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The map label for this gene is uvrC [H]

Identifier: 126696315

GI number: 126696315

Start: 845419

End: 847377

Strand: Direct

Name: uvrC [H]

Synonym: P9301_09771

Alternate gene names: 126696315

Gene position: 845419-847377 (Clockwise)

Preceding gene: 126696314

Following gene: 126696316

Centisome position: 51.49

GC content: 27.51

Gene sequence:

>1959_bases
ATGAGTAATTCCTCTATCGAAAAAATAAATAACAAATATAATTTTAAAATTGAATATAAATTAATTAATAATAAGGAGTT
ATTAAAATCAAGATTATCCGAAATTCCAAAGTCATCTGGTTGTTATCTTTTTAAAGATATTGATAATAACCTACTTTATA
TCGGTAAATCTAAAAAACTACGCAGTAGAGTAAGTAGTTATTTCAATAATTATTCAGATTTAACTCCCCGATTAAGTTTG
ATGGTCCGTCAAATAACTGAAATAGAAATAATAGTCACAGATAGCGAATATGAAGCATTAAATTTAGAGTCAAATTTAAT
TAAAACAAACAAACCATATTTTAATATTCTTTTAAAAGATGATAAGAAATATCCATATCTTTGTATAACTTGGAGTGAAA
AATATCCTCGAATATTTATTACAAGAAGAAGAAGAAATAGAAATAATTTAGATAGATATTATGGACCTTATGTTGATGTT
GGATTATTAAGGAGAACATTATTTACGATAAAAAAAATATTTCCACTTAGACAAAGACCAAGGCCAGTCTATAAAGATAG
AACTTGTTTGAATTATTCAATAGGAAGATGTCCAGGTGTTTGCCAAGAAGTTATATCATCTGACGATTATAAAAAAATAA
TGAAACAAGTATCTATGATATTTCAGGGAAGAAATGATGACTTAGAAATATTTTTACAAAAAAAAATGCTTCAATTTTCA
AATGATTTAGATTATGAGAATGCAGCAAAAATAAGAGACCAAATTTCAGGTTTAAAATTATTAACTGAATCACAAAAAAT
ATCAATACCAGATTCTTCAATTAATAGAGATATCTTTGGAATAGTTTCAGAAAAAAATGTAGCTAGTATACAAATTTTCC
AAATGAGATCAGGTAAGCTCATTGGGAGAATTGGCTATAGTCAAAAATTAAATAATGAAGATGAAAATCTTATTTTACAA
AAGATATTAGAAGAGCATTATATGAATGTTGAACCTGTAGAAATACCATCAGAAATTCTTATTCAATATAACCTTCCAAA
ACAAGCAACCATAGAGGATTGGTTAACGGAGCTAAGAAAAAAGAAAGTAAAAATCCTAATCCCAAAAAGAAATAAAAAAC
ATGAAACTGTAGAAATGGTTTTAAAAAATGCAAAATTGGAATTAGATAGAATATTAAATGGGATACAAGATAATGAATCA
TCAATTGAGGATCTTGCCCAAATACTTGAATTAAGCGAACAACCTAAAAGAATTGAAGGCTATGATATAAGCCATATTCA
AGGTAGTGACCCTGTAGCATCACAAGTCGTTTTTATTGATGGGGTTCCTTCTAAACAGCATTATAGGAAATATAAAATTA
AAGATCCAAACGTTTCTATAGGACATAGTGATGATTTTGCTTCGATATATGAAGTAATACAAAGAAGGTTTAAAAAATGG
TCAAGATTTAAAGAAAGCGGAGGGGATTTTTCAATATTAAATGATAAAACGAACAGTAAATTAGACAATGAACTTCTATC
AGATTGGCCTGATTTAATAATGATTGATGGAGGAAAAGGACAGTTAAATGCAGCTATTAAAGCATTAAAAGAATTAAATC
TTGAGGAAGAAGTAACTATATGTTCATTGGCAAAAAAAAATGAAGAAATATTTATTCCAGGATTTACTAAGTCTCTTGAT
ACTGATGAAAATCAAAAAGGAGTTCTTCTATTAAGAAGGGTAAGAGATGAAGCACATAGATTTGCATTATCTTTTCATAG
AGACAAAAGATCTAAAAGAATGAATAGATCTCAATTGTCCCAAATCAGTGGATTAGGACCATCAAGAATAAGAGAATTGC
TTGAGCATTTCAAATCAATAGACGCGATAAGAATAGCTAGTAAGGAGGATTTATCAAAAGTTAAAGGACTTGGAAAAAAT
TCAGTTAATGATATATATGAATATTTTAACGAGTTATAA

Upstream 100 bases:

>100_bases
CGTTTTTGTAGGAGAGGTGCAATCTGCTTATCTGAATAATGATGTTGACTCACTAAATTTATCTTCAACTGGCTGGAACT
ATGGAGGTTAACCACTATAA

Downstream 100 bases:

>100_bases
ATATTAATTAAATTTTGAAAAATAGATTTCTTGATATTGTTAAATATAACTATATTAAAAACATATATTTTTAAATTAAT
CTAGTAATTTGGCAGCTGAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 652; Mature: 651

Protein sequence:

>652_residues
MSNSSIEKINNKYNFKIEYKLINNKELLKSRLSEIPKSSGCYLFKDIDNNLLYIGKSKKLRSRVSSYFNNYSDLTPRLSL
MVRQITEIEIIVTDSEYEALNLESNLIKTNKPYFNILLKDDKKYPYLCITWSEKYPRIFITRRRRNRNNLDRYYGPYVDV
GLLRRTLFTIKKIFPLRQRPRPVYKDRTCLNYSIGRCPGVCQEVISSDDYKKIMKQVSMIFQGRNDDLEIFLQKKMLQFS
NDLDYENAAKIRDQISGLKLLTESQKISIPDSSINRDIFGIVSEKNVASIQIFQMRSGKLIGRIGYSQKLNNEDENLILQ
KILEEHYMNVEPVEIPSEILIQYNLPKQATIEDWLTELRKKKVKILIPKRNKKHETVEMVLKNAKLELDRILNGIQDNES
SIEDLAQILELSEQPKRIEGYDISHIQGSDPVASQVVFIDGVPSKQHYRKYKIKDPNVSIGHSDDFASIYEVIQRRFKKW
SRFKESGGDFSILNDKTNSKLDNELLSDWPDLIMIDGGKGQLNAAIKALKELNLEEEVTICSLAKKNEEIFIPGFTKSLD
TDENQKGVLLLRRVRDEAHRFALSFHRDKRSKRMNRSQLSQISGLGPSRIRELLEHFKSIDAIRIASKEDLSKVKGLGKN
SVNDIYEYFNEL

Sequences:

>Translated_652_residues
MSNSSIEKINNKYNFKIEYKLINNKELLKSRLSEIPKSSGCYLFKDIDNNLLYIGKSKKLRSRVSSYFNNYSDLTPRLSL
MVRQITEIEIIVTDSEYEALNLESNLIKTNKPYFNILLKDDKKYPYLCITWSEKYPRIFITRRRRNRNNLDRYYGPYVDV
GLLRRTLFTIKKIFPLRQRPRPVYKDRTCLNYSIGRCPGVCQEVISSDDYKKIMKQVSMIFQGRNDDLEIFLQKKMLQFS
NDLDYENAAKIRDQISGLKLLTESQKISIPDSSINRDIFGIVSEKNVASIQIFQMRSGKLIGRIGYSQKLNNEDENLILQ
KILEEHYMNVEPVEIPSEILIQYNLPKQATIEDWLTELRKKKVKILIPKRNKKHETVEMVLKNAKLELDRILNGIQDNES
SIEDLAQILELSEQPKRIEGYDISHIQGSDPVASQVVFIDGVPSKQHYRKYKIKDPNVSIGHSDDFASIYEVIQRRFKKW
SRFKESGGDFSILNDKTNSKLDNELLSDWPDLIMIDGGKGQLNAAIKALKELNLEEEVTICSLAKKNEEIFIPGFTKSLD
TDENQKGVLLLRRVRDEAHRFALSFHRDKRSKRMNRSQLSQISGLGPSRIRELLEHFKSIDAIRIASKEDLSKVKGLGKN
SVNDIYEYFNEL
>Mature_651_residues
SNSSIEKINNKYNFKIEYKLINNKELLKSRLSEIPKSSGCYLFKDIDNNLLYIGKSKKLRSRVSSYFNNYSDLTPRLSLM
VRQITEIEIIVTDSEYEALNLESNLIKTNKPYFNILLKDDKKYPYLCITWSEKYPRIFITRRRRNRNNLDRYYGPYVDVG
LLRRTLFTIKKIFPLRQRPRPVYKDRTCLNYSIGRCPGVCQEVISSDDYKKIMKQVSMIFQGRNDDLEIFLQKKMLQFSN
DLDYENAAKIRDQISGLKLLTESQKISIPDSSINRDIFGIVSEKNVASIQIFQMRSGKLIGRIGYSQKLNNEDENLILQK
ILEEHYMNVEPVEIPSEILIQYNLPKQATIEDWLTELRKKKVKILIPKRNKKHETVEMVLKNAKLELDRILNGIQDNESS
IEDLAQILELSEQPKRIEGYDISHIQGSDPVASQVVFIDGVPSKQHYRKYKIKDPNVSIGHSDDFASIYEVIQRRFKKWS
RFKESGGDFSILNDKTNSKLDNELLSDWPDLIMIDGGKGQLNAAIKALKELNLEEEVTICSLAKKNEEIFIPGFTKSLDT
DENQKGVLLLRRVRDEAHRFALSFHRDKRSKRMNRSQLSQISGLGPSRIRELLEHFKSIDAIRIASKEDLSKVKGLGKNS
VNDIYEYFNEL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=633, Percent_Identity=31.2796208530806, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1788037, Length=208, Percent_Identity=29.8076923076923, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 75919; Mature: 75788

