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The map label for this gene is hisG [H]

Identifier: 126695924

GI number: 126695924

Start: 511726

End: 512364

Strand: Direct

Name: hisG [H]

Synonym: P9301_05861

Alternate gene names: 126695924

Gene position: 511726-512364 (Clockwise)

Preceding gene: 126695920

Following gene: 126695925

Centisome position: 31.17

GC content: 33.65

Gene sequence:

>639_bases
ATGTTTACTATAGCTTTACCAAAAGGAGCTCTGTTAAAAGATTCAATTTCAACTTTTAAAAGAGCTGGGTTAGATTTCTC
TGATGCATTGGAGAAAAATAATAGATCATTAACTTTCGAATCAAATTGCAAACGGGCTAAAGCTTTATTGGTAAGGAATG
GAGATGTTCCTGTTTATGTAAGTTATGGCCAAGCTGATTTGGGTATTGTTGGGTATGACGTTTTACGAGAATCTGAATTA
AAAGTTGCAAAGTTATTAGATTTAGGATTTGGAGGCTGTCATATGTCGTTGGCAGTTAAGAAAAATAGCAATTATTTAAA
ACCAACTGATCTCCCAGCGAATTGTAAAGTAGCAAGTAAATTTATAAAGACAGCAAGATTTTATTTTGAAGAATTAAATA
TTCCTGTAGAAATTGTTCATTTGACAGGATCCGTGGAGCTTGGTCCTATTACAGGTATGGCAGAGGCAATAGTTGATTTG
GTGGCAACCGGAAAGACTCTTAAAGAGAATGGTTTAATTAAAATAGATGATCTTTTCTACTCGACTGCGAGACTAATAGG
AAACCCTTTATCTATGAGGTTAGATGATAATCATCTCAGAGATACGATTTTATCAATAGAATCTACTAACGATACATAA

Upstream 100 bases:

>100_bases
AATAACATTATCATTTAAAACTCTTAGTCCGATTATATTTTGAGCTTTATTAAATTCCATTGTTAACTTAGAATGAAGAA
TCCTTGGAAGAAATTGATCT

Downstream 100 bases:

>100_bases
AAAAAGCTTAATGTTTAGTGATTTTAGAAGGATTAAAAAGTTAGGTAAATATTTAACTAAAGATAAAAAAACAATCTATC
TAATCTTGATAGTATTGTTA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MFTIALPKGALLKDSISTFKRAGLDFSDALEKNNRSLTFESNCKRAKALLVRNGDVPVYVSYGQADLGIVGYDVLRESEL
KVAKLLDLGFGGCHMSLAVKKNSNYLKPTDLPANCKVASKFIKTARFYFEELNIPVEIVHLTGSVELGPITGMAEAIVDL
VATGKTLKENGLIKIDDLFYSTARLIGNPLSMRLDDNHLRDTILSIESTNDT

Sequences:

>Translated_212_residues
MFTIALPKGALLKDSISTFKRAGLDFSDALEKNNRSLTFESNCKRAKALLVRNGDVPVYVSYGQADLGIVGYDVLRESEL
KVAKLLDLGFGGCHMSLAVKKNSNYLKPTDLPANCKVASKFIKTARFYFEELNIPVEIVHLTGSVELGPITGMAEAIVDL
VATGKTLKENGLIKIDDLFYSTARLIGNPLSMRLDDNHLRDTILSIESTNDT
>Mature_212_residues
MFTIALPKGALLKDSISTFKRAGLDFSDALEKNNRSLTFESNCKRAKALLVRNGDVPVYVSYGQADLGIVGYDVLRESEL
KVAKLLDLGFGGCHMSLAVKKNSNYLKPTDLPANCKVASKFIKTARFYFEELNIPVEIVHLTGSVELGPITGMAEAIVDL
VATGKTLKENGLIKIDDLFYSTARLIGNPLSMRLDDNHLRDTILSIESTNDT

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=214, Percent_Identity=32.2429906542056, Blast_Score=88, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=196, Percent_Identity=34.1836734693878, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23230; Mature: 23230

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTIALPKGALLKDSISTFKRAGLDFSDALEKNNRSLTFESNCKRAKALLVRNGDVPVYV
CEEEECCCCCHHHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCCEEEEEEECCCEEEEE
SYGQADLGIVGYDVLRESELKVAKLLDLGFGGCHMSLAVKKNSNYLKPTDLPANCKVASK
ECCCCCCCEEEHHHHCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHH
FIKTARFYFEELNIPVEIVHLTGSVELGPITGMAEAIVDLVATGKTLKENGLIKIDDLFY
HHHHHHHHHHHCCCCEEEEEEECCEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEHHHHH
STARLIGNPLSMRLDDNHLRDTILSIESTNDT
HHHHHHCCCEEEEECCHHHHHHEEEEECCCCC
>Mature Secondary Structure
MFTIALPKGALLKDSISTFKRAGLDFSDALEKNNRSLTFESNCKRAKALLVRNGDVPVYV
CEEEECCCCCHHHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCCEEEEEEECCCEEEEE
SYGQADLGIVGYDVLRESELKVAKLLDLGFGGCHMSLAVKKNSNYLKPTDLPANCKVASK
ECCCCCCCEEEHHHHCCCCHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHH
FIKTARFYFEELNIPVEIVHLTGSVELGPITGMAEAIVDLVATGKTLKENGLIKIDDLFY
HHHHHHHHHHHCCCCEEEEEEECCEEECCCCHHHHHHHHHHHCCCCCCCCCCEEEHHHHH
STARLIGNPLSMRLDDNHLRDTILSIESTNDT
HHHHHHCCCEEEEECCHHHHHHEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA