Click here to switch to the map view.

The map label for this gene is ldh [H]

Identifier: 126699780

GI number: 126699780

Start: 2503130

End: 2504098

Strand: Direct

Name: ldh [H]

Synonym: CD2164

Alternate gene names: 126699780

Gene position: 2503130-2504098 (Clockwise)

Preceding gene: 126699773

Following gene: 126699786

Centisome position: 58.34

GC content: 31.37

Gene sequence:

>969_bases
ATGGCAATAAAGCCAAGAAAAATATCTATTGTAGGTTCAGGGCATGTTGGTTCTCATTGTGGATTTAGTTTAATAACTCA
AGGAGTTTGTGATGAACTCTTTATGATTGATATAGATGAATCTAAATCAAAAGCTCAAGCTTTAGATTTAGCTGATGCAG
TTTCATATCTGCCACATAAAGTACATATAGAAAAAGGAACTTTTTCTGACTGTAAAGATTCTGACATAGTAGTGATAAGT
GTTGCAGACTCTTCAGAAGGGCCTTTACGTAGACAAAACACAACTAGATTAGATTTACTAAGACCAACTATTGGAATGAT
AAAATCTATAGTAAAACCCATAGTTGATTCTGGCTTTGATGGTATATTTGTAGTCATATCTAATCCTGTTGATGTAGTTA
CAAATTATATTTGGGAAAAATCTGGCTTTCCTAAAAACAAAGTCATTGGAACTGGAACAGCTTTAGATTCAACAAGACTT
AGAAGGATTTTATCTGAAGAAACTGGAATCGCTCAACAATCAATTCAAGCTTATTCTATGGGTGAACATGGAGATTCTCA
AATGGTTCCTTGGTCTCATGTTTCAATTGGTGGTAAACCAATCTTAGACATGATAAAAGACAACCCAAGTATTTATAGCA
ATTTAGACTTACCATCAATAGTTGAAAAAAATAAAAAAACAGGAATAAGTATAATAAATGGTAAAGATTGTACAGAATTT
GGTATAGGTACTGCTTTAGTAGAAATTGTAAAAGCTATACTACACAATGAGAAAAAAGTTCTTCCAGTTTCTACATTACT
AGAAGGTCAATATAACGAAAGAAATGTATTTGCAGGTGTTCCATGTGTTATAGGAAAAGATGGTATTGAACAAATTATTG
AAATCAATATGACTGAATATGAGCAAAACGAATTTAATAAATCTTGTTCTGTTTTAAGGGAATATATTGCACTTTCAAAA
ACACTTTAG

Upstream 100 bases:

>100_bases
TAAATTTTCTGAAATAATAGAATATTAAAATATTCAAAAACAGCTTTTAATAACATCTATAATTTTCAATGTATCGTTAT
TTTAGGGGGAGTGATTTAAA

Downstream 100 bases:

>100_bases
ATTCAATATTCTTTCTTACACTAAAAGCAGGTAAATGACTTATTGAAAAAACTTTTAACTAAGTTAATGTTTAAATCATT
TGTACCTGCTTTTAATTTTA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MAIKPRKISIVGSGHVGSHCGFSLITQGVCDELFMIDIDESKSKAQALDLADAVSYLPHKVHIEKGTFSDCKDSDIVVIS
VADSSEGPLRRQNTTRLDLLRPTIGMIKSIVKPIVDSGFDGIFVVISNPVDVVTNYIWEKSGFPKNKVIGTGTALDSTRL
RRILSEETGIAQQSIQAYSMGEHGDSQMVPWSHVSIGGKPILDMIKDNPSIYSNLDLPSIVEKNKKTGISIINGKDCTEF
GIGTALVEIVKAILHNEKKVLPVSTLLEGQYNERNVFAGVPCVIGKDGIEQIIEINMTEYEQNEFNKSCSVLREYIALSK
TL

Sequences:

>Translated_322_residues
MAIKPRKISIVGSGHVGSHCGFSLITQGVCDELFMIDIDESKSKAQALDLADAVSYLPHKVHIEKGTFSDCKDSDIVVIS
VADSSEGPLRRQNTTRLDLLRPTIGMIKSIVKPIVDSGFDGIFVVISNPVDVVTNYIWEKSGFPKNKVIGTGTALDSTRL
RRILSEETGIAQQSIQAYSMGEHGDSQMVPWSHVSIGGKPILDMIKDNPSIYSNLDLPSIVEKNKKTGISIINGKDCTEF
GIGTALVEIVKAILHNEKKVLPVSTLLEGQYNERNVFAGVPCVIGKDGIEQIIEINMTEYEQNEFNKSCSVLREYIALSK
TL
>Mature_321_residues
AIKPRKISIVGSGHVGSHCGFSLITQGVCDELFMIDIDESKSKAQALDLADAVSYLPHKVHIEKGTFSDCKDSDIVVISV
ADSSEGPLRRQNTTRLDLLRPTIGMIKSIVKPIVDSGFDGIFVVISNPVDVVTNYIWEKSGFPKNKVIGTGTALDSTRLR
RILSEETGIAQQSIQAYSMGEHGDSQMVPWSHVSIGGKPILDMIKDNPSIYSNLDLPSIVEKNKKTGISIINGKDCTEFG
IGTALVEIVKAILHNEKKVLPVSTLLEGQYNERNVFAGVPCVIGKDGIEQIIEINMTEYEQNEFNKSCSVLREYIALSKT
L

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI47059044, Length=317, Percent_Identity=34.0694006309148, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI221136809, Length=317, Percent_Identity=34.0694006309148, Blast_Score=195, Evalue=5e-50,
Organism=Homo sapiens, GI15082234, Length=314, Percent_Identity=31.8471337579618, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI9257228, Length=310, Percent_Identity=31.9354838709677, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI4504973, Length=310, Percent_Identity=31.9354838709677, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI291575128, Length=312, Percent_Identity=31.4102564102564, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI4557032, Length=312, Percent_Identity=31.4102564102564, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI5031857, Length=310, Percent_Identity=30.3225806451613, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI260099723, Length=310, Percent_Identity=30.3225806451613, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI260099727, Length=192, Percent_Identity=32.8125, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI207028494, Length=192, Percent_Identity=32.8125, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI260099725, Length=192, Percent_Identity=32.8125, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI103472011, Length=294, Percent_Identity=27.2108843537415, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI103472015, Length=186, Percent_Identity=29.5698924731183, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17535107, Length=297, Percent_Identity=29.6296296296296, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17136226, Length=316, Percent_Identity=30.379746835443, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI45550422, Length=319, Percent_Identity=28.5266457680251, Blast_Score=153, Evalue=1e-37,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 35209; Mature: 35078

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIKPRKISIVGSGHVGSHCGFSLITQGVCDELFMIDIDESKSKAQALDLADAVSYLPHK
CCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCE
VHIEKGTFSDCKDSDIVVISVADSSEGPLRRQNTTRLDLLRPTIGMIKSIVKPIVDSGFD
EEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GIFVVISNPVDVVTNYIWEKSGFPKNKVIGTGTALDSTRLRRILSEETGIAQQSIQAYSM
EEEEEECCCHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHCC
GEHGDSQMVPWSHVSIGGKPILDMIKDNPSIYSNLDLPSIVEKNKKTGISIINGKDCTEF
CCCCCCCCCCCCEECCCCCHHHHHHCCCCCCEECCCCHHHHHCCCCCCEEEECCCCCHHH
GIGTALVEIVKAILHNEKKVLPVSTLLEGQYNERNVFAGVPCVIGKDGIEQIIEINMTEY
HHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCEEECCCEEECCHHHHHHHHCCCHHH
EQNEFNKSCSVLREYIALSKTL
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIKPRKISIVGSGHVGSHCGFSLITQGVCDELFMIDIDESKSKAQALDLADAVSYLPHK
CCCCEEEEEEECCCCCCCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHCCCE
VHIEKGTFSDCKDSDIVVISVADSSEGPLRRQNTTRLDLLRPTIGMIKSIVKPIVDSGFD
EEEECCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
GIFVVISNPVDVVTNYIWEKSGFPKNKVIGTGTALDSTRLRRILSEETGIAQQSIQAYSM
EEEEEECCCHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHCC
GEHGDSQMVPWSHVSIGGKPILDMIKDNPSIYSNLDLPSIVEKNKKTGISIINGKDCTEF
CCCCCCCCCCCCEECCCCCHHHHHHCCCCCCEECCCCHHHHHCCCCCCEEEECCCCCHHH
GIGTALVEIVKAILHNEKKVLPVSTLLEGQYNERNVFAGVPCVIGKDGIEQIIEINMTEY
HHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCCCEEECCCEEECCHHHHHHHHCCCHHH
EQNEFNKSCSVLREYIALSKTL
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11889109 [H]