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The map label for this gene is cry2 [H]

Identifier: 126695730

GI number: 126695730

Start: 347540

End: 349036

Strand: Reverse

Name: cry2 [H]

Synonym: P9301_03921

Alternate gene names: 126695730

Gene position: 349036-347540 (Counterclockwise)

Preceding gene: 126695733

Following gene: 126695729

Centisome position: 21.26

GC content: 28.46

Gene sequence:

>1497_bases
ATGAAAGGAATAAATATCTTATGGTTTAAGAAAGATTTAAGAATTTTTGATAACGAAGCTCTCTGTGAGGCTATAAAAGA
TAATGATATTTTACCTATTTATATTATTGAGTTAGATATTTGGAACCAAAATACTCATTCAGATAGACAATGGCAATTTT
GCAAAGAAAGTTTAATAGATTTAAGAAATGCACTTGCTGAGATTGGACAACCATTAATTATTAGGACTGGGAATGTTATT
AATATATTTGATGAAATTAGTTCAAAATTTAAGATCAAAGGTTTATATAGCCATCAAGAAACCGGAGATTGGCTTACTTA
TAAAAGAGATCAAAAAGTAAGGGAATGGGCTTTAAGTAAAAATATTATTTGGAAGGAATTTCTACAATTTTCAGTTTTCA
GAGGAAATTTAGATAGGAATAATTGGTCTAAAAAGTGGCAAAAAAATTCTGAAAAAAACTTACTTAAAGCACCATTAAGA
ATTAATTCTATTAACTTAAATATTGGAGAAATACCCTCAGACAAAATTTTTTCCTTTAAAAAAGAAACTTGTCCAGGAAG
AATGCAAGGTGGAAGAAAGAAAGGTTTAGAGAGAATGCAATACTTCTTTAGTAATAAATTAGATTCTTATTCAAAAGATA
TATCTAGCCCAGAAAAATCATTTGATAGTTGTACAAGACTATCCCCATATATTTGTTGGGGATGCATTTCATTAAAAGAA
ATTTTTAAAAGGGCAAATATATCAAAAAACAATAATTCTAGGATGTTAAAAAGCAGATTAACTTGGCATTGTCATTTTAT
TCAGAAACTTGAAAGTGAACCAGAACTAGAGTTTAGGGAATACCATCCTTTTTTTAAAAATATTAGAGAAAAAAATAATG
AATTACTTTATTCATGGAGTTCAGGTAATACGGGCTTTCCTTTTATAGATGCATGTATGCGTTCATTAAATTTCAATGGA
TGGATTAACTTCAGGATGCGAGCGATGTTAATGTCTTTTGCTAGCTATAATTTATGGCTACCATGGCAAGATTCAGGTTC
TGAATTAGCAAATAAATTTGTAGATTATGAGCCTGGAATACATTGGAACCAATGCCAAATGCAATCTGGAACTACGTCTA
TAAATACGAATAGAATTTATAATCCTATTAAGCAGGGAAAAGATCATGATCCTCAAGGTAAATTTATAAAAAAATGGATA
CCAGAATTAAAAGATATATCACTTAATTTCATTCATGAACCATGGCTACTATCTATATTTAATCAAGAAGAATATGAAAA
AATTAATTACATAAGACCAATAATTGACATCCCAATTAGCACTAGAACTGCAAAGAAGAAAATTCAGGAAATCACTAAAA
AGGATGGATATTGGGATATCTCAAAAGAAATTTATTTAAAGCATGGCTCAAGAAAAAGGCCTAGAAAAAACATAAATAAT
AAAAAAAATGTTTCTAAGGAAAAGGAAAAACAATACGAACTGAAATTAGATTTCTAA

Upstream 100 bases:

>100_bases
TTTGTTATTTTCATTTTTTTGATTTTTAGTTATTCTAAAATTTTTTATATTTTTTACCTACAAACTTAATCTTATTTTTC
TAGGATTAAAAGAAAAAATT

Downstream 100 bases:

>100_bases
ATTTTATTGTCAGAAATTTCCAGTTTCCTTTTATCGCCTAGGAAAGTTTTTTAAATTTTGAAATTAAATAAATAATTCCA
CGATGAACTAATGCAAGCTT

Product: putative deoxyribodipyrimidine photolyase

Products: 2 pyrimidine residues (in DNA) [C]

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MKGINILWFKKDLRIFDNEALCEAIKDNDILPIYIIELDIWNQNTHSDRQWQFCKESLIDLRNALAEIGQPLIIRTGNVI
NIFDEISSKFKIKGLYSHQETGDWLTYKRDQKVREWALSKNIIWKEFLQFSVFRGNLDRNNWSKKWQKNSEKNLLKAPLR
INSINLNIGEIPSDKIFSFKKETCPGRMQGGRKKGLERMQYFFSNKLDSYSKDISSPEKSFDSCTRLSPYICWGCISLKE
IFKRANISKNNNSRMLKSRLTWHCHFIQKLESEPELEFREYHPFFKNIREKNNELLYSWSSGNTGFPFIDACMRSLNFNG
WINFRMRAMLMSFASYNLWLPWQDSGSELANKFVDYEPGIHWNQCQMQSGTTSINTNRIYNPIKQGKDHDPQGKFIKKWI
PELKDISLNFIHEPWLLSIFNQEEYEKINYIRPIIDIPISTRTAKKKIQEITKKDGYWDISKEIYLKHGSRKRPRKNINN
KKNVSKEKEKQYELKLDF

Sequences:

>Translated_498_residues
MKGINILWFKKDLRIFDNEALCEAIKDNDILPIYIIELDIWNQNTHSDRQWQFCKESLIDLRNALAEIGQPLIIRTGNVI
NIFDEISSKFKIKGLYSHQETGDWLTYKRDQKVREWALSKNIIWKEFLQFSVFRGNLDRNNWSKKWQKNSEKNLLKAPLR
INSINLNIGEIPSDKIFSFKKETCPGRMQGGRKKGLERMQYFFSNKLDSYSKDISSPEKSFDSCTRLSPYICWGCISLKE
IFKRANISKNNNSRMLKSRLTWHCHFIQKLESEPELEFREYHPFFKNIREKNNELLYSWSSGNTGFPFIDACMRSLNFNG
WINFRMRAMLMSFASYNLWLPWQDSGSELANKFVDYEPGIHWNQCQMQSGTTSINTNRIYNPIKQGKDHDPQGKFIKKWI
PELKDISLNFIHEPWLLSIFNQEEYEKINYIRPIIDIPISTRTAKKKIQEITKKDGYWDISKEIYLKHGSRKRPRKNINN
KKNVSKEKEKQYELKLDF
>Mature_498_residues
MKGINILWFKKDLRIFDNEALCEAIKDNDILPIYIIELDIWNQNTHSDRQWQFCKESLIDLRNALAEIGQPLIIRTGNVI
NIFDEISSKFKIKGLYSHQETGDWLTYKRDQKVREWALSKNIIWKEFLQFSVFRGNLDRNNWSKKWQKNSEKNLLKAPLR
INSINLNIGEIPSDKIFSFKKETCPGRMQGGRKKGLERMQYFFSNKLDSYSKDISSPEKSFDSCTRLSPYICWGCISLKE
IFKRANISKNNNSRMLKSRLTWHCHFIQKLESEPELEFREYHPFFKNIREKNNELLYSWSSGNTGFPFIDACMRSLNFNG
WINFRMRAMLMSFASYNLWLPWQDSGSELANKFVDYEPGIHWNQCQMQSGTTSINTNRIYNPIKQGKDHDPQGKFIKKWI
PELKDISLNFIHEPWLLSIFNQEEYEKINYIRPIIDIPISTRTAKKKIQEITKKDGYWDISKEIYLKHGSRKRPRKNINN
KKNVSKEKEKQYELKLDF

Specific function: Has no photolyase activity [H]

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=490, Percent_Identity=24.0816326530612, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI4758072, Length=503, Percent_Identity=23.4592445328032, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI188536103, Length=299, Percent_Identity=25.4180602006689, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1786926, Length=465, Percent_Identity=23.2258064516129, Blast_Score=139, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6324962, Length=503, Percent_Identity=24.2544731610338, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17137248, Length=462, Percent_Identity=24.6753246753247, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24585455, Length=462, Percent_Identity=24.6753246753247, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24648152, Length=509, Percent_Identity=22.0039292730845, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: 4.1.99.3 [C]

Molecular weight: Translated: 59293; Mature: 59293

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGINILWFKKDLRIFDNEALCEAIKDNDILPIYIIELDIWNQNTHSDRQWQFCKESLID
CCCCEEEEEECCCHHCCCHHHHHHHCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHH
LRNALAEIGQPLIIRTGNVINIFDEISSKFKIKGLYSHQETGDWLTYKRDQKVREWALSK
HHHHHHHCCCCEEEECCCEEEHHHHHCCCEEEEEEECCCCCCCCEEECHHHHHHHHHHHC
NIIWKEFLQFSVFRGNLDRNNWSKKWQKNSEKNLLKAPLRINSINLNIGEIPSDKIFSFK
CHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHCCCEEEEEEEEECCCCCCHHHHCCH
KETCPGRMQGGRKKGLERMQYFFSNKLDSYSKDISSPEKSFDSCTRLSPYICWGCISLKE
HHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHH
IFKRANISKNNNSRMLKSRLTWHCHFIQKLESEPELEFREYHPFFKNIREKNNELLYSWS
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHCCCCEEEEEC
SGNTGFPFIDACMRSLNFNGWINFRMRAMLMSFASYNLWLPWQDSGSELANKFVDYEPGI
CCCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCC
HWNQCQMQSGTTSINTNRIYNPIKQGKDHDPQGKFIKKWIPELKDISLNFIHEPWLLSIF
CCCCEECCCCCCCCCCHHHHCHHHCCCCCCCCHHHHHHHCCHHHCCCCEEECCCHHHHHH
NQEEYEKINYIRPIIDIPISTRTAKKKIQEITKKDGYWDISKEIYLKHGSRKRPRKNINN
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEECCHHEEEECCCCCCCHHCCCC
KKNVSKEKEKQYELKLDF
CCCCCHHHHHCEEEEECC
>Mature Secondary Structure
MKGINILWFKKDLRIFDNEALCEAIKDNDILPIYIIELDIWNQNTHSDRQWQFCKESLID
CCCCEEEEEECCCHHCCCHHHHHHHCCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHH
LRNALAEIGQPLIIRTGNVINIFDEISSKFKIKGLYSHQETGDWLTYKRDQKVREWALSK
HHHHHHHCCCCEEEECCCEEEHHHHHCCCEEEEEEECCCCCCCCEEECHHHHHHHHHHHC
NIIWKEFLQFSVFRGNLDRNNWSKKWQKNSEKNLLKAPLRINSINLNIGEIPSDKIFSFK
CHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHCCCEEEEEEEEECCCCCCHHHHCCH
KETCPGRMQGGRKKGLERMQYFFSNKLDSYSKDISSPEKSFDSCTRLSPYICWGCISLKE
HHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHH
IFKRANISKNNNSRMLKSRLTWHCHFIQKLESEPELEFREYHPFFKNIREKNNELLYSWS
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHCCCCEEEEEC
SGNTGFPFIDACMRSLNFNGWINFRMRAMLMSFASYNLWLPWQDSGSELANKFVDYEPGI
CCCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCCC
HWNQCQMQSGTTSINTNRIYNPIKQGKDHDPQGKFIKKWIPELKDISLNFIHEPWLLSIF
CCCCEECCCCCCCCCCHHHHCHHHCCCCCCCCHHHHHHHCCHHHCCCCEEECCCHHHHHH
NQEEYEKINYIRPIIDIPISTRTAKKKIQEITKKDGYWDISKEIYLKHGSRKRPRKNINN
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEECCHHEEEECCCCCCCHHCCCC
KKNVSKEKEKQYELKLDF
CCCCCHHHHHCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: ATP; FADH2; Flavin; pterin [C]

Metal ions: NA

Kcat value (1/min): 2.4 [C]

Specific activity: NA

Km value (mM): NA

Substrates: cyclobutadipyrimidine (in DNA) [C]

Specific reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA) [C]

General reaction: C-C-bond cleavage [C]

Inhibitor: yeast DNA [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]