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The map label for this gene is pepP [H]

Identifier: 126696970

GI number: 126696970

Start: 1364524

End: 1365849

Strand: Reverse

Name: pepP [H]

Synonym: P9301_16321

Alternate gene names: 126696970

Gene position: 1365849-1364524 (Counterclockwise)

Preceding gene: 126696975

Following gene: 126696969

Centisome position: 83.19

GC content: 34.39

Gene sequence:

>1326_bases
ATGTTTAAACCTGAAAATAAAGTTTTTGAAGAAAGAAGAGAAATCTTCCTAAATAAATTAAATGGAAAAGCTGCTATTAT
CCCTGGTGCTAGGCTTGTAAAGCATCATGCTGATTGCGAATATCCTTTTAGACAAGATAGTAATTTTTGGTATTTAACCG
GTTTCGATGAGCCAGATGCAATTGCTCTTTTCTTATCGCATAAGCCCAAGGGAGAGAGATTTATTATGTTTGTTGCTCCT
AAAGATGTTATAAGCGAAGTCTGGCATGGCTTTAGATGGGGTTTAGAAGGTGCTGAAAAAGAGTTTAACGCTGATAAGGC
TCACTCAATAAACGAATTAAAAGATTTACTCCCATCCTATATAAATGGTTCTGATGAACTCGTTTTTTCTATTGGTAAGC
ATCCATCAGTTGAGAAAATAATATTGGAAATTTTTTCACAACAACTTGAAAACCGCTCAAGATTAGGCATTGGTGGAAAT
TCTATAAAATCTCCAGAAATTTTTTTAAATGAGATGAGATTAATTAAAAGTGAATTTGAAATAAAAAGAATGAGAGAGGC
TATTCAAATCTCAGCAGAAGCTCATGAATTAGTTAGAGAATCAATCTCATCAAAGAAAAATGAAAGACAAATTCAGGGTC
TTCTAGAGGGATTTTTTCTGGAAAAAGGGGCAAGAGGACCAGCTTATAACTCTATTGTTGCATCAGGAGATAACGCTTGT
ATTTTACATTACACTTCAAATAACTCGCCCTTGAAGAAGGAAGATTTATTGTTAGTGGATGCTGGTTGCTCACTAATTGA
TTATTACAATGGAGACATAACAAGAACTATTCCAATTGGTGGTAAATTTTCTAATGAGCAAAAAGTTATCTATGAAATCG
TATTAAGTGCGCAGAAAAATGCAATTAAAAGTGCTGTAAAAGGATCCAATTCTAGTCTTGTTCATAATGTTGCTTTAACA
ATTCTTATAGAAGGATTAAAAGAAATTGGTTTATTGTCAGGCAGTACTGAGGAGATAATTGAGAATCAATCTTATAAACA
TCTTTACATGCATAGAACTGGACATTGGCTTGGTTTAGATGTTCATGATGTTGGAGCATACAGAATGGGGGACTATGAAG
TGCCATTACAGAATGGAATGATTCTTACGGTAGAACCTGGGATCTACATAAGTGATAGGATCCCAGTACCTGAGGGACAA
CCCCCTATAGATGAGAAATGGAAAGGCATAGGGATAAGAATTGAAGACGATGTCCTTGTCAAAGATGAAAACCCAGAAGT
TTTAAGTATTGCTGCACTAAAAGAAATTTCTGATTTAGAATTTTGA

Upstream 100 bases:

>100_bases
ACTAAACCGTAAACACTTGGTTCCATTAAAATAGATTAGTTACTAAATCTGTATTAATTCATTCTTCCATTTTTTTTTTA
AACACGCCAATACACAATCT

Downstream 100 bases:

>100_bases
AATTTGACTTATCAAGTTAATAGATTTATTTTTTATTAAGTTTAAAGATCAAAAATGAACCAGCCCGATTCATATGATTC
GAAACTCTCACAAGCAAGAG

Product: putative aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MFKPENKVFEERREIFLNKLNGKAAIIPGARLVKHHADCEYPFRQDSNFWYLTGFDEPDAIALFLSHKPKGERFIMFVAP
KDVISEVWHGFRWGLEGAEKEFNADKAHSINELKDLLPSYINGSDELVFSIGKHPSVEKIILEIFSQQLENRSRLGIGGN
SIKSPEIFLNEMRLIKSEFEIKRMREAIQISAEAHELVRESISSKKNERQIQGLLEGFFLEKGARGPAYNSIVASGDNAC
ILHYTSNNSPLKKEDLLLVDAGCSLIDYYNGDITRTIPIGGKFSNEQKVIYEIVLSAQKNAIKSAVKGSNSSLVHNVALT
ILIEGLKEIGLLSGSTEEIIENQSYKHLYMHRTGHWLGLDVHDVGAYRMGDYEVPLQNGMILTVEPGIYISDRIPVPEGQ
PPIDEKWKGIGIRIEDDVLVKDENPEVLSIAALKEISDLEF

Sequences:

>Translated_441_residues
MFKPENKVFEERREIFLNKLNGKAAIIPGARLVKHHADCEYPFRQDSNFWYLTGFDEPDAIALFLSHKPKGERFIMFVAP
KDVISEVWHGFRWGLEGAEKEFNADKAHSINELKDLLPSYINGSDELVFSIGKHPSVEKIILEIFSQQLENRSRLGIGGN
SIKSPEIFLNEMRLIKSEFEIKRMREAIQISAEAHELVRESISSKKNERQIQGLLEGFFLEKGARGPAYNSIVASGDNAC
ILHYTSNNSPLKKEDLLLVDAGCSLIDYYNGDITRTIPIGGKFSNEQKVIYEIVLSAQKNAIKSAVKGSNSSLVHNVALT
ILIEGLKEIGLLSGSTEEIIENQSYKHLYMHRTGHWLGLDVHDVGAYRMGDYEVPLQNGMILTVEPGIYISDRIPVPEGQ
PPIDEKWKGIGIRIEDDVLVKDENPEVLSIAALKEISDLEF
>Mature_441_residues
MFKPENKVFEERREIFLNKLNGKAAIIPGARLVKHHADCEYPFRQDSNFWYLTGFDEPDAIALFLSHKPKGERFIMFVAP
KDVISEVWHGFRWGLEGAEKEFNADKAHSINELKDLLPSYINGSDELVFSIGKHPSVEKIILEIFSQQLENRSRLGIGGN
SIKSPEIFLNEMRLIKSEFEIKRMREAIQISAEAHELVRESISSKKNERQIQGLLEGFFLEKGARGPAYNSIVASGDNAC
ILHYTSNNSPLKKEDLLLVDAGCSLIDYYNGDITRTIPIGGKFSNEQKVIYEIVLSAQKNAIKSAVKGSNSSLVHNVALT
ILIEGLKEIGLLSGSTEEIIENQSYKHLYMHRTGHWLGLDVHDVGAYRMGDYEVPLQNGMILTVEPGIYISDRIPVPEGQ
PPIDEKWKGIGIRIEDDVLVKDENPEVLSIAALKEISDLEF

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=412, Percent_Identity=33.7378640776699, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI149589008, Length=467, Percent_Identity=27.4089935760171, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI260593665, Length=300, Percent_Identity=32.6666666666667, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI260593663, Length=249, Percent_Identity=32.5301204819277, Blast_Score=122, Evalue=8e-28,
Organism=Escherichia coli, GI1789275, Length=439, Percent_Identity=36.2186788154898, Blast_Score=290, Evalue=9e-80,
Organism=Escherichia coli, GI1788728, Length=261, Percent_Identity=31.0344827586207, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790282, Length=312, Percent_Identity=29.4871794871795, Blast_Score=95, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17508215, Length=477, Percent_Identity=28.0922431865828, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71989583, Length=266, Percent_Identity=30.8270676691729, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320922, Length=445, Percent_Identity=34.1573033707865, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6321118, Length=420, Percent_Identity=30.952380952381, Blast_Score=167, Evalue=4e-42,
Organism=Drosophila melanogaster, GI19920384, Length=407, Percent_Identity=33.1695331695332, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21357079, Length=436, Percent_Identity=30.045871559633, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49650; Mature: 49650

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKPENKVFEERREIFLNKLNGKAAIIPGARLVKHHADCEYPFRQDSNFWYLTGFDEPDA
CCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHCCCCCCCCCCCCCEEEEECCCCCCE
IALFLSHKPKGERFIMFVAPKDVISEVWHGFRWGLEGAEKEFNADKAHSINELKDLLPSY
EEEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHCCCCHHCCHHHHHHHHHHH
INGSDELVFSIGKHPSVEKIILEIFSQQLENRSRLGIGGNSIKSPEIFLNEMRLIKSEFE
HCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
IKRMREAIQISAEAHELVRESISSKKNERQIQGLLEGFFLEKGARGPAYNSIVASGDNAC
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEE
ILHYTSNNSPLKKEDLLLVDAGCSLIDYYNGDITRTIPIGGKFSNEQKVIYEIVLSAQKN
EEEECCCCCCCCCCCEEEEECCCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
AIKSAVKGSNSSLVHNVALTILIEGLKEIGLLSGSTEEIIENQSYKHLYMHRTGHWLGLD
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEEECCCEEEEE
VHDVGAYRMGDYEVPLQNGMILTVEPGIYISDRIPVPEGQPPIDEKWKGIGIRIEDDVLV
EECCCCEECCCEECCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCEEE
KDENPEVLSIAALKEISDLEF
ECCCCCEEEHHHHHHHHCCCC
>Mature Secondary Structure
MFKPENKVFEERREIFLNKLNGKAAIIPGARLVKHHADCEYPFRQDSNFWYLTGFDEPDA
CCCCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHHCCCCCCCCCCCCCEEEEECCCCCCE
IALFLSHKPKGERFIMFVAPKDVISEVWHGFRWGLEGAEKEFNADKAHSINELKDLLPSY
EEEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHCCCCHHCCHHHHHHHHHHH
INGSDELVFSIGKHPSVEKIILEIFSQQLENRSRLGIGGNSIKSPEIFLNEMRLIKSEFE
HCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
IKRMREAIQISAEAHELVRESISSKKNERQIQGLLEGFFLEKGARGPAYNSIVASGDNAC
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEE
ILHYTSNNSPLKKEDLLLVDAGCSLIDYYNGDITRTIPIGGKFSNEQKVIYEIVLSAQKN
EEEECCCCCCCCCCCEEEEECCCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
AIKSAVKGSNSSLVHNVALTILIEGLKEIGLLSGSTEEIIENQSYKHLYMHRTGHWLGLD
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEEECCCEEEEE
VHDVGAYRMGDYEVPLQNGMILTVEPGIYISDRIPVPEGQPPIDEKWKGIGIRIEDDVLV
EECCCCEECCCEECCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCEEE
KDENPEVLSIAALKEISDLEF
ECCCCCEEEHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]