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The map label for this gene is cobQ

Identifier: 126696690

GI number: 126696690

Start: 1129542

End: 1131071

Strand: Direct

Name: cobQ

Synonym: P9301_13521

Alternate gene names: 126696690

Gene position: 1129542-1131071 (Clockwise)

Preceding gene: 126696688

Following gene: 126696691

Centisome position: 68.8

GC content: 31.5

Gene sequence:

>1530_bases
ATGGAATTAGAGGCAAAATTACATGAAATAAAGAAACCAATAATGGTCCTAGGTACTTCCAGTGGAGCAGGAAAATCATT
AACAGTTACTGCTATTTGTAGGATTCTTAAAAACTTAGGCGAAGAACCAATCCCTTTTAAAGGACAAAATATGAGCAACA
ACGCTTGGGTTGATTGGGAAGGTGGAGAAATGGCATATTCACAAGCACTTCAGGCTTTTGCTTGTGGTATTAATCCCGCT
GCAGAGATGAATCCCATTTTATTAAAACCACAAGGAAACTCAATAAGCGAGGTGATTCACCTTGGCAAAAGCATAGGGAC
CACCACTGCAAAAAATTACTATAAGGATTGGTTTACTCCAGGTTGGGAAGTAATTAAAAAAAGTTTAAAGTCTATTTACG
AAGGAAATCCGAATTGCCGTTTAATTATCGAAGGGGCTGGAAGTCCGGTAGAGATGAATTTAATTCATAGAGATCTGACT
AATTTAAGAGTTGCTAAATATTTAAATGCAAATTGCATTTTGGTTACTGATATTGAAAGGGGAGGCGTATTTGCACAAAT
AATTGGTACTCTTGAATTAATGAAGCCTGAAGAAAAGAAGCTTATTAAGGGAATTATTATAAATAGATTCAGAGGAGACC
TTTCATTATTTGAAGATGGGAAGAAATGGATAGAGAATAAGACTCAAATCCCTGTTGTTGGAATTATTCCATGGTTAAAT
GATTCATTTCCCCCAGAGGACTCTTTAGATTTAATAGAAAAAAAATCACTTTCTAAAAATCCTGAAATCAAAGTTGGAAT
TATAAAATTACCATCTATTAGTAACTTCTCGGATTTTGATCCACTAGAAAATGAAGAAACGATATTTATTGAATGGATTA
GAAAATCACAAAATCTAAGTAAGTATGACTTCATCATTCTGCCGGGAAGTAAACAAACGATTAAAGATCAAATATTTCTT
GAAAATTCTGGTTTATCTAAGGATATAAGGGACTATTCAAAAAACAAAGGAAATATTGTTGGAATATGTGGAGGCTTACA
AATGTTAGGGACTACACTTGAAGATCCATATTTTAAAGAGGGTTCCAAAAATTATTCTGAACAAAAAATTAAAGGTATTG
GATTACTACCCTTAAAAACGACTTTCTTTAAAAAAAAATTAACACGTCAAATTAAATCTAAATCTATATGGCCGTGCCAA
TCAGAAATTAATGGATTTGAAATTCATAATGGTCAAACTGTATTAGATGAAATCCAAAGTTCATTAAAGATTAATCCAAT
TTTTGAAGATTCAGATCTTGGTTGGTATAAAGAAAATAATAAAGGAGGAACTATTGCAGGAACATATATTCATGGAATCT
TTGAAAATGACAGTTGGAGAGAGCATTATATTAATTTAATAAGGAAGAGTAAAAATCTACCAACATTAAACAAAAAATCA
ATATCTTATAAAGAGAAGAGACAATTCATTATTGATAATCTTGCGAATGAATTCCACAAACATTTAAATCTCAAATCATT
TTTAAGTTGA

Upstream 100 bases:

>100_bases
TTCTAGATTGAGAAGCAGAGGCTAGAATTAACACAAATTTTTTACCAAATTATAATTCAATTTAATAATTAATAAATTTT
AAAATTAATATAAATTACTA

Downstream 100 bases:

>100_bases
AAGAAACAAAAAATACAAAAGTAATATGGCCAAACAATAAAGAAACCTTTGTTTCAGATGGTGATAACTGGTTTTCTTCT
GCTAAAAAAGCAGGTTTAGA

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MELEAKLHEIKKPIMVLGTSSGAGKSLTVTAICRILKNLGEEPIPFKGQNMSNNAWVDWEGGEMAYSQALQAFACGINPA
AEMNPILLKPQGNSISEVIHLGKSIGTTTAKNYYKDWFTPGWEVIKKSLKSIYEGNPNCRLIIEGAGSPVEMNLIHRDLT
NLRVAKYLNANCILVTDIERGGVFAQIIGTLELMKPEEKKLIKGIIINRFRGDLSLFEDGKKWIENKTQIPVVGIIPWLN
DSFPPEDSLDLIEKKSLSKNPEIKVGIIKLPSISNFSDFDPLENEETIFIEWIRKSQNLSKYDFIILPGSKQTIKDQIFL
ENSGLSKDIRDYSKNKGNIVGICGGLQMLGTTLEDPYFKEGSKNYSEQKIKGIGLLPLKTTFFKKKLTRQIKSKSIWPCQ
SEINGFEIHNGQTVLDEIQSSLKINPIFEDSDLGWYKENNKGGTIAGTYIHGIFENDSWREHYINLIRKSKNLPTLNKKS
ISYKEKRQFIIDNLANEFHKHLNLKSFLS

Sequences:

>Translated_509_residues
MELEAKLHEIKKPIMVLGTSSGAGKSLTVTAICRILKNLGEEPIPFKGQNMSNNAWVDWEGGEMAYSQALQAFACGINPA
AEMNPILLKPQGNSISEVIHLGKSIGTTTAKNYYKDWFTPGWEVIKKSLKSIYEGNPNCRLIIEGAGSPVEMNLIHRDLT
NLRVAKYLNANCILVTDIERGGVFAQIIGTLELMKPEEKKLIKGIIINRFRGDLSLFEDGKKWIENKTQIPVVGIIPWLN
DSFPPEDSLDLIEKKSLSKNPEIKVGIIKLPSISNFSDFDPLENEETIFIEWIRKSQNLSKYDFIILPGSKQTIKDQIFL
ENSGLSKDIRDYSKNKGNIVGICGGLQMLGTTLEDPYFKEGSKNYSEQKIKGIGLLPLKTTFFKKKLTRQIKSKSIWPCQ
SEINGFEIHNGQTVLDEIQSSLKINPIFEDSDLGWYKENNKGGTIAGTYIHGIFENDSWREHYINLIRKSKNLPTLNKKS
ISYKEKRQFIIDNLANEFHKHLNLKSFLS
>Mature_509_residues
MELEAKLHEIKKPIMVLGTSSGAGKSLTVTAICRILKNLGEEPIPFKGQNMSNNAWVDWEGGEMAYSQALQAFACGINPA
AEMNPILLKPQGNSISEVIHLGKSIGTTTAKNYYKDWFTPGWEVIKKSLKSIYEGNPNCRLIIEGAGSPVEMNLIHRDLT
NLRVAKYLNANCILVTDIERGGVFAQIIGTLELMKPEEKKLIKGIIINRFRGDLSLFEDGKKWIENKTQIPVVGIIPWLN
DSFPPEDSLDLIEKKSLSKNPEIKVGIIKLPSISNFSDFDPLENEETIFIEWIRKSQNLSKYDFIILPGSKQTIKDQIFL
ENSGLSKDIRDYSKNKGNIVGICGGLQMLGTTLEDPYFKEGSKNYSEQKIKGIGLLPLKTTFFKKKLTRQIKSKSIWPCQ
SEINGFEIHNGQTVLDEIQSSLKINPIFEDSDLGWYKENNKGGTIAGTYIHGIFENDSWREHYINLIRKSKNLPTLNKKS
ISYKEKRQFIIDNLANEFHKHLNLKSFLS

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_PROM0 (A3PE00)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001091576.1
- ProteinModelPortal:   A3PE00
- STRING:   A3PE00
- GeneID:   4912438
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_13521
- eggNOG:   COG1492
- HOGENOM:   HBG302271
- OMA:   AHTDLNP
- ProtClustDB:   PRK00784
- BioCyc:   PMAR167546:P9301ORF_1372-MONOMER
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 57488; Mature: 57488

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 343-343 ACT_SITE 451-451

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELEAKLHEIKKPIMVLGTSSGAGKSLTVTAICRILKNLGEEPIPFKGQNMSNNAWVDWE
CCCHHHHHHCCCCEEEEECCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEC
GGEMAYSQALQAFACGINPAAEMNPILLKPQGNSISEVIHLGKSIGTTTAKNYYKDWFTP
CCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHCCC
GWEVIKKSLKSIYEGNPNCRLIIEGAGSPVEMNLIHRDLTNLRVAKYLNANCILVTDIER
CHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEECCC
GGVFAQIIGTLELMKPEEKKLIKGIIINRFRGDLSLFEDGKKWIENKTQIPVVGIIPWLN
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECCCC
DSFPPEDSLDLIEKKSLSKNPEIKVGIIKLPSISNFSDFDPLENEETIFIEWIRKSQNLS
CCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCC
KYDFIILPGSKQTIKDQIFLENSGLSKDIRDYSKNKGNIVGICGGLQMLGTTLEDPYFKE
CEEEEEECCCCHHHCCEEEEECCCCCHHHHHHHCCCCCEEEEECCHHHHHHHHCCCCCCC
GSKNYSEQKIKGIGLLPLKTTFFKKKLTRQIKSKSIWPCQSEINGFEIHNGQTVLDEIQS
CCCCCCHHHHCCCEEECHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEECCCHHHHHHHH
SLKINPIFEDSDLGWYKENNKGGTIAGTYIHGIFENDSWREHYINLIRKSKNLPTLNKKS
HCEECCEEECCCCCCEEECCCCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCC
ISYKEKRQFIIDNLANEFHKHLNLKSFLS
CCHHHHHHHHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure
MELEAKLHEIKKPIMVLGTSSGAGKSLTVTAICRILKNLGEEPIPFKGQNMSNNAWVDWE
CCCHHHHHHCCCCEEEEECCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEC
GGEMAYSQALQAFACGINPAAEMNPILLKPQGNSISEVIHLGKSIGTTTAKNYYKDWFTP
CCHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHCCC
GWEVIKKSLKSIYEGNPNCRLIIEGAGSPVEMNLIHRDLTNLRVAKYLNANCILVTDIER
CHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCEEEEEECCC
GGVFAQIIGTLELMKPEEKKLIKGIIINRFRGDLSLFEDGKKWIENKTQIPVVGIIPWLN
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEEEECCCC
DSFPPEDSLDLIEKKSLSKNPEIKVGIIKLPSISNFSDFDPLENEETIFIEWIRKSQNLS
CCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEECCCCCCC
KYDFIILPGSKQTIKDQIFLENSGLSKDIRDYSKNKGNIVGICGGLQMLGTTLEDPYFKE
CEEEEEECCCCHHHCCEEEEECCCCCHHHHHHHCCCCCEEEEECCHHHHHHHHCCCCCCC
GSKNYSEQKIKGIGLLPLKTTFFKKKLTRQIKSKSIWPCQSEINGFEIHNGQTVLDEIQS
CCCCCCHHHHCCCEEECHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEECCCHHHHHHHH
SLKINPIFEDSDLGWYKENNKGGTIAGTYIHGIFENDSWREHYINLIRKSKNLPTLNKKS
HCEECCEEECCCCCCEEECCCCCEEEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCC
ISYKEKRQFIIDNLANEFHKHLNLKSFLS
CCHHHHHHHHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA