Click here to switch to the map view.

The map label for this gene is cobD [H]

Identifier: 126700306

GI number: 126700306

Start: 3110738

End: 3111814

Strand: Direct

Name: cobD [H]

Synonym: CD2692

Alternate gene names: 126700306

Gene position: 3110738-3111814 (Clockwise)

Preceding gene: 126700301

Following gene: 126700314

Centisome position: 72.51

GC content: 26.93

Gene sequence:

>1077_bases
ATGAGCACAAATCATGGAGCTAATTTATATAGTTTATCTAGTAAGTATGGCTTTTCAAAGGAAGAATTTATGGACTTTAG
CTCAAATATAAATCCTTTTGGTACATCAAGTTTAGCCAAACAATACATTGTAAACAATATAGATATGGTATCTATGTATC
CTGACCCTGATTACATAGACTTAAAAACTTCTATATCCAATTACTGCAAGTGTTCTATAGATAATATAGTACTTGGCAGT
GGAGCTACAGAACTAATTTCATCATTTATACATACAATTAATCCTAAACAGGCTCTTTTACTCTCTCCAGCCTATTCAGA
GTATGAAAAAGAGTTATCTAAAATTAATTGTTCTATAGAAAAATACTTTGCAAAAGAAGAAGATAATTTTCATATAAATT
TAGAAAATCTTATAAAAACTATCAATGCTAAAGATTATGATTTGGTAGTAATCTGTAATCCTAGTAATCCAACTGGATTT
GCATTTACTAAAGTAGAAGTGAGAGAAATTTTAAAAAATACAGACTCATTTTTAATGATTGATGAGACTTATGTAGAGTT
TACTGATACAGATACATACTCTTGTACTCAATTAGTTGATGATTATTCTAATTTATTCGTTATAAGAGGTACATCAAAAT
TTTTTTCAACGCCTGGAATAAGGCTTGGATATGGTCTTATATCTAACACTAATGTCAAAAATGAAATAAATAAAAATCTA
GATTTATGGAATATAAACATAATCGCTTCTAAAATGGGTGAAATCATGTTTAGTGATTTAGATTTTATATCAAATACTAT
TTCCTTAATGAACACTGAAAGAGATTACCTGCTTAAAGAGCTTAAGAATATAAAAAGCTTAGATATATACAATACTAAAG
GTAATTTCATATTGTGTAAAATCAAGACAAAGGAATTGACTGCTAAATCTCTTCGAGAGCAACTGCTCCCACAAAAAATA
ATAATAAGAGATTGTTGTTCATTTAAAGGTCTAGATGAGTATTTCTTTAGAGTATGTATATTAAAACCTAATGAAAATAA
ATTATTAATATCATCTCTTAAATCAATTTTTAAATAA

Upstream 100 bases:

>100_bases
AAAATTTGGAATAACGATTCCTTTGTATTATAATCTATATGTACATATATTAATCAGTTATTTTTATCGATTATATAATT
TTATTTTTGGAGGTACTTTT

Downstream 100 bases:

>100_bases
AAAAATCACTTTATTTTATAATTTTTTATACCATAAAAAATGAGCTATCTCTATTTGAGATAACTCATTTTTGATTATTA
AAAAACTAGGCACTTTGCTC

Product: aminotransferase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSTNHGANLYSLSSKYGFSKEEFMDFSSNINPFGTSSLAKQYIVNNIDMVSMYPDPDYIDLKTSISNYCKCSIDNIVLGS
GATELISSFIHTINPKQALLLSPAYSEYEKELSKINCSIEKYFAKEEDNFHINLENLIKTINAKDYDLVVICNPSNPTGF
AFTKVEVREILKNTDSFLMIDETYVEFTDTDTYSCTQLVDDYSNLFVIRGTSKFFSTPGIRLGYGLISNTNVKNEINKNL
DLWNINIIASKMGEIMFSDLDFISNTISLMNTERDYLLKELKNIKSLDIYNTKGNFILCKIKTKELTAKSLREQLLPQKI
IIRDCCSFKGLDEYFFRVCILKPNENKLLISSLKSIFK

Sequences:

>Translated_358_residues
MSTNHGANLYSLSSKYGFSKEEFMDFSSNINPFGTSSLAKQYIVNNIDMVSMYPDPDYIDLKTSISNYCKCSIDNIVLGS
GATELISSFIHTINPKQALLLSPAYSEYEKELSKINCSIEKYFAKEEDNFHINLENLIKTINAKDYDLVVICNPSNPTGF
AFTKVEVREILKNTDSFLMIDETYVEFTDTDTYSCTQLVDDYSNLFVIRGTSKFFSTPGIRLGYGLISNTNVKNEINKNL
DLWNINIIASKMGEIMFSDLDFISNTISLMNTERDYLLKELKNIKSLDIYNTKGNFILCKIKTKELTAKSLREQLLPQKI
IIRDCCSFKGLDEYFFRVCILKPNENKLLISSLKSIFK
>Mature_357_residues
STNHGANLYSLSSKYGFSKEEFMDFSSNINPFGTSSLAKQYIVNNIDMVSMYPDPDYIDLKTSISNYCKCSIDNIVLGSG
ATELISSFIHTINPKQALLLSPAYSEYEKELSKINCSIEKYFAKEEDNFHINLENLIKTINAKDYDLVVICNPSNPTGFA
FTKVEVREILKNTDSFLMIDETYVEFTDTDTYSCTQLVDDYSNLFVIRGTSKFFSTPGIRLGYGLISNTNVKNEINKNLD
LWNINIIASKMGEIMFSDLDFISNTISLMNTERDYLLKELKNIKSLDIYNTKGNFILCKIKTKELTAKSLREQLLPQKII
IRDCCSFKGLDEYFFRVCILKPNENKLLISSLKSIFK

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=311, Percent_Identity=23.4726688102894, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322075, Length=308, Percent_Identity=26.6233766233766, Blast_Score=88, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 40864; Mature: 40733

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNHGANLYSLSSKYGFSKEEFMDFSSNINPFGTSSLAKQYIVNNIDMVSMYPDPDYID
CCCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCCCCEEE
LKTSISNYCKCSIDNIVLGSGATELISSFIHTINPKQALLLSPAYSEYEKELSKINCSIE
EHHHHHHHEEEEECCEEECCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCHHH
KYFAKEEDNFHINLENLIKTINAKDYDLVVICNPSNPTGFAFTKVEVREILKNTDSFLMI
HHHCCCCCCEEEEHHHHHHHCCCCCEEEEEEECCCCCCCEEEEHHHHHHHHCCCCCEEEE
DETYVEFTDTDTYSCTQLVDDYSNLFVIRGTSKFFSTPGIRLGYGLISNTNVKNEINKNL
EEEEEEEECCCCCHHHHHHHCCCCEEEEEECHHHHCCCCCEEEEEEECCCCCHHHHHCCC
DLWNINIIASKMGEIMFSDLDFISNTISLMNTERDYLLKELKNIKSLDIYNTKGNFILCK
EEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCEEEEE
IKTKELTAKSLREQLLPQKIIIRDCCSFKGLDEYFFRVCILKPNENKLLISSLKSIFK
EEHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHEEEEEEECCCCCCHHHHHHHHHHC
>Mature Secondary Structure 
STNHGANLYSLSSKYGFSKEEFMDFSSNINPFGTSSLAKQYIVNNIDMVSMYPDPDYID
CCCCCCCEEEECCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCCCCEEE
LKTSISNYCKCSIDNIVLGSGATELISSFIHTINPKQALLLSPAYSEYEKELSKINCSIE
EHHHHHHHEEEEECCEEECCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHCCHHH
KYFAKEEDNFHINLENLIKTINAKDYDLVVICNPSNPTGFAFTKVEVREILKNTDSFLMI
HHHCCCCCCEEEEHHHHHHHCCCCCEEEEEEECCCCCCCEEEEHHHHHHHHCCCCCEEEE
DETYVEFTDTDTYSCTQLVDDYSNLFVIRGTSKFFSTPGIRLGYGLISNTNVKNEINKNL
EEEEEEEECCCCCHHHHHHHCCCCEEEEEECHHHHCCCCCEEEEEEECCCCCHHHHHCCC
DLWNINIIASKMGEIMFSDLDFISNTISLMNTERDYLLKELKNIKSLDIYNTKGNFILCK
EEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCEEEEE
IKTKELTAKSLREQLLPQKIIIRDCCSFKGLDEYFFRVCILKPNENKLLISSLKSIFK
EEHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHEEEEEEECCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]