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The map label for this gene is thlA [H]

Identifier: 134299743

GI number: 134299743

Start: 2080037

End: 2081161

Strand: Reverse

Name: thlA [H]

Synonym: Dred_1892

Alternate gene names: 134299743

Gene position: 2081161-2080037 (Counterclockwise)

Preceding gene: 134299744

Following gene: 134299742

Centisome position: 57.68

GC content: 44.36

Gene sequence:

>1125_bases
ATGGGAGTTGATATTACTGTAGGGAAGGAAGCCATCAAGCGGGCAGGAATTGATCCATCCATGGTTGATGAAATTACCCT
GGGGCAGGTTTATCCTCATATGCAAGGCTCGTTGCCAGCACGATGGGTAGGAATGGCCTGCGGACTAGATGTTAAGAGTA
GTGCAGTTAATGTTAACCAAAATTGTACCTCTGGTATGCGGGCCCTTGAAATTGCCGCTCATAATATCATGCTTGGTAAT
ACAGACATTGCTTTGGTGGTAGGTACAGAAAGTATGACCAACGTTCCTTATTTGCTCCCAAATGCAAGGATGGGTTACAG
GATGAATGCACAAACTGTTGAGGATGGCCTGATTCGTGATGCTTTATTCTGCCCTTTTACGGGTGCTCATATGGCCATAA
CCGCAGAAAATGTTGCCGAAAAATATGGAATTACCCGCGATGAATGTGACCAACTGGCCCTTATTAGTCACCAACGTGCC
AGCAAAGCAGTTGAAGAGGGAACTTTTAAACGAGAGGTAGTGCCGGTAGAGCTTAAAGGAAAAAAAGGACAGGTAACTTA
TTTTGAAAAAGATGAGCATTTAATAGCTGATGCCAATCTTGAAGCAATGAGTAAATTACCCCCGGTTTTTAAAAAAGGAG
GAACAGTTACCGCCGCCAATGCTTCTGGTATCAATGATGGAGCAGCAGCAACTATCCTAATGTCTAAGGAGAAAGCAAGG
GAATTGGGTATCAAGCCGCTTTTAAGATTAGTCAACATTTGCAGTGAGGGAATAGAACCTACAGTAATGGGATTGGGTCC
AGCAGTGGCTATTCCTAAAGTCCTTAAAAAGGCTAACCTGAACTTTGAAGATATAGAGTATTGGGAAATTAACGAGGCCT
TTGCTGCTCAGTTCTTGGGGGTAGGCAGGATGCTAAAAGAAGATTATGGCATGGAATTAACATTGGATAAAGTCAACCAT
AATGGCTCTGGAATCGCTCTGGGACACCCGGTTGGATGTACCGGTCTACGTCTAATAGTATCTTTATACTATGAAATGGA
ACGCCTGGGACTGACTCTGGGTGGAGCTTCCCTGTGTGTTGGAGATGGACCAGCGATGGCTTCCCTATGGAGCAGAGAAA
TATAG

Upstream 100 bases:

>100_bases
TGAGAGATTTTTGCTATTAAAAGCTACTTGTAGAAGTAATTACTACAAAAAACAGGAGGTATGAGTAATGGATTTAAGGG
GTTAGGAACTGTGGTGCAAT

Downstream 100 bases:

>100_bases
CCTTTAATAAAAAAATCATTGTTTAGAGGTGTTAATTTGCCACCCAAGAAGGCTACGAAGCTTGGCTAAATAAGTATGTC
CTTGGCACAAAGGATTGGGA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MGVDITVGKEAIKRAGIDPSMVDEITLGQVYPHMQGSLPARWVGMACGLDVKSSAVNVNQNCTSGMRALEIAAHNIMLGN
TDIALVVGTESMTNVPYLLPNARMGYRMNAQTVEDGLIRDALFCPFTGAHMAITAENVAEKYGITRDECDQLALISHQRA
SKAVEEGTFKREVVPVELKGKKGQVTYFEKDEHLIADANLEAMSKLPPVFKKGGTVTAANASGINDGAAATILMSKEKAR
ELGIKPLLRLVNICSEGIEPTVMGLGPAVAIPKVLKKANLNFEDIEYWEINEAFAAQFLGVGRMLKEDYGMELTLDKVNH
NGSGIALGHPVGCTGLRLIVSLYYEMERLGLTLGGASLCVGDGPAMASLWSREI

Sequences:

>Translated_374_residues
MGVDITVGKEAIKRAGIDPSMVDEITLGQVYPHMQGSLPARWVGMACGLDVKSSAVNVNQNCTSGMRALEIAAHNIMLGN
TDIALVVGTESMTNVPYLLPNARMGYRMNAQTVEDGLIRDALFCPFTGAHMAITAENVAEKYGITRDECDQLALISHQRA
SKAVEEGTFKREVVPVELKGKKGQVTYFEKDEHLIADANLEAMSKLPPVFKKGGTVTAANASGINDGAAATILMSKEKAR
ELGIKPLLRLVNICSEGIEPTVMGLGPAVAIPKVLKKANLNFEDIEYWEINEAFAAQFLGVGRMLKEDYGMELTLDKVNH
NGSGIALGHPVGCTGLRLIVSLYYEMERLGLTLGGASLCVGDGPAMASLWSREI
>Mature_373_residues
GVDITVGKEAIKRAGIDPSMVDEITLGQVYPHMQGSLPARWVGMACGLDVKSSAVNVNQNCTSGMRALEIAAHNIMLGNT
DIALVVGTESMTNVPYLLPNARMGYRMNAQTVEDGLIRDALFCPFTGAHMAITAENVAEKYGITRDECDQLALISHQRAS
KAVEEGTFKREVVPVELKGKKGQVTYFEKDEHLIADANLEAMSKLPPVFKKGGTVTAANASGINDGAAATILMSKEKARE
LGIKPLLRLVNICSEGIEPTVMGLGPAVAIPKVLKKANLNFEDIEYWEINEAFAAQFLGVGRMLKEDYGMELTLDKVNHN
GSGIALGHPVGCTGLRLIVSLYYEMERLGLTLGGASLCVGDGPAMASLWSREI

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=370, Percent_Identity=39.7297297297297, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI167614485, Length=364, Percent_Identity=39.2857142857143, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI4557237, Length=363, Percent_Identity=36.9146005509642, Blast_Score=221, Evalue=8e-58,
Organism=Homo sapiens, GI4501853, Length=365, Percent_Identity=36.1643835616438, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI4504327, Length=386, Percent_Identity=31.3471502590674, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI194353979, Length=212, Percent_Identity=27.8301886792453, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1788554, Length=368, Percent_Identity=44.5652173913043, Blast_Score=280, Evalue=9e-77,
Organism=Escherichia coli, GI87082165, Length=365, Percent_Identity=40, Blast_Score=268, Evalue=3e-73,
Organism=Escherichia coli, GI1787663, Length=366, Percent_Identity=37.1584699453552, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI48994986, Length=363, Percent_Identity=36.0881542699724, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1788683, Length=370, Percent_Identity=32.972972972973, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=369, Percent_Identity=37.6693766937669, Blast_Score=244, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI25147385, Length=355, Percent_Identity=36.3380281690141, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17535921, Length=368, Percent_Identity=37.7717391304348, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17535917, Length=357, Percent_Identity=29.9719887955182, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17551802, Length=371, Percent_Identity=33.6927223719677, Blast_Score=145, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6325229, Length=346, Percent_Identity=39.5953757225434, Blast_Score=229, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6322031, Length=357, Percent_Identity=35.5742296918768, Blast_Score=198, Evalue=9e-52,
Organism=Drosophila melanogaster, GI24655093, Length=359, Percent_Identity=42.6183844011142, Blast_Score=289, Evalue=3e-78,
Organism=Drosophila melanogaster, GI17648125, Length=360, Percent_Identity=39.1666666666667, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24640423, Length=360, Percent_Identity=37.2222222222222, Blast_Score=229, Evalue=3e-60,
Organism=Drosophila melanogaster, GI17137578, Length=390, Percent_Identity=31.2820512820513, Blast_Score=164, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40168; Mature: 40037

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVDITVGKEAIKRAGIDPSMVDEITLGQVYPHMQGSLPARWVGMACGLDVKSSAVNVNQ
CCCEEECCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHEEECCCCCCCEEECCC
NCTSGMRALEIAAHNIMLGNTDIALVVGTESMTNVPYLLPNARMGYRMNAQTVEDGLIRD
CHHHHHHHHHHHHCEEEECCCCEEEEECCCCCCCCCEECCCCCCCEEECHHHHHHHHHHH
ALFCPFTGAHMAITAENVAEKYGITRDECDQLALISHQRASKAVEEGTFKREVVPVELKG
HHCCCCCCCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
KKGQVTYFEKDEHLIADANLEAMSKLPPVFKKGGTVTAANASGINDGAAATILMSKEKAR
CCCCEEEEECCCCEEECCCHHHHHHCCHHHHCCCEEEECCCCCCCCCCEEEEEECHHHHH
ELGIKPLLRLVNICSEGIEPTVMGLGPAVAIPKVLKKANLNFEDIEYWEINEAFAAQFLG
HCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHH
VGRMLKEDYGMELTLDKVNHNGSGIALGHPVGCTGLRLIVSLYYEMERLGLTLGGASLCV
HHHHHHHHCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCEEECCCEEEE
GDGPAMASLWSREI
CCCHHHHHHHHCCC
>Mature Secondary Structure 
GVDITVGKEAIKRAGIDPSMVDEITLGQVYPHMQGSLPARWVGMACGLDVKSSAVNVNQ
CCEEECCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHEEECCCCCCCEEECCC
NCTSGMRALEIAAHNIMLGNTDIALVVGTESMTNVPYLLPNARMGYRMNAQTVEDGLIRD
CHHHHHHHHHHHHCEEEECCCCEEEEECCCCCCCCCEECCCCCCCEEECHHHHHHHHHHH
ALFCPFTGAHMAITAENVAEKYGITRDECDQLALISHQRASKAVEEGTFKREVVPVELKG
HHCCCCCCCEEEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
KKGQVTYFEKDEHLIADANLEAMSKLPPVFKKGGTVTAANASGINDGAAATILMSKEKAR
CCCCEEEEECCCCEEECCCHHHHHHCCHHHHCCCEEEECCCCCCCCCCEEEEEECHHHHH
ELGIKPLLRLVNICSEGIEPTVMGLGPAVAIPKVLKKANLNFEDIEYWEINEAFAAQFLG
HCCHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHH
VGRMLKEDYGMELTLDKVNHNGSGIALGHPVGCTGLRLIVSLYYEMERLGLTLGGASLCV
HHHHHHHHCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCEEECCCEEEE
GDGPAMASLWSREI
CCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA