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The map label for this gene is btuE [H]

Identifier: 126696433

GI number: 126696433

Start: 934881

End: 935360

Strand: Direct

Name: btuE [H]

Synonym: P9301_10951

Alternate gene names: 126696433

Gene position: 934881-935360 (Clockwise)

Preceding gene: 126696429

Following gene: 126696436

Centisome position: 56.94

GC content: 35.0

Gene sequence:

>480_bases
ATGCAAGTTGACGTACAAAATACTACTGTTCTTTCCGCAGACGGATCATCCATACAACTAGGTGAATATTCAGGGGAAGT
AATTTTAGTTGTTAATGTAGCTAGTTACTGCGGAAATACTGCTCAGTATGAGGATCTTCAAAAGCTACATGATTTATATT
CAACAAAAGGCCTAAGAATACTTGCATTCCCTTGTAATGATTTCGGAAAACAAGAACCCGACTCTCTTTCAGAAATAAAA
GATTTTTGCACAACAAAATATGGAATTAAATTTGAAATCTATGAAAAAGTTCATGCCAAAGGCAACACAACAGAACCATA
CACAACCCTTAACAAAGTTGAACCTGAAGGTGATGTTGAATGGAATTTCGAGAAGTTTCTGATAGGTAAAGATAGTAAAG
TAATTGCAAGATTCAAGCCAACTGTTAAACCGTTTGACGAAAACTTAATAGCCGCTATCGAAGTTGCTTTAGATTCATAA

Upstream 100 bases:

>100_bases
AAAAATTAAAACTTATAAAAGAAATAACCAAAACCACTATAAAAATTAAACACAATAAAGTCTATACAATGCTATCTTCA
AAGGGTGATTTTTTTTAAAC

Downstream 100 bases:

>100_bases
AAACCTTCCTAGTAATAATTAATTTAATTTAAAATTACATTAATTATCAGAATCAACTTCTACGTCTATTATTTCATCTT
TAACAGTTCTTTTTTTAGGT

Product: glutathione peroxidase

Products: glutathione disulfide; H2O

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MQVDVQNTTVLSADGSSIQLGEYSGEVILVVNVASYCGNTAQYEDLQKLHDLYSTKGLRILAFPCNDFGKQEPDSLSEIK
DFCTTKYGIKFEIYEKVHAKGNTTEPYTTLNKVEPEGDVEWNFEKFLIGKDSKVIARFKPTVKPFDENLIAAIEVALDS

Sequences:

>Translated_159_residues
MQVDVQNTTVLSADGSSIQLGEYSGEVILVVNVASYCGNTAQYEDLQKLHDLYSTKGLRILAFPCNDFGKQEPDSLSEIK
DFCTTKYGIKFEIYEKVHAKGNTTEPYTTLNKVEPEGDVEWNFEKFLIGKDSKVIARFKPTVKPFDENLIAAIEVALDS
>Mature_159_residues
MQVDVQNTTVLSADGSSIQLGEYSGEVILVVNVASYCGNTAQYEDLQKLHDLYSTKGLRILAFPCNDFGKQEPDSLSEIK
DFCTTKYGIKFEIYEKVHAKGNTTEPYTTLNKVEPEGDVEWNFEKFLIGKDSKVIARFKPTVKPFDENLIAAIEVALDS

Specific function: Important in the cellular metabolism or defense processes particular to this pathogen [H]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=139, Percent_Identity=43.1654676258993, Blast_Score=114, Evalue=3e-26,
Organism=Homo sapiens, GI90903240, Length=139, Percent_Identity=43.1654676258993, Blast_Score=114, Evalue=5e-26,
Organism=Homo sapiens, GI90903238, Length=120, Percent_Identity=44.1666666666667, Blast_Score=100, Evalue=4e-22,
Organism=Homo sapiens, GI15618997, Length=140, Percent_Identity=37.8571428571429, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI192455698, Length=132, Percent_Identity=36.3636363636364, Blast_Score=93, Evalue=9e-20,
Organism=Homo sapiens, GI6006001, Length=156, Percent_Identity=37.8205128205128, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI4557629, Length=163, Percent_Identity=32.5153374233129, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI33186887, Length=139, Percent_Identity=35.9712230215827, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI41406084, Length=157, Percent_Identity=32.484076433121, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1788003, Length=181, Percent_Identity=37.5690607734807, Blast_Score=131, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17535473, Length=160, Percent_Identity=39.375, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193210707, Length=161, Percent_Identity=38.5093167701863, Blast_Score=116, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17506887, Length=147, Percent_Identity=39.4557823129252, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71993584, Length=138, Percent_Identity=38.4057971014493, Blast_Score=108, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17550320, Length=174, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI193209493, Length=175, Percent_Identity=32.5714285714286, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71993573, Length=86, Percent_Identity=41.8604651162791, Blast_Score=76, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI193210709, Length=64, Percent_Identity=50, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71999642, Length=65, Percent_Identity=46.1538461538462, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319721, Length=135, Percent_Identity=42.2222222222222, Blast_Score=119, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322228, Length=135, Percent_Identity=40.7407407407407, Blast_Score=113, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322826, Length=154, Percent_Identity=35.7142857142857, Blast_Score=109, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24656772, Length=145, Percent_Identity=38.6206896551724, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24656767, Length=145, Percent_Identity=38.6206896551724, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24656777, Length=145, Percent_Identity=38.6206896551724, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI85726443, Length=146, Percent_Identity=35.6164383561644, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: 1.11.1.9

Molecular weight: Translated: 17768; Mature: 17768

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVDVQNTTVLSADGSSIQLGEYSGEVILVVNVASYCGNTAQYEDLQKLHDLYSTKGLRI
CEEECCCCEEEECCCCEEEEECCCCCEEEEEEEHHHCCCCCCHHHHHHHHHHHHCCCCEE
LAFPCNDFGKQEPDSLSEIKDFCTTKYGIKFEIYEKVHAKGNTTEPYTTLNKVEPEGDVE
EEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCE
WNFEKFLIGKDSKVIARFKPTVKPFDENLIAAIEVALDS
ECCEEEEECCCCEEEEEECCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MQVDVQNTTVLSADGSSIQLGEYSGEVILVVNVASYCGNTAQYEDLQKLHDLYSTKGLRI
CEEECCCCEEEECCCCEEEEECCCCCEEEEEEEHHHCCCCCCHHHHHHHHHHHHCCCCEE
LAFPCNDFGKQEPDSLSEIKDFCTTKYGIKFEIYEKVHAKGNTTEPYTTLNKVEPEGDVE
EEECCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCE
WNFEKFLIGKDSKVIARFKPTVKPFDENLIAAIEVALDS
ECCEEEEECCCCEEEEEECCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutathione; H2O2

Specific reaction: 2 glutathione + H2O2 = glutathione disulfide + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10722605; 10761919 [H]