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The map label for this gene is xpt

Identifier: 134300019

GI number: 134300019

Start: 2376938

End: 2377504

Strand: Reverse

Name: xpt

Synonym: Dred_2173

Alternate gene names: 134300019

Gene position: 2377504-2376938 (Counterclockwise)

Preceding gene: 134300020

Following gene: 134300018

Centisome position: 65.89

GC content: 42.15

Gene sequence:

>567_bases
ATGCAATTGAAAGAAATCATAGAAAACAATGCCGAAGTTGTTTCGGATCAAATATTAAGGGTAGATTCCTTTATCAACCA
TATGATTGACCCAAATGTTATGATGGAAATCGGAGAAGAATTTGCACGTCGTTTTAGGGACGACAAAATAACTAAAGTGT
TAACCATAGAAGCCTCTGGGATTGCCATTGGTTTAACAACCGCTCTGGCACTACGAACACCGTTACTATTTGCCAAGAAA
AAGGTTCCATCTACGCTGGGCGACTCCTATGTATCGAACATTTATTCTTTTACCAAGAACGAGTCTGTAACTGTTTCTGT
GGCAAAGCAATATTTGAAATCCGACGATAAAATACTTATTGTGGATGATTTTTTGGCCCGGGGCGAAGCTCTCAAGGGGT
TAGCTCATCTGGTAAAGCAAGCAGATGCCGAACTAGTTGGGGTAGGCATTGTCATAGAAAAGGCCTTTCAGGGGGGCGGT
AAGGCTTTGCGGGATGCTGGTGTTAGAATTGAGTCTCTGATCAAAGTAAGTAGTCTCGAAGGTGGAAAACTGCATCTGGA
GGAATAG

Upstream 100 bases:

>100_bases
TAACTCGAAAGGCTATGGCTAACCGGGTTGGTTCTCCAGGCGCATTAGGCTTGCCCTATGACCGTGAAGAACGCTGATAA
TGACATTAGGGGGAGTTAAT

Downstream 100 bases:

>100_bases
AAAAAGTTATCAACAGATATGACCGGTTACTATGCCGGTCTTTTTTAGCATATCAGAAAGTATAAAACTTTCCGATATGC
ATAAGGGCAAACTAAGGCTC

Product: xanthine phosphoribosyltransferase

Products: NA

Alternate protein names: XPRTase

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MQLKEIIENNAEVVSDQILRVDSFINHMIDPNVMMEIGEEFARRFRDDKITKVLTIEASGIAIGLTTALALRTPLLFAKK
KVPSTLGDSYVSNIYSFTKNESVTVSVAKQYLKSDDKILIVDDFLARGEALKGLAHLVKQADAELVGVGIVIEKAFQGGG
KALRDAGVRIESLIKVSSLEGGKLHLEE

Sequences:

>Translated_188_residues
MQLKEIIENNAEVVSDQILRVDSFINHMIDPNVMMEIGEEFARRFRDDKITKVLTIEASGIAIGLTTALALRTPLLFAKK
KVPSTLGDSYVSNIYSFTKNESVTVSVAKQYLKSDDKILIVDDFLARGEALKGLAHLVKQADAELVGVGIVIEKAFQGGG
KALRDAGVRIESLIKVSSLEGGKLHLEE
>Mature_188_residues
MQLKEIIENNAEVVSDQILRVDSFINHMIDPNVMMEIGEEFARRFRDDKITKVLTIEASGIAIGLTTALALRTPLLFAKK
KVPSTLGDSYVSNIYSFTKNESVTVSVAKQYLKSDDKILIVDDFLARGEALKGLAHLVKQADAELVGVGIVIEKAFQGGG
KALRDAGVRIESLIKVSSLEGGKLHLEE

Specific function: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XPT subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XPT_DESRM (A4J6I7)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113515.1
- ProteinModelPortal:   A4J6I7
- SMR:   A4J6I7
- STRING:   A4J6I7
- GeneID:   4956399
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_2173
- eggNOG:   COG0503
- HOGENOM:   HBG288993
- OMA:   ATVYSFT
- BioCyc:   DRED349161:DRED_2173-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01184
- InterPro:   IPR000836
- InterPro:   IPR010079
- TIGRFAMs:   TIGR01744

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.22

Molecular weight: Translated: 20571; Mature: 20571

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 19-19 BINDING 26-26 BINDING 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLKEIIENNAEVVSDQILRVDSFINHMIDPNVMMEIGEEFARRFRDDKITKVLTIEASG
CCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCC
IAIGLTTALALRTPLLFAKKKVPSTLGDSYVSNIYSFTKNESVTVSVAKQYLKSDDKILI
EEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEE
VDDFLARGEALKGLAHLVKQADAELVGVGIVIEKAFQGGGKALRDAGVRIESLIKVSSLE
EHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCC
GGKLHLEE
CCEEEECC
>Mature Secondary Structure
MQLKEIIENNAEVVSDQILRVDSFINHMIDPNVMMEIGEEFARRFRDDKITKVLTIEASG
CCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCC
IAIGLTTALALRTPLLFAKKKVPSTLGDSYVSNIYSFTKNESVTVSVAKQYLKSDDKILI
EEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCEEE
VDDFLARGEALKGLAHLVKQADAELVGVGIVIEKAFQGGGKALRDAGVRIESLIKVSSLE
EHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHCCC
GGKLHLEE
CCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA