Click here to switch to the map view.

The map label for this gene is ffh [H]

Identifier: 134299902

GI number: 134299902

Start: 2251096

End: 2252436

Strand: Reverse

Name: ffh [H]

Synonym: Dred_2056

Alternate gene names: 134299902

Gene position: 2252436-2251096 (Counterclockwise)

Preceding gene: 134299903

Following gene: 134299901

Centisome position: 62.43

GC content: 44.37

Gene sequence:

>1341_bases
ATGTTTAAGGGCTTAGGCGAACGACTGGATGAAATTTTCAAATCGTTAAAGGGTAAAGGACGCCTTACCGAAGATGATGT
TAATCATGCTATGCGGGAAGTTAAGATGGCTCTCTTGGAGGCAGACGTTAACTTTAAGGTTGTTAAAGAATTTGTGGCTC
AGGTAAAGGGAAGGGCTGTTGGACAGGATGTTTTGGAAAGTCTCAGCCCGGCCCAGCAAGTTATCAAAATTGTTAGGGAC
GAGTTAACAGAATTACTGGGCGGTACCCAGGCAAAGATAAATCTTTCACCTAAGCCCCCCACCATTATTATGCTGGTGGG
TCTGCAGGGTGCTGGTAAAACCACCACAGCAGGCAAATTAGCAAAGCTATTAAGTAAGCAGGGGCGTCGGCCTTTAATGG
TGGCTGGAGACATTTACCGCCCGGCTGCCATTAAGCAATTACAGGTTCTGGGTGATCAGCTAAATATTCCGGTATTTTCC
ATGGGACAAGAAAATCCCGTTAAAATTGCCCAATCAGCGGTGGAACAAGCCAACAGTACTGGTAGGGACTTAGTGATTAT
TGATACAGCGGGTCGACTACACATTAATGAAGAATTAATGGATGAACTGGCCAATATTAAATCTACTGTTAGGCCCCATG
AAATCCTGCTGGTTGTAGATGCCATGACAGGTCAAGAAGCTGTTAATGTGGCGGATACCTTTAACCAAAAGCTTGGTTTA
GATGGTATTGTTATGACCAAGCTAGACGGTGATGCCAGGGGTGGTGCTGCTTTATCCGTTAGGAAGGTAACTGGGACACC
CATTAAGTTTGCCGGCATGGGCGAAAAATTAGATGCTTTGGAACCCTTTTACCCGGATCGCATGGCAGACCGGATTTTGG
GCATGGGTGATGTCCTAACCCTAATCGAGAAGGCCCAGGCAAATTTTGATGCTGAGCAGGCTGCCAAATTAAACAAGAAA
ATTCGTCAGGCGGATTTTAATCTGGAGGATTTTTTGGAACAGATGCAGCAAGTAAAAAAGCTAGGTCCACTGGAACAAGT
ACTAGGTATGATTCCGGGTATGGGTAAATTAACCAAGCAGCTTAAAGATCAGCAACTGGATGGCAAAGAATTGGCACAAG
TGGAAGCCATAATTTACTCTATGACTGTTTGGGAACGCCACCATCCTGAAAAGATCGATGGCAGCCGTAAAAAAAGGATT
GCCCGGGGCAGTGGCACAAGGGTACAGGATGTAAATCAATTGTTAAAGCAGTTTGAACAAACAAGAAAGATGATGAAACA
GATATCCAATATGACCAAGGGTGGCAAGAAGGGAAAAATGAAATTACCTTTCTTTCAATAA

Upstream 100 bases:

>100_bases
AGGATTGGAAAAATCCAAAGGCATACTAAAAAAAATATTAGAAAAACGCCAGGATCTTTAAATCGTTAATCCATAAATAA
TATGTAAAGGAGGCGTCTGA

Downstream 100 bases:

>100_bases
ATAATTTGATACCTGTTTAAGGAGGTGAAAATACAATGGCTGTTAAAATTCGTCTGAGACGTATGGGGGCTAAGAAAAAC
CCCTTTTACCGTATAGTGGT

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MFKGLGERLDEIFKSLKGKGRLTEDDVNHAMREVKMALLEADVNFKVVKEFVAQVKGRAVGQDVLESLSPAQQVIKIVRD
ELTELLGGTQAKINLSPKPPTIIMLVGLQGAGKTTTAGKLAKLLSKQGRRPLMVAGDIYRPAAIKQLQVLGDQLNIPVFS
MGQENPVKIAQSAVEQANSTGRDLVIIDTAGRLHINEELMDELANIKSTVRPHEILLVVDAMTGQEAVNVADTFNQKLGL
DGIVMTKLDGDARGGAALSVRKVTGTPIKFAGMGEKLDALEPFYPDRMADRILGMGDVLTLIEKAQANFDAEQAAKLNKK
IRQADFNLEDFLEQMQQVKKLGPLEQVLGMIPGMGKLTKQLKDQQLDGKELAQVEAIIYSMTVWERHHPEKIDGSRKKRI
ARGSGTRVQDVNQLLKQFEQTRKMMKQISNMTKGGKKGKMKLPFFQ

Sequences:

>Translated_446_residues
MFKGLGERLDEIFKSLKGKGRLTEDDVNHAMREVKMALLEADVNFKVVKEFVAQVKGRAVGQDVLESLSPAQQVIKIVRD
ELTELLGGTQAKINLSPKPPTIIMLVGLQGAGKTTTAGKLAKLLSKQGRRPLMVAGDIYRPAAIKQLQVLGDQLNIPVFS
MGQENPVKIAQSAVEQANSTGRDLVIIDTAGRLHINEELMDELANIKSTVRPHEILLVVDAMTGQEAVNVADTFNQKLGL
DGIVMTKLDGDARGGAALSVRKVTGTPIKFAGMGEKLDALEPFYPDRMADRILGMGDVLTLIEKAQANFDAEQAAKLNKK
IRQADFNLEDFLEQMQQVKKLGPLEQVLGMIPGMGKLTKQLKDQQLDGKELAQVEAIIYSMTVWERHHPEKIDGSRKKRI
ARGSGTRVQDVNQLLKQFEQTRKMMKQISNMTKGGKKGKMKLPFFQ
>Mature_446_residues
MFKGLGERLDEIFKSLKGKGRLTEDDVNHAMREVKMALLEADVNFKVVKEFVAQVKGRAVGQDVLESLSPAQQVIKIVRD
ELTELLGGTQAKINLSPKPPTIIMLVGLQGAGKTTTAGKLAKLLSKQGRRPLMVAGDIYRPAAIKQLQVLGDQLNIPVFS
MGQENPVKIAQSAVEQANSTGRDLVIIDTAGRLHINEELMDELANIKSTVRPHEILLVVDAMTGQEAVNVADTFNQKLGL
DGIVMTKLDGDARGGAALSVRKVTGTPIKFAGMGEKLDALEPFYPDRMADRILGMGDVLTLIEKAQANFDAEQAAKLNKK
IRQADFNLEDFLEQMQQVKKLGPLEQVLGMIPGMGKLTKQLKDQQLDGKELAQVEAIIYSMTVWERHHPEKIDGSRKKRI
ARGSGTRVQDVNQLLKQFEQTRKMMKQISNMTKGGKKGKMKLPFFQ

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=451, Percent_Identity=33.0376940133038, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI226371618, Length=352, Percent_Identity=35.5113636363636, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI89061728, Length=147, Percent_Identity=36.734693877551, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI23308697, Length=298, Percent_Identity=26.8456375838926, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI295424842, Length=298, Percent_Identity=26.8456375838926, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=51.7564402810305, Blast_Score=444, Evalue=1e-126,
Organism=Escherichia coli, GI1789874, Length=237, Percent_Identity=38.3966244725738, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17539958, Length=446, Percent_Identity=31.390134529148, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI193206261, Length=296, Percent_Identity=30.0675675675676, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6325345, Length=436, Percent_Identity=32.5688073394495, Blast_Score=230, Evalue=4e-61,
Organism=Saccharomyces cerevisiae, GI6320498, Length=211, Percent_Identity=28.9099526066351, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17647949, Length=451, Percent_Identity=30.820399113082, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24641198, Length=248, Percent_Identity=33.0645161290323, Blast_Score=109, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49170; Mature: 49170

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKGLGERLDEIFKSLKGKGRLTEDDVNHAMREVKMALLEADVNFKVVKEFVAQVKGRAV
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHH
GQDVLESLSPAQQVIKIVRDELTELLGGTQAKINLSPKPPTIIMLVGLQGAGKTTTAGKL
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHH
AKLLSKQGRRPLMVAGDIYRPAAIKQLQVLGDQLNIPVFSMGQENPVKIAQSAVEQANST
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCC
GRDLVIIDTAGRLHINEELMDELANIKSTVRPHEILLVVDAMTGQEAVNVADTFNQKLGL
CCEEEEEECCCCEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCC
DGIVMTKLDGDARGGAALSVRKVTGTPIKFAGMGEKLDALEPFYPDRMADRILGMGDVLT
CCEEEEEECCCCCCCCEEEEEEECCCCEEECCCCCHHHHCCCCCCHHHHHHHHCHHHHHH
LIEKAQANFDAEQAAKLNKKIRQADFNLEDFLEQMQQVKKLGPLEQVLGMIPGMGKLTKQ
HHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHH
LKDQQLDGKELAQVEAIIYSMTVWERHHPEKIDGSRKKRIARGSGTRVQDVNQLLKQFEQ
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHH
TRKMMKQISNMTKGGKKGKMKLPFFQ
HHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MFKGLGERLDEIFKSLKGKGRLTEDDVNHAMREVKMALLEADVNFKVVKEFVAQVKGRAV
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHH
GQDVLESLSPAQQVIKIVRDELTELLGGTQAKINLSPKPPTIIMLVGLQGAGKTTTAGKL
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHH
AKLLSKQGRRPLMVAGDIYRPAAIKQLQVLGDQLNIPVFSMGQENPVKIAQSAVEQANST
HHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCC
GRDLVIIDTAGRLHINEELMDELANIKSTVRPHEILLVVDAMTGQEAVNVADTFNQKLGL
CCEEEEEECCCCEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCC
DGIVMTKLDGDARGGAALSVRKVTGTPIKFAGMGEKLDALEPFYPDRMADRILGMGDVLT
CCEEEEEECCCCCCCCEEEEEEECCCCEEECCCCCHHHHCCCCCCHHHHHHHHCHHHHHH
LIEKAQANFDAEQAAKLNKKIRQADFNLEDFLEQMQQVKKLGPLEQVLGMIPGMGKLTKQ
HHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHH
LKDQQLDGKELAQVEAIIYSMTVWERHHPEKIDGSRKKRIARGSGTRVQDVNQLLKQFEQ
HHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHH
TRKMMKQISNMTKGGKKGKMKLPFFQ
HHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]