Click here to switch to the map view.

The map label for this gene is bacA [H]

Identifier: 126699005

GI number: 126699005

Start: 1622771

End: 1624960

Strand: Direct

Name: bacA [H]

Synonym: CD1403

Alternate gene names: 126699005

Gene position: 1622771-1624960 (Clockwise)

Preceding gene: 126699002

Following gene: 126699006

Centisome position: 37.82

GC content: 27.99

Gene sequence:

>2190_bases
ATGTATGAAGTTAATTTAGAACGAGCTATGAATTATTGGATGGATTTGTTAGATGATTATACGAATATAGCAAAAATTCC
AAATGATTTTTTTTATAAAGATTGTTCTGATGAAGTAGTAGATGAGGTTTTTAAGATGAATATTGAGAAACATGAAAGGT
TAATTCAATATTCTAAAGTGAACAATATTAGCATAGACTCTATCATAGAAACTATATATGGCCTTATACTTCAAAAGTAT
ATATATGAAGATGATGTAGTTTTTGGTAAAACAATGAATATAATTCCAATAAGAGTAAGAGTTAGACAAAGTGAAAAATT
TATAGATGTTGTAAGGAAGCTAAAAAGGCAGTGGAGCAGGTCTTTAGAGTATGGATACTATTTGTTATCAGATATAGAGA
ATAAAAATCATCTAAATACTAAGCTTATAAACACAATATTTATAGCTAAAAGTTTTGATTTATCATATGATTATGACATA
GAAAAAAAAGGATATGATTTATCTGTAATAGTATATACTAAGAGGGCACTTAAAATAAAAATAAAGTATAAACCATCTAT
ATATAAAAGAGAAACTATTAGAAGAATTTTAAATCAATTTGATTATATAATAGAGCAAATAATAGAAGATAATGATATTT
TAATAGAAGATTTAGAATTTGTATGTAAGGAAGAAGAAAAAGTATTATTGGAAGACTTTAATAATAATCAATATGAAATA
CCATATGATAAAAGTTATGTTGATTTATTTAGGGAGCAAGTTAAGGTAACACCTAGTAATATAGCTACTAGGGATGAAAA
TAGAAAGTTAACATATAAAGAATTGGATGAAGTAACTGATAAACTTGCAGGTTATTTAAATCATATAGGAGTGGAAAGTG
AAGACATAGTAGCTGTAATGTTACCAAGAGATATTAACATAATTATTACAGCAATAGGGATTATGAAATCAGGGGGAGCA
TTTTTTCCAATAGACACAAGTAATCCAGAAGAAAGATTGAATTACCTTCTTGAAGATAGTAATGCAAAAGTAGTGATAAC
TACAGATGAACTCAAAAGTAAGGTTGTAAATGAGAATACCATAGTACTCGATGTAAATGATGAAGAAATGTTTAAGTTTG
GATATGAATTAACTGAAAAAATAACATCATCAAATTGTGCATATACGATATCTACTTCAGGGTCAACTGGTAGGCCAAAG
ACCATAGCTATAGAACATAAGAGTTTAGTAAATATGTGTTATTATAGCGTAAAATCTATAAGCGCTACAGAAAATGATAT
ATGTGGTATATACTTAAGTTTCAGTTTTGATGCTGTAATGAAACAACTATTCCCTTATTTGCTTGTAGGTGCATCAATAG
ATATTATGCCTGAAGAAGCTAAATTTGATGAATATACAGTAAATGAATACTGTGAGGAAAATGACATAACTATACTAGCA
TTGCCAACAGCATTTGCAAGGTTATTTATACAAAATTGCAATAATAATTCACTTAGAGTTGTACAGACTGGAGGAGAAAG
ATTAAAAGGATATAGAAAGCGTAATTATGAACTATATAATGAGTATGGACCAACCGAATTTACTGTTGTATCGACTTCTT
TTCATGTGGACAGAGAGTATGGAAAAATACCAATAGGAAAACCTATATTTAATACTTATGCATATGTATTAGATAAAAAG
AACAAACTATGTCCAATTGGAGCTCCAGGAGAGCTATGTCTATCAGGCATTCAAATATCAAGAGGATATTTAAATAAAAA
AGGGCTAACAGAGCAAGTATTTGTAAAGAATCCTTACAAAACTTGTGAACATAATAAGTTAATGTATAGAACTGGTGATT
TAGTAAGATGGTTAGATGATGGAAATTTAGATTATATTGGAAGGATGGACAATCAAGTAAAAATTGATGAGTTTAGGATA
GAGCTATATGAGATTGAAAATATAATAAATAATATTACAGAAATTAAAAGTGTTGTTTGTATATCGAGAACAAATGATGA
TGGAGATATGTATATATGTGCATATTATGTAATTGATGAGGAAGATAGTGGTAAGATAAATGAAAGAACTATTAGAGAAT
ATTTAAATGAGCATCTACCTCCATATATGATTCCAACAATAATAATGAGGATAGATAAGATACCAGTTACACCAATCGGA
AAAGTAAATAAAAGAGCATTACCAGAATAA

Upstream 100 bases:

>100_bases
TTAGAGCTTGCATATGTATTATTAATATATTTATATATTGTGAAAATAAAATTCCAAAAGAATTTTTTCTATAGACTTAG
TAGTAAGGGGGAATTTTGAT

Downstream 100 bases:

>100_bases
TTTTTTATTATGATAGGTGTCATAAAGTGATTTCAGACATTTCTTTATGACACTTATTTTTATAAAATAATCAATTTGCA
TAAAAACAAGAATTTTCTGT

Product: nonribosomal peptide synthetase

Products: NA

Alternate protein names: BA1; ATP-dependent isoleucine adenylase; IleA; Isoleucine activase; ATP-dependent cysteine adenylase; CysA; Cysteine activase; ATP-dependent leucine adenylase; LeuA; Leucine activase; ATP-dependent glutamate adenylase; GluA; Glutamate activase; ATP-dependent isoleucine adenylase; IleA; Isoleucine activase; Glutamate racemase [H]

Number of amino acids: Translated: 729; Mature: 729

Protein sequence:

>729_residues
MYEVNLERAMNYWMDLLDDYTNIAKIPNDFFYKDCSDEVVDEVFKMNIEKHERLIQYSKVNNISIDSIIETIYGLILQKY
IYEDDVVFGKTMNIIPIRVRVRQSEKFIDVVRKLKRQWSRSLEYGYYLLSDIENKNHLNTKLINTIFIAKSFDLSYDYDI
EKKGYDLSVIVYTKRALKIKIKYKPSIYKRETIRRILNQFDYIIEQIIEDNDILIEDLEFVCKEEEKVLLEDFNNNQYEI
PYDKSYVDLFREQVKVTPSNIATRDENRKLTYKELDEVTDKLAGYLNHIGVESEDIVAVMLPRDINIIITAIGIMKSGGA
FFPIDTSNPEERLNYLLEDSNAKVVITTDELKSKVVNENTIVLDVNDEEMFKFGYELTEKITSSNCAYTISTSGSTGRPK
TIAIEHKSLVNMCYYSVKSISATENDICGIYLSFSFDAVMKQLFPYLLVGASIDIMPEEAKFDEYTVNEYCEENDITILA
LPTAFARLFIQNCNNNSLRVVQTGGERLKGYRKRNYELYNEYGPTEFTVVSTSFHVDREYGKIPIGKPIFNTYAYVLDKK
NKLCPIGAPGELCLSGIQISRGYLNKKGLTEQVFVKNPYKTCEHNKLMYRTGDLVRWLDDGNLDYIGRMDNQVKIDEFRI
ELYEIENIINNITEIKSVVCISRTNDDGDMYICAYYVIDEEDSGKINERTIREYLNEHLPPYMIPTIIMRIDKIPVTPIG
KVNKRALPE

Sequences:

>Translated_729_residues
MYEVNLERAMNYWMDLLDDYTNIAKIPNDFFYKDCSDEVVDEVFKMNIEKHERLIQYSKVNNISIDSIIETIYGLILQKY
IYEDDVVFGKTMNIIPIRVRVRQSEKFIDVVRKLKRQWSRSLEYGYYLLSDIENKNHLNTKLINTIFIAKSFDLSYDYDI
EKKGYDLSVIVYTKRALKIKIKYKPSIYKRETIRRILNQFDYIIEQIIEDNDILIEDLEFVCKEEEKVLLEDFNNNQYEI
PYDKSYVDLFREQVKVTPSNIATRDENRKLTYKELDEVTDKLAGYLNHIGVESEDIVAVMLPRDINIIITAIGIMKSGGA
FFPIDTSNPEERLNYLLEDSNAKVVITTDELKSKVVNENTIVLDVNDEEMFKFGYELTEKITSSNCAYTISTSGSTGRPK
TIAIEHKSLVNMCYYSVKSISATENDICGIYLSFSFDAVMKQLFPYLLVGASIDIMPEEAKFDEYTVNEYCEENDITILA
LPTAFARLFIQNCNNNSLRVVQTGGERLKGYRKRNYELYNEYGPTEFTVVSTSFHVDREYGKIPIGKPIFNTYAYVLDKK
NKLCPIGAPGELCLSGIQISRGYLNKKGLTEQVFVKNPYKTCEHNKLMYRTGDLVRWLDDGNLDYIGRMDNQVKIDEFRI
ELYEIENIINNITEIKSVVCISRTNDDGDMYICAYYVIDEEDSGKINERTIREYLNEHLPPYMIPTIIMRIDKIPVTPIG
KVNKRALPE
>Mature_729_residues
MYEVNLERAMNYWMDLLDDYTNIAKIPNDFFYKDCSDEVVDEVFKMNIEKHERLIQYSKVNNISIDSIIETIYGLILQKY
IYEDDVVFGKTMNIIPIRVRVRQSEKFIDVVRKLKRQWSRSLEYGYYLLSDIENKNHLNTKLINTIFIAKSFDLSYDYDI
EKKGYDLSVIVYTKRALKIKIKYKPSIYKRETIRRILNQFDYIIEQIIEDNDILIEDLEFVCKEEEKVLLEDFNNNQYEI
PYDKSYVDLFREQVKVTPSNIATRDENRKLTYKELDEVTDKLAGYLNHIGVESEDIVAVMLPRDINIIITAIGIMKSGGA
FFPIDTSNPEERLNYLLEDSNAKVVITTDELKSKVVNENTIVLDVNDEEMFKFGYELTEKITSSNCAYTISTSGSTGRPK
TIAIEHKSLVNMCYYSVKSISATENDICGIYLSFSFDAVMKQLFPYLLVGASIDIMPEEAKFDEYTVNEYCEENDITILA
LPTAFARLFIQNCNNNSLRVVQTGGERLKGYRKRNYELYNEYGPTEFTVVSTSFHVDREYGKIPIGKPIFNTYAYVLDKK
NKLCPIGAPGELCLSGIQISRGYLNKKGLTEQVFVKNPYKTCEHNKLMYRTGDLVRWLDDGNLDYIGRMDNQVKIDEFRI
ELYEIENIINNITEIKSVVCISRTNDDGDMYICAYYVIDEEDSGKINERTIREYLNEHLPPYMIPTIIMRIDKIPVTPIG
KVNKRALPE

Specific function: Activates five amino acids, incorporates two D-amino acids, releases and cyclizes the mature bacitracin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 5 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI38505220, Length=495, Percent_Identity=25.0505050505051, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI122937307, Length=526, Percent_Identity=24.3346007604563, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI45580730, Length=528, Percent_Identity=21.969696969697, Blast_Score=92, Evalue=3e-18,
Organism=Homo sapiens, GI42544132, Length=523, Percent_Identity=23.1357552581262, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1786801, Length=679, Percent_Identity=27.8350515463918, Blast_Score=256, Evalue=5e-69,
Organism=Escherichia coli, GI1788107, Length=544, Percent_Identity=20.7720588235294, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI1786810, Length=514, Percent_Identity=22.568093385214, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI221142682, Length=501, Percent_Identity=21.7564870259481, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17556356, Length=446, Percent_Identity=26.9058295964126, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI32563687, Length=505, Percent_Identity=22.970297029703, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994690, Length=614, Percent_Identity=22.6384364820847, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994703, Length=550, Percent_Identity=22.1818181818182, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71994694, Length=550, Percent_Identity=22.1818181818182, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71996755, Length=510, Percent_Identity=22.5490196078431, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115534440, Length=547, Percent_Identity=23.0347349177331, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI32564422, Length=359, Percent_Identity=21.7270194986072, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32564420, Length=359, Percent_Identity=21.7270194986072, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17531443, Length=544, Percent_Identity=21.6911764705882, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319591, Length=648, Percent_Identity=23.1481481481481, Blast_Score=147, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6319699, Length=524, Percent_Identity=20.4198473282443, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24648676, Length=519, Percent_Identity=25.0481695568401, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24581924, Length=571, Percent_Identity=21.8914185639229, Blast_Score=84, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR013624
- InterPro:   IPR010060
- InterPro:   IPR006163
- InterPro:   IPR006162 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF08415 NRPS; PF00550 PP-binding [H]

EC number: =5.1.1.3 [H]

Molecular weight: Translated: 84849; Mature: 84849

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYEVNLERAMNYWMDLLDDYTNIAKIPNDFFYKDCSDEVVDEVFKMNIEKHERLIQYSKV
CEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCC
NNISIDSIIETIYGLILQKYIYEDDVVFGKTMNIIPIRVRVRQSEKFIDVVRKLKRQWSR
CCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEEEECCHHHHHHHHHHHHHHHH
SLEYGYYLLSDIENKNHLNTKLINTIFIAKSFDLSYDYDIEKKGYDLSVIVYTKRALKIK
CHHCCEEEEECCCCCCCCHHHHHHEEEEEEECCCCCCCCCCCCCCEEEEEEEEEEEEEEE
IKYKPSIYKRETIRRILNQFDYIIEQIIEDNDILIEDLEFVCKEEEKVLLEDFNNNQYEI
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHCCCCCCEEEC
PYDKSYVDLFREQVKVTPSNIATRDENRKLTYKELDEVTDKLAGYLNHIGVESEDIVAVM
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
LPRDINIIITAIGIMKSGGAFFPIDTSNPEERLNYLLEDSNAKVVITTDELKSKVVNENT
ECCCCEEEEEEEEHHCCCCEEEECCCCCHHHHHHHHEECCCCEEEEECHHHHHHHCCCCE
IVLDVNDEEMFKFGYELTEKITSSNCAYTISTSGSTGRPKTIAIEHKSLVNMCYYSVKSI
EEEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHC
SATENDICGIYLSFSFDAVMKQLFPYLLVGASIDIMPEEAKFDEYTVNEYCEENDITILA
CCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHCCCCCEEEEE
LPTAFARLFIQNCNNNSLRVVQTGGERLKGYRKRNYELYNEYGPTEFTVVSTSFHVDREY
EHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCEEECCCCCCEEEEEEEEEEEECCC
GKIPIGKPIFNTYAYVLDKKNKLCPIGAPGELCLSGIQISRGYLNKKGLTEQVFVKNPYK
CCCCCCCHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCC
TCEHNKLMYRTGDLVRWLDDGNLDYIGRMDNQVKIDEFRIELYEIENIINNITEIKSVVC
CCCCCEEEEECCCEEEEECCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHEEE
ISRTNDDGDMYICAYYVIDEEDSGKINERTIREYLNEHLPPYMIPTIIMRIDKIPVTPIG
EEEECCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC
KVNKRALPE
CCCCCCCCC
>Mature Secondary Structure
MYEVNLERAMNYWMDLLDDYTNIAKIPNDFFYKDCSDEVVDEVFKMNIEKHERLIQYSKV
CEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHCC
NNISIDSIIETIYGLILQKYIYEDDVVFGKTMNIIPIRVRVRQSEKFIDVVRKLKRQWSR
CCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEEEEECCHHHHHHHHHHHHHHHH
SLEYGYYLLSDIENKNHLNTKLINTIFIAKSFDLSYDYDIEKKGYDLSVIVYTKRALKIK
CHHCCEEEEECCCCCCCCHHHHHHEEEEEEECCCCCCCCCCCCCCEEEEEEEEEEEEEEE
IKYKPSIYKRETIRRILNQFDYIIEQIIEDNDILIEDLEFVCKEEEKVLLEDFNNNQYEI
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHCCCCCCEEEC
PYDKSYVDLFREQVKVTPSNIATRDENRKLTYKELDEVTDKLAGYLNHIGVESEDIVAVM
CCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEE
LPRDINIIITAIGIMKSGGAFFPIDTSNPEERLNYLLEDSNAKVVITTDELKSKVVNENT
ECCCCEEEEEEEEHHCCCCEEEECCCCCHHHHHHHHEECCCCEEEEECHHHHHHHCCCCE
IVLDVNDEEMFKFGYELTEKITSSNCAYTISTSGSTGRPKTIAIEHKSLVNMCYYSVKSI
EEEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHC
SATENDICGIYLSFSFDAVMKQLFPYLLVGASIDIMPEEAKFDEYTVNEYCEENDITILA
CCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCHHHHCCCCCEEEEE
LPTAFARLFIQNCNNNSLRVVQTGGERLKGYRKRNYELYNEYGPTEFTVVSTSFHVDREY
EHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCEEECCCCCCEEEEEEEEEEEECCC
GKIPIGKPIFNTYAYVLDKKNKLCPIGAPGELCLSGIQISRGYLNKKGLTEQVFVKNPYK
CCCCCCCHHHHHHHHEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCCC
TCEHNKLMYRTGDLVRWLDDGNLDYIGRMDNQVKIDEFRIELYEIENIINNITEIKSVVC
CCCCCEEEEECCCEEEEECCCCEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHEEE
ISRTNDDGDMYICAYYVIDEEDSGKINERTIREYLNEHLPPYMIPTIIMRIDKIPVTPIG
EEEECCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC
KVNKRALPE
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9427658 [H]