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The map label for this gene is uppS [H]

Identifier: 134299820

GI number: 134299820

Start: 2168694

End: 2169485

Strand: Reverse

Name: uppS [H]

Synonym: Dred_1973

Alternate gene names: 134299820

Gene position: 2169485-2168694 (Counterclockwise)

Preceding gene: 134299821

Following gene: 134299819

Centisome position: 60.13

GC content: 40.15

Gene sequence:

>792_bases
ATGATGCTGAGAAAGATAACCAGTCTATTTTCTAGACCAAAGGTTACAGCCGATGAAAATACACTTCTTCAATCTATAGA
CCGAAATAAGCTCCCGCAACATATTGCTATTATTATGGATGGCAACGGACGATGGGCACAACGCAGGGGCATGCCAAGGT
CCCTGGGACACCGAGCGGGTGTTGAATCTTTACGAAATATTGTAAAGCTCTGTTCAGAAATTGGTATTGGATATTTAACA
TGTTATGCATTTTCCACCGAGAACTGGAAACGTCCCCAAAAGGAAGTATCCTATTTAATGGATTTACTGGTGGAATATCT
GGAAAAAGAGGTTGTAGAGCTACATAAAAATAATGTTAGAGTAAATGCCATAGGTCGTCTGGAAGAACTGCCCCAAAGGG
CCCAGGAGGCATTACAGGCTGCCTTTCAAAAAACAAAAAACAATACCGGGCTAACTTTAAATTTAGCGTTAAACTATGGT
GGACGAACGGAAATTACTGATGCAGTTATTAAAATTGCTAACATGGTCAAAAGTAACGAAATGGAAGTTGCCAATATAAA
TGATAAACTAATTTGTGATTCCCTTTATACCGCAGGTATGCCGGATCCTGAGTTGTTAATCAGACCTTCTGGAGAGTGTA
GAATAAGTAATTTTCTTCTCTGGCAGCTTGCTTATACAGAATTTTGGTTGGCAGACGTGATGTGGCCGGATTTTCAACGT
TACCATTTATTACAAGCTATCATTGGGTTTCAACGTCGGGAACGGCGATTTGGTGGACTAAACAAAAAGTAG

Upstream 100 bases:

>100_bases
GGCACATGCTTGGATATCTGCCCTACCGGAGCCATTATTGAAGAGTAATGCAGTAAACCCCCTTCATATCCGGAAGGGGG
TTGTTATATTGGAGGCTCAA

Downstream 100 bases:

>100_bases
GTTGGTGGACAAATTGTTGCACCTGCGAGTGCTAAGCGCAGTCATAGGAATACCAGTAATAGTTTTAGCAGCTTGGTTTG
GTGATTGGGTACTGTGGTTA

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MMLRKITSLFSRPKVTADENTLLQSIDRNKLPQHIAIIMDGNGRWAQRRGMPRSLGHRAGVESLRNIVKLCSEIGIGYLT
CYAFSTENWKRPQKEVSYLMDLLVEYLEKEVVELHKNNVRVNAIGRLEELPQRAQEALQAAFQKTKNNTGLTLNLALNYG
GRTEITDAVIKIANMVKSNEMEVANINDKLICDSLYTAGMPDPELLIRPSGECRISNFLLWQLAYTEFWLADVMWPDFQR
YHLLQAIIGFQRRERRFGGLNKK

Sequences:

>Translated_263_residues
MMLRKITSLFSRPKVTADENTLLQSIDRNKLPQHIAIIMDGNGRWAQRRGMPRSLGHRAGVESLRNIVKLCSEIGIGYLT
CYAFSTENWKRPQKEVSYLMDLLVEYLEKEVVELHKNNVRVNAIGRLEELPQRAQEALQAAFQKTKNNTGLTLNLALNYG
GRTEITDAVIKIANMVKSNEMEVANINDKLICDSLYTAGMPDPELLIRPSGECRISNFLLWQLAYTEFWLADVMWPDFQR
YHLLQAIIGFQRRERRFGGLNKK
>Mature_263_residues
MMLRKITSLFSRPKVTADENTLLQSIDRNKLPQHIAIIMDGNGRWAQRRGMPRSLGHRAGVESLRNIVKLCSEIGIGYLT
CYAFSTENWKRPQKEVSYLMDLLVEYLEKEVVELHKNNVRVNAIGRLEELPQRAQEALQAAFQKTKNNTGLTLNLALNYG
GRTEITDAVIKIANMVKSNEMEVANINDKLICDSLYTAGMPDPELLIRPSGECRISNFLLWQLAYTEFWLADVMWPDFQR
YHLLQAIIGFQRRERRFGGLNKK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=229, Percent_Identity=38.8646288209607, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI45580738, Length=229, Percent_Identity=38.8646288209607, Blast_Score=162, Evalue=2e-40,
Organism=Escherichia coli, GI1786371, Length=234, Percent_Identity=46.1538461538462, Blast_Score=217, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=35.3982300884956, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=40, Blast_Score=139, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6323748, Length=253, Percent_Identity=29.6442687747036, Blast_Score=105, Evalue=6e-24,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=35.5555555555556, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30244; Mature: 30244

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLRKITSLFSRPKVTADENTLLQSIDRNKLPQHIAIIMDGNGRWAQRRGMPRSLGHRAG
CHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHCCCCHHHHHHHH
VESLRNIVKLCSEIGIGYLTCYAFSTENWKRPQKEVSYLMDLLVEYLEKEVVELHKNNVR
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
VNAIGRLEELPQRAQEALQAAFQKTKNNTGLTLNLALNYGGRTEITDAVIKIANMVKSNE
EEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCC
MEVANINDKLICDSLYTAGMPDPELLIRPSGECRISNFLLWQLAYTEFWLADVMWPDFQR
CEEECCCCHHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHH
YHLLQAIIGFQRRERRFGGLNKK
HHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MMLRKITSLFSRPKVTADENTLLQSIDRNKLPQHIAIIMDGNGRWAQRRGMPRSLGHRAG
CHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHCCCCHHHHHHHH
VESLRNIVKLCSEIGIGYLTCYAFSTENWKRPQKEVSYLMDLLVEYLEKEVVELHKNNVR
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
VNAIGRLEELPQRAQEALQAAFQKTKNNTGLTLNLALNYGGRTEITDAVIKIANMVKSNE
EEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCC
MEVANINDKLICDSLYTAGMPDPELLIRPSGECRISNFLLWQLAYTEFWLADVMWPDFQR
CEEECCCCHHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHH
YHLLQAIIGFQRRERRFGGLNKK
HHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12552129 [H]