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The map label for this gene is upp [H]

Identifier: 134299181

GI number: 134299181

Start: 1411211

End: 1411849

Strand: Reverse

Name: upp [H]

Synonym: Dred_1318

Alternate gene names: 134299181

Gene position: 1411849-1411211 (Counterclockwise)

Preceding gene: 134299182

Following gene: 134299180

Centisome position: 39.13

GC content: 41.63

Gene sequence:

>639_bases
ATGGAAACCGTAACGATTCTCCGTCATCCACTGGCGGATGAACAGCTTCAATTAATAAGAAATAAAGAAAGTGACATAAC
AATTTTTCGTGCAGCTATGACACGCCTAGGGTGTTTGTTGGCCATTGAGGCTACTAAGGACGCACCCACCAAAGAAATGA
AAATAACCACTCCTATGGAAGTTGAAACAACTATATCCGCCTTAGAGGACGATAAAATCCTCTTGGTCCCCATTTTACGT
GCGGGATTAGGATTGGTAGAAAGTTTCCTAACTTTTTTACCCAAAGCCAAAGTTGCCCATATTGGTATGTCCAGGGATCA
CGATACACTGGAGGCTAAGCTTTATGTTAATAGCCTGCCGAAAAATTTAAAGGATTTTAAACAAGTTCTGGTGCTTGATC
CAATGTTGGCTACCGGTAACAGTTGTGTAAAGGCTTTGGAGGTCCTAGAAGAGTTTGGAGCCGATTCTTCTAAAATAAAA
GTAGCTTGTGCCTTTGCGGTAAAACAAGGATTAGATCAGATTGCTGATAAATTTCCAAAAGTAAGAGTTGTGGCAGGGGT
AGTAGATCCAGTCCTTACCAGTATTGGTTATATTTCCCCGGGTTGCGGAGATGCAGGAGACAGGTTATACTTACTCTAA

Upstream 100 bases:

>100_bases
AATTTATATCGAATTTTGGGTATTTGGAAATTGATCTGGCATATCCTATTAGTCTTACTAAGCACGGTACTGCCGGAATA
CAAAGGAGGCAGTGTAAAGA

Downstream 100 bases:

>100_bases
TGACAATCTAATATTATGTCTGGCACCTTTAAATTAGTACAGAGAGACTAATAAGGTAGCGATAGCAGGATAAGTATATT
CCTATAGTTATTTAGCTCCT

Product: phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
METVTILRHPLADEQLQLIRNKESDITIFRAAMTRLGCLLAIEATKDAPTKEMKITTPMEVETTISALEDDKILLVPILR
AGLGLVESFLTFLPKAKVAHIGMSRDHDTLEAKLYVNSLPKNLKDFKQVLVLDPMLATGNSCVKALEVLEEFGADSSKIK
VACAFAVKQGLDQIADKFPKVRVVAGVVDPVLTSIGYISPGCGDAGDRLYLL

Sequences:

>Translated_212_residues
METVTILRHPLADEQLQLIRNKESDITIFRAAMTRLGCLLAIEATKDAPTKEMKITTPMEVETTISALEDDKILLVPILR
AGLGLVESFLTFLPKAKVAHIGMSRDHDTLEAKLYVNSLPKNLKDFKQVLVLDPMLATGNSCVKALEVLEEFGADSSKIK
VACAFAVKQGLDQIADKFPKVRVVAGVVDPVLTSIGYISPGCGDAGDRLYLL
>Mature_212_residues
METVTILRHPLADEQLQLIRNKESDITIFRAAMTRLGCLLAIEATKDAPTKEMKITTPMEVETTISALEDDKILLVPILR
AGLGLVESFLTFLPKAKVAHIGMSRDHDTLEAKLYVNSLPKNLKDFKQVLVLDPMLATGNSCVKALEVLEEFGADSSKIK
VACAFAVKQGLDQIADKFPKVRVVAGVVDPVLTSIGYISPGCGDAGDRLYLL

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI21450816, Length=185, Percent_Identity=28.1081081081081, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI301129207, Length=193, Percent_Identity=26.9430051813472, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI57863312, Length=193, Percent_Identity=26.9430051813472, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87082118, Length=207, Percent_Identity=35.7487922705314, Blast_Score=129, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17539892, Length=212, Percent_Identity=27.3584905660377, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17539894, Length=212, Percent_Identity=27.3584905660377, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6321920, Length=194, Percent_Identity=32.4742268041237, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324339, Length=174, Percent_Identity=28.1609195402299, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45550449, Length=191, Percent_Identity=32.4607329842932, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI28573516, Length=191, Percent_Identity=32.4607329842932, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28573514, Length=191, Percent_Identity=32.4607329842932, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28573512, Length=191, Percent_Identity=32.4607329842932, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23093; Mature: 23093

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METVTILRHPLADEQLQLIRNKESDITIFRAAMTRLGCLLAIEATKDAPTKEMKITTPME
CCCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCEEECCCCH
VETTISALEDDKILLVPILRAGLGLVESFLTFLPKAKVAHIGMSRDHDTLEAKLYVNSLP
HHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHCC
KNLKDFKQVLVLDPMLATGNSCVKALEVLEEFGADSSKIKVACAFAVKQGLDQIADKFPK
CHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCC
VRVVAGVVDPVLTSIGYISPGCGDAGDRLYLL
EEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEC
>Mature Secondary Structure
METVTILRHPLADEQLQLIRNKESDITIFRAAMTRLGCLLAIEATKDAPTKEMKITTPME
CCCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCCEEECCCCH
VETTISALEDDKILLVPILRAGLGLVESFLTFLPKAKVAHIGMSRDHDTLEAKLYVNSLP
HHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHCC
KNLKDFKQVLVLDPMLATGNSCVKALEVLEEFGADSSKIKVACAFAVKQGLDQIADKFPK
CHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCC
VRVVAGVVDPVLTSIGYISPGCGDAGDRLYLL
EEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]