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The map label for this gene is lon [H]

Identifier: 126697035

GI number: 126697035

Start: 1429919

End: 1430575

Strand: Reverse

Name: lon [H]

Synonym: P9301_16971

Alternate gene names: 126697035

Gene position: 1430575-1429919 (Counterclockwise)

Preceding gene: 126697036

Following gene: 126697034

Centisome position: 87.13

GC content: 34.7

Gene sequence:

>657_bases
ATGGGAGAACTCTCAGTAAGGGAATTACCTTTATTTCCTTTGCCAGAGGTAGTTCTTTTTCCTCAAGAAGTATTGCCTTT
GCATATCTTTGAATCGAGATATAGGATGATGCTTCAATCTGTTCTTGAAGGTGATTCCATGTTTGGAGTTATCAAGTTTG
ATCCAACTACTAAAAGTATGGCTAACGTTGGATGTTGCGCGCAAATTATAAAACATCAAACTGCAGAGGATGGGAGAAGT
AATATTATCACTCTCGGACAACAAAGATTTCAAGTTTTAGAAATTATGCGTTCGACGCCATTTTATTCCGCGATGGTTAG
TTGGATTAGCGATGATAATATTGATGACTTTCAAAAATTAGATTCTCTAAAAGACTCAGTAAAAGAAGCACTTAGTGATG
TTATAAATTTAACAAGTAAATTGACTAATACCAAGAAAAATCTACCTGACAAATTACCTGATAACCCAATGGATTTATCA
TTTTGGATTGGAGCTCATTTGGGCGGACCTGTTGCTGAGGAACAGCAAAAACTTCTTGAAGAAAGAAATACTTTTACCCG
TTTGCAAAGAGAATATGAAATGCTTGATCATACAAGAAAACAACTTGCAGCAAGAACAGTATTGAAAGAAAGTTTTCCTG
ACATAAAAGAAAATTAA

Upstream 100 bases:

>100_bases
AACTAGATCTTCCTAGTGGTGTAGATATAGAAGTTAAACTTTAATAAATCCCGAAACCGTCCTAAATTGATTAATATAAA
CAATAAGAAATGAGGTTTAA

Downstream 100 bases:

>100_bases
ATGTTTGAATTATTAATCCCTTTTTTTTTACTAGTTTTATTATTACTATTGCTATCTATAATCTGGAGAATTAAAGCTAG
AAAATATATTTCTTCCAGCA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MGELSVRELPLFPLPEVVLFPQEVLPLHIFESRYRMMLQSVLEGDSMFGVIKFDPTTKSMANVGCCAQIIKHQTAEDGRS
NIITLGQQRFQVLEIMRSTPFYSAMVSWISDDNIDDFQKLDSLKDSVKEALSDVINLTSKLTNTKKNLPDKLPDNPMDLS
FWIGAHLGGPVAEEQQKLLEERNTFTRLQREYEMLDHTRKQLAARTVLKESFPDIKEN

Sequences:

>Translated_218_residues
MGELSVRELPLFPLPEVVLFPQEVLPLHIFESRYRMMLQSVLEGDSMFGVIKFDPTTKSMANVGCCAQIIKHQTAEDGRS
NIITLGQQRFQVLEIMRSTPFYSAMVSWISDDNIDDFQKLDSLKDSVKEALSDVINLTSKLTNTKKNLPDKLPDNPMDLS
FWIGAHLGGPVAEEQQKLLEERNTFTRLQREYEMLDHTRKQLAARTVLKESFPDIKEN
>Mature_217_residues
GELSVRELPLFPLPEVVLFPQEVLPLHIFESRYRMMLQSVLEGDSMFGVIKFDPTTKSMANVGCCAQIIKHQTAEDGRSN
IITLGQQRFQVLEIMRSTPFYSAMVSWISDDNIDDFQKLDSLKDSVKEALSDVINLTSKLTNTKKNLPDKLPDNPMDLSF
WIGAHLGGPVAEEQQKLLEERNTFTRLQREYEMLDHTRKQLAARTVLKESFPDIKEN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG2802

COG function: function code R; Uncharacterized protein, similar to the N-terminal domain of Lon protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI148528975, Length=182, Percent_Identity=29.1208791208791, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI73747840, Length=168, Percent_Identity=30.3571428571429, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI37622896, Length=160, Percent_Identity=29.375, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI87080813, Length=141, Percent_Identity=32.6241134751773, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 24947; Mature: 24816

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGELSVRELPLFPLPEVVLFPQEVLPLHIFESRYRMMLQSVLEGDSMFGVIKFDPTTKSM
CCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHH
ANVGCCAQIIKHQTAEDGRSNIITLGQQRFQVLEIMRSTPFYSAMVSWISDDNIDDFQKL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHH
DSLKDSVKEALSDVINLTSKLTNTKKNLPDKLPDNPMDLSFWIGAHLGGPVAEEQQKLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHH
ERNTFTRLQREYEMLDHTRKQLAARTVLKESFPDIKEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GELSVRELPLFPLPEVVLFPQEVLPLHIFESRYRMMLQSVLEGDSMFGVIKFDPTTKSM
CCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHH
ANVGCCAQIIKHQTAEDGRSNIITLGQQRFQVLEIMRSTPFYSAMVSWISDDNIDDFQKL
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHH
DSLKDSVKEALSDVINLTSKLTNTKKNLPDKLPDNPMDLSFWIGAHLGGPVAEEQQKLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHH
ERNTFTRLQREYEMLDHTRKQLAARTVLKESFPDIKEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA