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The map label for this gene is lysC [H]

Identifier: 126697176

GI number: 126697176

Start: 1560172

End: 1561932

Strand: Direct

Name: lysC [H]

Synonym: P9301_18381

Alternate gene names: 126697176

Gene position: 1560172-1561932 (Clockwise)

Preceding gene: 126697175

Following gene: 126697179

Centisome position: 95.02

GC content: 35.04

Gene sequence:

>1761_bases
ATGGCTTTACTAGTAAAAAAATTTGGCGGTACTTCTGTAGGTGATATTAGAAAAATTAAAAATATTGCAAGTAGCATCTG
TCAAAGTAAAGAAGCAGGAAATGAAATTGTCGTAGTTGTCTCTGCAATGGGGCAAACTACAGATGATTTAAATTGTTTAG
CGGAATCAATTAGTAAAAATCCTAATCGAAGAGAATTGGATATGCTTCTCTCAACTGGAGAGCAAGTAACCATAGCTCTT
CTCTCAATGGCATTAAACGAATACGGAATACCTGCAATTTCAATGACCGGTAGCCAGGTTGGAATTATTACTGAATCAAT
TCACGGGAAAGCGAGAATTCTGGATATTAAAACAGAAAGGATCCAAAATTATATAAATCAAGGTTTTGTAGTTGTAGTAG
CTGGATTTCAAGGAACAACCTTAAGCCATACGGGTTCAATGGAAATTACAACTTTGGGTAGAGGTGGTTCAGATACTTCG
GCAGTAGCTTTATCAACAGCTTTAGGAGCTGAGACGTGCGAAATTTATACAGACGTTCCAGGGGTTCTTACTACTGATCC
AAGAATTGTGCCTAATGCAAAACTCTTAGATGAAATTAGCTGCGAGGAAATGCTTGAACTTGCAAGTGTCGGTGCGTCAG
TTCTGCATCCAAGAGCAGTAGAAATTGCTCGCAATTATGGAATTAAATTGTGTGTCAAATCAAGCCAAAGTGACTCAAGT
GGGACTCTCCTAGAAAGTCAAATCAAAGCTCTCCCGCTAAAAAGAGGAAGCTTAGAATTAACAAAAACAGTCAATAGTCT
TGAGGTATTAGAAAACCAGGCAGTATTCAGTCTCTCAAATATTCCTGATAGGCCTGGGATTGCTGCACAAATATTTGAAA
AACTTTCAGAAGCAAGTATTAGTGTAGATTTAATAATACAAGCGACAAATGATGGGAATAAAAACGATATTACATTTACT
GTTAGTGAATTAGAAGTTAAAAAGACTGCAGAACAATGTGAACTTATAACTAGTCAATTAGGAGGAGAATATAACTTAAA
AACAAACATGACTAAATTAAGTATTCAAGGAGCAGGCATTATGGGCAGACCTAGTGTTTCAGCTGATTTATTTGATACTT
TATCTCAAGCGAATATCAATGTCAGGTTAATAGCTACTAGTGAAATTAAAGTCAGCTGTGTAATTGAAATCAATAATATA
CCAAAAGCTATTAGATTTGTTGCTGAGAAATTTAAGTTATCAGATACACAAATATTTGTTAATCCAATCAATAAAAAACA
AGATCAACCTGAAGTAAGAGGAATTGCATTAGATAAAAACCAAGTTCAAGTAAGTTTTCGAAAACTGCCTGATCGTCCAG
GTGTAGCAGCATCGATATGTTTAGCATTAGCTGAAAATAATTTACTTATCGACACTATCGTTCAGTCTGAAAGAATTTCC
TCTTTAAAAACTAAGGATATTAGTCTTACAATGAATAAACAAGATAGAGAAAAAGCTAACTTAGTTTTTGAGGCCTTAAC
AAAAAAATTACCCGGATCATACATTGAAGATGGCCCTGCTATAGCCAAAGTAAGTACTGTAGGAGCGGGAATGGCATTTA
AGGTTGGAACGGCTGGAAAAATATTTAGAGCATTAGCTGACCAAAAAATCAATATTGAAATGATTGCCACTAGTGAAATC
AGGACTTCATGTATTGTCTTAGAAAAAGATTGCGACAAAGCAGTTAATGCGATTCATAATCATTTCGAATTAGACAAATA
A

Upstream 100 bases:

