The gene/protein map for NC_009091 is currently unavailable.
Definition Prochlorococcus marinus str. MIT 9301, complete genome.
Accession NC_009091
Length 1,641,879

Click here to switch to the map view.

The map label for this gene is serS

Identifier: 126696727

GI number: 126696727

Start: 1156322

End: 1157599

Strand: Direct

Name: serS

Synonym: P9301_13891

Alternate gene names: 126696727

Gene position: 1156322-1157599 (Clockwise)

Preceding gene: 126696726

Following gene: 126696728

Centisome position: 70.43

GC content: 32.08

Gene sequence:

>1278_bases
GTGTTAGATCAAAAATTAATAAGAGAAAACCCAACATTTGTTGAAGAGAATTTATCCCTTAGAGGAAAGGTTTACAAGAT
ATCTCATATACACGAATTAACTGTTAAGAAAAAAGAAATTGACATAGAAATATCCAGCCTCCAATCTGAGAGTAAAAAAT
TAAGCAAATTAATCGGTCAAGTTATTGGAAAATCCCAAAATAATAATTCAAAAGAATTAAATGACTTAAAAAAAAAGGGA
AACGAATACAGAATTAAAATTTCTGAGCTCGAAGAGAAACAAAGAATATTAGACAAAGAAGTAGATGATGAGGTTTATAA
TTTGCCAAATTTTCCTAGCAAAGACGCGCCTATTGGGAAAGATGAAAGTGATAATTTACAAATAAAAACTTGGGGGGATC
CTCTAATAAAAGAGAATATAAAATCACACTGGGAAATAGGAGAAAGTCTTAATCTTTTTGACTTTGTAAAATCAACAAAA
ATATCAAAAAGTCGTTTTGTCACTCTTATAGGCAATGGTGCCAGATTAGAGAGGGCATTAATTAATTTTATGCTCGATAT
GCATACTAAAAATGGTTACTTGGAGTTAATGCCGCCAGCTTTAGTAAATTCAGAAAGTCTTACCGGATCTGGTCAATTAC
CAAAATTTTCAAATGAAAGTTTTAAGTGTTTTAATGACGATTTATGGCTTTCTCCAACGGCTGAAGTTCCACTAACTGCT
TTTCATAGAAACGAACTTATTGATCCCAAGAAGTTACCTATTAAGTATGTTGCATATAGCCCATGTTTTAGGAGAGAGGC
TGGCAGTTATGGAAGGGATACTAAAGGTTTAATAAGACTTCATCAATTTAATAAGGTTGAACTCTATTGGTTTTGTGATC
CAAGTAAATCTTTAGAAGCTCATAAAAAGATTACTTCTGATGCAGAAAGCATTTTAAAAAAGCTTAACTTACCTTACAGA
TTAGTTGATATTTGTACTGGAGACTTGGGCTTTTCTTCAAGTAGAACTTTTGATCTTGAAGTTTGGCTTCCCAGTAGTAA
ATGTTATAGAGAAATTTCAAGTTGCAGTAATTGTCTTGACTTTCAAGCACGTAGATCATCAATAAGATCAAAGATTGATA
AAAAAAATACATATATACATACATTAAATGGCAGTGGTCTTGCTATTGGAAGAACAATGGCAGCGATACTTGAGAATGGC
CAACAAACAGATGGTAGCGTTAAGATTCCAGATGCTCTGGTTCCATATTTTGGATCAAATTTTTTAAAAACTGCTTAA

Upstream 100 bases:

>100_bases
TTCCATAAGTCAGGAATCATTAATTAAGTTAATTTTTAATCAAAAAACCCAAATAATGAATTGAGATTAACTATCTTAAT
TAATGTAATAAAAAAAAAGA

Downstream 100 bases:

>100_bases
TATAAAAAAATGAATGTTTTAACCTCAATAACAGTACTTGGATTCCTAATATTTTTTCATGAGATGGGTCATTTTCTTGC
GGCCATTTTACAGGGAATAT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLDQKLIRENPTFVEENLSLRGKVYKISHIHELTVKKKEIDIEISSLQSESKKLSKLIGQVIGKSQNNNSKELNDLKKKG
NEYRIKISELEEKQRILDKEVDDEVYNLPNFPSKDAPIGKDESDNLQIKTWGDPLIKENIKSHWEIGESLNLFDFVKSTK
ISKSRFVTLIGNGARLERALINFMLDMHTKNGYLELMPPALVNSESLTGSGQLPKFSNESFKCFNDDLWLSPTAEVPLTA
FHRNELIDPKKLPIKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFCDPSKSLEAHKKITSDAESILKKLNLPYR
LVDICTGDLGFSSSRTFDLEVWLPSSKCYREISSCSNCLDFQARRSSIRSKIDKKNTYIHTLNGSGLAIGRTMAAILENG
QQTDGSVKIPDALVPYFGSNFLKTA

Sequences:

>Translated_425_residues
MLDQKLIRENPTFVEENLSLRGKVYKISHIHELTVKKKEIDIEISSLQSESKKLSKLIGQVIGKSQNNNSKELNDLKKKG
NEYRIKISELEEKQRILDKEVDDEVYNLPNFPSKDAPIGKDESDNLQIKTWGDPLIKENIKSHWEIGESLNLFDFVKSTK
ISKSRFVTLIGNGARLERALINFMLDMHTKNGYLELMPPALVNSESLTGSGQLPKFSNESFKCFNDDLWLSPTAEVPLTA
FHRNELIDPKKLPIKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFCDPSKSLEAHKKITSDAESILKKLNLPYR
LVDICTGDLGFSSSRTFDLEVWLPSSKCYREISSCSNCLDFQARRSSIRSKIDKKNTYIHTLNGSGLAIGRTMAAILENG
QQTDGSVKIPDALVPYFGSNFLKTA
>Mature_425_residues
MLDQKLIRENPTFVEENLSLRGKVYKISHIHELTVKKKEIDIEISSLQSESKKLSKLIGQVIGKSQNNNSKELNDLKKKG
NEYRIKISELEEKQRILDKEVDDEVYNLPNFPSKDAPIGKDESDNLQIKTWGDPLIKENIKSHWEIGESLNLFDFVKSTK
ISKSRFVTLIGNGARLERALINFMLDMHTKNGYLELMPPALVNSESLTGSGQLPKFSNESFKCFNDDLWLSPTAEVPLTA
FHRNELIDPKKLPIKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFCDPSKSLEAHKKITSDAESILKKLNLPYR
LVDICTGDLGFSSSRTFDLEVWLPSSKCYREISSCSNCLDFQARRSSIRSKIDKKNTYIHTLNGSGLAIGRTMAAILENG
QQTDGSVKIPDALVPYFGSNFLKTA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=335, Percent_Identity=35.5223880597015, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI8923421, Length=399, Percent_Identity=30.5764411027569, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI225579074, Length=403, Percent_Identity=30.272952853598, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1787120, Length=428, Percent_Identity=44.6261682242991, Blast_Score=377, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17539260, Length=336, Percent_Identity=34.5238095238095, Blast_Score=217, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI17542084, Length=333, Percent_Identity=29.1291291291291, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=347, Percent_Identity=36.5994236311239, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6321799, Length=387, Percent_Identity=31.7829457364341, Blast_Score=190, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24581334, Length=388, Percent_Identity=32.9896907216495, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI17737985, Length=391, Percent_Identity=28.9002557544757, Blast_Score=162, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_PROM0 (A3PE37)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001091613.1
- ProteinModelPortal:   A3PE37
- SMR:   A3PE37
- STRING:   A3PE37
- GeneID:   4912306
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_13891
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- ProtClustDB:   PRK05431
- BioCyc:   PMAR167546:P9301ORF_1411-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48296; Mature: 48296

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 287-287 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MLDQKLIRENPTFVEENLSLRGKVYKISHIHELTVKKKEIDIEISSLQSESKKLSKLIGQ
CCCHHHHHCCCCEEECCCCCCEEEEEEECHHHHHEEHHHEEEEHHHHHHHHHHHHHHHHH
VIGKSQNNNSKELNDLKKKGNEYRIKISELEEKQRILDKEVDDEVYNLPNFPSKDAPIGK
HHCCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCC
DESDNLQIKTWGDPLIKENIKSHWEIGESLNLFDFVKSTKISKSRFVTLIGNGARLERAL
CCCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEECCCHHHHHHH
INFMLDMHTKNGYLELMPPALVNSESLTGSGQLPKFSNESFKCFNDDLWLSPTAEVPLTA
HHHHHHHCCCCCEEEECCCHHCCCCCCCCCCCCCCCCCCCCEEECCCEEECCCCCCCEEE
FHRNELIDPKKLPIKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFCDPSKSLEA
HHHHCCCCCCCCCEEEEEECCHHHHHCCCCCCCCHHHEEEEECCEEEEEEEECCCCCHHH
HKKITSDAESILKKLNLPYRLVDICTGDLGFSSSRTFDLEVWLPSSKCYREISSCSNCLD
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
FQARRSSIRSKIDKKNTYIHTLNGSGLAIGRTMAAILENGQQTDGSVKIPDALVPYFGSN
HHHHHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCEECCHHHHHHHCCC
FLKTA
HHCCC
>Mature Secondary Structure
MLDQKLIRENPTFVEENLSLRGKVYKISHIHELTVKKKEIDIEISSLQSESKKLSKLIGQ
CCCHHHHHCCCCEEECCCCCCEEEEEEECHHHHHEEHHHEEEEHHHHHHHHHHHHHHHHH
VIGKSQNNNSKELNDLKKKGNEYRIKISELEEKQRILDKEVDDEVYNLPNFPSKDAPIGK
HHCCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCC
DESDNLQIKTWGDPLIKENIKSHWEIGESLNLFDFVKSTKISKSRFVTLIGNGARLERAL
CCCCCEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEECCCHHHHHHH
INFMLDMHTKNGYLELMPPALVNSESLTGSGQLPKFSNESFKCFNDDLWLSPTAEVPLTA
HHHHHHHCCCCCEEEECCCHHCCCCCCCCCCCCCCCCCCCCEEECCCEEECCCCCCCEEE
FHRNELIDPKKLPIKYVAYSPCFRREAGSYGRDTKGLIRLHQFNKVELYWFCDPSKSLEA
HHHHCCCCCCCCCEEEEEECCHHHHHCCCCCCCCHHHEEEEECCEEEEEEEECCCCCHHH
HKKITSDAESILKKLNLPYRLVDICTGDLGFSSSRTFDLEVWLPSSKCYREISSCSNCLD
HHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
FQARRSSIRSKIDKKNTYIHTLNGSGLAIGRTMAAILENGQQTDGSVKIPDALVPYFGSN
HHHHHHHHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHCCCCCCCCEECCHHHHHHHCCC
FLKTA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA