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The map label for this gene is sstT [H]

Identifier: 134298773

GI number: 134298773

Start: 967134

End: 968333

Strand: Reverse

Name: sstT [H]

Synonym: Dred_0908

Alternate gene names: 134298773

Gene position: 968333-967134 (Counterclockwise)

Preceding gene: 134298777

Following gene: 134298772

Centisome position: 26.84

GC content: 44.67

Gene sequence:

>1200_bases
ATGAAGAAAGTAGGACTCTTAACCAGATTAATTATTGGACTTATTTTTGGTATTTTAGTTGGTTATGTTTCTAAAGAATT
CTTACAATTTGATGCCTTGGTTCGTTTGCTGGCAACTTTTAACGGTATCTTTGGCGGATTCTTATCCTATGTTATTCCTC
TTATCATTATTGGTTTTGTGGCCCCCGGTATTGCTGAACTGGGTAAAGGGGCTGGCAGACTTCTTGGTATCACTACCCTG
TTTGCCTATGTATCCACTGTCATTGCCGGTACCTTTGCTTTCCTTGTCGGCACGGGCCTACTTCCCAAGATTGTAACCGC
GGTAGGTGGACATGCTTCTAACCCTGAAGAAGCGCTGGTGAAAGGCTTTTTCCAAGTAGATATGCCTCCTATAATGGGTG
TAATGACTGCATTAATCACTGCTTTCCTGTTTGGTCTCGGTATGGCTTCCATTAAAAATAAATCTCTGTACCAAGTAACG
AAGGATTTCCAGGAGATTATTGAGAAAGTTATCCAAAGCGTCATTATTCCTTTACTTCCCATCCACATTGCCGGTATTTT
TGCCAACATGACCTATGCCGGTGAAGTGGCAAAGATCATGAAAATCTTTGGTTCTGTATTTGCCATTGTAATATTATGTC
ACCTGATTATGCTTGTATTCCAGTACGTCATTGCCGGAACCACAACTGGCAAGAATCCCTTTACTGCTTTGAAAAATATG
GTTCCTGCTTATCTGACAGCCATTGGTACGCAGTCCTCCGCTGCTACCATCCCGGTAACCCTGCGCTGTGCTAAAAAGAA
TGGTATTTCCGATGGAGTAGCAGATTTCGCAATACCCCTATGCGCCACCATCCATTTATCTGGTAGTACTATCACCTTGA
CCATGTGTGCAATGGCTGTTATGATGATGGGCGGTATTGATCCCAGCTTCGGTATGATGTTTCCCTTTGTTTTGATGCTT
GGTGTCACTATGGTTGCGGCTCCCGGTGTCCCCGGTGGTGCTGTCATGGCAGCCCTTGGGTTACTCCAATCTATGTTGGG
TTTCAACGAAGCACAACTGGGCCTTATGATTGCACTTTACCTAACTCAGGACAGCTTTGGTACTGCCTGCAACGTAACCG
GCGATGGAGCTATCGCCTTGCTGTCTAACAAATTTGCTAAGGGCTCAGGTACCGTTGCAACTGGAGTTGAGGTCGCTTAA

Upstream 100 bases:

>100_bases
TAATCAACTAATAGCTTTTTTAATATCGAAAGGAGGTAAAATAGCAAAATACTTTGATCATTTACAACATCTTAGTCTAA
TCAGAAAGTGAGGTATTATG

Downstream 100 bases:

>100_bases
CTAATTATTTAGAAGAAAATAACCCATATTGTTAAACAGGGAGTCGTAAAGGCTCCCTGTTTTTGTATTAAGGTTCTCTT
ATCTATACCTTAATGCTTTT

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Na(+)/serine-threonine symporter [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKKVGLLTRLIIGLIFGILVGYVSKEFLQFDALVRLLATFNGIFGGFLSYVIPLIIIGFVAPGIAELGKGAGRLLGITTL
FAYVSTVIAGTFAFLVGTGLLPKIVTAVGGHASNPEEALVKGFFQVDMPPIMGVMTALITAFLFGLGMASIKNKSLYQVT
KDFQEIIEKVIQSVIIPLLPIHIAGIFANMTYAGEVAKIMKIFGSVFAIVILCHLIMLVFQYVIAGTTTGKNPFTALKNM
VPAYLTAIGTQSSAATIPVTLRCAKKNGISDGVADFAIPLCATIHLSGSTITLTMCAMAVMMMGGIDPSFGMMFPFVLML
GVTMVAAPGVPGGAVMAALGLLQSMLGFNEAQLGLMIALYLTQDSFGTACNVTGDGAIALLSNKFAKGSGTVATGVEVA

Sequences:

>Translated_399_residues
MKKVGLLTRLIIGLIFGILVGYVSKEFLQFDALVRLLATFNGIFGGFLSYVIPLIIIGFVAPGIAELGKGAGRLLGITTL
FAYVSTVIAGTFAFLVGTGLLPKIVTAVGGHASNPEEALVKGFFQVDMPPIMGVMTALITAFLFGLGMASIKNKSLYQVT
KDFQEIIEKVIQSVIIPLLPIHIAGIFANMTYAGEVAKIMKIFGSVFAIVILCHLIMLVFQYVIAGTTTGKNPFTALKNM
VPAYLTAIGTQSSAATIPVTLRCAKKNGISDGVADFAIPLCATIHLSGSTITLTMCAMAVMMMGGIDPSFGMMFPFVLML
GVTMVAAPGVPGGAVMAALGLLQSMLGFNEAQLGLMIALYLTQDSFGTACNVTGDGAIALLSNKFAKGSGTVATGVEVA
>Mature_399_residues
MKKVGLLTRLIIGLIFGILVGYVSKEFLQFDALVRLLATFNGIFGGFLSYVIPLIIIGFVAPGIAELGKGAGRLLGITTL
FAYVSTVIAGTFAFLVGTGLLPKIVTAVGGHASNPEEALVKGFFQVDMPPIMGVMTALITAFLFGLGMASIKNKSLYQVT
KDFQEIIEKVIQSVIIPLLPIHIAGIFANMTYAGEVAKIMKIFGSVFAIVILCHLIMLVFQYVIAGTTTGKNPFTALKNM
VPAYLTAIGTQSSAATIPVTLRCAKKNGISDGVADFAIPLCATIHLSGSTITLTMCAMAVMMMGGIDPSFGMMFPFVLML
GVTMVAAPGVPGGAVMAALGLLQSMLGFNEAQLGLMIALYLTQDSFGTACNVTGDGAIALLSNKFAKGSGTVATGVEVA

Specific function: Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=149, Percent_Identity=32.2147651006711, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI169790839, Length=241, Percent_Identity=25.7261410788382, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI66773030, Length=266, Percent_Identity=27.4436090225564, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI21314632, Length=175, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI194239697, Length=169, Percent_Identity=29.585798816568, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4827012, Length=241, Percent_Identity=25.7261410788382, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI223468566, Length=171, Percent_Identity=25.7309941520468, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI223468564, Length=171, Percent_Identity=25.7309941520468, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71983106, Length=150, Percent_Identity=30.6666666666667, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71983099, Length=150, Percent_Identity=30.6666666666667, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17537407, Length=147, Percent_Identity=31.2925170068027, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583025, Length=161, Percent_Identity=27.3291925465839, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17137668, Length=161, Percent_Identity=27.3291925465839, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24583023, Length=161, Percent_Identity=27.3291925465839, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR023025 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 41606; Mature: 41606

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EECCCCCCEEECCCCCHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKVGLLTRLIIGLIFGILVGYVSKEFLQFDALVRLLATFNGIFGGFLSYVIPLIIIGFV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APGIAELGKGAGRLLGITTLFAYVSTVIAGTFAFLVGTGLLPKIVTAVGGHASNPEEALV
CCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHH
KGFFQVDMPPIMGVMTALITAFLFGLGMASIKNKSLYQVTKDFQEIIEKVIQSVIIPLLP
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IHIAGIFANMTYAGEVAKIMKIFGSVFAIVILCHLIMLVFQYVIAGTTTGKNPFTALKNM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
VPAYLTAIGTQSSAATIPVTLRCAKKNGISDGVADFAIPLCATIHLSGSTITLTMCAMAV
HHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHEEECCCHHHHHHHHHHH
MMMGGIDPSFGMMFPFVLMLGVTMVAAPGVPGGAVMAALGLLQSMLGFNEAQLGLMIALY
HHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHE
LTQDSFGTACNVTGDGAIALLSNKFAKGSGTVATGVEVA
EECCCCCCEEECCCCCHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA