Click here to switch to the map view.

The map label for this gene is purC [H]

Identifier: 126696863

GI number: 126696863

Start: 1292324

End: 1293061

Strand: Reverse

Name: purC [H]

Synonym: P9301_15251

Alternate gene names: 126696863

Gene position: 1293061-1292324 (Counterclockwise)

Preceding gene: 126696866

Following gene: 126696862

Centisome position: 78.75

GC content: 26.02

Gene sequence:

>738_bases
ATGAATAATAAACATGAGTTAATATATGAAGGAAAAGCAAAAAAAATATTTACGCATGATGATGCTGATAAAGTAAAAAT
TGAATTTAAAGACGATGCTACAGCTTTTAATGCTTTAAAAAAAGAAAAATTTGAAGGGAAAGGCAAACTTAATTGCTTAA
TAAGTGCAAGAATTTTTGAGATTCTCATTGAGAAGAATATTCCAACACATTTTATTCAACTCGAAAATGAAAATACAATG
ATTGCAAAAAAAATAAAAGTAATTCCATTAGAAATTGTTCTAAGGAATACTGCTTATGGTTCTTTATGTAAACAAACGAC
TATAAAACCTGGAACTTCTCTATCAAAACCATTAATTGATATCTACCTTAAAAATGATGAACTTAATGATCCTCTTATTA
CAAAAGATAGAATTAAATTAATGAACATATTAAGCTCTGATGATTTAGAGTTAATAATTAATCTAACTTTAAAAGTTAAT
GAAATTCTGAAAAGTTTCTTTAAAAATATTCAACTTCAGCTTGTAGATTTCAAGTTGGAATATGGTTATGATCTTAAAAA
TAACATTCTTCTGGGAGATGAAATAAGTCCTGATAATTGTAGATTATGGGATCTAAACCAAAAAAATGGTACAATCGTTA
GTCTAGATAAAGATAGATTTAGGAATGATTTAGGTGGTTTAATTGAAGCTTATAGTGAAATTCACCGAAGAATTAACAAT
TTTCTTATGCCTAAATGA

Upstream 100 bases:

>100_bases
ATAATCAGCTAAAATGAAATCAAATCTTTTGAACTTGATCTCTAATAATTATGTTAATTACAAAAAGTACTTTTAGTAAT
CACAATTAGGTCTTAAATTA

Downstream 100 bases:

>100_bases
ATAAATATTAACTTAATTTATTTTCATCAAAAGTATCATGCAAAAACATTCTTCAAAATTTGGAAAGGTTTTCACAAGTG
TTGCCTGTACTCCCTTGATT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MNNKHELIYEGKAKKIFTHDDADKVKIEFKDDATAFNALKKEKFEGKGKLNCLISARIFEILIEKNIPTHFIQLENENTM
IAKKIKVIPLEIVLRNTAYGSLCKQTTIKPGTSLSKPLIDIYLKNDELNDPLITKDRIKLMNILSSDDLELIINLTLKVN
EILKSFFKNIQLQLVDFKLEYGYDLKNNILLGDEISPDNCRLWDLNQKNGTIVSLDKDRFRNDLGGLIEAYSEIHRRINN
FLMPK

Sequences:

>Translated_245_residues
MNNKHELIYEGKAKKIFTHDDADKVKIEFKDDATAFNALKKEKFEGKGKLNCLISARIFEILIEKNIPTHFIQLENENTM
IAKKIKVIPLEIVLRNTAYGSLCKQTTIKPGTSLSKPLIDIYLKNDELNDPLITKDRIKLMNILSSDDLELIINLTLKVN
EILKSFFKNIQLQLVDFKLEYGYDLKNNILLGDEISPDNCRLWDLNQKNGTIVSLDKDRFRNDLGGLIEAYSEIHRRINN
FLMPK
>Mature_245_residues
MNNKHELIYEGKAKKIFTHDDADKVKIEFKDDATAFNALKKEKFEGKGKLNCLISARIFEILIEKNIPTHFIQLENENTM
IAKKIKVIPLEIVLRNTAYGSLCKQTTIKPGTSLSKPLIDIYLKNDELNDPLITKDRIKLMNILSSDDLELIINLTLKVN
EILKSFFKNIQLQLVDFKLEYGYDLKNNILLGDEISPDNCRLWDLNQKNGTIVSLDKDRFRNDLGGLIEAYSEIHRRINN
FLMPK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=227, Percent_Identity=30.8370044052863, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI5453539, Length=227, Percent_Identity=30.8370044052863, Blast_Score=104, Evalue=8e-23,
Organism=Homo sapiens, GI119220559, Length=234, Percent_Identity=29.9145299145299, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1788820, Length=237, Percent_Identity=39.662447257384, Blast_Score=183, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17531275, Length=225, Percent_Identity=31.5555555555556, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24583917, Length=255, Percent_Identity=28.2352941176471, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI18860083, Length=225, Percent_Identity=28.4444444444444, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 28296; Mature: 28296

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS01057 SAICAR_SYNTHETASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKHELIYEGKAKKIFTHDDADKVKIEFKDDATAFNALKKEKFEGKGKLNCLISARIFE
CCCCCCEEEECCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEHHHHHH
ILIEKNIPTHFIQLENENTMIAKKIKVIPLEIVLRNTAYGSLCKQTTIKPGTSLSKPLID
HHHHCCCCEEEEEECCCCEEEEEEEEEEEEEEEEECCCCHHHHHHCCCCCCCCCCCCEEE
IYLKNDELNDPLITKDRIKLMNILSSDDLELIINLTLKVNEILKSFFKNIQLQLVDFKLE
EEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEEHHHHHHHHHHCCEEEEEEEEEE
YGYDLKNNILLGDEISPDNCRLWDLNQKNGTIVSLDKDRFRNDLGGLIEAYSEIHRRINN
CCCCCCCCEEECCCCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
FLMPK
HCCCC
>Mature Secondary Structure
MNNKHELIYEGKAKKIFTHDDADKVKIEFKDDATAFNALKKEKFEGKGKLNCLISARIFE
CCCCCCEEEECCCCEEEECCCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEHHHHHH
ILIEKNIPTHFIQLENENTMIAKKIKVIPLEIVLRNTAYGSLCKQTTIKPGTSLSKPLID
HHHHCCCCEEEEEECCCCEEEEEEEEEEEEEEEEECCCCHHHHHHCCCCCCCCCCCCEEE
IYLKNDELNDPLITKDRIKLMNILSSDDLELIINLTLKVNEILKSFFKNIQLQLVDFKLE
EEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEEEEHHHHHHHHHHCCEEEEEEEEEE
YGYDLKNNILLGDEISPDNCRLWDLNQKNGTIVSLDKDRFRNDLGGLIEAYSEIHRRINN
CCCCCCCCEEECCCCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
FLMPK
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]