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The map label for this gene is hisA

Identifier: 126699156

GI number: 126699156

Start: 1799659

End: 1800381

Strand: Direct

Name: hisA

Synonym: CD1552

Alternate gene names: 126699156

Gene position: 1799659-1800381 (Clockwise)

Preceding gene: 126699155

Following gene: 126699157

Centisome position: 41.95

GC content: 29.88

Gene sequence:

>723_bases
ATGATAATATTTCCAGCAATAGATATAAAAGATAATAAGTGTGTAAGACTCACACAAGGAGAATTTGACAAAGTAAATGT
ATATTATGATAATCCATTAGAAGTAGCATATAAATGGAAAAATGAAGGAGCAGAATATATACATATAGTAGATTTAAATG
GTGCTAGAAGTGAATTTGGTGTAAATACAAAAATAATTGAGGACATAGCAAACAATATAGATATACCTATTCAAGTTGGC
GGTGGAGTTAGGGATAAGGAAAAAGTCAAAAGTTTAATAAATGCTGGTGTTACTAGAGTAATATTAGGTAGTATAGCGAT
TGAAAATTTGAATTTAGTTGAAGAATTGGTCAATGAATATAAAGAGAAAATTGTAGTTTCTATAGATGCTAAAGATGGAA
AAGTAGCAGTTAGGGGATGGGAAGTTGTAAGCAATGTAGACTCATTAACATTATGTAAACAACTTGAAAAGATAGGTGTA
CAAACTATTGTTTATACAGATATATCAAAAGATGGGATGTTACAAGGTCCAAATTTTGATATATATGAAAGAATAGCAAA
GGAAACATCACTAAATGTTATTGCTTCTGGAGGCGTAACTTCTATAGAAGACGTAAAAAGACTAAAAGCTATGAACTTAT
ATGGTGCAATAATAGGTAAAGCGCTTTATGATAAAAAGATAGACTTTAAGGAGGCACAACAATTATGCTTACTAGGAGAA
TAA

Upstream 100 bases:

>100_bases
CTATTGTTAGAAAAGGCAATGTATATGGTATACAATTTCATCCTGAAAAAAGTGGAGAAGTAGGGTTAAATATATTAAGA
GCATATGGGGAGATGATAAA

Downstream 100 bases:

>100_bases
TACCTTGTCTAGATGTGAGAAATGGAAGAGTTGTAAAGGGGAAAAAATTTAAAGATATAGTAGATGTTGATAGTCCAGAA
GTACTTGGAAAATTTTATAG

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylidene amino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MIIFPAIDIKDNKCVRLTQGEFDKVNVYYDNPLEVAYKWKNEGAEYIHIVDLNGARSEFGVNTKIIEDIANNIDIPIQVG
GGVRDKEKVKSLINAGVTRVILGSIAIENLNLVEELVNEYKEKIVVSIDAKDGKVAVRGWEVVSNVDSLTLCKQLEKIGV
QTIVYTDISKDGMLQGPNFDIYERIAKETSLNVIASGGVTSIEDVKRLKAMNLYGAIIGKALYDKKIDFKEAQQLCLLGE

Sequences:

>Translated_240_residues
MIIFPAIDIKDNKCVRLTQGEFDKVNVYYDNPLEVAYKWKNEGAEYIHIVDLNGARSEFGVNTKIIEDIANNIDIPIQVG
GGVRDKEKVKSLINAGVTRVILGSIAIENLNLVEELVNEYKEKIVVSIDAKDGKVAVRGWEVVSNVDSLTLCKQLEKIGV
QTIVYTDISKDGMLQGPNFDIYERIAKETSLNVIASGGVTSIEDVKRLKAMNLYGAIIGKALYDKKIDFKEAQQLCLLGE
>Mature_240_residues
MIIFPAIDIKDNKCVRLTQGEFDKVNVYYDNPLEVAYKWKNEGAEYIHIVDLNGARSEFGVNTKIIEDIANNIDIPIQVG
GGVRDKEKVKSLINAGVTRVILGSIAIENLNLVEELVNEYKEKIVVSIDAKDGKVAVRGWEVVSNVDSLTLCKQLEKIGV
QTIVYTDISKDGMLQGPNFDIYERIAKETSLNVIASGGVTSIEDVKRLKAMNLYGAIIGKALYDKKIDFKEAQQLCLLGE

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=238, Percent_Identity=34.8739495798319, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1788336, Length=241, Percent_Identity=23.2365145228216, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_CLOD6 (Q18C71)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001088053.1
- ProteinModelPortal:   Q18C71
- SMR:   Q18C71
- STRING:   Q18C71
- GeneID:   4913343
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD1552
- NMPDR:   fig|1496.1.peg.3366
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   CLSK2534932
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 26624; Mature: 26624

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIFPAIDIKDNKCVRLTQGEFDKVNVYYDNPLEVAYKWKNEGAEYIHIVDLNGARSEFG
CEEECEEECCCCCEEEEECCCCEEEEEEECCCEEEEEEECCCCCCEEEEEECCCCCHHCC
VNTKIIEDIANNIDIPIQVGGGVRDKEKVKSLINAGVTRVILGSIAIENLNLVEELVNEY
CCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHH
KEKIVVSIDAKDGKVAVRGWEVVSNVDSLTLCKQLEKIGVQTIVYTDISKDGMLQGPNFD
HHEEEEEEECCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCH
IYERIAKETSLNVIASGGVTSIEDVKRLKAMNLYGAIIGKALYDKKIDFKEAQQLCLLGE
HHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MIIFPAIDIKDNKCVRLTQGEFDKVNVYYDNPLEVAYKWKNEGAEYIHIVDLNGARSEFG
CEEECEEECCCCCEEEEECCCCEEEEEEECCCEEEEEEECCCCCCEEEEEECCCCCHHCC
VNTKIIEDIANNIDIPIQVGGGVRDKEKVKSLINAGVTRVILGSIAIENLNLVEELVNEY
CCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHH
KEKIVVSIDAKDGKVAVRGWEVVSNVDSLTLCKQLEKIGVQTIVYTDISKDGMLQGPNFD
HHEEEEEEECCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCH
IYERIAKETSLNVIASGGVTSIEDVKRLKAMNLYGAIIGKALYDKKIDFKEAQQLCLLGE
HHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA