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The map label for this gene is dnaX [H]

Identifier: 126697186

GI number: 126697186

Start: 1573675

End: 1575435

Strand: Direct

Name: dnaX [H]

Synonym: P9301_18481

Alternate gene names: 126697186

Gene position: 1573675-1575435 (Clockwise)

Preceding gene: 126697185

Following gene: 126697189

Centisome position: 95.85

GC content: 29.36

Gene sequence:

>1761_bases
ATGCCAAATATACATAAGCCTTTTCATCAAAAATATAGACCAAACAACTTAGACGAACTGGTTGGGCAAAAATTTATATC
CATTACACTCAAGCAAGCACTATTAACAAAAAAAATTGCTCCTGCATATCTTTTTAATGGTCCAAGAGGCACTGGAAAAA
CATCTAGTGCAAGAATATTTGCAAAATCACTAAATTGCCAGGCATTCGACCAACCTACGATAACTCCTTGTTGTAAATGT
GACTTATGCAGACAAATTACAGATGGGAGCGCTCTAGATATTATCGAGATTGATGCAGCATCAAATACAGGAGTAGAAAA
TATAAGAGAAATTATAGAAAGAGCGAGATTTGCACCTACTCAAGCGAGATGGAAAGTATATGTTATTGATGAATGTCATA
TGCTTTCAACAGCAGCTTCAAATGCTTTACTAAAAACTATTGAAGAACCGCCCTCAAGAGTTGTATTTATCCTGGCGACG
ACAAATCCTGAGAGAGTATTAAGTACAATAAAAAGTAGATGTCAAAAGTTTGATTTTAGAAGAATAAGCCCTAGTGATAT
TTTTCAACATTTATCAGAAATCGCCGAAAAAGAATCCATTAAATACGAAGTTCAGGCCTTAAAAATGATTGCAAAAAGAT
CTAATGGAGGTATGAGAGATGCACAAAGCCTCCTTGAACAATTGAATCTTTTACCAGAAGGGATAACAATTAATAATATC
CAAAACCTCCTAGGGGAAGTATCAGAAAATGAATTAACAAATCTGATTAAATCATTGGTTGAGAATAATCCAGAGTCATT
AATTATCACATGCAACAAATTATATGATGCTGGCAACGAACCTCTTCAAATAATTATCGGATTATTGAATATAACAAGAG
ATCTACTATTACATACTACAAATAATAAATACTCAGATCTTTATTATACGTCTGATGAATTTCAAGATGAATTGAATAAA
ATCTCAAAAACAATAAATAAATCAACAATAATTAATTGGCATAATAATCTGAGAAATATTGAATATCAAATCAAATCAAG
TGATAATCCAAGGCTTTGGTTTGAAATACATTTAACTGGCCTTCTAGGTAATCAAGAGATAAATAGTTCTGAGAATAAGC
AAAGTAAAAATAATAAGACTAAGGAGAATCATGAAAGTAGAGAAAACATTCCAATTGTTAATAAAGAAAATATTTCTAAT
GAAATTCAAAAACCAAGTATCAAGAAAAATATAACTCGCGATGAATTAATTGAAAAAAAAGACGAAAAATTTGAAAAATT
TGAAGTTCTTGAAAAAGAAAGTATTGAAAATATTTCTGACAATAACCAAAATAATCCAGAATCAAATAATTTAAATGATA
AATGGGAATTAATTCTTTCTAAAGTTGAGTTACCATCAACAAGAATGTTACTTTCACAACAAGCAGAACTTGAAAGTATT
GATTCCGAGAAAATTACAATTGCATTATCTCCAAACTGGGAAAGTATGATAAAAAGCAGAAAAGTTATAATTGAAAATTC
TGTCAGGAAGATATTTGGAGATCAAATAATACTTAATTTTTCAACCAAACAATTAAATAAAAATAAACCAACAAAGACTT
CAGAAATAACACAAAATGAAGTAAATAAATTTCGACCAATAAAAAAAATAGAAACACAAACTAATGCATCAACAAAAATA
TCTAACGAGGAAACTTATGATGATAGTTCAAAAAACTTAGCAAATTTTTTCAATGGAGAAATTATAGACCTTGATGAATA
A

Upstream 100 bases:

>100_bases
ACTACCTTCAGGATCAAAAAGAGTCATTAAAGAGTCTGCATAAAATTAGAGTTTAATTTTTTTAATTTAATCCCGAATTT
TTCTAATGAATGAAAAATAA

Downstream 100 bases:

>100_bases
ATTAAACTCCAGTATGAAGAGTTTTGCGCCAGAGTATCTTTTTAGGAAAAATAGACATCTTTATTGTTACCCAAGGGATT
ACTAAAAACCAATGTGATAA

Product: DNA polymerase, gamma and tau subunits

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MPNIHKPFHQKYRPNNLDELVGQKFISITLKQALLTKKIAPAYLFNGPRGTGKTSSARIFAKSLNCQAFDQPTITPCCKC
DLCRQITDGSALDIIEIDAASNTGVENIREIIERARFAPTQARWKVYVIDECHMLSTAASNALLKTIEEPPSRVVFILAT
TNPERVLSTIKSRCQKFDFRRISPSDIFQHLSEIAEKESIKYEVQALKMIAKRSNGGMRDAQSLLEQLNLLPEGITINNI
QNLLGEVSENELTNLIKSLVENNPESLIITCNKLYDAGNEPLQIIIGLLNITRDLLLHTTNNKYSDLYYTSDEFQDELNK
ISKTINKSTIINWHNNLRNIEYQIKSSDNPRLWFEIHLTGLLGNQEINSSENKQSKNNKTKENHESRENIPIVNKENISN
EIQKPSIKKNITRDELIEKKDEKFEKFEVLEKESIENISDNNQNNPESNNLNDKWELILSKVELPSTRMLLSQQAELESI
DSEKITIALSPNWESMIKSRKVIIENSVRKIFGDQIILNFSTKQLNKNKPTKTSEITQNEVNKFRPIKKIETQTNASTKI
SNEETYDDSSKNLANFFNGEIIDLDE

Sequences:

>Translated_586_residues
MPNIHKPFHQKYRPNNLDELVGQKFISITLKQALLTKKIAPAYLFNGPRGTGKTSSARIFAKSLNCQAFDQPTITPCCKC
DLCRQITDGSALDIIEIDAASNTGVENIREIIERARFAPTQARWKVYVIDECHMLSTAASNALLKTIEEPPSRVVFILAT
TNPERVLSTIKSRCQKFDFRRISPSDIFQHLSEIAEKESIKYEVQALKMIAKRSNGGMRDAQSLLEQLNLLPEGITINNI
QNLLGEVSENELTNLIKSLVENNPESLIITCNKLYDAGNEPLQIIIGLLNITRDLLLHTTNNKYSDLYYTSDEFQDELNK
ISKTINKSTIINWHNNLRNIEYQIKSSDNPRLWFEIHLTGLLGNQEINSSENKQSKNNKTKENHESRENIPIVNKENISN
EIQKPSIKKNITRDELIEKKDEKFEKFEVLEKESIENISDNNQNNPESNNLNDKWELILSKVELPSTRMLLSQQAELESI
DSEKITIALSPNWESMIKSRKVIIENSVRKIFGDQIILNFSTKQLNKNKPTKTSEITQNEVNKFRPIKKIETQTNASTKI
SNEETYDDSSKNLANFFNGEIIDLDE
>Mature_585_residues
PNIHKPFHQKYRPNNLDELVGQKFISITLKQALLTKKIAPAYLFNGPRGTGKTSSARIFAKSLNCQAFDQPTITPCCKCD
LCRQITDGSALDIIEIDAASNTGVENIREIIERARFAPTQARWKVYVIDECHMLSTAASNALLKTIEEPPSRVVFILATT
NPERVLSTIKSRCQKFDFRRISPSDIFQHLSEIAEKESIKYEVQALKMIAKRSNGGMRDAQSLLEQLNLLPEGITINNIQ
NLLGEVSENELTNLIKSLVENNPESLIITCNKLYDAGNEPLQIIIGLLNITRDLLLHTTNNKYSDLYYTSDEFQDELNKI
SKTINKSTIINWHNNLRNIEYQIKSSDNPRLWFEIHLTGLLGNQEINSSENKQSKNNKTKENHESRENIPIVNKENISNE
IQKPSIKKNITRDELIEKKDEKFEKFEVLEKESIENISDNNQNNPESNNLNDKWELILSKVELPSTRMLLSQQAELESID
SEKITIALSPNWESMIKSRKVIIENSVRKIFGDQIILNFSTKQLNKNKPTKTSEITQNEVNKFRPIKKIETQTNASTKIS
NEETYDDSSKNLANFFNGEIIDLDE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=290, Percent_Identity=26.8965517241379, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI31881687, Length=290, Percent_Identity=26.8965517241379, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI6677723, Length=254, Percent_Identity=26.3779527559055, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI194306571, Length=251, Percent_Identity=26.2948207171315, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI194306567, Length=251, Percent_Identity=26.2948207171315, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI31563534, Length=293, Percent_Identity=22.8668941979522, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1786676, Length=283, Percent_Identity=39.9293286219081, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1787119, Length=325, Percent_Identity=26.4615384615385, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71986063, Length=271, Percent_Identity=25.830258302583, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17541988, Length=335, Percent_Identity=24.1791044776119, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17554730, Length=275, Percent_Identity=26.9090909090909, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322528, Length=328, Percent_Identity=25.9146341463415, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324039, Length=302, Percent_Identity=25.4966887417219, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324478, Length=295, Percent_Identity=24.7457627118644, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17647857, Length=292, Percent_Identity=23.2876712328767, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI18859927, Length=274, Percent_Identity=28.4671532846715, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19921076, Length=268, Percent_Identity=24.2537313432836, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 66969; Mature: 66837

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNIHKPFHQKYRPNNLDELVGQKFISITLKQALLTKKIAPAYLFNGPRGTGKTSSARIF
CCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCCCCCCCCEEE
AKSLNCQAFDQPTITPCCKCDLCRQITDGSALDIIEIDAASNTGVENIREIIERARFAPT
EECCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCC
QARWKVYVIDECHMLSTAASNALLKTIEEPPSRVVFILATTNPERVLSTIKSRCQKFDFR
CCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCC
RISPSDIFQHLSEIAEKESIKYEVQALKMIAKRSNGGMRDAQSLLEQLNLLPEGITINNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHH
QNLLGEVSENELTNLIKSLVENNPESLIITCNKLYDAGNEPLQIIIGLLNITRDLLLHTT
HHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHEEEC
NNKYSDLYYTSDEFQDELNKISKTINKSTIINWHNNLRNIEYQIKSSDNPRLWFEIHLTG
CCCCCCEEECCHHHHHHHHHHHHHHCHHEEEEECCCCCCEEEEEECCCCCEEEEEEEEEE
LLGNQEINSSENKQSKNNKTKENHESRENIPIVNKENISNEIQKPSIKKNITRDELIEKK
EECCCCCCCCCCHHHCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCHHHCCCHHHHHHHH
DEKFEKFEVLEKESIENISDNNQNNPESNNLNDKWELILSKVELPSTRMLLSQQAELESI
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHC
DSEKITIALSPNWESMIKSRKVIIENSVRKIFGDQIILNFSTKQLNKNKPTKTSEITQNE
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCCCHHHHHHHH
VNKFRPIKKIETQTNASTKISNEETYDDSSKNLANFFNGEIIDLDE
HHHHCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCC
>Mature Secondary Structure 
PNIHKPFHQKYRPNNLDELVGQKFISITLKQALLTKKIAPAYLFNGPRGTGKTSSARIF
CCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCCCCCCCCCEEE
AKSLNCQAFDQPTITPCCKCDLCRQITDGSALDIIEIDAASNTGVENIREIIERARFAPT
EECCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCC
QARWKVYVIDECHMLSTAASNALLKTIEEPPSRVVFILATTNPERVLSTIKSRCQKFDFR
CCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCC
RISPSDIFQHLSEIAEKESIKYEVQALKMIAKRSNGGMRDAQSLLEQLNLLPEGITINNI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHH
QNLLGEVSENELTNLIKSLVENNPESLIITCNKLYDAGNEPLQIIIGLLNITRDLLLHTT
HHHHHHCCHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHEEEC
NNKYSDLYYTSDEFQDELNKISKTINKSTIINWHNNLRNIEYQIKSSDNPRLWFEIHLTG
CCCCCCEEECCHHHHHHHHHHHHHHCHHEEEEECCCCCCEEEEEECCCCCEEEEEEEEEE
LLGNQEINSSENKQSKNNKTKENHESRENIPIVNKENISNEIQKPSIKKNITRDELIEKK
EECCCCCCCCCCHHHCCCCCHHHHHHHCCCCCCCCCCCHHHHCCCCHHHCCCHHHHHHHH
DEKFEKFEVLEKESIENISDNNQNNPESNNLNDKWELILSKVELPSTRMLLSQQAELESI
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHC
DSEKITIALSPNWESMIKSRKVIIENSVRKIFGDQIILNFSTKQLNKNKPTKTSEITQNE
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCCCHHHHHHHH
VNKFRPIKKIETQTNASTKISNEETYDDSSKNLANFFNGEIIDLDE
HHHHCCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]