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The map label for this gene is add [H]

Identifier: 126699354

GI number: 126699354

Start: 2024021

End: 2025010

Strand: Direct

Name: add [H]

Synonym: CD1747

Alternate gene names: 126699354

Gene position: 2024021-2025010 (Clockwise)

Preceding gene: 126699351

Following gene: 126699355

Centisome position: 47.18

GC content: 26.77

Gene sequence:

>990_bases
ATGTTTGAAAATTTACCTAAGATAGATTTACATTGCCACTTAGATGGAAGTGTTAGAGTAGAAACCATGCTTGATATAGC
TATTAAAGAGAAAATAGATTTACCTTCAAATAATATGGATGAAATAAAAAAATTAGCAAAGGTTTCTTTTAATTGTACTT
CACTAGATGAATATTTAGAAAAATTTGATTTACCCTTAAAAGTAATGCAATCTAAGGAAAATTTAAAAAGAATTACTTTT
GAACTTTTGGAAGATGCAAGTAGAGAAAATGTAAAATATATTGAAATTAGATTTGCACCATTACTTCACACCCAAAAAGG
TATGAGTGTTAAAAATATAATTGAGGGTATAATTGAAGGAATTAGAGAAGCTGAAAGTATTTATGATATAAAAGGCAATT
TAATATTAGGTTGTATGAGAACAATGACCTCAAAAGAGGCATTATTAGTAATTGAAGAAGGGAAATCATTTGTAAATAAA
GGTGTTGTAGCAGTAGACTTGTGTGGTCCAGAGAAAGAGGGATTTTGTAAGGAATATAAAGATGTTTTTAAATTAGCAAG
AGAATATGGATATAAAGTTACAATACATGCAGGAGAAGCTGCAAGTGGAGAAAATGTATTAGATGCTATAAATATTTTAA
AGGCGGATAGGATTGGTCATGGGGTAAAAATTAAAGACCATAAAAAGGCGTATAATTTAGTTAAAGATAAAAAAATATTG
CTTGAATTATGTCCAACTAGTAATGTACAAACTAAGACAGTAGATTCTTATGAAGCACATCCATTTTATACTTTTTATAA
AGATAATTTACATGTAAGTATAAATACTGATAATAGAACTGTATCAGATATAAATTTAAGTTCAGAACTAAATGTTATAT
TTGATACTTTTAAACTAGGATTAGAAGACTATAAAATAATTTATAGAAATGCAGTAGAAGCTAGTTTTGCAGATAAAGAA
ACTAAAGAGTATTTGAATAGTTTAATTTAA

Upstream 100 bases:

>100_bases
TGACTTTTTTAGAATTAAAAACTGTAGTATATTGATATAATAGAAATAAGACTTAAAAATCTGTTGATAGTATTATTTAT
AAGTACAGTAGGAGGATAAA

Downstream 100 bases:

>100_bases
TAGATAAAAATATTTAAACTTTAAATTAAGCTATTAAATTGACAAAAATACATTGTATTAGGAGAAAAAATGTGAAAGAT
TATGAAGATGTTGTTTATAT

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MFENLPKIDLHCHLDGSVRVETMLDIAIKEKIDLPSNNMDEIKKLAKVSFNCTSLDEYLEKFDLPLKVMQSKENLKRITF
ELLEDASRENVKYIEIRFAPLLHTQKGMSVKNIIEGIIEGIREAESIYDIKGNLILGCMRTMTSKEALLVIEEGKSFVNK
GVVAVDLCGPEKEGFCKEYKDVFKLAREYGYKVTIHAGEAASGENVLDAINILKADRIGHGVKIKDHKKAYNLVKDKKIL
LELCPTSNVQTKTVDSYEAHPFYTFYKDNLHVSINTDNRTVSDINLSSELNVIFDTFKLGLEDYKIIYRNAVEASFADKE
TKEYLNSLI

Sequences:

>Translated_329_residues
MFENLPKIDLHCHLDGSVRVETMLDIAIKEKIDLPSNNMDEIKKLAKVSFNCTSLDEYLEKFDLPLKVMQSKENLKRITF
ELLEDASRENVKYIEIRFAPLLHTQKGMSVKNIIEGIIEGIREAESIYDIKGNLILGCMRTMTSKEALLVIEEGKSFVNK
GVVAVDLCGPEKEGFCKEYKDVFKLAREYGYKVTIHAGEAASGENVLDAINILKADRIGHGVKIKDHKKAYNLVKDKKIL
LELCPTSNVQTKTVDSYEAHPFYTFYKDNLHVSINTDNRTVSDINLSSELNVIFDTFKLGLEDYKIIYRNAVEASFADKE
TKEYLNSLI
>Mature_329_residues
MFENLPKIDLHCHLDGSVRVETMLDIAIKEKIDLPSNNMDEIKKLAKVSFNCTSLDEYLEKFDLPLKVMQSKENLKRITF
ELLEDASRENVKYIEIRFAPLLHTQKGMSVKNIIEGIIEGIREAESIYDIKGNLILGCMRTMTSKEALLVIEEGKSFVNK
GVVAVDLCGPEKEGFCKEYKDVFKLAREYGYKVTIHAGEAASGENVLDAINILKADRIGHGVKIKDHKKAYNLVKDKKIL
LELCPTSNVQTKTVDSYEAHPFYTFYKDNLHVSINTDNRTVSDINLSSELNVIFDTFKLGLEDYKIIYRNAVEASFADKE
TKEYLNSLI

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family [H]

Homologues:

Organism=Homo sapiens, GI47078295, Length=344, Percent_Identity=28.1976744186047, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI226693318, Length=334, Percent_Identity=27.5449101796407, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI61175224, Length=226, Percent_Identity=28.3185840707965, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787910, Length=327, Percent_Identity=33.3333333333333, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI32565969, Length=333, Percent_Identity=29.7297297297297, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17538512, Length=333, Percent_Identity=29.7297297297297, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI115537133, Length=326, Percent_Identity=29.1411042944785, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324188, Length=335, Percent_Identity=24.4776119402985, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24645260, Length=327, Percent_Identity=25.9938837920489, Blast_Score=104, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001365
- InterPro:   IPR006330 [H]

Pfam domain/function: PF00962 A_deaminase [H]

EC number: =3.5.4.4 [H]

Molecular weight: Translated: 37418; Mature: 37418

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLPKIDLHCHLDGSVRVETMLDIAIKEKIDLPSNNMDEIKKLAKVSFNCTSLDEYLE
CCCCCCCEEEEEECCCCEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHH
KFDLPLKVMQSKENLKRITFELLEDASRENVKYIEIRFAPLLHTQKGMSVKNIIEGIIEG
HHCCCHHHHHCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEHHCCCCCCCHHHHHHHHHHH
IREAESIYDIKGNLILGCMRTMTSKEALLVIEEGKSFVNKGVVAVDLCGPEKEGFCKEYK
HHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCHHHHHCCCEEEEECCCCCCCHHHHHH
DVFKLAREYGYKVTIHAGEAASGENVLDAINILKADRIGHGVKIKDHKKAYNLVKDKKIL
HHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCEEE
LELCPTSNVQTKTVDSYEAHPFYTFYKDNLHVSINTDNRTVSDINLSSELNVIFDTFKLG
EEECCCCCCCEEECCCCCCCCEEEEEECEEEEEEECCCCEEEEECCCCCHHHHHHHHHHC
LEDYKIIYRNAVEASFADKETKEYLNSLI
CHHHHHHHHHHHHHHHCHHHHHHHHHHCC
>Mature Secondary Structure
MFENLPKIDLHCHLDGSVRVETMLDIAIKEKIDLPSNNMDEIKKLAKVSFNCTSLDEYLE
CCCCCCCEEEEEECCCCEEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHH
KFDLPLKVMQSKENLKRITFELLEDASRENVKYIEIRFAPLLHTQKGMSVKNIIEGIIEG
HHCCCHHHHHCHHHHHHHHHHHHHCCCCCCEEEEEEEEEEHHCCCCCCCHHHHHHHHHHH
IREAESIYDIKGNLILGCMRTMTSKEALLVIEEGKSFVNKGVVAVDLCGPEKEGFCKEYK
HHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCHHHHHCCCEEEEECCCCCCCHHHHHH
DVFKLAREYGYKVTIHAGEAASGENVLDAINILKADRIGHGVKIKDHKKAYNLVKDKKIL
HHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHCEEE
LELCPTSNVQTKTVDSYEAHPFYTFYKDNLHVSINTDNRTVSDINLSSELNVIFDTFKLG
EEECCCCCCCEEECCCCCCCCEEEEEECEEEEEEECCCCEEEEECCCCCHHHHHHHHHHC
LEDYKIIYRNAVEASFADKETKEYLNSLI
CHHHHHHHHHHHHHHHCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA