Click here to switch to the map view.

The map label for this gene is cobW [H]

Identifier: 126696176

GI number: 126696176

Start: 727854

End: 728918

Strand: Direct

Name: cobW [H]

Synonym: P9301_08381

Alternate gene names: 126696176

Gene position: 727854-728918 (Clockwise)

Preceding gene: 126696175

Following gene: 126696177

Centisome position: 44.33

GC content: 29.39

Gene sequence:

>1065_bases
ATGAAAAAAAAAATTCCAGTTATTGTTGTTTCGGGATTTCTTGGTTCAGGTAAAACAACTTTTCTAAGATATCTATTAAA
AGAGAGTAATAAAAAATTTGGTTTAATAATCAATGAATTTGGTGATGTTGGAATTGACGGTGATTTGATTAAAAGTTGTG
ATAAATGTGATGAATCTGAAGACGACTGCGTTATCGAATTAAACAATGGATGCTTATGTTGCACTGTTCAAGATGACTTT
GTTCCATCAATAAAAGCTCTCCTAGAATTTAATCCTCCTATCGAATCAATAATTATCGAAACAAGTGGGTTGGCACTACC
AATTCCCTTAATTCAAGCACTTAACTGGCCTGAGATTAGGTCTTCCATCTACCTTGATGTTGTTGTTGGTATCGTTAATG
GAGAATCAATGCTAAATGGTTCCCCAATTAATGATTTAAATAAAATAACAAAACAATATAATGAGACAGATAAAATTGAT
CACAACGCCACTATAGATGAACTTTTTGAGGAGCAACTAGAAGTTTCTGATATCGTTTTAGTCTCTAGATCAGATATCTT
AAATGATGATCAGTTTGACGTTGTAAAAAATAAAATTCAAGGAAGTCTAAATTCATCTACACCAGTCCTTAAATCCAAGA
ATGGCAAAATTGATTTAAATTATCTATTTGATTTTAATTTTAAAAAAGAGACTTATAAAGAATTTTTAACGGAAGAACAT
GACCATAATCATGTTGAGCTTGTATCAGATTCATTTAAATTAAATTATTTCCTTGAAAAAAATGACTTTGAAAAGGAGAT
GTCAAAAATCTTGGATGAATTAAACATTCTTCGAATAAAAGGACGTATTTGGATACCAAACAAATCATTGCCTTTACAAA
TACAAATTGTAGGAAAGAAAATTAATACTTGGTTTGAAGAAGCTCCAAACAATTGTTGGAGACCAAATGATAATGCTGGG
CTTGAATTAGTAATAATTTCCTTTGATGAAAAATCTATACAAACTTTCAATAAAAAAATTAAAGAGAAATTTAAGATTTT
AAGTGACCCAAAAATAGCAATTTGA

Upstream 100 bases:

>100_bases
AAGTCGTACACAACAAAAACAATTATGTGCGATTGCCAATGGCACAAATAGTTCTACAGGAGAGAGTACAGAATACAGCT
TAGGTTGTTAATCATCAAAG

Downstream 100 bases:

>100_bases
CTTTATAGTTACTTGTCGGGATACTTACTTCAGTAGACAGCCCAAGATGGAAAATTCAAAAATTGCTTTAAAAGAGATAA
TCTCTGAAGAAGTTTCTTCA

Product: putative cobalamin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MKKKIPVIVVSGFLGSGKTTFLRYLLKESNKKFGLIINEFGDVGIDGDLIKSCDKCDESEDDCVIELNNGCLCCTVQDDF
VPSIKALLEFNPPIESIIIETSGLALPIPLIQALNWPEIRSSIYLDVVVGIVNGESMLNGSPINDLNKITKQYNETDKID
HNATIDELFEEQLEVSDIVLVSRSDILNDDQFDVVKNKIQGSLNSSTPVLKSKNGKIDLNYLFDFNFKKETYKEFLTEEH
DHNHVELVSDSFKLNYFLEKNDFEKEMSKILDELNILRIKGRIWIPNKSLPLQIQIVGKKINTWFEEAPNNCWRPNDNAG
LELVIISFDEKSIQTFNKKIKEKFKILSDPKIAI

Sequences:

>Translated_354_residues
MKKKIPVIVVSGFLGSGKTTFLRYLLKESNKKFGLIINEFGDVGIDGDLIKSCDKCDESEDDCVIELNNGCLCCTVQDDF
VPSIKALLEFNPPIESIIIETSGLALPIPLIQALNWPEIRSSIYLDVVVGIVNGESMLNGSPINDLNKITKQYNETDKID
HNATIDELFEEQLEVSDIVLVSRSDILNDDQFDVVKNKIQGSLNSSTPVLKSKNGKIDLNYLFDFNFKKETYKEFLTEEH
DHNHVELVSDSFKLNYFLEKNDFEKEMSKILDELNILRIKGRIWIPNKSLPLQIQIVGKKINTWFEEAPNNCWRPNDNAG
LELVIISFDEKSIQTFNKKIKEKFKILSDPKIAI
>Mature_354_residues
MKKKIPVIVVSGFLGSGKTTFLRYLLKESNKKFGLIINEFGDVGIDGDLIKSCDKCDESEDDCVIELNNGCLCCTVQDDF
VPSIKALLEFNPPIESIIIETSGLALPIPLIQALNWPEIRSSIYLDVVVGIVNGESMLNGSPINDLNKITKQYNETDKID
HNATIDELFEEQLEVSDIVLVSRSDILNDDQFDVVKNKIQGSLNSSTPVLKSKNGKIDLNYLFDFNFKKETYKEFLTEEH
DHNHVELVSDSFKLNYFLEKNDFEKEMSKILDELNILRIKGRIWIPNKSLPLQIQIVGKKINTWFEEAPNNCWRPNDNAG
LELVIISFDEKSIQTFNKKIKEKFKILSDPKIAI

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI148727351, Length=349, Percent_Identity=25.5014326647564, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI126722884, Length=348, Percent_Identity=26.1494252873563, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI146231952, Length=349, Percent_Identity=26.0744985673352, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI33469141, Length=352, Percent_Identity=25.5681818181818, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI223941779, Length=333, Percent_Identity=27.3273273273273, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI223941776, Length=346, Percent_Identity=25.1445086705202, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI119120938, Length=167, Percent_Identity=34.7305389221557, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI87082430, Length=337, Percent_Identity=25.8160237388724, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1788499, Length=239, Percent_Identity=26.3598326359833, Blast_Score=84, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324356, Length=232, Percent_Identity=29.3103448275862, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 40283; Mature: 40283

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKIPVIVVSGFLGSGKTTFLRYLLKESNKKFGLIINEFGDVGIDGDLIKSCDKCDESE
CCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCC
DDCVIELNNGCLCCTVQDDFVPSIKALLEFNPPIESIIIETSGLALPIPLIQALNWPEIR
CCEEEEECCCEEEEEECCCHHHHHHHHHHCCCCHHHEEEECCCCEECHHHHHHCCCHHHH
SSIYLDVVVGIVNGESMLNGSPINDLNKITKQYNETDKIDHNATIDELFEEQLEVSDIVL
HHEEEEEEEEEECCCHHCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHEEE
VSRSDILNDDQFDVVKNKIQGSLNSSTPVLKSKNGKIDLNYLFDFNFKKETYKEFLTEEH
EECCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCEEEEEEEEEECCCHHHHHHHHCCCC
DHNHVELVSDSFKLNYFLEKNDFEKEMSKILDELNILRIKGRIWIPNKSLPLQIQIVGKK
CCCEEEEEECCEEEEEEECCCCHHHHHHHHHHHCCEEEEECEEEECCCCCCEEEEEECCH
INTWFEEAPNNCWRPNDNAGLELVIISFDEKSIQTFNKKIKEKFKILSDPKIAI
HHHHHHHCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKKKIPVIVVSGFLGSGKTTFLRYLLKESNKKFGLIINEFGDVGIDGDLIKSCDKCDESE
CCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCC
DDCVIELNNGCLCCTVQDDFVPSIKALLEFNPPIESIIIETSGLALPIPLIQALNWPEIR
CCEEEEECCCEEEEEECCCHHHHHHHHHHCCCCHHHEEEECCCCEECHHHHHHCCCHHHH
SSIYLDVVVGIVNGESMLNGSPINDLNKITKQYNETDKIDHNATIDELFEEQLEVSDIVL
HHEEEEEEEEEECCCHHCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCHHHEEE
VSRSDILNDDQFDVVKNKIQGSLNSSTPVLKSKNGKIDLNYLFDFNFKKETYKEFLTEEH
EECCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCEEEEEEEEEECCCHHHHHHHHCCCC
DHNHVELVSDSFKLNYFLEKNDFEKEMSKILDELNILRIKGRIWIPNKSLPLQIQIVGKK
CCCEEEEEECCEEEEEEECCCCHHHHHHHHHHHCCEEEEECEEEECCCCCCEEEEEECCH
INTWFEEAPNNCWRPNDNAGLELVIISFDEKSIQTFNKKIKEKFKILSDPKIAI
HHHHHHHCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1655697 [H]