>100_bases
ACTAAAACAAGGTAATAATCCTATAAATGTTTTTACGGAGAAATTAATTAATTTAAGTTAACCAAATTATAAGTTTAAGA
ATTTACATTATGATTTAAAT

Downstream 100 bases:

>100_bases
GTTTCTTTTTAATTATTTCTTGCCAATTTTTGTCTTAATTTTTTGATTCTATCCCTCAAATTTGCTGCTTCTTCAAAATT
TAACTCTTTTGCAGCATCTT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase; ASK [H]

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MALLVKKFGGTSVGDIRKIKNIASSICQSKEAGNEIVVVVSAMGQTTDDLNCLAESISKNPNRRELDMLLSTGEQVTIAL
LSMALNEYGIPAISMTGSQVGIITESIHGKARILDIKTERIQNYINQGFVVVVAGFQGTTLSHTGSMEITTLGRGGSDTS
AVALSTALGAETCEIYTDVPGVLTTDPRIVPNAKLLDEISCEEMLELASVGASVLHPRAVEIARNYGIKLCVKSSQSDSS
GTLLESQIKALPLKRGSLELTKTVNSLEVLENQAVFSLSNIPDRPGIAAQIFEKLSEASISVDLIIQATNDGNKNDITFT
VSELEVKKTAEQCELITSQLGGEYNLKTNMTKLSIQGAGIMGRPSVSADLFDTLSQANINVRLIATSEIKVSCVIEINNI
PKAIRFVAEKFKLSDTQIFVNPINKKQDQPEVRGIALDKNQVQVSFRKLPDRPGVAASICLALAENNLLIDTIVQSERIS
SLKTKDISLTMNKQDREKANLVFEALTKKLPGSYIEDGPAIAKVSTVGAGMAFKVGTAGKIFRALADQKINIEMIATSEI
RTSCIVLEKDCDKAVNAIHNHFELDK

Sequences:

>Translated_586_residues
MALLVKKFGGTSVGDIRKIKNIASSICQSKEAGNEIVVVVSAMGQTTDDLNCLAESISKNPNRRELDMLLSTGEQVTIAL
LSMALNEYGIPAISMTGSQVGIITESIHGKARILDIKTERIQNYINQGFVVVVAGFQGTTLSHTGSMEITTLGRGGSDTS
AVALSTALGAETCEIYTDVPGVLTTDPRIVPNAKLLDEISCEEMLELASVGASVLHPRAVEIARNYGIKLCVKSSQSDSS
GTLLESQIKALPLKRGSLELTKTVNSLEVLENQAVFSLSNIPDRPGIAAQIFEKLSEASISVDLIIQATNDGNKNDITFT
VSELEVKKTAEQCELITSQLGGEYNLKTNMTKLSIQGAGIMGRPSVSADLFDTLSQANINVRLIATSEIKVSCVIEINNI
PKAIRFVAEKFKLSDTQIFVNPINKKQDQPEVRGIALDKNQVQVSFRKLPDRPGVAASICLALAENNLLIDTIVQSERIS
SLKTKDISLTMNKQDREKANLVFEALTKKLPGSYIEDGPAIAKVSTVGAGMAFKVGTAGKIFRALADQKINIEMIATSEI
RTSCIVLEKDCDKAVNAIHNHFELDK
>Mature_585_residues
ALLVKKFGGTSVGDIRKIKNIASSICQSKEAGNEIVVVVSAMGQTTDDLNCLAESISKNPNRRELDMLLSTGEQVTIALL
SMALNEYGIPAISMTGSQVGIITESIHGKARILDIKTERIQNYINQGFVVVVAGFQGTTLSHTGSMEITTLGRGGSDTSA
VALSTALGAETCEIYTDVPGVLTTDPRIVPNAKLLDEISCEEMLELASVGASVLHPRAVEIARNYGIKLCVKSSQSDSSG
TLLESQIKALPLKRGSLELTKTVNSLEVLENQAVFSLSNIPDRPGIAAQIFEKLSEASISVDLIIQATNDGNKNDITFTV
SELEVKKTAEQCELITSQLGGEYNLKTNMTKLSIQGAGIMGRPSVSADLFDTLSQANINVRLIATSEIKVSCVIEINNIP
KAIRFVAEKFKLSDTQIFVNPINKKQDQPEVRGIALDKNQVQVSFRKLPDRPGVAASICLALAENNLLIDTIVQSERISS
LKTKDISLTMNKQDREKANLVFEALTKKLPGSYIEDGPAIAKVSTVGAGMAFKVGTAGKIFRALADQKINIEMIATSEIR
TSCIVLEKDCDKAVNAIHNHFELDK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=383, Percent_Identity=31.331592689295, Blast_Score=126, Evalue=5e-30,
Organism=Escherichia coli, GI1790455, Length=359, Percent_Identity=31.1977715877437, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790376, Length=289, Percent_Identity=25.2595155709343, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320893, Length=409, Percent_Identity=25.1833740831296, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 63069; Mature: 62938

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLVKKFGGTSVGDIRKIKNIASSICQSKEAGNEIVVVVSAMGQTTDDLNCLAESISKN
CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHCC
PNRRELDMLLSTGEQVTIALLSMALNEYGIPAISMTGSQVGIITESIHGKARILDIKTER
CCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCEEEEEEEHHH
IQNYINQGFVVVVAGFQGTTLSHTGSMEITTLGRGGSDTSAVALSTALGAETCEIYTDVP
HHHHHCCCEEEEEECCCCCEECCCCCEEEEEECCCCCCCHHEEEHHHCCCCEEEEEECCC
GVLTTDPRIVPNAKLLDEISCEEMLELASVGASVLHPRAVEIARNYGIKLCVKSSQSDSS
CCEECCCCCCCCHHHHHHCCHHHHHHHHHCCHHHHCCHHHHHHHCCCEEEEEECCCCCCC
GTLLESQIKALPLKRGSLELTKTVNSLEVLENQAVFSLSNIPDRPGIAAQIFEKLSEASI
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCE
SVDLIIQATNDGNKNDITFTVSELEVKKTAEQCELITSQLGGEYNLKTNMTKLSIQGAGI
EEEEEEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCCC
MGRPSVSADLFDTLSQANINVRLIATSEIKVSCVIEINNIPKAIRFVAEKFKLSDTQIFV
CCCCCCCHHHHHHHHHCCCEEEEEEECCEEEEEEEEECCCHHHHHHHHHHHCCCCCEEEE
NPINKKQDQPEVRGIALDKNQVQVSFRKLPDRPGVAASICLALAENNLLIDTIVQSERIS
ECCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHH
SLKTKDISLTMNKQDREKANLVFEALTKKLPGSYIEDGPAIAKVSTVGAGMAFKVGTAGK
HCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEECCHHH
IFRALADQKINIEMIATSEIRTSCIVLEKDCDKAVNAIHNHFELDK
HHHHHCCCCEEEEEEEECCCCEEEEEEECHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ALLVKKFGGTSVGDIRKIKNIASSICQSKEAGNEIVVVVSAMGQTTDDLNCLAESISKN
EEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHCC
PNRRELDMLLSTGEQVTIALLSMALNEYGIPAISMTGSQVGIITESIHGKARILDIKTER
CCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCEEEEEEEHHH
IQNYINQGFVVVVAGFQGTTLSHTGSMEITTLGRGGSDTSAVALSTALGAETCEIYTDVP
HHHHHCCCEEEEEECCCCCEECCCCCEEEEEECCCCCCCHHEEEHHHCCCCEEEEEECCC
GVLTTDPRIVPNAKLLDEISCEEMLELASVGASVLHPRAVEIARNYGIKLCVKSSQSDSS
CCEECCCCCCCCHHHHHHCCHHHHHHHHHCCHHHHCCHHHHHHHCCCEEEEEECCCCCCC
GTLLESQIKALPLKRGSLELTKTVNSLEVLENQAVFSLSNIPDRPGIAAQIFEKLSEASI
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCE
SVDLIIQATNDGNKNDITFTVSELEVKKTAEQCELITSQLGGEYNLKTNMTKLSIQGAGI
EEEEEEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEEECCCC
MGRPSVSADLFDTLSQANINVRLIATSEIKVSCVIEINNIPKAIRFVAEKFKLSDTQIFV
CCCCCCCHHHHHHHHHCCCEEEEEEECCEEEEEEEEECCCHHHHHHHHHHHCCCCCEEEE
NPINKKQDQPEVRGIALDKNQVQVSFRKLPDRPGVAASICLALAENNLLIDTIVQSERIS
ECCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEHHHHHHHHH
SLKTKDISLTMNKQDREKANLVFEALTKKLPGSYIEDGPAIAKVSTVGAGMAFKVGTAGK
HCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEECCHHH
IFRALADQKINIEMIATSEIRTSCIVLEKDCDKAVNAIHNHFELDK
HHHHHCCCCEEEEEEEECCCCEEEEEEECHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10074061 [H]