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The map label for this gene is ponA [H]

Identifier: 134299503

GI number: 134299503

Start: 1798596

End: 1801082

Strand: Reverse

Name: ponA [H]

Synonym: Dred_1646

Alternate gene names: 134299503

Gene position: 1801082-1798596 (Counterclockwise)

Preceding gene: 134299506

Following gene: 134299479

Centisome position: 49.92

GC content: 44.87

Gene sequence:

>2487_bases
TTGGCAAAACGCAAAAGCCGAAGGCTTAGACCTGGACGCTTAATTTTACTTATTACAATTCTCATTGTTACGATAGGTGG
CCTGGCATCGCTGGGCTTTTTTGCCTATGCAATGTCGGACATGCCTGCCTTTAACCCCCAGGCCTTAGAGAATATGGTGC
CCACTTCAATTTATGATAAGGATGGCAACCTAGTAACAAGAATTGGTACAGAAAACCGAGAACCTATTCAATTAAGTGAA
GTACCTGCAACAGTGAAGGATGCCGTTCTAGCAACTGAAGATGAGCATTTCTACGATCATCACGGCATAAACTTTCGTAG
CTTAGGGCGTGCTGTTTTTAGAAACGTAGCTGCTGGTGAAATCCGTGAAGGCTTTAGCACAATTACCATGCAGTTAGTTA
AACTATCTTACCTGTCACCAGAACGTAGCATGAAACGAAAAATGCAGGAAGTTATTTTAACCCTCCAGATGGAAAGACAT
TTCATGAAAGATGAAATCTTTGAAATGTACCTTAACAAAATATACTTTGGTCAAGGAGCCTATGGGATTCAATCTGCCGC
CCAAATATATTTTGGCAAGGATTTAAAAACCGATGAATTAACCCTGGAAGAGGCTGCTTTTCTGGCAGGAATACCCCAGG
CGCCATCTGCTTACTCTCGCTACCTGGACAGTGGAAAATCCTTAGATGATGGAGAGAACTCAGAACAAGATAAGAAAAAA
CTTGAAGAACAGCATCAAAAGGATTATGACTTAACTCTTAATCGGCGTAATATTGTTTTATTAAGAATGAAAGAGGCCGG
TAAAATTACGGAAGAGGAACGTCAAGCTGCTGCTTCAAAACCCCTGCCTGACGGTACTAAAATGCAGGCAACTAGGTATC
CGTACCCCTACTTTATTGATTATGTAACAGAAAAACTGGTTCAAAAATATGGGCCAGATATGGTCTATAAGGGTGGTCTT
AAGGTTTATACAACTTTAGACCCCAAAATACAAAAAACCGTTGAATTGGCCATGGCCAATGCCAAAAATTTTCCTAATTA
CAAACCGGACAAAAACGGACTACCACAACCCCAGGGTGCTGCAGTCTTTATGGAACCCGGTACGGGGTATTTAAGGGCCA
TAGTTGGCGGGCGCGAGCACACGCACCAAAGGGCACTGAACCGTGCTACCCAGTATCAGATTCTTTCCAATGGCAGCAAA
ATAGGTCGTCAACCCGGTTCTTCCATTAAACCTATTGTTGCCTACGGACCTGCCGTTGAATACAAAGGTATGGGTCCTGC
TTCGGTCATTGATGATATCCCAACCTCCTTTGGCAATTACAGTCCAAAGAACTCGGGCGGTGGTTTCAGAGGATTGATTA
CCATGCGGCAGGCCCTAACTAGCTCCGTAAATATTGTGGCAGTTAAGCTTTTAAACTCCGTCGGTATTAGTCAAGCTGTG
AAATTTGCCCAGGGATTAGGAATAACTACTCTGGATGCCAATCGGGATGGTCTTGCCATGGCCCTGGGAGGCGTTAGCAG
CGGGGTTGTACCCTTAGATATGGTAGGAGCCTATGGTGCCTTTGCCAACCAAGGTATTTATGTCAAACCCCATGCAATTA
TTCGCGTAGAGCGTTTTGATGGGTCCATTGTGGAGGAATTTAAACCAGAACGCAGACAAGCCATGAAGGCTACCACCGCT
TACTTAATTACAGACATGCTGCGATCCGCTGTGCAATCAGGTACTGGCAGTCGGGCAAACCTTGGAGCAAGGCCCGTTGC
AGGTAAAACCGGTACCACCGATGAAGGTAAGGATATCTGGTTTGTGGGTTACACTCCTGAACTGGTAGGGGCAGTTTGGA
TCGGCCATGACTTGCCAACAAGAATGCCCCAGGCCTACGGCGGCATTTACCCTGCGATGATCTGGCGTGAGGTTATGAGC
AAGTCCCTGGCAGATGTACCAGTTCGCCCCTTTACAAAGCCCTCGGGGATTGTTTACGCCACTGTGGATAGTAAATCCGG
TCTTTTGCCCGGACCTAATACACCATCGGATCATATGGTACACGATATGTTTGCCCAAGGTACCATTCCCACTAAGGTTG
ATGATTTACATCAAATTATGGAAGTTTGTGCCACCACCGGAGAACTACCAAATGATTATTGTACAGACCGCATAACCAAG
GTGGTCATAAAAACACCTTATACAGTCCCTCCAAATGTAGCAGATTTTGCACTGAGGGCACCCGTAAAAACGTGTTCTCT
CCATACTGAGAACGGCATTGACCCGGCTGTGGCAGAGAAGTATAAACTGACAATTCCGGATAGCCCAGAAAATCAGGAAA
TGAATAACGGTAATCAAGAAGGAACCAACACCGTAACTCCCAAACCAAATGAAGGAGATAATTGGTTGCCAGGAACCACT
GGTTCCAATACTAACGAAAGTGAAGCTAAAAAAAAATTTCGTAAAGCAGCCAAGGTAAAAGAAACCTACCAACGAATTAT
TGAATAA

Upstream 100 bases:

>100_bases
CAGTAGGTGACAAGAAAACAAAAATTCTGCTCTGCCACCAGTATAGTATGGTATAATTTTGTTATCATTGCCTTATATTT
TCTCATAAGGAGGTTTTCTT

Downstream 100 bases:

>100_bases
TTATCTTTTATTAAAAACGCCGGCAAAATCCCCATGGGTTTTGCCGGCGTTCTTTAGTCTTATTCTTTTTAAGGCTTACG
CCTCGCCTAAAGGCTCTTGT

Product: 1A family penicillin-binding protein

Products: NA

Alternate protein names: PBP1; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 828; Mature: 827

Protein sequence:

>828_residues
MAKRKSRRLRPGRLILLITILIVTIGGLASLGFFAYAMSDMPAFNPQALENMVPTSIYDKDGNLVTRIGTENREPIQLSE
VPATVKDAVLATEDEHFYDHHGINFRSLGRAVFRNVAAGEIREGFSTITMQLVKLSYLSPERSMKRKMQEVILTLQMERH
FMKDEIFEMYLNKIYFGQGAYGIQSAAQIYFGKDLKTDELTLEEAAFLAGIPQAPSAYSRYLDSGKSLDDGENSEQDKKK
LEEQHQKDYDLTLNRRNIVLLRMKEAGKITEEERQAAASKPLPDGTKMQATRYPYPYFIDYVTEKLVQKYGPDMVYKGGL
KVYTTLDPKIQKTVELAMANAKNFPNYKPDKNGLPQPQGAAVFMEPGTGYLRAIVGGREHTHQRALNRATQYQILSNGSK
IGRQPGSSIKPIVAYGPAVEYKGMGPASVIDDIPTSFGNYSPKNSGGGFRGLITMRQALTSSVNIVAVKLLNSVGISQAV
KFAQGLGITTLDANRDGLAMALGGVSSGVVPLDMVGAYGAFANQGIYVKPHAIIRVERFDGSIVEEFKPERRQAMKATTA
YLITDMLRSAVQSGTGSRANLGARPVAGKTGTTDEGKDIWFVGYTPELVGAVWIGHDLPTRMPQAYGGIYPAMIWREVMS
KSLADVPVRPFTKPSGIVYATVDSKSGLLPGPNTPSDHMVHDMFAQGTIPTKVDDLHQIMEVCATTGELPNDYCTDRITK
VVIKTPYTVPPNVADFALRAPVKTCSLHTENGIDPAVAEKYKLTIPDSPENQEMNNGNQEGTNTVTPKPNEGDNWLPGTT
GSNTNESEAKKKFRKAAKVKETYQRIIE

Sequences:

>Translated_828_residues
MAKRKSRRLRPGRLILLITILIVTIGGLASLGFFAYAMSDMPAFNPQALENMVPTSIYDKDGNLVTRIGTENREPIQLSE
VPATVKDAVLATEDEHFYDHHGINFRSLGRAVFRNVAAGEIREGFSTITMQLVKLSYLSPERSMKRKMQEVILTLQMERH
FMKDEIFEMYLNKIYFGQGAYGIQSAAQIYFGKDLKTDELTLEEAAFLAGIPQAPSAYSRYLDSGKSLDDGENSEQDKKK
LEEQHQKDYDLTLNRRNIVLLRMKEAGKITEEERQAAASKPLPDGTKMQATRYPYPYFIDYVTEKLVQKYGPDMVYKGGL
KVYTTLDPKIQKTVELAMANAKNFPNYKPDKNGLPQPQGAAVFMEPGTGYLRAIVGGREHTHQRALNRATQYQILSNGSK
IGRQPGSSIKPIVAYGPAVEYKGMGPASVIDDIPTSFGNYSPKNSGGGFRGLITMRQALTSSVNIVAVKLLNSVGISQAV
KFAQGLGITTLDANRDGLAMALGGVSSGVVPLDMVGAYGAFANQGIYVKPHAIIRVERFDGSIVEEFKPERRQAMKATTA
YLITDMLRSAVQSGTGSRANLGARPVAGKTGTTDEGKDIWFVGYTPELVGAVWIGHDLPTRMPQAYGGIYPAMIWREVMS
KSLADVPVRPFTKPSGIVYATVDSKSGLLPGPNTPSDHMVHDMFAQGTIPTKVDDLHQIMEVCATTGELPNDYCTDRITK
VVIKTPYTVPPNVADFALRAPVKTCSLHTENGIDPAVAEKYKLTIPDSPENQEMNNGNQEGTNTVTPKPNEGDNWLPGTT
GSNTNESEAKKKFRKAAKVKETYQRIIE
>Mature_827_residues
AKRKSRRLRPGRLILLITILIVTIGGLASLGFFAYAMSDMPAFNPQALENMVPTSIYDKDGNLVTRIGTENREPIQLSEV
PATVKDAVLATEDEHFYDHHGINFRSLGRAVFRNVAAGEIREGFSTITMQLVKLSYLSPERSMKRKMQEVILTLQMERHF
MKDEIFEMYLNKIYFGQGAYGIQSAAQIYFGKDLKTDELTLEEAAFLAGIPQAPSAYSRYLDSGKSLDDGENSEQDKKKL
EEQHQKDYDLTLNRRNIVLLRMKEAGKITEEERQAAASKPLPDGTKMQATRYPYPYFIDYVTEKLVQKYGPDMVYKGGLK
VYTTLDPKIQKTVELAMANAKNFPNYKPDKNGLPQPQGAAVFMEPGTGYLRAIVGGREHTHQRALNRATQYQILSNGSKI
GRQPGSSIKPIVAYGPAVEYKGMGPASVIDDIPTSFGNYSPKNSGGGFRGLITMRQALTSSVNIVAVKLLNSVGISQAVK
FAQGLGITTLDANRDGLAMALGGVSSGVVPLDMVGAYGAFANQGIYVKPHAIIRVERFDGSIVEEFKPERRQAMKATTAY
LITDMLRSAVQSGTGSRANLGARPVAGKTGTTDEGKDIWFVGYTPELVGAVWIGHDLPTRMPQAYGGIYPAMIWREVMSK
SLADVPVRPFTKPSGIVYATVDSKSGLLPGPNTPSDHMVHDMFAQGTIPTKVDDLHQIMEVCATTGELPNDYCTDRITKV
VIKTPYTVPPNVADFALRAPVKTCSLHTENGIDPAVAEKYKLTIPDSPENQEMNNGNQEGTNTVTPKPNEGDNWLPGTTG
SNTNESEAKKKFRKAAKVKETYQRIIE

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein. Note=Probably found all over the whole cell at low concentrations. Also localizes to the division site in vegetative cells [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 fibronectin type-III domain [H]

Homologues:

Organism=Escherichia coli, GI1786343, Length=604, Percent_Identity=30.2980132450331, Blast_Score=204, Evalue=2e-53,
Organism=Escherichia coli, GI87082258, Length=329, Percent_Identity=32.2188449848024, Blast_Score=196, Evalue=5e-51,
Organism=Escherichia coli, GI1788867, Length=601, Percent_Identity=27.7870216306156, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI1789601, Length=240, Percent_Identity=29.5833333333333, Blast_Score=81, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR008957
- InterPro:   IPR003961
- InterPro:   IPR001264
- InterPro:   IPR013783
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00041 fn3; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.1.129; 3.4.-.- [C]

Molecular weight: Translated: 91059; Mature: 90928

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRKSRRLRPGRLILLITILIVTIGGLASLGFFAYAMSDMPAFNPQALENMVPTSIYDK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEECC
DGNLVTRIGTENREPIQLSEVPATVKDAVLATEDEHFYDHHGINFRSLGRAVFRNVAAGE
CCCEEEEECCCCCCCEEHHHCCCHHHHHHEECCCCCHHHCCCCCHHHHHHHHHHHHHHHH
IREGFSTITMQLVKLSYLSPERSMKRKMQEVILTLQMERHFMKDEIFEMYLNKIYFGQGA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YGIQSAAQIYFGKDLKTDELTLEEAAFLAGIPQAPSAYSRYLDSGKSLDDGENSEQDKKK
CCHHHHHHHEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHH
LEEQHQKDYDLTLNRRNIVLLRMKEAGKITEEERQAAASKPLPDGTKMQATRYPYPYFID
HHHHHCCCCCEEECCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCEECCCCHHHHH
YVTEKLVQKYGPDMVYKGGLKVYTTLDPKIQKTVELAMANAKNFPNYKPDKNGLPQPQGA
HHHHHHHHHHCCCEEEECCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
AVFMEPGTGYLRAIVGGREHTHQRALNRATQYQILSNGSKIGRQPGSSIKPIVAYGPAVE
EEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEECCCCC
YKGMGPASVIDDIPTSFGNYSPKNSGGGFRGLITMRQALTSSVNIVAVKLLNSVGISQAV
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHH
KFAQGLGITTLDANRDGLAMALGGVSSGVVPLDMVGAYGAFANQGIYVKPHAIIRVERFD
HHHHCCCEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCEEECCCEEEEEECCC
GSIVEEFKPERRQAMKATTAYLITDMLRSAVQSGTGSRANLGARPVAGKTGTTDEGKDIW
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEE
FVGYTPELVGAVWIGHDLPTRMPQAYGGIYPAMIWREVMSKSLADVPVRPFTKPSGIVYA
EEECCHHHHHHHHCCCCCCHHCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
TVDSKSGLLPGPNTPSDHMVHDMFAQGTIPTKVDDLHQIMEVCATTGELPNDYCTDRITK
EECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VVIKTPYTVPPNVADFALRAPVKTCSLHTENGIDPAVAEKYKLTIPDSPENQEMNNGNQE
HHEECCCCCCCCHHHHHHHCCHHHHEECCCCCCCHHHHCCEEEECCCCCCCCCCCCCCCC
GTNTVTPKPNEGDNWLPGTTGSNTNESEAKKKFRKAAKVKETYQRIIE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKRKSRRLRPGRLILLITILIVTIGGLASLGFFAYAMSDMPAFNPQALENMVPTSIYDK
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEECC
DGNLVTRIGTENREPIQLSEVPATVKDAVLATEDEHFYDHHGINFRSLGRAVFRNVAAGE
CCCEEEEECCCCCCCEEHHHCCCHHHHHHEECCCCCHHHCCCCCHHHHHHHHHHHHHHHH
IREGFSTITMQLVKLSYLSPERSMKRKMQEVILTLQMERHFMKDEIFEMYLNKIYFGQGA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YGIQSAAQIYFGKDLKTDELTLEEAAFLAGIPQAPSAYSRYLDSGKSLDDGENSEQDKKK
CCHHHHHHHEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHH
LEEQHQKDYDLTLNRRNIVLLRMKEAGKITEEERQAAASKPLPDGTKMQATRYPYPYFID
HHHHHCCCCCEEECCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCEECCCCHHHHH
YVTEKLVQKYGPDMVYKGGLKVYTTLDPKIQKTVELAMANAKNFPNYKPDKNGLPQPQGA
HHHHHHHHHHCCCEEEECCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
AVFMEPGTGYLRAIVGGREHTHQRALNRATQYQILSNGSKIGRQPGSSIKPIVAYGPAVE
EEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEEEECCCCC
YKGMGPASVIDDIPTSFGNYSPKNSGGGFRGLITMRQALTSSVNIVAVKLLNSVGISQAV
CCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHH
KFAQGLGITTLDANRDGLAMALGGVSSGVVPLDMVGAYGAFANQGIYVKPHAIIRVERFD
HHHHCCCEEEECCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCEEECCCEEEEEECCC
GSIVEEFKPERRQAMKATTAYLITDMLRSAVQSGTGSRANLGARPVAGKTGTTDEGKDIW
CHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEE
FVGYTPELVGAVWIGHDLPTRMPQAYGGIYPAMIWREVMSKSLADVPVRPFTKPSGIVYA
EEECCHHHHHHHHCCCCCCHHCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEE
TVDSKSGLLPGPNTPSDHMVHDMFAQGTIPTKVDDLHQIMEVCATTGELPNDYCTDRITK
EECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VVIKTPYTVPPNVADFALRAPVKTCSLHTENGIDPAVAEKYKLTIPDSPENQEMNNGNQE
HHEECCCCCCCCHHHHHHHCCHHHHEECCCCCCCHHHHCCEEEECCCCCCCCCCCCCCCC
GTNTVTPKPNEGDNWLPGTTGSNTNESEAKKKFRKAAKVKETYQRIIE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7814321; 8760912; 9384377; 9721295; 10322023 [H]