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The map label for this gene is pheA [H]

Identifier: 126699445

GI number: 126699445

Start: 2125730

End: 2126926

Strand: Direct

Name: pheA [H]

Synonym: CD1836

Alternate gene names: 126699445

Gene position: 2125730-2126926 (Clockwise)

Preceding gene: 126699444

Following gene: 126699446

Centisome position: 49.55

GC content: 26.23

Gene sequence:

>1197_bases
ATGGAGGATTTAACGAGATATAGAAATGAGATTGACAATATAGATAAAGAGCTTATTCAATTATTTGAAAAGAGAATGAA
TACAGTTCTTGAAATTGCCAGACATAAAATGAAAAATAATACTACTATACTTCAAAAAGATAGAGAAGAAAAAGTACTAA
GTAGAGCTGTAGATAATTTAGATAATAAAGCATATTCACAAGAAACGGTACAGTTTTTTAATTCTATAATGGAAATTAGT
AGAGGATTACAAAAAAGATTGATAGATAATGATGGTGAGCAGAAAATCGAGTTTGGTTTAGATTCATCAAATAAGAATTT
TGATTTGTCAAATGTAAATAAATATAAGTCTTTAAAAGATGAATTAAATAAAAAAAATATCCTAGTAGGGTTTCCTGGAA
AATCAGGTTCATTTACAGAAGAAGCACTAAATAAATTCTTCAACAAAAAAATATCAAAAAAACAATTTAAAGAATTTGAA
GATGTTTTCATAGCACTTAAAAATAAAGAAATAAACTATGGAATAATCCCCATAGAAAATTCATCTACAGGAGCTATCTC
TGAAACTTATGACCTTTTGAGAAAGTACGGTTTTTATATAGTTGGAGAAGAATGTATAAAAATAGACCAAAATTTAATAG
GGATAAAAGACACAAAGCTTGAAGATATAAAAGAAATATATTCTCATCCACAAGGTATAGGACAATGTAGTGAATTTTTA
AAACAAAATAGTACATGGAAATTGATACCATTTAATAACACAGCAACAAGTGCAGAACTTGTAAGAAAACTTCAAGATAA
AACAAAAGCAGCAATTGCAAGCAAAAAAGCTGCAAGTATTTATGGATTAGAAATAATAAGTCCTTGTATAAATGATATAG
CAAACAACTATACAAGATTTGTAGTAATCAGTAATCAAATACACATTGAAGAAGAATCAAACAAAATGAGTGTAGTATTT
TCTGTTGAACATGAAGCAGGAAAACTTTATAAAGTACTTGGATACTTTGCTAAAAATAATATAAATATGACAAAAATAGA
ATCAAGACCTATGAAAAATGCCTCATGGAGATATTTCTTTTATATAGATTTTGAGTGTTCTATATACAATGCTAAAGTGT
ACGATTTATTAGAATTGATAGAACATAATACAGCATATTTTAAATTTATGGGAGTATATAAAAATAAAACTGAATAG

Upstream 100 bases:

>100_bases
TTAAAGGCAGACATGACCCTTGTATAGTTCAAAGGGCTATACCTGTAATAGAAGCAGTAACAGCCATTGGAATTTTTGAT
TTGATGAAAGGACGATAATA

Downstream 100 bases:

>100_bases
ATAAGATAAATTTTTATTTAATTTATAATTATTAGGAGGTGTAAGTATGAATTTTTTCGGTCTAGTAGGTGAAAAACTCT
CTCACAGTGTTTCACCTCAA

Product: P-protein

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MEDLTRYRNEIDNIDKELIQLFEKRMNTVLEIARHKMKNNTTILQKDREEKVLSRAVDNLDNKAYSQETVQFFNSIMEIS
RGLQKRLIDNDGEQKIEFGLDSSNKNFDLSNVNKYKSLKDELNKKNILVGFPGKSGSFTEEALNKFFNKKISKKQFKEFE
DVFIALKNKEINYGIIPIENSSTGAISETYDLLRKYGFYIVGEECIKIDQNLIGIKDTKLEDIKEIYSHPQGIGQCSEFL
KQNSTWKLIPFNNTATSAELVRKLQDKTKAAIASKKAASIYGLEIISPCINDIANNYTRFVVISNQIHIEEESNKMSVVF
SVEHEAGKLYKVLGYFAKNNINMTKIESRPMKNASWRYFFYIDFECSIYNAKVYDLLELIEHNTAYFKFMGVYKNKTE

Sequences:

>Translated_398_residues
MEDLTRYRNEIDNIDKELIQLFEKRMNTVLEIARHKMKNNTTILQKDREEKVLSRAVDNLDNKAYSQETVQFFNSIMEIS
RGLQKRLIDNDGEQKIEFGLDSSNKNFDLSNVNKYKSLKDELNKKNILVGFPGKSGSFTEEALNKFFNKKISKKQFKEFE
DVFIALKNKEINYGIIPIENSSTGAISETYDLLRKYGFYIVGEECIKIDQNLIGIKDTKLEDIKEIYSHPQGIGQCSEFL
KQNSTWKLIPFNNTATSAELVRKLQDKTKAAIASKKAASIYGLEIISPCINDIANNYTRFVVISNQIHIEEESNKMSVVF
SVEHEAGKLYKVLGYFAKNNINMTKIESRPMKNASWRYFFYIDFECSIYNAKVYDLLELIEHNTAYFKFMGVYKNKTE
>Mature_398_residues
MEDLTRYRNEIDNIDKELIQLFEKRMNTVLEIARHKMKNNTTILQKDREEKVLSRAVDNLDNKAYSQETVQFFNSIMEIS
RGLQKRLIDNDGEQKIEFGLDSSNKNFDLSNVNKYKSLKDELNKKNILVGFPGKSGSFTEEALNKFFNKKISKKQFKEFE
DVFIALKNKEINYGIIPIENSSTGAISETYDLLRKYGFYIVGEECIKIDQNLIGIKDTKLEDIKEIYSHPQGIGQCSEFL
KQNSTWKLIPFNNTATSAELVRKLQDKTKAAIASKKAASIYGLEIISPCINDIANNYTRFVVISNQIHIEEESNKMSVVF
SVEHEAGKLYKVLGYFAKNNINMTKIESRPMKNASWRYFFYIDFECSIYNAKVYDLLELIEHNTAYFKFMGVYKNKTE

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=403, Percent_Identity=27.0471464019851, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6324013, Length=309, Percent_Identity=25.8899676375405, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010952
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 46177; Mature: 46177

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS00857 PREPHENATE_DEHYDR_1 ; PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDLTRYRNEIDNIDKELIQLFEKRMNTVLEIARHKMKNNTTILQKDREEKVLSRAVDNL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHH
DNKAYSQETVQFFNSIMEISRGLQKRLIDNDGEQKIEFGLDSSNKNFDLSNVNKYKSLKD
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHH
ELNKKNILVGFPGKSGSFTEEALNKFFNKKISKKQFKEFEDVFIALKNKEINYGIIPIEN
HCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEECC
SSTGAISETYDLLRKYGFYIVGEECIKIDQNLIGIKDTKLEDIKEIYSHPQGIGQCSEFL
CCCCCHHHHHHHHHHCCCEEECHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHH
KQNSTWKLIPFNNTATSAELVRKLQDKTKAAIASKKAASIYGLEIISPCINDIANNYTRF
HCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VVISNQIHIEEESNKMSVVFSVEHEAGKLYKVLGYFAKNNINMTKIESRPMKNASWRYFF
EEEECEEEEEECCCEEEEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEE
YIDFECSIYNAKVYDLLELIEHNTAYFKFMGVYKNKTE
EEEEEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCCC
>Mature Secondary Structure
MEDLTRYRNEIDNIDKELIQLFEKRMNTVLEIARHKMKNNTTILQKDREEKVLSRAVDNL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHH
DNKAYSQETVQFFNSIMEISRGLQKRLIDNDGEQKIEFGLDSSNKNFDLSNVNKYKSLKD
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHH
ELNKKNILVGFPGKSGSFTEEALNKFFNKKISKKQFKEFEDVFIALKNKEINYGIIPIEN
HCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEECC
SSTGAISETYDLLRKYGFYIVGEECIKIDQNLIGIKDTKLEDIKEIYSHPQGIGQCSEFL
CCCCCHHHHHHHHHHCCCEEECHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHH
KQNSTWKLIPFNNTATSAELVRKLQDKTKAAIASKKAASIYGLEIISPCINDIANNYTRF
HCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VVISNQIHIEEESNKMSVVFSVEHEAGKLYKVLGYFAKNNINMTKIESRPMKNASWRYFF
EEEECEEEEEECCCEEEEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEE
YIDFECSIYNAKVYDLLELIEHNTAYFKFMGVYKNKTE
EEEEEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10781569; 10993077 [H]