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The map label for this gene is mutM

Identifier: 126695693

GI number: 126695693

Start: 327717

End: 328595

Strand: Reverse

Name: mutM

Synonym: P9301_03551

Alternate gene names: 126695693

Gene position: 328595-327717 (Counterclockwise)

Preceding gene: 126695694

Following gene: 126695692

Centisome position: 20.01

GC content: 30.94

Gene sequence:

>879_bases
TTGCCTGAATTACCTGAAGTAGAAACTGTTCGCAGAGGTTTAGAGCAAAAACTTAATAATTTTATTATTAAAAAAGTAGA
AGTTTGTAGGGATTCAACTGTCGCATACCCATCAAACAAAGAAGAATTCATTAAAGGACTTAAGAACTCACTTATTTATA
AATGGGATAGAAGAGGAAAATATTTAATTGCTCAATTAAAAGAAGTTCAAAATGAGAATACTGAATTTCCTCTAGAAAAT
TCACAAAATAATGGATTTCTTGTAGTTCATCTAAGAATGACTGGATACTTCAAATTTATTGAAAACTCAACTCATCCTTG
TAAACATACAAGAATAAGATTTTTTGATAAAAATAATAATGAGCTTAGGTACGTTGACGTAAGAAGTTTTGGTCAAATGT
GGTGGATTAATAAAGACCTATCCATAAACAAAGTAATTAAAGGATTAGGTTCATTAGGACCAGAACCATTTTCTAAAGAC
TTTAATGCAAATTATCTTAAGGAAGCTATTTCAAAAAGAACAAAATCTATAAAAGCTATTTTATTAGATCAAACAATAGT
TGCAGGCATAGGTAATATTTATGCTGATGAAAGTTTATACTCTGCTGGCATCTCACCTTTTAGGGAAGCTCGCACAATAA
AGAAGAATGAATTAATCAAGCTCAAAAAATCAATTGTAATTGTATTAAAAAAAAGTATAGGTTCTGGCGGGACGACATTT
AGCGATTTTAGGGACTTGGAAGGAGAGAATGGGAATTTTGGTTTGCAGACAAATGTCTATCGGAGAACTGGAAGAGAATG
TCGTAAATGTGGAAATTTAATTGAGAGACAAAAAATTACTGGAAGAAGTACCCATTGGTGTCCTAATTGCCAAAAATAA

Upstream 100 bases:

>100_bases
GTCAGATTCGATAAAGTAAATTACGCTGGAATAAGCGGAACAGACGGTGGAGCAAATACAAATAATTTCGCTGAAAGTGA
ATTAGAGAAAGCTTAAATAA

Downstream 100 bases:

>100_bases
AAAAGGGCTTACTCAAGAAGAGTAAACCCTTTTAAATATTTTTACCTGGCATTGAGCTATTTTCTCAAGGGGCTACCCCC
TAAATATTTTCGCCGCTGAA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MPELPEVETVRRGLEQKLNNFIIKKVEVCRDSTVAYPSNKEEFIKGLKNSLIYKWDRRGKYLIAQLKEVQNENTEFPLEN
SQNNGFLVVHLRMTGYFKFIENSTHPCKHTRIRFFDKNNNELRYVDVRSFGQMWWINKDLSINKVIKGLGSLGPEPFSKD
FNANYLKEAISKRTKSIKAILLDQTIVAGIGNIYADESLYSAGISPFREARTIKKNELIKLKKSIVIVLKKSIGSGGTTF
SDFRDLEGENGNFGLQTNVYRRTGRECRKCGNLIERQKITGRSTHWCPNCQK

Sequences:

>Translated_292_residues
MPELPEVETVRRGLEQKLNNFIIKKVEVCRDSTVAYPSNKEEFIKGLKNSLIYKWDRRGKYLIAQLKEVQNENTEFPLEN
SQNNGFLVVHLRMTGYFKFIENSTHPCKHTRIRFFDKNNNELRYVDVRSFGQMWWINKDLSINKVIKGLGSLGPEPFSKD
FNANYLKEAISKRTKSIKAILLDQTIVAGIGNIYADESLYSAGISPFREARTIKKNELIKLKKSIVIVLKKSIGSGGTTF
SDFRDLEGENGNFGLQTNVYRRTGRECRKCGNLIERQKITGRSTHWCPNCQK
>Mature_291_residues
PELPEVETVRRGLEQKLNNFIIKKVEVCRDSTVAYPSNKEEFIKGLKNSLIYKWDRRGKYLIAQLKEVQNENTEFPLENS
QNNGFLVVHLRMTGYFKFIENSTHPCKHTRIRFFDKNNNELRYVDVRSFGQMWWINKDLSINKVIKGLGSLGPEPFSKDF
NANYLKEAISKRTKSIKAILLDQTIVAGIGNIYADESLYSAGISPFREARTIKKNELIKLKKSIVIVLKKSIGSGGTTFS
DFRDLEGENGNFGLQTNVYRRTGRECRKCGNLIERQKITGRSTHWCPNCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=292, Percent_Identity=38.6986301369863, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1786932, Length=300, Percent_Identity=21.6666666666667, Blast_Score=73, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_PROM0 (A3PB53)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001090579.1
- ProteinModelPortal:   A3PB53
- SMR:   A3PB53
- STRING:   A3PB53
- GeneID:   4912190
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_03551
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- ProtClustDB:   PRK13945
- BioCyc:   PMAR167546:P9301ORF_0364-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 33654; Mature: 33523

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 60-60 ACT_SITE 282-282 BINDING 109-109 BINDING 128-128 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRGLEQKLNNFIIKKVEVCRDSTVAYPSNKEEFIKGLKNSLIYKWDRRGK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEEECCCCH
YLIAQLKEVQNENTEFPLENSQNNGFLVVHLRMTGYFKFIENSTHPCKHTRIRFFDKNNN
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECHHHHHHCCCCCCCCCCEEEEEECCCC
ELRYVDVRSFGQMWWINKDLSINKVIKGLGSLGPEPFSKDFNANYLKEAISKRTKSIKAI
EEEEEEHHHCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLDQTIVAGIGNIYADESLYSAGISPFREARTIKKNELIKLKKSIVIVLKKSIGSGGTTF
HHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCH
SDFRDLEGENGNFGLQTNVYRRTGRECRKCGNLIERQKITGRSTHWCPNCQK
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVRRGLEQKLNNFIIKKVEVCRDSTVAYPSNKEEFIKGLKNSLIYKWDRRGK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHEEEECCCCH
YLIAQLKEVQNENTEFPLENSQNNGFLVVHLRMTGYFKFIENSTHPCKHTRIRFFDKNNN
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECHHHHHHCCCCCCCCCCEEEEEECCCC
ELRYVDVRSFGQMWWINKDLSINKVIKGLGSLGPEPFSKDFNANYLKEAISKRTKSIKAI
EEEEEEHHHCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLDQTIVAGIGNIYADESLYSAGISPFREARTIKKNELIKLKKSIVIVLKKSIGSGGTTF
HHHHHHHHHHHHHHHCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCH
SDFRDLEGENGNFGLQTNVYRRTGRECRKCGNLIERQKITGRSTHWCPNCQK
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA