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The map label for this gene is mrdB [H]

Identifier: 126697109

GI number: 126697109

Start: 1494881

End: 1496149

Strand: Reverse

Name: mrdB [H]

Synonym: P9301_17711

Alternate gene names: 126697109

Gene position: 1496149-1494881 (Counterclockwise)

Preceding gene: 126697110

Following gene: 126697108

Centisome position: 91.12

GC content: 30.02

Gene sequence:

>1269_bases
ATGTTTAAGAGAATTTCTTTATTAAATAACAGAGGATTTTTACAAAAAAAAGACAACTTTAATAGAGGTTTTTTATTTTC
TCCACTACTTATTGTTCCCCTGTTTTTAGTTATTATTTCGGGTTTTTTGATAAAAAGTATTCAGGGTGATTTTTTAGTAT
CGAACTATCTAGCTCATATCTTAACTGGTTTTTTAGGTTATTTCTTAGCATTTTTTATTTCTTATATACCGTTAGAGAGA
CTTAGAAAGTATGTAGTTCCATTTTATTTTTGTACTCTAATATCCTTATTACTTATTTATTTTTTTGGGATTTCAGTTTC
TGGAGCTCAAAGATGGCTAAACTTGGGCATCTTTTCTTTTCAGCCTTCAGAGGTAGCTAAACTTAGTAGTGTATTAACTC
TTGCTTTAGTACTCGACAAAAAAATAATCCAAACAATAAGAGATTTAGTATTGCCCTTATTAGTAGTTGTTATTCCTTGG
TTATTAATTTTCTTTCAACCGGACTTAGGTACCTCTTTAGTTTTAATTGTTTTGACAGGTGTCATGCTCTATTGGTCTCA
AATGCCCATAGAGTGGATTTTGATATTAGTGTTTTGTATTATCACATCAATACTATATCTAACCTTACCAAATCTTCTTA
TTTTCTGGATTCCAGCTATAGGATATCTTGCTTATAGATCTTCAAAAAAGAAAATTATTTCTTCTGCTCTCGCTATTTCG
TTCCATTTATTAGTGGCAAAATTTACACCAATTTTGTGGCAATATGGCTTAAAAGAATATCAAAAAGATAGATTAGTTTT
ATTTTTAGATCCAAGTAGAGATCCATTAGGTGGAGGATATCATTTGATACAGAGTAAAATTGCAATTGGTTCTGGAGGAT
TATTTGGGACTGGTTTACTACAAGGTAAGCTGACTAATTTGCAATTTATACCTGAACAACATACTGATTTTATATTCAGT
GCTTTAGGGGAAGAATTAGGTTTTGTGGGGTGCGTTATAGTTTTATTTTTGTTCTTTTTTTTAATTAAAAAACTCATTAA
TACTGCAACAATTGCTAGGACTAACTATGAATCTCTAATTGTTATTGGAATAGCCTCAACTTTTTTATTTCAAATAATCA
TTAATGTATTTATGACTATTGGATTAGGACCAGTTACTGGAATTCCCCTTCCTTTTATGAGCTATGGTCGAACCTCATTG
GTGACTAATTTTATATCTATTGGATTTGCTTTATCTATATTGAAACGTTCTAGATCACTAAGAAGTTGA

Upstream 100 bases:

>100_bases
AAGGTGTACCAATCTCAATAAGCCAGCCGAATAAAGAAAGCTCTTTAGTATTTGGTAATTTAGCTCAATTAATTAAGAAC
CAATTTGTTAATACTTATTG

Downstream 100 bases:

>100_bases
TGAAATCACAAATAACTATAAAAAAACTTCAAGACCTTTTGATTAAAGGAGTCCAGACTATATATGTAGAGGATGATATA
TCCAGAAGAATGTGGTGGGC

Product: cell division membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MFKRISLLNNRGFLQKKDNFNRGFLFSPLLIVPLFLVIISGFLIKSIQGDFLVSNYLAHILTGFLGYFLAFFISYIPLER
LRKYVVPFYFCTLISLLLIYFFGISVSGAQRWLNLGIFSFQPSEVAKLSSVLTLALVLDKKIIQTIRDLVLPLLVVVIPW
LLIFFQPDLGTSLVLIVLTGVMLYWSQMPIEWILILVFCIITSILYLTLPNLLIFWIPAIGYLAYRSSKKKIISSALAIS
FHLLVAKFTPILWQYGLKEYQKDRLVLFLDPSRDPLGGGYHLIQSKIAIGSGGLFGTGLLQGKLTNLQFIPEQHTDFIFS
ALGEELGFVGCVIVLFLFFFLIKKLINTATIARTNYESLIVIGIASTFLFQIIINVFMTIGLGPVTGIPLPFMSYGRTSL
VTNFISIGFALSILKRSRSLRS

Sequences:

>Translated_422_residues
MFKRISLLNNRGFLQKKDNFNRGFLFSPLLIVPLFLVIISGFLIKSIQGDFLVSNYLAHILTGFLGYFLAFFISYIPLER
LRKYVVPFYFCTLISLLLIYFFGISVSGAQRWLNLGIFSFQPSEVAKLSSVLTLALVLDKKIIQTIRDLVLPLLVVVIPW
LLIFFQPDLGTSLVLIVLTGVMLYWSQMPIEWILILVFCIITSILYLTLPNLLIFWIPAIGYLAYRSSKKKIISSALAIS
FHLLVAKFTPILWQYGLKEYQKDRLVLFLDPSRDPLGGGYHLIQSKIAIGSGGLFGTGLLQGKLTNLQFIPEQHTDFIFS
ALGEELGFVGCVIVLFLFFFLIKKLINTATIARTNYESLIVIGIASTFLFQIIINVFMTIGLGPVTGIPLPFMSYGRTSL
VTNFISIGFALSILKRSRSLRS
>Mature_422_residues
MFKRISLLNNRGFLQKKDNFNRGFLFSPLLIVPLFLVIISGFLIKSIQGDFLVSNYLAHILTGFLGYFLAFFISYIPLER
LRKYVVPFYFCTLISLLLIYFFGISVSGAQRWLNLGIFSFQPSEVAKLSSVLTLALVLDKKIIQTIRDLVLPLLVVVIPW
LLIFFQPDLGTSLVLIVLTGVMLYWSQMPIEWILILVFCIITSILYLTLPNLLIFWIPAIGYLAYRSSKKKIISSALAIS
FHLLVAKFTPILWQYGLKEYQKDRLVLFLDPSRDPLGGGYHLIQSKIAIGSGGLFGTGLLQGKLTNLQFIPEQHTDFIFS
ALGEELGFVGCVIVLFLFFFLIKKLINTATIARTNYESLIVIGIASTFLFQIIINVFMTIGLGPVTGIPLPFMSYGRTSL
VTNFISIGFALSILKRSRSLRS

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=358, Percent_Identity=35.195530726257, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1786277, Length=360, Percent_Identity=29.1666666666667, Blast_Score=146, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 47580; Mature: 47580

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CC
>Mature Secondary Structure
MFKRISLLNNRGFLQKKDNFNRGFLFSPLLIVPLFLVIISGFLIKSIQGDFLVSNYLAHI
CCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LTGFLGYFLAFFISYIPLERLRKYVVPFYFCTLISLLLIYFFGISVSGAQRWLNLGIFSF
HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
QPSEVAKLSSVLTLALVLDKKIIQTIRDLVLPLLVVVIPWLLIFFQPDLGTSLVLIVLTG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VMLYWSQMPIEWILILVFCIITSILYLTLPNLLIFWIPAIGYLAYRSSKKKIISSALAIS
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FHLLVAKFTPILWQYGLKEYQKDRLVLFLDPSRDPLGGGYHLIQSKIAIGSGGLFGTGLL
HHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCCHHHHHH
QGKLTNLQFIPEQHTDFIFSALGEELGFVGCVIVLFLFFFLIKKLINTATIARTNYESLI
HCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
VIGIASTFLFQIIINVFMTIGLGPVTGIPLPFMSYGRTSLVTNFISIGFALSILKRSRSL
EHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCC
RS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]