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The map label for this gene is purK [H]

Identifier: 126696074

GI number: 126696074

Start: 656308

End: 657498

Strand: Direct

Name: purK [H]

Synonym: P9301_07361

Alternate gene names: 126696074

Gene position: 656308-657498 (Clockwise)

Preceding gene: 126696072

Following gene: 126696075

Centisome position: 39.97

GC content: 30.81

Gene sequence:

>1191_bases
ATGAGTTTAAAAAAAAATATAAACGATTTTAAGAAAAATTATTCCCTGGGAATAATTGGAGGTGGTCAATTGGCTTTGAT
GTTAACCGAGGCAGCAAAAAAAAGAGATCTTGAAGTATGTGTGCAAACAAAATCTTGTGATGATCCTGCTGGGTTAAAAG
CAGATCATGTCATAGAAGCTGATCCTTTAAAGATAAGAGGTAATAAATCATTAATTAATGAGTGTGAAAAAATAATTTTT
GAAAATGAATGGATAAAAATTGATAAATTAAATTTAATTGACAATAAAGATATTTTTGTTCCAAGCCTTAATGCAATTAA
GCCATTAGTAGATAGGTTTTCTCAAAAAAAATTAATAGAAAGAATGAATATTCCCTGCCCAAAATGGATAAGTATTGAAG
ATTTTAAAAATCTCTCGGATCAGGAAATCAATAATTGGACTTTTCCTCTAATGGCAAAATCAAATAAAGGTGGATATGAC
GGCAAAGGGAACAGAAAAATAAAGACAAAAGAAGATTTAGATTCTTTTTTAAAAGAGAACAATTCTAATGAATGGTTAAT
AGAAGAATGGATAGAGTATGAAAAAGAACTGGCTCTTGTTGGTTCGAGAGATAGGACCGGTAAGATAAGATTCTTTCCAA
TAGTTGAGACGTTCCAATCAAACCACGTTTGTGATTGGGTTCTTGCCCCTGGAACAAATGAATATGATTTGAACTTATTT
GCAATAAATATTTTCTCTTCAATAGTCAATGAACTTAATTACGTTGGAGTTTTAGCTATTGAATTCTTCTATGGAGATAA
TGGTCTTTTAATTAATGAAATAGCTCCTAGAACACATAACTCAGCTCATTTCTCTATTGAAGCTTGCACTTCAAGTCAGT
TTGATCAATATGTTTGCATTTCTTCTGGGATAATGCCACCTGAAATTAAAATGAACTGTGAAGGTGCAATTATGATAAAT
TTACTGGGTTTAAAAAAGAATTTCCCAATCTCAATGGAAACCAGAATTAAAATGTTATCTGAAATTGAGGGTTCTAATAT
TCATTGTTATGGCAAATCTCGCGAAATTCTGGGAAGAAAAATGGCTCACATCACATTTTTATTAAATGGTAAAACGCATT
TAGAAAGATATGATGAAGCTCAAATTTTATTAACTATGGTAAGAGACATTTGGCCATCTCCAAATGCATAA

Upstream 100 bases:

>100_bases
AAATATTTGGTATTAAATACTTTATATATTAGCAAAATCTAAGCTCTAGATCCTTAAAAATTCAGTTGTTAAGAATTAGA
AATGGTAATAAAATCATGCT

Downstream 100 bases:

>100_bases
AAAAATAAGTTAGAGTTAGATTACTGGATCTTTGGTTAAGTTCTTCTTTATGTGCTCTGATCTGACTCTCTTTCGACATG
AGGAGACTGTCGTGATGCGG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MSLKKNINDFKKNYSLGIIGGGQLALMLTEAAKKRDLEVCVQTKSCDDPAGLKADHVIEADPLKIRGNKSLINECEKIIF
ENEWIKIDKLNLIDNKDIFVPSLNAIKPLVDRFSQKKLIERMNIPCPKWISIEDFKNLSDQEINNWTFPLMAKSNKGGYD
GKGNRKIKTKEDLDSFLKENNSNEWLIEEWIEYEKELALVGSRDRTGKIRFFPIVETFQSNHVCDWVLAPGTNEYDLNLF
AINIFSSIVNELNYVGVLAIEFFYGDNGLLINEIAPRTHNSAHFSIEACTSSQFDQYVCISSGIMPPEIKMNCEGAIMIN
LLGLKKNFPISMETRIKMLSEIEGSNIHCYGKSREILGRKMAHITFLLNGKTHLERYDEAQILLTMVRDIWPSPNA

Sequences:

>Translated_396_residues
MSLKKNINDFKKNYSLGIIGGGQLALMLTEAAKKRDLEVCVQTKSCDDPAGLKADHVIEADPLKIRGNKSLINECEKIIF
ENEWIKIDKLNLIDNKDIFVPSLNAIKPLVDRFSQKKLIERMNIPCPKWISIEDFKNLSDQEINNWTFPLMAKSNKGGYD
GKGNRKIKTKEDLDSFLKENNSNEWLIEEWIEYEKELALVGSRDRTGKIRFFPIVETFQSNHVCDWVLAPGTNEYDLNLF
AINIFSSIVNELNYVGVLAIEFFYGDNGLLINEIAPRTHNSAHFSIEACTSSQFDQYVCISSGIMPPEIKMNCEGAIMIN
LLGLKKNFPISMETRIKMLSEIEGSNIHCYGKSREILGRKMAHITFLLNGKTHLERYDEAQILLTMVRDIWPSPNA
>Mature_395_residues
SLKKNINDFKKNYSLGIIGGGQLALMLTEAAKKRDLEVCVQTKSCDDPAGLKADHVIEADPLKIRGNKSLINECEKIIFE
NEWIKIDKLNLIDNKDIFVPSLNAIKPLVDRFSQKKLIERMNIPCPKWISIEDFKNLSDQEINNWTFPLMAKSNKGGYDG
KGNRKIKTKEDLDSFLKENNSNEWLIEEWIEYEKELALVGSRDRTGKIRFFPIVETFQSNHVCDWVLAPGTNEYDLNLFA
INIFSSIVNELNYVGVLAIEFFYGDNGLLINEIAPRTHNSAHFSIEACTSSQFDQYVCISSGIMPPEIKMNCEGAIMINL
LGLKKNFPISMETRIKMLSEIEGSNIHCYGKSREILGRKMAHITFLLNGKTHLERYDEAQILLTMVRDIWPSPNA

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=377, Percent_Identity=26.2599469496021, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324702, Length=377, Percent_Identity=30.5039787798408, Blast_Score=153, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 45150; Mature: 45018

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKKNINDFKKNYSLGIIGGGQLALMLTEAAKKRDLEVCVQTKSCDDPAGLKADHVIEA
CCCCCCHHHHHHCCCEEEEECCEEEEEEEHHHHCCCEEEEEEECCCCCCCCCCCCCEECC
DPLKIRGNKSLINECEKIIFENEWIKIDKLNLIDNKDIFVPSLNAIKPLVDRFSQKKLIE
CCEEEECCHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHH
RMNIPCPKWISIEDFKNLSDQEINNWTFPLMAKSNKGGYDGKGNRKIKTKEDLDSFLKEN
HHCCCCCCCEEHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHC
NSNEWLIEEWIEYEKELALVGSRDRTGKIRFFPIVETFQSNHVCDWVLAPGTNEYDLNLF
CCCCCHHHHHHHHHHHEEEECCCCCCCCEEEEEEHHHHCCCCEEEEEECCCCCCEEEEEE
AINIFSSIVNELNYVGVLAIEFFYGDNGLLINEIAPRTHNSAHFSIEACTSSQFDQYVCI
EHHHHHHHHHHHCCEEEEEEEEEECCCCEEEECCCCCCCCCCEEEEEECCCCCCCCEEEE
SSGIMPPEIKMNCEGAIMINLLGLKKNFPISMETRIKMLSEIEGSNIHCYGKSREILGRK
CCCCCCCCEEECCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHE
MAHITFLLNGKTHLERYDEAQILLTMVRDIWPSPNA
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SLKKNINDFKKNYSLGIIGGGQLALMLTEAAKKRDLEVCVQTKSCDDPAGLKADHVIEA
CCCCCHHHHHHCCCEEEEECCEEEEEEEHHHHCCCEEEEEEECCCCCCCCCCCCCEECC
DPLKIRGNKSLINECEKIIFENEWIKIDKLNLIDNKDIFVPSLNAIKPLVDRFSQKKLIE
CCEEEECCHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHH
RMNIPCPKWISIEDFKNLSDQEINNWTFPLMAKSNKGGYDGKGNRKIKTKEDLDSFLKEN
HHCCCCCCCEEHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHC
NSNEWLIEEWIEYEKELALVGSRDRTGKIRFFPIVETFQSNHVCDWVLAPGTNEYDLNLF
CCCCCHHHHHHHHHHHEEEECCCCCCCCEEEEEEHHHHCCCCEEEEEECCCCCCEEEEEE
AINIFSSIVNELNYVGVLAIEFFYGDNGLLINEIAPRTHNSAHFSIEACTSSQFDQYVCI
EHHHHHHHHHHHCCEEEEEEEEEECCCCEEEECCCCCCCCCCEEEEEECCCCCCCCEEEE
SSGIMPPEIKMNCEGAIMINLLGLKKNFPISMETRIKMLSEIEGSNIHCYGKSREILGRK
CCCCCCCCEEECCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHE
MAHITFLLNGKTHLERYDEAQILLTMVRDIWPSPNA
EEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA