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The map label for this gene is hemA

Identifier: 126696166

GI number: 126696166

Start: 718682

End: 719992

Strand: Direct

Name: hemA

Synonym: P9301_08281

Alternate gene names: 126696166

Gene position: 718682-719992 (Clockwise)

Preceding gene: 126696165

Following gene: 126696167

Centisome position: 43.77

GC content: 33.41

Gene sequence:

>1311_bases
ATGCATATTGTTGTCGTCGGACTGAGTCATCGCACGGCACCTGTCGAAGTGCGTGAGAAGTTAAGTATTCCTGACCAATC
CATAACAGAGTCATTGAAAGCATTAAAAGCTTTCTCTGATGTATTAGAGGTATCAATTTTAAGTACTTGTAATAGGCTGG
AAATATATGCGCTAGTAAAGGATAAAAATACTGGAATTTCATCTATTAAAGAATTCATATCAGAATATTCTGGAATTATT
TTTGACGATTTAAATCCACATCTTTTTTGCTTTAGACAGGAAGAAGCAGTTTTGCATTTGATGAAAGTTTCGGCAGGACT
TGATAGCCTCGTTTTGGGTGAAGGACAAATCCTTTCGCAGGTAAAAAAAATGATGAGATTAGGTCAAGAGAATCAATCTA
CTGGACCAATACTTAATAGATTATTAACTCAATCAGTTAGTACAGGTAAAAAAGTAAGATCCGAAACAAATTTAGGAACT
GGAGCCGTGTCAATCAGTTCGGCAGCGGTAGAACTAGCACAATTAAAAATTGGACAAGAAAAAGGTTTCGATAATCTTGT
AAGTTTGGAATCAGAAAATGTTCTTGTAGTTGGCGCTGGAAGAATGAGTAGGCTTTTAATAACTCATTTAAAATCAAAAG
GATGTCATAAACTTATCCTTTTAAATAGAAATATTGATAGAGCTTTAAATCTTGCTCAAGACTTCCCTGATTTAGAGATT
GTTTGTAAAGGTTTAAACGAATTAGAAGAAAACATATCATTATCTTCGCTTGTTTTCACCAGTACTGCTTCTGAAGAGCC
AATTATTGATCTCACAAAAATTGAAAAAATAAATTTGAGTAATAGACTTAAATTTATTGATATTGGTGTGCCGAGAAATA
TATCTAATGATGTCAAACAACATGAATTTGTAAAATCATTTGATGTTGATGACTTACAAGAGGTCGTTTCAAGAAATCAA
GAATTTAGACAGAAAATAGCAAAGGAAGCGGAATCTTTAGTAGAAGAAGAAAGGATCATTTTTCTAGAATGGTGGGCAAG
TTTAGAGGCCGTTCCAGTAATTAATAAACTTAGATCAGATTTGGAGTTAATTAGAAAGGAGGAATTACAAAAAGCACTAA
GTAGAATGGGACCAGATTTTTCGGCTCGAGAAAGAAAAGTTGTGGAAGCTCTGACTAAAGGAATAATTAATAAAATACTT
CATACGCCGGTCACCAAGTTGAGAAGTCCTCAATCAAGAGAAGAAAGACAAGTTTCTTTGAAAATCGTTGAAAAATTGTT
TTCTTTGGTAGAAGAGGATAAAAATAACTAA

Upstream 100 bases:

>100_bases
AGTTATTAGTACGTTAGATAGTACTGCAAGGTTCACAAATACTGTCCATATAAAAGATGGTGCTAAGAGTATCAGCCTTT
AAAAATTCACTTTTAATTTT

Downstream 100 bases:

>100_bases
CTTTTTTCTATTTATATTAAGTTTTTCCAGTGATTTATCGAAATACCTTTGTAAACTGACCATTTGTATTTCTAAATATG
CCCATAATCAGTTACTTTAG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MHIVVVGLSHRTAPVEVREKLSIPDQSITESLKALKAFSDVLEVSILSTCNRLEIYALVKDKNTGISSIKEFISEYSGII
FDDLNPHLFCFRQEEAVLHLMKVSAGLDSLVLGEGQILSQVKKMMRLGQENQSTGPILNRLLTQSVSTGKKVRSETNLGT
GAVSISSAAVELAQLKIGQEKGFDNLVSLESENVLVVGAGRMSRLLITHLKSKGCHKLILLNRNIDRALNLAQDFPDLEI
VCKGLNELEENISLSSLVFTSTASEEPIIDLTKIEKINLSNRLKFIDIGVPRNISNDVKQHEFVKSFDVDDLQEVVSRNQ
EFRQKIAKEAESLVEEERIIFLEWWASLEAVPVINKLRSDLELIRKEELQKALSRMGPDFSARERKVVEALTKGIINKIL
HTPVTKLRSPQSREERQVSLKIVEKLFSLVEEDKNN

Sequences:

>Translated_436_residues
MHIVVVGLSHRTAPVEVREKLSIPDQSITESLKALKAFSDVLEVSILSTCNRLEIYALVKDKNTGISSIKEFISEYSGII
FDDLNPHLFCFRQEEAVLHLMKVSAGLDSLVLGEGQILSQVKKMMRLGQENQSTGPILNRLLTQSVSTGKKVRSETNLGT
GAVSISSAAVELAQLKIGQEKGFDNLVSLESENVLVVGAGRMSRLLITHLKSKGCHKLILLNRNIDRALNLAQDFPDLEI
VCKGLNELEENISLSSLVFTSTASEEPIIDLTKIEKINLSNRLKFIDIGVPRNISNDVKQHEFVKSFDVDDLQEVVSRNQ
EFRQKIAKEAESLVEEERIIFLEWWASLEAVPVINKLRSDLELIRKEELQKALSRMGPDFSARERKVVEALTKGIINKIL
HTPVTKLRSPQSREERQVSLKIVEKLFSLVEEDKNN
>Mature_436_residues
MHIVVVGLSHRTAPVEVREKLSIPDQSITESLKALKAFSDVLEVSILSTCNRLEIYALVKDKNTGISSIKEFISEYSGII
FDDLNPHLFCFRQEEAVLHLMKVSAGLDSLVLGEGQILSQVKKMMRLGQENQSTGPILNRLLTQSVSTGKKVRSETNLGT
GAVSISSAAVELAQLKIGQEKGFDNLVSLESENVLVVGAGRMSRLLITHLKSKGCHKLILLNRNIDRALNLAQDFPDLEI
VCKGLNELEENISLSSLVFTSTASEEPIIDLTKIEKINLSNRLKFIDIGVPRNISNDVKQHEFVKSFDVDDLQEVVSRNQ
EFRQKIAKEAESLVEEERIIFLEWWASLEAVPVINKLRSDLELIRKEELQKALSRMGPDFSARERKVVEALTKGIINKIL
HTPVTKLRSPQSREERQVSLKIVEKLFSLVEEDKNN

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=413, Percent_Identity=34.1404358353511, Blast_Score=205, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_PROM0 (A3PCH6)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001091052.1
- ProteinModelPortal:   A3PCH6
- STRING:   A3PCH6
- GeneID:   4911484
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_08281
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- BioCyc:   PMAR167546:P9301ORF_0843-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 48898; Mature: 48898

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIVVVGLSHRTAPVEVREKLSIPDQSITESLKALKAFSDVLEVSILSTCNRLEIYALVK
CEEEEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
DKNTGISSIKEFISEYSGIIFDDLNPHLFCFRQEEAVLHLMKVSAGLDSLVLGEGQILSQ
CCCCCHHHHHHHHHHHCCEEEECCCCCEEEEEHHHHHHHHHHHHCCCCHHEECCCHHHHH
VKKMMRLGQENQSTGPILNRLLTQSVSTGKKVRSETNLGTGAVSISSAAVELAQLKIGQE
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCHH
KGFDNLVSLESENVLVVGAGRMSRLLITHLKSKGCHKLILLNRNIDRALNLAQDFPDLEI
CCCCHHHEECCCCEEEEECCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCHHH
VCKGLNELEENISLSSLVFTSTASEEPIIDLTKIEKINLSNRLKFIDIGVPRNISNDVKQ
HHHHHHHHHHCCCHHHEEEECCCCCCCCEEHHHHHEECCCCCEEEEEECCCCCCHHHHHH
HEFVKSFDVDDLQEVVSRNQEFRQKIAKEAESLVEEERIIFLEWWASLEAVPVINKLRSD
HHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEEHHCCCHHHHHHHHHHH
LELIRKEELQKALSRMGPDFSARERKVVEALTKGIINKILHTPVTKLRSPQSREERQVSL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHH
KIVEKLFSLVEEDKNN
HHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHIVVVGLSHRTAPVEVREKLSIPDQSITESLKALKAFSDVLEVSILSTCNRLEIYALVK
CEEEEEECCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
DKNTGISSIKEFISEYSGIIFDDLNPHLFCFRQEEAVLHLMKVSAGLDSLVLGEGQILSQ
CCCCCHHHHHHHHHHHCCEEEECCCCCEEEEEHHHHHHHHHHHHCCCCHHEECCCHHHHH
VKKMMRLGQENQSTGPILNRLLTQSVSTGKKVRSETNLGTGAVSISSAAVELAQLKIGQE
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHCHH
KGFDNLVSLESENVLVVGAGRMSRLLITHLKSKGCHKLILLNRNIDRALNLAQDFPDLEI
CCCCHHHEECCCCEEEEECCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCHHH
VCKGLNELEENISLSSLVFTSTASEEPIIDLTKIEKINLSNRLKFIDIGVPRNISNDVKQ
HHHHHHHHHHCCCHHHEEEECCCCCCCCEEHHHHHEECCCCCEEEEEECCCCCCHHHHHH
HEFVKSFDVDDLQEVVSRNQEFRQKIAKEAESLVEEERIIFLEWWASLEAVPVINKLRSD
HHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCEEEEEEHHCCCHHHHHHHHHHH
LELIRKEELQKALSRMGPDFSARERKVVEALTKGIINKILHTPVTKLRSPQSREERQVSL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHH
KIVEKLFSLVEEDKNN
HHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA