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The map label for this gene is purM

Identifier: 126697119

GI number: 126697119

Start: 1502580

End: 1503623

Strand: Reverse

Name: purM

Synonym: P9301_17811

Alternate gene names: 126697119

Gene position: 1503623-1502580 (Counterclockwise)

Preceding gene: 126697121

Following gene: 126697118

Centisome position: 91.58

GC content: 30.27

Gene sequence:

>1044_bases
ATGGATTACAAAACATCAGGTGTTGATATAGAAGCTGGGCGAGAATTTGTTTCCGAAATTAAACAGGCAGTTGAAGCAAC
TCATACATCTAATGTGATTGAGGGTATTGGCGGGTTCGGAGGTTTGTTTAGAATTCCTATCGATAGTTTTAAAAAACCAG
TTCTTGTTTCAGGGACTGATGGTGTTGGAACAAAATTAGAATTAGCTCAAAGTAAAAACTTTCACTTTGAGGTTGGCATT
GATTTAGTTGCTATGTGCATGAACGATATTATTACTAGTGGTGCAAGACCTTTATTTTTTCTAGATTATATTGCTACAGG
TAAGCTTGATAAGAAACAATTATTGAGGGTTGTTCAGGGAATTTCACATGGATGCGGAGAAAATAACTGTTCATTACTTG
GCGGAGAAACTGCTGAAATGCCTGGATTTTATTCAAAAAATAAGTATGATCTTGCAGGATTTTGTGTTGGAATAGTTGAT
GAGGATAAGCTTATTAATGGTAAAAAAGTCTCTGAAAATGACTTAATAATTGCTTTAAAAAGTAATGGAGTTCATAGTAA
CGGCTTTAGTTTAGTAAGAAAAATTATTCAAAACAATAATCAAATAGATAAAGAATTTGAAAAAGTTTCTCACTTAAATT
TTTATGATGAGTTATTAAAACCTACAAAAATTTACAATAATGTGATTAACCAAATGTTATCTGAAGATATTGAAATTAAA
GCAATGTCTCATATAACTGGAGGAGGAATTCCAGAAAATTTACCAAGATGTATTCCTTCTGATTTTATTCCTTATATCAA
TACCAGTTCTTGGCAAATACCTACTTTATTTAAATTCTTAAAAGAGAAAGGATCTATTCCTGAAAGAGATTTTTGGAATA
CTTTTAATCTTGGAGTTGGATTTTGTTTAATTATTGATAAACAATTTAAGGACGCGATATTAAGTATCTGCAAAGATTAT
GGTATAGATAGTTGGGAAATTGGAAAGATAGTTCGAAAAAATGATTCAACAATTAGTAAATTTTTACCAGAAATTTTAAC
TTAA

Upstream 100 bases:

>100_bases
ACTTTGTTTTTAAAAAATAAATCTATTTGATAAATAATTACTGGACAAAAGTAATCTTAGGAGGAATATCTATATAGGTA
AAGTCTATCATTTTTATTTC

Downstream 100 bases:

>100_bases
ATTTTTTTATCTTTTTTAAATGAGTTTTAAAAAATTATTTTTTATACCCAAATGAAAAAGTTGGGTGTAATATAATAAAA
TTACAGCCGAATTATATCGG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MDYKTSGVDIEAGREFVSEIKQAVEATHTSNVIEGIGGFGGLFRIPIDSFKKPVLVSGTDGVGTKLELAQSKNFHFEVGI
DLVAMCMNDIITSGARPLFFLDYIATGKLDKKQLLRVVQGISHGCGENNCSLLGGETAEMPGFYSKNKYDLAGFCVGIVD
EDKLINGKKVSENDLIIALKSNGVHSNGFSLVRKIIQNNNQIDKEFEKVSHLNFYDELLKPTKIYNNVINQMLSEDIEIK
AMSHITGGGIPENLPRCIPSDFIPYINTSSWQIPTLFKFLKEKGSIPERDFWNTFNLGVGFCLIIDKQFKDAILSICKDY
GIDSWEIGKIVRKNDSTISKFLPEILT

Sequences:

>Translated_347_residues
MDYKTSGVDIEAGREFVSEIKQAVEATHTSNVIEGIGGFGGLFRIPIDSFKKPVLVSGTDGVGTKLELAQSKNFHFEVGI
DLVAMCMNDIITSGARPLFFLDYIATGKLDKKQLLRVVQGISHGCGENNCSLLGGETAEMPGFYSKNKYDLAGFCVGIVD
EDKLINGKKVSENDLIIALKSNGVHSNGFSLVRKIIQNNNQIDKEFEKVSHLNFYDELLKPTKIYNNVINQMLSEDIEIK
AMSHITGGGIPENLPRCIPSDFIPYINTSSWQIPTLFKFLKEKGSIPERDFWNTFNLGVGFCLIIDKQFKDAILSICKDY
GIDSWEIGKIVRKNDSTISKFLPEILT
>Mature_347_residues
MDYKTSGVDIEAGREFVSEIKQAVEATHTSNVIEGIGGFGGLFRIPIDSFKKPVLVSGTDGVGTKLELAQSKNFHFEVGI
DLVAMCMNDIITSGARPLFFLDYIATGKLDKKQLLRVVQGISHGCGENNCSLLGGETAEMPGFYSKNKYDLAGFCVGIVD
EDKLINGKKVSENDLIIALKSNGVHSNGFSLVRKIIQNNNQIDKEFEKVSHLNFYDELLKPTKIYNNVINQMLSEDIEIK
AMSHITGGGIPENLPRCIPSDFIPYINTSSWQIPTLFKFLKEKGSIPERDFWNTFNLGVGFCLIIDKQFKDAILSICKDY
GIDSWEIGKIVRKNDSTISKFLPEILT

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=340, Percent_Identity=43.2352941176471, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI209869995, Length=340, Percent_Identity=43.2352941176471, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI209869993, Length=340, Percent_Identity=43.2352941176471, Blast_Score=290, Evalue=2e-78,
Organism=Escherichia coli, GI1788845, Length=336, Percent_Identity=46.1309523809524, Blast_Score=313, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI17567511, Length=350, Percent_Identity=36.5714285714286, Blast_Score=211, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6321203, Length=338, Percent_Identity=40.8284023668639, Blast_Score=257, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24582400, Length=301, Percent_Identity=36.5448504983389, Blast_Score=196, Evalue=1e-50,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_PROM0 (A3PF79)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001092005.1
- ProteinModelPortal:   A3PF79
- SMR:   A3PF79
- STRING:   A3PF79
- GeneID:   4911847
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_17811
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- ProtClustDB:   PRK05385
- BioCyc:   PMAR167546:P9301ORF_1817-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 38538; Mature: 38538

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKTSGVDIEAGREFVSEIKQAVEATHTSNVIEGIGGFGGLFRIPIDSFKKPVLVSGTD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHCCCCEEEECCC
GVGTKLELAQSKNFHFEVGIDLVAMCMNDIITSGARPLFFLDYIATGKLDKKQLLRVVQG
CCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCHHHHHHHHHH
ISHGCGENNCSLLGGETAEMPGFYSKNKYDLAGFCVGIVDEDKLINGKKVSENDLIIALK
HHCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEECCCCEEEEEE
SNGVHSNGFSLVRKIIQNNNQIDKEFEKVSHLNFYDELLKPTKIYNNVINQMLSEDIEIK
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
AMSHITGGGIPENLPRCIPSDFIPYINTSSWQIPTLFKFLKEKGSIPERDFWNTFNLGVG
EHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCE
FCLIIDKQFKDAILSICKDYGIDSWEIGKIVRKNDSTISKFLPEILT
EEEEECHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MDYKTSGVDIEAGREFVSEIKQAVEATHTSNVIEGIGGFGGLFRIPIDSFKKPVLVSGTD
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHCCCCEEEECCC
GVGTKLELAQSKNFHFEVGIDLVAMCMNDIITSGARPLFFLDYIATGKLDKKQLLRVVQG
CCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCHHHHHHHHHH
ISHGCGENNCSLLGGETAEMPGFYSKNKYDLAGFCVGIVDEDKLINGKKVSENDLIIALK
HHCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEECCCCEEEEEE
SNGVHSNGFSLVRKIIQNNNQIDKEFEKVSHLNFYDELLKPTKIYNNVINQMLSEDIEIK
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEE
AMSHITGGGIPENLPRCIPSDFIPYINTSSWQIPTLFKFLKEKGSIPERDFWNTFNLGVG
EHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCCCE
FCLIIDKQFKDAILSICKDYGIDSWEIGKIVRKNDSTISKFLPEILT
EEEEECHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA