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The map label for this gene is cysK [H]

Identifier: 126699270

GI number: 126699270

Start: 1938472

End: 1939434

Strand: Direct

Name: cysK [H]

Synonym: CD1665

Alternate gene names: 126699270

Gene position: 1938472-1939434 (Clockwise)

Preceding gene: 126699267

Following gene: 126699271

Centisome position: 45.18

GC content: 33.23

Gene sequence:

>963_bases
ATGCGTGTACTTAATAATGTTACAGAGGCTATAGGCAATACTCATATGTTACATTTATCCAAAATAGCAGATGAATTTGG
AGTTCAAGGTAATATTTATGCAAAGATGGAATACTTAAATCCGGGATTTAGTAAAAAGGACCGTGTAGCATTACAAATGA
TTACCGAAGCAGAAAATGCAGGTTTATTAGTTCCAGGTCAAGCAGTTGTGGAATTAACAAGTGGTAATACTGGAACAGGA
CTAGCAATAGCTTGTGCATGTAAAGGATATAAATTTATAGCGTGTATGTCAAAAGGAAATTCTATGGAAAGAGCAAGAAT
GATGAAAGCTTTAGGTGCTGAAGTAGTTCTTGTAGACCAAATGCCTAATTCAGTTCATGGACAGGTATCTGGTGAAGATT
TGGCACTTGTAGAAATTGAGGCTCAAAAAATAGCAAAAGAAAGAAATGCATTTAGAGCAGACCAATTTAATTTAGAAGCT
TGTAATCATGCACATGAAAAGTATACAGCAGAAGAAATGTGGGAACAATTGGATGGAAATATTGATGTATTTGTAGATTT
TCTTGGAAGTGGTAGTACTTTTGCAGGATGTTCAAAAACACTTAAAAAACATAATTCTTCTATCAAATGTTATGTTGTTG
AACCTGAAACAGCAGCAATTTATTCAGGTAAAGAAATAACTGACCAAGGGCATAAAATACAAGGTGGAGGATATTCTATG
GATTTGCCATTAGTAGACAAGAAACTTATTGATGGTTATATTCAAGTTACAGACGAGGAGGCAACTGATGTAGCAAGAAA
ATTAGCTAAATTAGAAGGTGTATTTGCAGGATTTTCTTCAGGGGCAAATGTATGTGCAGCAATTAAGTTGTTAAAGAGCA
GTGAAAAAGGAAAAAATATAGTTTTAACTCTTAATGATAGTGGTTTAAAATATTTAAGTACTGATTTATATGAAGAATTG
TAA

Upstream 100 bases:

>100_bases
TAATGAACGTTAAATACACTGTACATCCGTAATATAAATTATACTGCATAAAGAGTGGTTTTTCAACGGATGATAGTTGA
GAGATTAAGGGGGAATTGTA

Downstream 100 bases:

>100_bases
TAATAGCACAATAGTTATGCAATGTTTTTTAAATTAAGTATATAGATTTAAATTATAAAAAGTATCTCAATGTAATTTTT
GAAAGTTATAAAGGAGATAC

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRVLNNVTEAIGNTHMLHLSKIADEFGVQGNIYAKMEYLNPGFSKKDRVALQMITEAENAGLLVPGQAVVELTSGNTGTG
LAIACACKGYKFIACMSKGNSMERARMMKALGAEVVLVDQMPNSVHGQVSGEDLALVEIEAQKIAKERNAFRADQFNLEA
CNHAHEKYTAEEMWEQLDGNIDVFVDFLGSGSTFAGCSKTLKKHNSSIKCYVVEPETAAIYSGKEITDQGHKIQGGGYSM
DLPLVDKKLIDGYIQVTDEEATDVARKLAKLEGVFAGFSSGANVCAAIKLLKSSEKGKNIVLTLNDSGLKYLSTDLYEEL

Sequences:

>Translated_320_residues
MRVLNNVTEAIGNTHMLHLSKIADEFGVQGNIYAKMEYLNPGFSKKDRVALQMITEAENAGLLVPGQAVVELTSGNTGTG
LAIACACKGYKFIACMSKGNSMERARMMKALGAEVVLVDQMPNSVHGQVSGEDLALVEIEAQKIAKERNAFRADQFNLEA
CNHAHEKYTAEEMWEQLDGNIDVFVDFLGSGSTFAGCSKTLKKHNSSIKCYVVEPETAAIYSGKEITDQGHKIQGGGYSM
DLPLVDKKLIDGYIQVTDEEATDVARKLAKLEGVFAGFSSGANVCAAIKLLKSSEKGKNIVLTLNDSGLKYLSTDLYEEL
>Mature_320_residues
MRVLNNVTEAIGNTHMLHLSKIADEFGVQGNIYAKMEYLNPGFSKKDRVALQMITEAENAGLLVPGQAVVELTSGNTGTG
LAIACACKGYKFIACMSKGNSMERARMMKALGAEVVLVDQMPNSVHGQVSGEDLALVEIEAQKIAKERNAFRADQFNLEA
CNHAHEKYTAEEMWEQLDGNIDVFVDFLGSGSTFAGCSKTLKKHNSSIKCYVVEPETAAIYSGKEITDQGHKIQGGGYSM
DLPLVDKKLIDGYIQVTDEEATDVARKLAKLEGVFAGFSSGANVCAAIKLLKSSEKGKNIVLTLNDSGLKYLSTDLYEEL

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=316, Percent_Identity=33.2278481012658, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI295821200, Length=316, Percent_Identity=33.2278481012658, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI4557415, Length=316, Percent_Identity=33.2278481012658, Blast_Score=180, Evalue=1e-45,
Organism=Escherichia coli, GI1788754, Length=326, Percent_Identity=38.3435582822086, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI2367138, Length=317, Percent_Identity=31.8611987381703, Blast_Score=157, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17535051, Length=314, Percent_Identity=41.7197452229299, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17562970, Length=314, Percent_Identity=39.4904458598726, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI32566674, Length=306, Percent_Identity=39.8692810457516, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17561720, Length=314, Percent_Identity=38.5350318471338, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI115535073, Length=317, Percent_Identity=35.6466876971609, Blast_Score=172, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI25147552, Length=319, Percent_Identity=33.8557993730408, Blast_Score=134, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI32566672, Length=226, Percent_Identity=36.283185840708, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=30.625, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17561716, Length=123, Percent_Identity=37.3983739837398, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=297, Percent_Identity=34.6801346801347, Blast_Score=154, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6321449, Length=331, Percent_Identity=34.1389728096677, Blast_Score=136, Evalue=5e-33,
Organism=Drosophila melanogaster, GI24643623, Length=316, Percent_Identity=33.5443037974684, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI20129101, Length=316, Percent_Identity=33.5443037974684, Blast_Score=155, Evalue=3e-38,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34678; Mature: 34678

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLNNVTEAIGNTHMLHLSKIADEFGVQGNIYAKMEYLNPGFSKKDRVALQMITEAENA
CCHHHHHHHHHCCCEEEHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCC
GLLVPGQAVVELTSGNTGTGLAIACACKGYKFIACMSKGNSMERARMMKALGAEVVLVDQ
CEEECCCEEEEEECCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEC
MPNSVHGQVSGEDLALVEIEAQKIAKERNAFRADQFNLEACNHAHEKYTAEEMWEQLDGN
CCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCC
IDVFVDFLGSGSTFAGCSKTLKKHNSSIKCYVVEPETAAIYSGKEITDQGHKIQGGGYSM
EEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEECCCEECCCCCEECCCCEEE
DLPLVDKKLIDGYIQVTDEEATDVARKLAKLEGVFAGFSSGANVCAAIKLLKSSEKGKNI
CCCHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEE
VLTLNDSGLKYLSTDLYEEL
EEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure
MRVLNNVTEAIGNTHMLHLSKIADEFGVQGNIYAKMEYLNPGFSKKDRVALQMITEAENA
CCHHHHHHHHHCCCEEEHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCCC
GLLVPGQAVVELTSGNTGTGLAIACACKGYKFIACMSKGNSMERARMMKALGAEVVLVDQ
CEEECCCEEEEEECCCCCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEC
MPNSVHGQVSGEDLALVEIEAQKIAKERNAFRADQFNLEACNHAHEKYTAEEMWEQLDGN
CCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCC
IDVFVDFLGSGSTFAGCSKTLKKHNSSIKCYVVEPETAAIYSGKEITDQGHKIQGGGYSM
EEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEECCCEECCCCCEECCCCEEE
DLPLVDKKLIDGYIQVTDEEATDVARKLAKLEGVFAGFSSGANVCAAIKLLKSSEKGKNI
CCCHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEE
VLTLNDSGLKYLSTDLYEEL
EEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA