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The map label for this gene is purE [H]

Identifier: 126695525

GI number: 126695525

Start: 172569

End: 173060

Strand: Reverse

Name: purE [H]

Synonym: P9301_01871

Alternate gene names: 126695525

Gene position: 173060-172569 (Counterclockwise)

Preceding gene: 126695527

Following gene: 126695522

Centisome position: 10.54

GC content: 33.54

Gene sequence:

>492_bases
ATGGGTAGTGATTCAGATCTTAAAACATTGAAACCAGCTATCAATATTTTAAAAGAATTTGGAATAAAAACTGAAGTTTG
TATACTTTCTGCTCATCGAACTCCTATTGAAATGATGGAATATGCAAAAAATGCAGAATCAGAAAACATAAAAGTAATAA
TTGCCGGTGCTGGTGGTGCTGCTCATCTTCCAGGAATGCTGGCATCCATAACTTGTATTCCTATTATTGGAGTACCAGTA
GAAAGTAAGACACTTAAGGGGATTGATTCTCTTTTATCAATAGTTCAAATGCCCGCTGGGATTCCAGTTGCAACAGTTGC
AATTAATGGAGCTCAGAATGCTGGATTATTAGCAATAGAGATGATCAGTTTATTTGATGCATCCATAAAGAAAACTTTAA
AAGAATTCAGAGAAAATCTACATACACAGGTAAGAACTAAAAATAGTAAGTTATCAACTATTGGACCTGACAATTATCTT
CAAAATAAATGA

Upstream 100 bases:

>100_bases
CTAACTGGCGCCAAATTAATTGCACGCCATTATAGGAAAGAATTGATTTGTTATTTTGTCAAAATTTAATTCTAAAGATA
TTTATAAAATTGCTGTCGTG

Downstream 100 bases:

>100_bases
AGTAATTTTTTTTATTAGGCCTTTTTAAGAAAGTTTTCTTTTTTAAGGTAGTTAATAACTTTCTCAACGGAATCATTTAA
ATCTAACGAACCTGTATCAA

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MGSDSDLKTLKPAINILKEFGIKTEVCILSAHRTPIEMMEYAKNAESENIKVIIAGAGGAAHLPGMLASITCIPIIGVPV
ESKTLKGIDSLLSIVQMPAGIPVATVAINGAQNAGLLAIEMISLFDASIKKTLKEFRENLHTQVRTKNSKLSTIGPDNYL
QNK

Sequences:

>Translated_163_residues
MGSDSDLKTLKPAINILKEFGIKTEVCILSAHRTPIEMMEYAKNAESENIKVIIAGAGGAAHLPGMLASITCIPIIGVPV
ESKTLKGIDSLLSIVQMPAGIPVATVAINGAQNAGLLAIEMISLFDASIKKTLKEFRENLHTQVRTKNSKLSTIGPDNYL
QNK
>Mature_162_residues
GSDSDLKTLKPAINILKEFGIKTEVCILSAHRTPIEMMEYAKNAESENIKVIIAGAGGAAHLPGMLASITCIPIIGVPVE
SKTLKGIDSLLSIVQMPAGIPVATVAINGAQNAGLLAIEMISLFDASIKKTLKEFRENLHTQVRTKNSKLSTIGPDNYLQ
NK

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=106, Percent_Identity=53.7735849056604, Blast_Score=121, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6324702, Length=163, Percent_Identity=53.3742331288344, Blast_Score=176, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17382; Mature: 17250

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSDSDLKTLKPAINILKEFGIKTEVCILSAHRTPIEMMEYAKNAESENIKVIIAGAGGA
CCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCCCEEEEEEECCCH
AHLPGMLASITCIPIIGVPVESKTLKGIDSLLSIVQMPAGIPVATVAINGAQNAGLLAIE
HHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHH
MISLFDASIKKTLKEFRENLHTQVRTKNSKLSTIGPDNYLQNK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCC
>Mature Secondary Structure 
GSDSDLKTLKPAINILKEFGIKTEVCILSAHRTPIEMMEYAKNAESENIKVIIAGAGGA
CCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCCCEEEEEEECCCH
AHLPGMLASITCIPIIGVPVESKTLKGIDSLLSIVQMPAGIPVATVAINGAQNAGLLAIE
HHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHH
MISLFDASIKKTLKEFRENLHTQVRTKNSKLSTIGPDNYLQNK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]