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The map label for this gene is cobS [H]

Identifier: 126695631

GI number: 126695631

Start: 269558

End: 270070

Strand: Reverse

Name: cobS [H]

Synonym: P9301_02931

Alternate gene names: 126695631

Gene position: 270070-269558 (Counterclockwise)

Preceding gene: 126695634

Following gene: 126695629

Centisome position: 16.45

GC content: 27.68

Gene sequence:

>513_bases
ATGGATACTTTCGATGGTATTTTTGCGGGCAAAAAGAAACGTTTAAAAGCCATGAAAGATAGTAAAGTTGGCTCCTTTGG
CGTTCAAGCTTTAGTTTTCATAACTTTAATTCAAATTGCTTGCATTCTGAAAATTCAAACACAAATAATTTTTGTTTTAC
CTATATGCTTATTTTGGGGAAGATTTTCAAATTTATTTTTTATAGAAAAGTTTAAATATATGAGTTATAAGAAAAAATCT
ATAAGTCACAAAAAGTTTTGGAATGGATTTAAAAAAGAATCTTTGATCTCAATTATTTTTCTTTTAATTTTCATTTCATA
CCAATTAGTTTCAATTACATCCCAAGCACTATTAATTAAATTTTTCATTCTTATTTTGGTTGGTATTTTTCTAAGCTATT
CTATCCCAAATATACTGGGTAATAAAATTGGAGGCTTCAATGGAGATGCCTGCGGTGCAAGTGTTGTACTAGTTGAAACT
GCAATTTTGTTTATGCATTCAATTCTTTTATAG

Upstream 100 bases:

>100_bases
TGTTTTCTTTAAAACAAACTCTTGGTCAATTTATGGCTCTGTATTAATTTGTTTAGCTTCAGGATATTTAATTACTGGCG
GTCTTCACCTCGATGGTTTA

Downstream 100 bases:

>100_bases
GAAGTTCTAAATAGAAAATATTTTTCTTCTTGAGATTTTTTAATTCTTCAGTAACATCAACCGAGTTTTTTTCCAGCAAT
CTCAATTTTCCTCCAATTTG

Product: cobalamin-5-phosphate synthase

Products: GMP; adenosylcobalamin

Alternate protein names: NA

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MDTFDGIFAGKKKRLKAMKDSKVGSFGVQALVFITLIQIACILKIQTQIIFVLPICLFWGRFSNLFFIEKFKYMSYKKKS
ISHKKFWNGFKKESLISIIFLLIFISYQLVSITSQALLIKFFILILVGIFLSYSIPNILGNKIGGFNGDACGASVVLVET
AILFMHSILL

Sequences:

>Translated_170_residues
MDTFDGIFAGKKKRLKAMKDSKVGSFGVQALVFITLIQIACILKIQTQIIFVLPICLFWGRFSNLFFIEKFKYMSYKKKS
ISHKKFWNGFKKESLISIIFLLIFISYQLVSITSQALLIKFFILILVGIFLSYSIPNILGNKIGGFNGDACGASVVLVET
AILFMHSILL
>Mature_170_residues
MDTFDGIFAGKKKRLKAMKDSKVGSFGVQALVFITLIQIACILKIQTQIIFVLPICLFWGRFSNLFFIEKFKYMSYKKKS
ISHKKFWNGFKKESLISIIFLLIFISYQLVSITSQALLIKFFILILVGIFLSYSIPNILGNKIGGFNGDACGASVVLVET
AILFMHSILL

Specific function: Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) [H]

COG id: COG0368

COG function: function code H; Cobalamin-5-phosphate synthase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobS family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003805 [H]

Pfam domain/function: PF02654 CobS [H]

EC number: 2.7.8.26

Molecular weight: Translated: 19225; Mature: 19225

Theoretical pI: Translated: 10.51; Mature: 10.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTFDGIFAGKKKRLKAMKDSKVGSFGVQALVFITLIQIACILKIQTQIIFVLPICLFWG
CCCCHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFSNLFFIEKFKYMSYKKKSISHKKFWNGFKKESLISIIFLLIFISYQLVSITSQALLIK
HHCCHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFILILVGIFLSYSIPNILGNKIGGFNGDACGASVVLVETAILFMHSILL
HHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MDTFDGIFAGKKKRLKAMKDSKVGSFGVQALVFITLIQIACILKIQTQIIFVLPICLFWG
CCCCHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFSNLFFIEKFKYMSYKKKSISHKKFWNGFKKESLISIIFLLIFISYQLVSITSQALLIK
HHCCHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFILILVGIFLSYSIPNILGNKIGGFNGDACGASVVLVETAILFMHSILL
HHHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: adenosylcobinamide-GDP; alpha-ribazole

Specific reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12917486 [H]