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSSIEKINNKYNFKIEYKLINNKELLKSRLSEIPKSSGCYLFKDIDNNLLYIGKSKKL
CCCCHHHHHCCCEEEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCHHH
RSRVSSYFNNYSDLTPRLSLMVRQITEIEIIVTDSEYEALNLESNLIKTNKPYFNILLKD
HHHHHHHHCCHHCCCHHHHHHHHHHCEEEEEEECCCCCEECCCCCCEECCCCEEEEEEEC
DKKYPYLCITWSEKYPRIFITRRRRNRNNLDRYYGPYVDVGLLRRTLFTIKKIFPLRQRP
CCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
RPVYKDRTCLNYSIGRCPGVCQEVISSDDYKKIMKQVSMIFQGRNDDLEIFLQKKMLQFS
CCCCCCCCEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
NDLDYENAAKIRDQISGLKLLTESQKISIPDSSINRDIFGIVSEKNVASIQIFQMRSGKL
CCCCCHHHHHHHHHHHHHHEEECCCEEECCCCCCCCCCEEEECCCCCCEEEEEEECCCCE
IGRIGYSQKLNNEDENLILQKILEEHYMNVEPVEIPSEILIQYNLPKQATIEDWLTELRK
EEECCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHEEEEECCCCCCCHHHHHHHHHH
KKVKILIPKRNKKHETVEMVLKNAKLELDRILNGIQDNESSIEDLAQILELSEQPKRIEG
CCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
YDISHIQGSDPVASQVVFIDGVPSKQHYRKYKIKDPNVSIGHSDDFASIYEVIQRRFKKW
CCCCCCCCCCCHHCEEEEEECCCCHHHHCEEECCCCCEECCCCCCHHHHHHHHHHHHHHH
SRFKESGGDFSILNDKTNSKLDNELLSDWPDLIMIDGGKGQLNAAIKALKELNLEEEVTI
HHHHHCCCCEEEECCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHH
CSLAKKNEEIFIPGFTKSLDTDENQKGVLLLRRVRDEAHRFALSFHRDKRSKRMNRSQLS
HHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
QISGLGPSRIRELLEHFKSIDAIRIASKEDLSKVKGLGKNSVNDIYEYFNEL
HHHCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SNSSIEKINNKYNFKIEYKLINNKELLKSRLSEIPKSSGCYLFKDIDNNLLYIGKSKKL
CCCHHHHHCCCEEEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCHHH
RSRVSSYFNNYSDLTPRLSLMVRQITEIEIIVTDSEYEALNLESNLIKTNKPYFNILLKD
HHHHHHHHCCHHCCCHHHHHHHHHHCEEEEEEECCCCCEECCCCCCEECCCCEEEEEEEC
DKKYPYLCITWSEKYPRIFITRRRRNRNNLDRYYGPYVDVGLLRRTLFTIKKIFPLRQRP
CCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
RPVYKDRTCLNYSIGRCPGVCQEVISSDDYKKIMKQVSMIFQGRNDDLEIFLQKKMLQFS
CCCCCCCCEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
NDLDYENAAKIRDQISGLKLLTESQKISIPDSSINRDIFGIVSEKNVASIQIFQMRSGKL
CCCCCHHHHHHHHHHHHHHEEECCCEEECCCCCCCCCCEEEECCCCCCEEEEEEECCCCE
IGRIGYSQKLNNEDENLILQKILEEHYMNVEPVEIPSEILIQYNLPKQATIEDWLTELRK
EEECCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCHHEEEEECCCCCCCHHHHHHHHHH
KKVKILIPKRNKKHETVEMVLKNAKLELDRILNGIQDNESSIEDLAQILELSEQPKRIEG
CCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
YDISHIQGSDPVASQVVFIDGVPSKQHYRKYKIKDPNVSIGHSDDFASIYEVIQRRFKKW
CCCCCCCCCCCHHCEEEEEECCCCHHHHCEEECCCCCEECCCCCCHHHHHHHHHHHHHHH
SRFKESGGDFSILNDKTNSKLDNELLSDWPDLIMIDGGKGQLNAAIKALKELNLEEEVTI
HHHHHCCCCEEEECCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHH
CSLAKKNEEIFIPGFTKSLDTDENQKGVLLLRRVRDEAHRFALSFHRDKRSKRMNRSQLS
HHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
QISGLGPSRIRELLEHFKSIDAIRIASKEDLSKVKGLGKNSVNDIYEYFNEL
HHHCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHHCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA