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The map label for this gene is guaB [H]

Identifier: 134299756

GI number: 134299756

Start: 2095302

End: 2096756

Strand: Reverse

Name: guaB [H]

Synonym: Dred_1906

Alternate gene names: 134299756

Gene position: 2096756-2095302 (Counterclockwise)

Preceding gene: 134299757

Following gene: 134299755

Centisome position: 58.11

GC content: 43.71

Gene sequence:

>1455_bases
TTGTATCCTGAAAAATTTGCAAAAGTTGGACTGACATTTGATGATGTGTTGCTGGTACCAGGAGCTTCAGAAGTCTTACC
AAGGGAAGTGGATACATCCACTTACTTAACCCAAGATATAAAATTGAACGTACCTATTATGAGTGCTGGTATGGATACTG
TAACTGAATCCCGTATGGCTATTGCTATGGCACGTGAAGGTGGCATCGGTGTAATCCACAAGAATATGTCCATTGCACGT
CAGGCATTAGAGGTGGACAAGGTAAAACGATCTGAACATGGTATTATAACGGATCCCATATTTTTATCCCCTGAAAGCCC
TGTTAGTGAGGCCCATGAGTTAATGGAAAGGTACCATATTTCTGGAGTTCCCATTACTGTGGATGGGAAGTTAGTGGGCA
TATTAACGAACCGAGATCTCCGATTTGAGACAAATGATAACCGCATTTGCGGTGACATTATGACAAAGGATAACTTAATT
ACTGCACCTGTAGGGACAACTCTCGATGAAGCAAAACAAATTTTAATGAAGCATAAGGTTGAAAAATTGCCCATTGTGGA
TGAAAATGGTAAGTTACGGGGTCTAATAACAATCAAGGATATCAAAAAGGCTAAAGAATATCCCAATTCGGCGAAAGATC
ACCGCGGTAGACTACGTGTAGCAGCTGCAGTGGGGGTTGCCTCTGACACCATGGAGAGAGTGCAAGCCCTTGTAAAAGCA
AAGGTTGATGTGATTGTCGTTGATACAGCCCATGGCCACTCTGCCTTAGTTGTAAAAACAGTTCAAAATATCCGGTCAGC
TTACCCAAATTTGAACATTATTGCTGGCAATGTTGCAACGACCGAGGCCACCAGAGACCTCATTGAAGCAGGTGCCAATG
CGATAAAAGTTGGTATTGGACCTGGGTCTATCTGCACAACCCGGGTTGTTGCTGGCGTTGGTGTACCTCAGATCACCGCT
GTATATGATTGTGCCCAGGAAGCGATGAAACATGGTATACCCGTAATAGCAGACGGAGGGATTAAATACTCCGGTGATAT
TGTAAAGGCCATTGCTGCAGGAGCAAGTGTAGTAATGTTAGGAAGTATTTTGGCCGGAACAGAGGAAAGCCCAGGGGAAA
AAGAAATTTACCAGGGTCGTAGCTACAAAGTGTATCGGGGTATGGGCTCCCTAGGAGCTATGAAAAAAGGTAGTGGAGAT
CGTTATTTCCAGGAGCAAGCCAAGAAGATGGTACCGGAAGGGGTAGAGGGACGCGTTCCCTATAAGGGTCAACTTTCCGA
TACGATATTCCAATTAGTGGGTGGCTTAAAGGCTGGTATGGGTTATACTGGTTCTCGCACCATAAACAACCTTAAAACAG
ATGCAAAATTTATTCGTATAACCCCGGCTGGTTTGAAAGAAAGCCATCCTCATGGTGTTAATATTACTAAGGAAGCACCC
AACTATAGTTTTTAA

Upstream 100 bases:

>100_bases
TTAAAATCAAATTAAAGATAATTTCTGGAACCTTTAAATATCCTGTGCTATAATGTATGAATAAAATTTTTTAGACACTA
TAGGAAGGGAGAAACACAAC

Downstream 100 bases:

>100_bases
TTATTTAATTTGAAGTAAGCGAAGGGCCTTCGTAACTATGTCTTGCTAAAGAAACCCCCACGGACAAGAAAATGTCCGTG
GGGGTTTTGCATTTTAGTAT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MYPEKFAKVGLTFDDVLLVPGASEVLPREVDTSTYLTQDIKLNVPIMSAGMDTVTESRMAIAMAREGGIGVIHKNMSIAR
QALEVDKVKRSEHGIITDPIFLSPESPVSEAHELMERYHISGVPITVDGKLVGILTNRDLRFETNDNRICGDIMTKDNLI
TAPVGTTLDEAKQILMKHKVEKLPIVDENGKLRGLITIKDIKKAKEYPNSAKDHRGRLRVAAAVGVASDTMERVQALVKA
KVDVIVVDTAHGHSALVVKTVQNIRSAYPNLNIIAGNVATTEATRDLIEAGANAIKVGIGPGSICTTRVVAGVGVPQITA
VYDCAQEAMKHGIPVIADGGIKYSGDIVKAIAAGASVVMLGSILAGTEESPGEKEIYQGRSYKVYRGMGSLGAMKKGSGD
RYFQEQAKKMVPEGVEGRVPYKGQLSDTIFQLVGGLKAGMGYTGSRTINNLKTDAKFIRITPAGLKESHPHGVNITKEAP
NYSF

Sequences:

>Translated_484_residues
MYPEKFAKVGLTFDDVLLVPGASEVLPREVDTSTYLTQDIKLNVPIMSAGMDTVTESRMAIAMAREGGIGVIHKNMSIAR
QALEVDKVKRSEHGIITDPIFLSPESPVSEAHELMERYHISGVPITVDGKLVGILTNRDLRFETNDNRICGDIMTKDNLI
TAPVGTTLDEAKQILMKHKVEKLPIVDENGKLRGLITIKDIKKAKEYPNSAKDHRGRLRVAAAVGVASDTMERVQALVKA
KVDVIVVDTAHGHSALVVKTVQNIRSAYPNLNIIAGNVATTEATRDLIEAGANAIKVGIGPGSICTTRVVAGVGVPQITA
VYDCAQEAMKHGIPVIADGGIKYSGDIVKAIAAGASVVMLGSILAGTEESPGEKEIYQGRSYKVYRGMGSLGAMKKGSGD
RYFQEQAKKMVPEGVEGRVPYKGQLSDTIFQLVGGLKAGMGYTGSRTINNLKTDAKFIRITPAGLKESHPHGVNITKEAP
NYSF
>Mature_484_residues
MYPEKFAKVGLTFDDVLLVPGASEVLPREVDTSTYLTQDIKLNVPIMSAGMDTVTESRMAIAMAREGGIGVIHKNMSIAR
QALEVDKVKRSEHGIITDPIFLSPESPVSEAHELMERYHISGVPITVDGKLVGILTNRDLRFETNDNRICGDIMTKDNLI
TAPVGTTLDEAKQILMKHKVEKLPIVDENGKLRGLITIKDIKKAKEYPNSAKDHRGRLRVAAAVGVASDTMERVQALVKA
KVDVIVVDTAHGHSALVVKTVQNIRSAYPNLNIIAGNVATTEATRDLIEAGANAIKVGIGPGSICTTRVVAGVGVPQITA
VYDCAQEAMKHGIPVIADGGIKYSGDIVKAIAAGASVVMLGSILAGTEESPGEKEIYQGRSYKVYRGMGSLGAMKKGSGD
RYFQEQAKKMVPEGVEGRVPYKGQLSDTIFQLVGGLKAGMGYTGSRTINNLKTDAKFIRITPAGLKESHPHGVNITKEAP
NYSF

