVNRFWERNDGPVPAFAPSCIEAMLNYHWPGNIRELANSVEQALALCDGNAVLPEHLSGKINGQFLNDE
RTDKKALSYHPGLSDATSVLNVKPEDLDQLDQQALLDLYHKVDGLYRAIHRTMGKKGITTVFPLTIQELEARAIEETLEF
FNGNVSMSARALGIGRNTLYRKAKEYNINISG

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=400, Percent_Identity=42.25, Blast_Score=331, Evalue=9e-92,
Organism=Escherichia coli, GI1790437, Length=379, Percent_Identity=44.5910290237467, Blast_Score=325, Evalue=5e-90,
Organism=Escherichia coli, GI1790299, Length=502, Percent_Identity=38.4462151394422, Blast_Score=316, Evalue=2e-87,
Organism=Escherichia coli, GI1788905, Length=396, Percent_Identity=40.1515151515151, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI87082117, Length=240, Percent_Identity=48.75, Blast_Score=240, Evalue=2e-64,
Organism=Escherichia coli, GI1789233, Length=362, Percent_Identity=39.2265193370166, Blast_Score=239, Evalue=4e-64,
Organism=Escherichia coli, GI1789087, Length=345, Percent_Identity=40.5797101449275, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI87082152, Length=247, Percent_Identity=46.1538461538462, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1786524, Length=243, Percent_Identity=46.9135802469136, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI87081872, Length=229, Percent_Identity=47.1615720524017, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI1787583, Length=241, Percent_Identity=43.9834024896266, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1789828, Length=296, Percent_Identity=31.4189189189189, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081858, Length=376, Percent_Identity=27.3936170212766, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1786784, Length=101, Percent_Identity=28.7128712871287, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 56983; Mature: 56983

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNAPGVLIIDDEQSVGTFFSRLLKPKGYRVGVACSGVQAHELVAKDHYDVAMVDLKLPD
CCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCEEEEEEECCC
ADGLSLLQHIKNVQPQCEVIIMTGYSTTRTAVKAIQYGAFDYIEKPFDDILLIEKLIEKA
CCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHH
LNFGMTDGQMDKETFSWSKVAEKIGFQVGRTPQMIKLVSIAERIAAKDINVLIQGETGTG
HHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCC
KEVLARFVHAASQRSDKPFLAINCGALPENLLESELFGHERGSFTGASVQRKGIFELANN
HHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHCCHHEECCC
GTLFLDEIGEASLAIQVKLLRVLETGEFLRVGGEKPVKTNVRIIAATNVDLEEAVKQKQF
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHH
REDLFYRLDVIRLVLPPLKERLEDIPQFVEHFVNRFWERNDGPVPAFAPSCIEAMLNYHW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC
PGNIRELANSVEQALALCDGNAVLPEHLSGKINGQFLNDERTDKKALSYHPGLSDATSVL
CCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEECCCCCCCHHHHHCCCCCCHHHHHH
NVKPEDLDQLDQQALLDLYHKVDGLYRAIHRTMGKKGITTVFPLTIQELEARAIEETLEF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHH
FNGNVSMSARALGIGRNTLYRKAKEYNINISG
HCCCCEEEEEEEECCHHHHHHHHHHCEEEECC
>Mature Secondary Structure
MVNAPGVLIIDDEQSVGTFFSRLLKPKGYRVGVACSGVQAHELVAKDHYDVAMVDLKLPD
CCCCCCEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCEEEEEEECCC
ADGLSLLQHIKNVQPQCEVIIMTGYSTTRTAVKAIQYGAFDYIEKPFDDILLIEKLIEKA
CCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHH
LNFGMTDGQMDKETFSWSKVAEKIGFQVGRTPQMIKLVSIAERIAAKDINVLIQGETGTG
HHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCC
KEVLARFVHAASQRSDKPFLAINCGALPENLLESELFGHERGSFTGASVQRKGIFELANN
HHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHCCHHEECCC
GTLFLDEIGEASLAIQVKLLRVLETGEFLRVGGEKPVKTNVRIIAATNVDLEEAVKQKQF
CEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHH
REDLFYRLDVIRLVLPPLKERLEDIPQFVEHFVNRFWERNDGPVPAFAPSCIEAMLNYHW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCC
PGNIRELANSVEQALALCDGNAVLPEHLSGKINGQFLNDERTDKKALSYHPGLSDATSVL
CCCHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCEECCCCCCCHHHHHCCCCCCHHHHHH
NVKPEDLDQLDQQALLDLYHKVDGLYRAIHRTMGKKGITTVFPLTIQELEARAIEETLEF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHH
FNGNVSMSARALGIGRNTLYRKAKEYNINISG
HCCCCEEEEEEEECCHHHHHHHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]