Click here to switch to the map view.

The map label for this gene is pyrC

Identifier: 126699130

GI number: 126699130

Start: 1768750

End: 1770015

Strand: Direct

Name: pyrC

Synonym: CD1526

Alternate gene names: 126699130

Gene position: 1768750-1770015 (Clockwise)

Preceding gene: 126699129

Following gene: 126699136

Centisome position: 41.23

GC content: 32.62

Gene sequence:

>1266_bases
ATGATTTTAATTAAAAATGGTAGAGTAATAGACCCTAAAAGTCAAAGAGATGAGAATATTGACTTAATTATAAAAGAAAA
TAAAATTTATAAAATAGGCAAGTTTGATGAAAGTGATGAATATGAAAAAATAATAGATGCTAGTGGTAATGTAGTTGCTC
CAGGTTTAGTGGATGTACATGTACACTTTAGAGACCCTGGGTTTACATATAAAGAAGATATAGAAAGTGGAGCTAAATCT
GCTGCTAGAGGTGGATTTACAACTGTTATATGTATGGCAAATACTAATCCTATTGTAGATAATGAAGATACTTTTAATTA
TGTTAAAGAAAAGTCAAAAAATGCATGTATAAATGTTTTACAAGCAGCAGCTATAACTAAAGGTTTTGAAGGTAAAGAGT
TAGTTGATATGGAAGCTCTTAAAAAAGCTGGTGTACCAGGGTTTACTGATGATGGATTACCTTTAATGGATAGCAATCTA
ATTATGGAGGCAATGATTAAGGCAAAAGAGTTGGATGTACCACTTAGTTTTCATGAAGAAGACCCTTCTTTAGTTGGAAA
TCCAGGTGTAAATGCAGGAAAGGTAGCTTCAGAACTAGGATTAAAAGGTGCATCAAGTGTAGCAGAAGATGTTATGGTAG
CCAGAGATTGTATGTTGGCACTAAAGACTGGTGCTAAAGTTGATATACAACATATAAGTTCAGGTGTATCTGTTGATATG
GTTAGATTTGCAAAATACTTAGGTGCAACTGTAGTTGCAGAAGCTTCACCACATCACTTTACATTGACTGAGGAAGATGT
ATTGGAGTTTGGAACAAATGCAAAAATGAATCCACCTCTAAGAAGTAAATGGGACAGAGATAAGATTATAGAGGGATTAA
ATGATGGTACTATTGAAATAATAGCAACGGACCATGCACCTCATAGTAAAGAAGAAAAAGATAGAGAGTTTATAAAAGCT
CCAAGTGGAATTATTGGGCTTGAAACTTCTTTAGCTCTTGGAATAACAAATTTGGTGCATAAAAATCATCTTAGTATGAT
GCAGTTAATAGAAAAAATGTCTATAAATCCTGCAAAGTTGTACAATTTAAATATTGGATTTATAGAAGAAGGGGCTGTAG
CAGACATTGTTATATTCAATCCAGAAGAAGAATGGACAGTTGAAAGCTTTGTTTCTAAAGCTGATAATTCACCATTTAAA
GGTAAATCTTTATATGGAAAGGTTAATTATACAATATGTAATGGGGAGATTGTATATAACGCCTAA

Upstream 100 bases:

>100_bases
AAGGCTATTGATGTCAAACGTAATTTTGTATTTAAGTATGTAAAATAATGTATAATATTATATGAGTCTATATAAATTAA
AAATATAAAGGAGAAATAAT

Downstream 100 bases:

>100_bases
TTTAAGATTATTTTTTTTAGGCGGAGTGTACAATGATTGAAAGTAAAAGATTGTATATTAGGAGAATGAGATTGATTAAT
CAAAATTGGAAGTATTAGTT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MILIKNGRVIDPKSQRDENIDLIIKENKIYKIGKFDESDEYEKIIDASGNVVAPGLVDVHVHFRDPGFTYKEDIESGAKS
AARGGFTTVICMANTNPIVDNEDTFNYVKEKSKNACINVLQAAAITKGFEGKELVDMEALKKAGVPGFTDDGLPLMDSNL
IMEAMIKAKELDVPLSFHEEDPSLVGNPGVNAGKVASELGLKGASSVAEDVMVARDCMLALKTGAKVDIQHISSGVSVDM
VRFAKYLGATVVAEASPHHFTLTEEDVLEFGTNAKMNPPLRSKWDRDKIIEGLNDGTIEIIATDHAPHSKEEKDREFIKA
PSGIIGLETSLALGITNLVHKNHLSMMQLIEKMSINPAKLYNLNIGFIEEGAVADIVIFNPEEEWTVESFVSKADNSPFK
GKSLYGKVNYTICNGEIVYNA

Sequences:

>Translated_421_residues
MILIKNGRVIDPKSQRDENIDLIIKENKIYKIGKFDESDEYEKIIDASGNVVAPGLVDVHVHFRDPGFTYKEDIESGAKS
AARGGFTTVICMANTNPIVDNEDTFNYVKEKSKNACINVLQAAAITKGFEGKELVDMEALKKAGVPGFTDDGLPLMDSNL
IMEAMIKAKELDVPLSFHEEDPSLVGNPGVNAGKVASELGLKGASSVAEDVMVARDCMLALKTGAKVDIQHISSGVSVDM
VRFAKYLGATVVAEASPHHFTLTEEDVLEFGTNAKMNPPLRSKWDRDKIIEGLNDGTIEIIATDHAPHSKEEKDREFIKA
PSGIIGLETSLALGITNLVHKNHLSMMQLIEKMSINPAKLYNLNIGFIEEGAVADIVIFNPEEEWTVESFVSKADNSPFK
GKSLYGKVNYTICNGEIVYNA
>Mature_421_residues
MILIKNGRVIDPKSQRDENIDLIIKENKIYKIGKFDESDEYEKIIDASGNVVAPGLVDVHVHFRDPGFTYKEDIESGAKS
AARGGFTTVICMANTNPIVDNEDTFNYVKEKSKNACINVLQAAAITKGFEGKELVDMEALKKAGVPGFTDDGLPLMDSNL
IMEAMIKAKELDVPLSFHEEDPSLVGNPGVNAGKVASELGLKGASSVAEDVMVARDCMLALKTGAKVDIQHISSGVSVDM
VRFAKYLGATVVAEASPHHFTLTEEDVLEFGTNAKMNPPLRSKWDRDKIIEGLNDGTIEIIATDHAPHSKEEKDREFIKA
PSGIIGLETSLALGITNLVHKNHLSMMQLIEKMSINPAKLYNLNIGFIEEGAVADIVIFNPEEEWTVESFVSKADNSPFK
GKSLYGKVNYTICNGEIVYNA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=369, Percent_Identity=30.0813008130081, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI19923821, Length=451, Percent_Identity=26.3858093126386, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI4503051, Length=451, Percent_Identity=24.8337028824834, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI62422571, Length=451, Percent_Identity=24.8337028824834, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI4503379, Length=446, Percent_Identity=23.3183856502242, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4503377, Length=452, Percent_Identity=24.5575221238938, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1786722, Length=437, Percent_Identity=28.8329519450801, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87082175, Length=445, Percent_Identity=26.7415730337079, Blast_Score=135, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI193204318, Length=370, Percent_Identity=31.0810810810811, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI86575075, Length=444, Percent_Identity=25.2252252252252, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71989490, Length=448, Percent_Identity=23.8839285714286, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17539558, Length=450, Percent_Identity=22.8888888888889, Blast_Score=82, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6322218, Length=401, Percent_Identity=27.431421446384, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24642586, Length=371, Percent_Identity=29.6495956873315, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI18859883, Length=416, Percent_Identity=26.9230769230769, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI221377917, Length=450, Percent_Identity=23.7777777777778, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17137462, Length=444, Percent_Identity=23.6486486486486, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_CLOD6 (Q18C47)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001088027.1
- ProteinModelPortal:   Q18C47
- SMR:   Q18C47
- STRING:   Q18C47
- GeneID:   4914653
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD1526
- NMPDR:   fig|1496.1.peg.3393
- eggNOG:   COG0044
- HOGENOM:   HBG724623
- OMA:   PRVAEES
- ProtClustDB:   PRK09357
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 45977; Mature: 45977

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILIKNGRVIDPKSQRDENIDLIIKENKIYKIGKFDESDEYEKIIDASGNVVAPGLVDVH
CEEECCCEEECCCCCCCCCEEEEEECCCEEEECCCCCCHHHHHHHCCCCCEECCCEEEEE
VHFRDPGFTYKEDIESGAKSAARGGFTTVICMANTNPIVDNEDTFNYVKEKSKNACINVL
EEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHH
QAAAITKGFEGKELVDMEALKKAGVPGFTDDGLPLMDSNLIMEAMIKAKELDVPLSFHEE
HHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCC
DPSLVGNPGVNAGKVASELGLKGASSVAEDVMVARDCMLALKTGAKVDIQHISSGVSVDM
CCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCCCCHHH
VRFAKYLGATVVAEASPHHFTLTEEDVLEFGTNAKMNPPLRSKWDRDKIIEGLNDGTIEI
HHHHHHHCCEEEECCCCCEEECCHHHHHHCCCCCCCCCCHHCCCCHHHHHHCCCCCEEEE
IATDHAPHSKEEKDREFIKAPSGIIGLETSLALGITNLVHKNHLSMMQLIEKMSINPAKL
EEECCCCCCCCHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
YNLNIGFIEEGAVADIVIFNPEEEWTVESFVSKADNSPFKGKSLYGKVNYTICNGEIVYN
EEEEECEECCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCEEEEC
A
C
>Mature Secondary Structure
MILIKNGRVIDPKSQRDENIDLIIKENKIYKIGKFDESDEYEKIIDASGNVVAPGLVDVH
CEEECCCEEECCCCCCCCCEEEEEECCCEEEECCCCCCHHHHHHHCCCCCEECCCEEEEE
VHFRDPGFTYKEDIESGAKSAARGGFTTVICMANTNPIVDNEDTFNYVKEKSKNACINVL
EEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHH
QAAAITKGFEGKELVDMEALKKAGVPGFTDDGLPLMDSNLIMEAMIKAKELDVPLSFHEE
HHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCC
DPSLVGNPGVNAGKVASELGLKGASSVAEDVMVARDCMLALKTGAKVDIQHISSGVSVDM
CCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCCCCHHH
VRFAKYLGATVVAEASPHHFTLTEEDVLEFGTNAKMNPPLRSKWDRDKIIEGLNDGTIEI
HHHHHHHCCEEEECCCCCEEECCHHHHHHCCCCCCCCCCHHCCCCHHHHHHCCCCCEEEE
IATDHAPHSKEEKDREFIKAPSGIIGLETSLALGITNLVHKNHLSMMQLIEKMSINPAKL
EEECCCCCCCCHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
YNLNIGFIEEGAVADIVIFNPEEEWTVESFVSKADNSPFKGKSLYGKVNYTICNGEIVYN
EEEEECEECCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEEEECCEEEEC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA