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The map label for this gene is menA [H]

Identifier: 126695534

GI number: 126695534

Start: 180600

End: 181517

Strand: Reverse

Name: menA [H]

Synonym: P9301_01961

Alternate gene names: 126695534

Gene position: 181517-180600 (Counterclockwise)

Preceding gene: 126695536

Following gene: 126695533

Centisome position: 11.06

GC content: 28.98

Gene sequence:

>918_bases
ATGGACGAAGATAAAAAAAAATTATGGAAAAAAGCAATAAAATGGCCTCTTTATTCTGTGGCCATTCTTCCAGTTTTAAT
AACAGGGGCTTACTTGCTCAATCAATATGAAGAGGTAAAAATTTATAATTTGATTTCATTTACTTTAGCTGCAATTTTGA
TATTACTTTGGGAAAATCTAACTAATGATTTATACGACGCAGAAACAGGAATCGATGAATTTAAATTCCATTCAATTGTA
AATCTTGTAAAAAATAAAAATATAATTTCATTTATTGCATATACATCTTTAGTTATTGGTTTATTAATAATTTTAATTAT
TTCAGTATCAACAAGTATAAACATTTTTATTTTGGTGGCAGCTTGCTGCTTCTTAGGATACTTATATCAAGGTCCTCCTT
TTAGATTAGGCTATCAAGGTTTAGGAGAACCATTATGCTGGCTTGCATTTGGACCTTTTGCGTACTCTGCAGTCTTAATT
GCGTTAAATCCATCTAATATTTACTTTAAAGATATTCCATGGAAAGTTTCTTTATTACTTGGTTCAGGACCTTCCTTGGC
AACAACTCTTGTGTTATTTTGTTCTCATTTTCATCAAATTTCTGAAGATAAAAAGCATGGGAAAAATTCCCCTTTAGTTC
GCTTAGGGGCAAAAAAAGGTTCTCAATTTGTGCCTTGGATAATTTTTACAATATATATTTTTCAACTTTTCACAATAGTT
TATGGATTTATTCCAGTTTTTTGTATCCTTTATTTGCTTAGTTTCCCTCAAGCAAAAAGACTTATAAATTTATTAAAATC
TTCGTATGCAAAACCTTCTGCAATAAAAAATTGCAAATTCATCGCAATAAAGTTTCAAACGCTTAATGGAATTGGTTTAA
TCACAGGATTAATATTTAATTACTTGCTAAATAAATGA

Upstream 100 bases:

>100_bases
ACTTATTGAAAATAACTAAAAATGATGCAATAAAGTAAAAAATGTAACTCAATTTATAAACTACATCCAATAATTATCTA
ATTTTGCATGTTAATTAAAA

Downstream 100 bases:

>100_bases
ACTTAATATTTCAAAAAAAATCTTATAGCTTTAAGTTATCGGCCAAAGTAGAAAATTCTAAAACCAATTACCATACAAAA
TCGGGTTGGATAATTAAATT

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MDEDKKKLWKKAIKWPLYSVAILPVLITGAYLLNQYEEVKIYNLISFTLAAILILLWENLTNDLYDAETGIDEFKFHSIV
NLVKNKNIISFIAYTSLVIGLLIILIISVSTSINIFILVAACCFLGYLYQGPPFRLGYQGLGEPLCWLAFGPFAYSAVLI
ALNPSNIYFKDIPWKVSLLLGSGPSLATTLVLFCSHFHQISEDKKHGKNSPLVRLGAKKGSQFVPWIIFTIYIFQLFTIV
YGFIPVFCILYLLSFPQAKRLINLLKSSYAKPSAIKNCKFIAIKFQTLNGIGLITGLIFNYLLNK

Sequences:

>Translated_305_residues
MDEDKKKLWKKAIKWPLYSVAILPVLITGAYLLNQYEEVKIYNLISFTLAAILILLWENLTNDLYDAETGIDEFKFHSIV
NLVKNKNIISFIAYTSLVIGLLIILIISVSTSINIFILVAACCFLGYLYQGPPFRLGYQGLGEPLCWLAFGPFAYSAVLI
ALNPSNIYFKDIPWKVSLLLGSGPSLATTLVLFCSHFHQISEDKKHGKNSPLVRLGAKKGSQFVPWIIFTIYIFQLFTIV
YGFIPVFCILYLLSFPQAKRLINLLKSSYAKPSAIKNCKFIAIKFQTLNGIGLITGLIFNYLLNK
>Mature_305_residues
MDEDKKKLWKKAIKWPLYSVAILPVLITGAYLLNQYEEVKIYNLISFTLAAILILLWENLTNDLYDAETGIDEFKFHSIV
NLVKNKNIISFIAYTSLVIGLLIILIISVSTSINIFILVAACCFLGYLYQGPPFRLGYQGLGEPLCWLAFGPFAYSAVLI
ALNPSNIYFKDIPWKVSLLLGSGPSLATTLVLFCSHFHQISEDKKHGKNSPLVRLGAKKGSQFVPWIIFTIYIFQLFTIV
YGFIPVFCILYLLSFPQAKRLINLLKSSYAKPSAIKNCKFIAIKFQTLNGIGLITGLIFNYLLNK

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011937
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 34401; Mature: 34401

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEDKKKLWKKAIKWPLYSVAILPVLITGAYLLNQYEEVKIYNLISFTLAAILILLWENL
CCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNDLYDAETGIDEFKFHSIVNLVKNKNIISFIAYTSLVIGLLIILIISVSTSINIFILVA
HHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ACCFLGYLYQGPPFRLGYQGLGEPLCWLAFGPFAYSAVLIALNPSNIYFKDIPWKVSLLL
HHHHHHHHHCCCCCEECHHHCCCCHHHHHCCHHHHHEEEEEECCCCEEEEECCEEEEEEE
GSGPSLATTLVLFCSHFHQISEDKKHGKNSPLVRLGAKKGSQFVPWIIFTIYIFQLFTIV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
YGFIPVFCILYLLSFPQAKRLINLLKSSYAKPSAIKNCKFIAIKFQTLNGIGLITGLIFN
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHCCCEEEEEEEEECCCHHHHHHHHHH
YLLNK
HHHCC
>Mature Secondary Structure
MDEDKKKLWKKAIKWPLYSVAILPVLITGAYLLNQYEEVKIYNLISFTLAAILILLWENL
CCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNDLYDAETGIDEFKFHSIVNLVKNKNIISFIAYTSLVIGLLIILIISVSTSINIFILVA
HHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
ACCFLGYLYQGPPFRLGYQGLGEPLCWLAFGPFAYSAVLIALNPSNIYFKDIPWKVSLLL
HHHHHHHHHCCCCCEECHHHCCCCHHHHHCCHHHHHEEEEEECCCCEEEEECCEEEEEEE
GSGPSLATTLVLFCSHFHQISEDKKHGKNSPLVRLGAKKGSQFVPWIIFTIYIFQLFTIV
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
YGFIPVFCILYLLSFPQAKRLINLLKSSYAKPSAIKNCKFIAIKFQTLNGIGLITGLIFN
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHCCCEEEEEEEEECCCHHHHHHHHHH
YLLNK
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]