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=479, Percent_Identity=43.4237995824635, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=43.4237995824635, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=43.4237995824635, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=43.4237995824635, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI66933016, Length=479, Percent_Identity=42.5887265135699, Blast_Score=365, Evalue=1e-101,
Organism=Homo sapiens, GI217035152, Length=489, Percent_Identity=42.7402862985685, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI217035148, Length=479, Percent_Identity=42.5887265135699, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI217035150, Length=479, Percent_Identity=40.5010438413361, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI50541956, Length=246, Percent_Identity=41.869918699187, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=41.7004048582996, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=41.7004048582996, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=41.7004048582996, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=40.650406504065, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1788855, Length=488, Percent_Identity=57.5819672131148, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1786293, Length=243, Percent_Identity=37.037037037037, Blast_Score=160, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=472, Percent_Identity=37.9237288135593, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=39.8104265402844, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17560440, Length=246, Percent_Identity=38.2113821138211, Blast_Score=174, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6322012, Length=458, Percent_Identity=41.4847161572052, Blast_Score=349, Evalue=6e-97,
Organism=Saccharomyces cerevisiae, GI6323585, Length=458, Percent_Identity=41.9213973799127, Blast_Score=343, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6323464, Length=458, Percent_Identity=43.0131004366812, Blast_Score=339, Evalue=5e-94,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=41.4201183431953, Blast_Score=267, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=42.2413793103448, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24641071, Length=480, Percent_Identity=43.3333333333333, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24641073, Length=480, Percent_Identity=43.3333333333333, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI28571163, Length=439, Percent_Identity=43.7357630979499, Blast_Score=332, Evalue=4e-91,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51958; Mature: 51958

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYPEKFAKVGLTFDDVLLVPGASEVLPREVDTSTYLTQDIKLNVPIMSAGMDTVTESRMA
CCCHHHHHCCCCCHHEEECCCCHHHCCCCCCCCCEEEECEEEECCEEECCCHHHHHHHEE
IAMAREGGIGVIHKNMSIARQALEVDKVKRSEHGIITDPIFLSPESPVSEAHELMERYHI
EEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCCEECCEEECCCCCHHHHHHHHHHHCC
SGVPITVDGKLVGILTNRDLRFETNDNRICGDIMTKDNLITAPVGTTLDEAKQILMKHKV
CCCCEEECCEEEEEEECCCEEEECCCCEEEEEEECCCCEEECCCCCCHHHHHHHHHHHHH
EKLPIVDENGKLRGLITIKDIKKAKEYPNSAKDHRGRLRVAAAVGVASDTMERVQALVKA
HHCCEECCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHC
KVDVIVVDTAHGHSALVVKTVQNIRSAYPNLNIIAGNVATTEATRDLIEAGANAIKVGIG
CCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCEEEEECC
PGSICTTRVVAGVGVPQITAVYDCAQEAMKHGIPVIADGGIKYSGDIVKAIAAGASVVML
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCHHHHH
GSILAGTEESPGEKEIYQGRSYKVYRGMGSLGAMKKGSGDRYFQEQAKKMVPEGVEGRVP
HHHHCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
YKGQLSDTIFQLVGGLKAGMGYTGSRTINNLKTDAKFIRITPAGLKESHPHGVNITKEAP
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCCCCEEECCCC
NYSF
CCCC
>Mature Secondary Structure
MYPEKFAKVGLTFDDVLLVPGASEVLPREVDTSTYLTQDIKLNVPIMSAGMDTVTESRMA
CCCHHHHHCCCCCHHEEECCCCHHHCCCCCCCCCEEEECEEEECCEEECCCHHHHHHHEE
IAMAREGGIGVIHKNMSIARQALEVDKVKRSEHGIITDPIFLSPESPVSEAHELMERYHI
EEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCCEECCEEECCCCCHHHHHHHHHHHCC
SGVPITVDGKLVGILTNRDLRFETNDNRICGDIMTKDNLITAPVGTTLDEAKQILMKHKV
CCCCEEECCEEEEEEECCCEEEECCCCEEEEEEECCCCEEECCCCCCHHHHHHHHHHHHH
EKLPIVDENGKLRGLITIKDIKKAKEYPNSAKDHRGRLRVAAAVGVASDTMERVQALVKA
HHCCEECCCCCEEEEEEHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHC
KVDVIVVDTAHGHSALVVKTVQNIRSAYPNLNIIAGNVATTEATRDLIEAGANAIKVGIG
CCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCEEEEECC
PGSICTTRVVAGVGVPQITAVYDCAQEAMKHGIPVIADGGIKYSGDIVKAIAAGASVVML
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHCCCHHHHH
GSILAGTEESPGEKEIYQGRSYKVYRGMGSLGAMKKGSGDRYFQEQAKKMVPEGVEGRVP
HHHHCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
YKGQLSDTIFQLVGGLKAGMGYTGSRTINNLKTDAKFIRITPAGLKESHPHGVNITKEAP
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCCCCEEECCCC
NYSF
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]