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The map label for this gene is pth

Identifier: 126695611

GI number: 126695611

Start: 252220

End: 252816

Strand: Reverse

Name: pth

Synonym: P9301_02731

Alternate gene names: 126695611

Gene position: 252816-252220 (Counterclockwise)

Preceding gene: 126695612

Following gene: 126695610

Centisome position: 15.4

GC content: 28.81

Gene sequence:

>597_bases
ATGCATGAAATATATTTAATTGGACTTGGGAATCCTGGGAAAAAATATTACAACAGTAGACACAATATAGGTTTTTTGCT
GCTTGAAAAGCTCTCAAAAAAATATAATTCAAATTTTTTATTAAAAGATAAACTTAAAAGTTCCTGCTCAGAATTTCAAA
TCAATAACTACACCTTTAGGTTATTTTTACCAAATACGTTTATGAATAACAGTGGTTATGCTGTCCGAGCAATCGTTGAT
TGGTACAAAGTAAACTTAGATCAAATTTTTATAATAGTCGATGATAAAGATCTTCCCCTTGGAAAAATAAGATTTAGAAG
AAAAGGAAGCTCAGGTGGACATAACGGGCTTAAAAGCATCATTGAACAATTGCAGTCACAAAACTTTAAGAGAATAAGAA
TTGGTATTGGGTCACCTCCCCTAATAAAAGGAGAAAATAATTTCAATACTATTTCACATGTATTAGGAAATATTTCTCTA
GAAGAAAAATTAATATTGGATAAAGTGTTTAAGAGAGTAATAGAATCCCTCGAACATCTAAATACTAAAAAAGAAGATCA
TATAATTAATGAATTAAACTCTTTTAACCAAGACTAA

Upstream 100 bases:

>100_bases
AGTTATCGCTAAATAACTTTTTTTGAAATTTTGTTTTTTTAATTAGTTATAGTTTATATATATTTATAATTCTCAATTAA
GTGAGATTTAGATATACATC

Downstream 100 bases:

>100_bases
CCTTAAGTAATGCGTTCAAAACCTGAAACGATTGCCAATGTAAGTGTTAAGGAATATTCCTTCTCAAAAAAGCAAATTCA
GGGGGTTGTAAAAGCTAGTC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MHEIYLIGLGNPGKKYYNSRHNIGFLLLEKLSKKYNSNFLLKDKLKSSCSEFQINNYTFRLFLPNTFMNNSGYAVRAIVD
WYKVNLDQIFIIVDDKDLPLGKIRFRRKGSSGGHNGLKSIIEQLQSQNFKRIRIGIGSPPLIKGENNFNTISHVLGNISL
EEKLILDKVFKRVIESLEHLNTKKEDHIINELNSFNQD

Sequences:

>Translated_198_residues
MHEIYLIGLGNPGKKYYNSRHNIGFLLLEKLSKKYNSNFLLKDKLKSSCSEFQINNYTFRLFLPNTFMNNSGYAVRAIVD
WYKVNLDQIFIIVDDKDLPLGKIRFRRKGSSGGHNGLKSIIEQLQSQNFKRIRIGIGSPPLIKGENNFNTISHVLGNISL
EEKLILDKVFKRVIESLEHLNTKKEDHIINELNSFNQD
>Mature_198_residues
MHEIYLIGLGNPGKKYYNSRHNIGFLLLEKLSKKYNSNFLLKDKLKSSCSEFQINNYTFRLFLPNTFMNNSGYAVRAIVD
WYKVNLDQIFIIVDDKDLPLGKIRFRRKGSSGGHNGLKSIIEQLQSQNFKRIRIGIGSPPLIKGENNFNTISHVLGNISL
EEKLILDKVFKRVIESLEHLNTKKEDHIINELNSFNQD

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=184, Percent_Identity=26.6304347826087, Blast_Score=88, Evalue=6e-18,
Organism=Escherichia coli, GI1787455, Length=191, Percent_Identity=34.5549738219895, Blast_Score=102, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_PROM0 (A3PAX1)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001090497.1
- ProteinModelPortal:   A3PAX1
- SMR:   A3PAX1
- STRING:   A3PAX1
- GeneID:   4912770
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_02731
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   PMAR167546:P9301ORF_0277-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 22902; Mature: 22902

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHEIYLIGLGNPGKKYYNSRHNIGFLLLEKLSKKYNSNFLLKDKLKSSCSEFQINNYTFR
CCEEEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCEEHHHHHCCHHHEEECCEEEE
LFLPNTFMNNSGYAVRAIVDWYKVNLDQIFIIVDDKDLPLGKIRFRRKGSSGGHNGLKSI
EEECCCEECCCCCEEEEEHHHHHCCCEEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHH
IEQLQSQNFKRIRIGIGSPPLIKGENNFNTISHVLGNISLEEKLILDKVFKRVIESLEHL
HHHHHHCCCEEEEEECCCCCEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
NTKKEDHIINELNSFNQD
CCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MHEIYLIGLGNPGKKYYNSRHNIGFLLLEKLSKKYNSNFLLKDKLKSSCSEFQINNYTFR
CCEEEEEECCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCEEHHHHHCCHHHEEECCEEEE
LFLPNTFMNNSGYAVRAIVDWYKVNLDQIFIIVDDKDLPLGKIRFRRKGSSGGHNGLKSI
EEECCCEECCCCCEEEEEHHHHHCCCEEEEEEECCCCCCCCCEEEEECCCCCCHHHHHHH
IEQLQSQNFKRIRIGIGSPPLIKGENNFNTISHVLGNISLEEKLILDKVFKRVIESLEHL
HHHHHHCCCEEEEEECCCCCEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
NTKKEDHIINELNSFNQD
CCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA