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The map label for this gene is aroA

Identifier: 126699443

GI number: 126699443

Start: 2123357

End: 2124670

Strand: Direct

Name: aroA

Synonym: CD1834

Alternate gene names: 126699443

Gene position: 2123357-2124670 (Clockwise)

Preceding gene: 126699442

Following gene: 126699444

Centisome position: 49.49

GC content: 29.98

Gene sequence:

>1314_bases
ATGGGAAGTCTAAAAATATATCCAAGTAAATTATCTGGAGATGTAAAAATACCACCATCAAAAAGTATGGCACATAGGGC
AGTTATTTGTTCATCTCTAAGCAATGGAAAAAGTAGAATTTCTAATATAGATTTTTCTGATGATATAATAGCTACTATAA
GAGCAATGACATCATTAGGAGCTATTATAGAAAAGAAAGAAGATATTTTAGAAATTTCGGGAATTTTTTCTAAAGAAGGT
ATTTTAAATAGAGAGAATCAGTTGAATCAACCTAAATTGACAATAGATTGTAATGAATCAGGCTCTACATTGAGATTTTT
AGTACCTATATCTTTAGCATTTGATGGTGTAAAAAGGTTTATAGGTAGAGGAAATCTTGGAAAAAGACCACTTGATACTT
ATTATGAGATATTTGACAGACAGAATATAAAATATAGTTACAAAGAAAATCAGTTAGATTTGATTATATCAGGTAAGCTT
AAACCAGATGAATTTAGAGTAAAAGGAAATATAAGTTCTCAGTTTATCACAGGTTTACTGTTTATATTGCCTACGCTAGA
GAGTGATTCAAAGATAATAATTACTACTGAGCTAGAATCTAAAGGATATTTAGATTTAACTCTTTCAACGATAAAAGATT
TTGGGGTAGAAATTATAAACAATAACTATAAAGAATTTATTATAAAAGGAAATCAAACGTATAAAGCGAGAGATTATAAA
GTAGAAGGAGATTATTCTCAAGGAGCATTTTATTTATCAGCAGATGCTATAGGAGAAGATATTAGCATATTAGACCTTAA
AGAAGATTCTCTTCAAGGGGATAGTGAAGTAGTTGAAATTTTATCTAGGATGGGAATGGAAATATTAAGAGAAGGCAACA
AAATAAAAGGAATAACAAATGGTTTAAATGGTACTTTGATAGATGCATCTCAATGCCCAGATATAATACCTGTATTATCT
GTAGTAGCATCCTTAAGTATAGGGAAGACTACAATAATTAATGCTGGTAGGCTTAGAATTAAAGAATGTGATAGACTTCA
TGCAATAAATGTTGAGTTAAGTAAACTTGGAGCAAATATAGAGGAGAAAGAGGATAGTTTGATAATCGAAGGAGTAAGCA
AGTTAAATGGTGGAGTAGAGGTGTGGAGTCACAAAGACCATAGAATTGCTATGACACTTGCAATTGCTTCTTGTAGATGT
GATAAACCAATAATATTAAAAGATTTTGAGTGTGTATCAAAATCTTATCCACATTTTTTTAAAGATTTTAAGATGTTAGG
AGGTCGAATTGATGAGTGGAATATGGGGAAATAA

Upstream 100 bases:

>100_bases
AAAAAAATCTAGGTGATACATTAAAAATAATACTTTTAAAAGATATTGGAGAGAGTATTATATATAATACTACTTCTAAA
TTTTTTCAGGAGGTAAGATA

Downstream 100 bases:

>100_bases
TTTAAAAGTATCAATTTTTGGAGAATCTCATGGAAATGCTATAGGTATAAATATAGATGGTCTTCCTTCGGGGATTGAAC
TTGACCTTGATAAGATTGAT

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MGSLKIYPSKLSGDVKIPPSKSMAHRAVICSSLSNGKSRISNIDFSDDIIATIRAMTSLGAIIEKKEDILEISGIFSKEG
ILNRENQLNQPKLTIDCNESGSTLRFLVPISLAFDGVKRFIGRGNLGKRPLDTYYEIFDRQNIKYSYKENQLDLIISGKL
KPDEFRVKGNISSQFITGLLFILPTLESDSKIIITTELESKGYLDLTLSTIKDFGVEIINNNYKEFIIKGNQTYKARDYK
VEGDYSQGAFYLSADAIGEDISILDLKEDSLQGDSEVVEILSRMGMEILREGNKIKGITNGLNGTLIDASQCPDIIPVLS
VVASLSIGKTTIINAGRLRIKECDRLHAINVELSKLGANIEEKEDSLIIEGVSKLNGGVEVWSHKDHRIAMTLAIASCRC
DKPIILKDFECVSKSYPHFFKDFKMLGGRIDEWNMGK

Sequences:

>Translated_437_residues
MGSLKIYPSKLSGDVKIPPSKSMAHRAVICSSLSNGKSRISNIDFSDDIIATIRAMTSLGAIIEKKEDILEISGIFSKEG
ILNRENQLNQPKLTIDCNESGSTLRFLVPISLAFDGVKRFIGRGNLGKRPLDTYYEIFDRQNIKYSYKENQLDLIISGKL
KPDEFRVKGNISSQFITGLLFILPTLESDSKIIITTELESKGYLDLTLSTIKDFGVEIINNNYKEFIIKGNQTYKARDYK
VEGDYSQGAFYLSADAIGEDISILDLKEDSLQGDSEVVEILSRMGMEILREGNKIKGITNGLNGTLIDASQCPDIIPVLS
VVASLSIGKTTIINAGRLRIKECDRLHAINVELSKLGANIEEKEDSLIIEGVSKLNGGVEVWSHKDHRIAMTLAIASCRC
DKPIILKDFECVSKSYPHFFKDFKMLGGRIDEWNMGK
>Mature_436_residues
GSLKIYPSKLSGDVKIPPSKSMAHRAVICSSLSNGKSRISNIDFSDDIIATIRAMTSLGAIIEKKEDILEISGIFSKEGI
LNRENQLNQPKLTIDCNESGSTLRFLVPISLAFDGVKRFIGRGNLGKRPLDTYYEIFDRQNIKYSYKENQLDLIISGKLK
PDEFRVKGNISSQFITGLLFILPTLESDSKIIITTELESKGYLDLTLSTIKDFGVEIINNNYKEFIIKGNQTYKARDYKV
EGDYSQGAFYLSADAIGEDISILDLKEDSLQGDSEVVEILSRMGMEILREGNKIKGITNGLNGTLIDASQCPDIIPVLSV
VASLSIGKTTIINAGRLRIKECDRLHAINVELSKLGANIEEKEDSLIIEGVSKLNGGVEVWSHKDHRIAMTLAIASCRCD
KPIILKDFECVSKSYPHFFKDFKMLGGRIDEWNMGK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family

Homologues:

Organism=Escherichia coli, GI1787137, Length=428, Percent_Identity=31.5420560747664, Blast_Score=205, Evalue=4e-54,
Organism=Saccharomyces cerevisiae, GI6320332, Length=477, Percent_Identity=24.1090146750524, Blast_Score=117, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROA_CLOD6 (Q187E3)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001088340.1
- ProteinModelPortal:   Q187E3
- SMR:   Q187E3
- STRING:   Q187E3
- GeneID:   4914602
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD1834
- NMPDR:   fig|1496.1.peg.2970
- eggNOG:   COG0128
- HOGENOM:   HBG646626
- OMA:   SSQFITS
- ProtClustDB:   PRK02427
- GO:   GO:0005737
- HAMAP:   MF_00210
- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.10
- PIRSF:   PIRSF000505
- TIGRFAMs:   TIGR01356

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.19

Molecular weight: Translated: 48582; Mature: 48450

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00104 EPSP_SYNTHASE_1; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSLKIYPSKLSGDVKIPPSKSMAHRAVICSSLSNGKSRISNIDFSDDIIATIRAMTSLG
CCCEEEEHHCCCCCEECCCCHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHH
AIIEKKEDILEISGIFSKEGILNRENQLNQPKLTIDCNESGSTLRFLVPISLAFDGVKRF
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHHH
IGRGNLGKRPLDTYYEIFDRQNIKYSYKENQLDLIISGKLKPDEFRVKGNISSQFITGLL
HCCCCCCCCCHHHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCEEEECCCHHHHHHHHH
FILPTLESDSKIIITTELESKGYLDLTLSTIKDFGVEIINNNYKEFIIKGNQTYKARDYK
HHHCCCCCCCEEEEEEEECCCCEEEEEHHHHHHCCHHEECCCCEEEEEECCCEEEEEEEE
VEGDYSQGAFYLSADAIGEDISILDLKEDSLQGDSEVVEILSRMGMEILREGNKIKGITN
ECCCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECC
GLNGTLIDASQCPDIIPVLSVVASLSIGKTTIINAGRLRIKECDRLHAINVELSKLGANI
CCCCCEEEHHHCCCHHHHHHHHHHCCCCCEEEEECCCEEEECCCCEEEEEEEHHHHCCCC
EEKEDSLIIEGVSKLNGGVEVWSHKDHRIAMTLAIASCRCDKPIILKDFECVSKSYPHFF
CCCCCCEEEEEHHHCCCCEEEECCCCCEEEEEEEEEHHCCCCCEEEECHHHHHCCCHHHH
KDFKMLGGRIDEWNMGK
HHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
GSLKIYPSKLSGDVKIPPSKSMAHRAVICSSLSNGKSRISNIDFSDDIIATIRAMTSLG
CCEEEEHHCCCCCEECCCCHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHH
AIIEKKEDILEISGIFSKEGILNRENQLNQPKLTIDCNESGSTLRFLVPISLAFDGVKRF
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEEEHHHHHHHHHHH
IGRGNLGKRPLDTYYEIFDRQNIKYSYKENQLDLIISGKLKPDEFRVKGNISSQFITGLL
HCCCCCCCCCHHHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCEEEECCCHHHHHHHHH
FILPTLESDSKIIITTELESKGYLDLTLSTIKDFGVEIINNNYKEFIIKGNQTYKARDYK
HHHCCCCCCCEEEEEEEECCCCEEEEEHHHHHHCCHHEECCCCEEEEEECCCEEEEEEEE
VEGDYSQGAFYLSADAIGEDISILDLKEDSLQGDSEVVEILSRMGMEILREGNKIKGITN
ECCCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECC
GLNGTLIDASQCPDIIPVLSVVASLSIGKTTIINAGRLRIKECDRLHAINVELSKLGANI
CCCCCEEEHHHCCCHHHHHHHHHHCCCCCEEEEECCCEEEECCCCEEEEEEEHHHHCCCC
EEKEDSLIIEGVSKLNGGVEVWSHKDHRIAMTLAIASCRCDKPIILKDFECVSKSYPHFF
CCCCCCEEEEEHHHCCCCEEEECCCCCEEEEEEEEEHHCCCCCEEEECHHHHHCCCHHHH
KDFKMLGGRIDEWNMGK
HHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA