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The map label for this gene is glpK2 [H]

Identifier: 126698985

GI number: 126698985

Start: 1600097

End: 1601611

Strand: Direct

Name: glpK2 [H]

Synonym: CD1382

Alternate gene names: 126698985

Gene position: 1600097-1601611 (Clockwise)

Preceding gene: 126698981

Following gene: 126698987

Centisome position: 37.3

GC content: 33.53

Gene sequence:

>1515_bases
ATGGAAAAGAAGTATGTAATGGCATTAGACCAAGGAACAACCAGTTCAAGAGCTATACTATTTAATAAAAAAGGCGAAAT
AGTGAAAATTGCACAAAAAGAGTTCAATCAAATTTATCCAAAAGCTGGATGGGTAGAGCATGACCCTATGGAAATATGGG
GGTCACAAAGTGGGGTAATGAGAGAAGTTATAGAAACAGCAGGTATAAGACCAGAAGAAATTGCTTCAATAGGGATAACT
AATCAAAGAGAGACTACGGTTGTTTGGAGTAGGTATACTGGTAAACCTATTTATAACGCAATAGTATGGCAGTGTAGGAG
AACGTCAGAAATATGTGATGAACTTAAAAATAAAGGATTGGAAGAATCAATAAAAGAAAAAACAGGTCTTTTAATAGATG
CATACTTTTCAGCAACAAAAGTAAAATGGATATTAGATAATGTAGAAGGAGCTAGGGAAAAAGCAGAACAAGGAGAGTTA
TTATTTGGAACTATAGATACATGGTTAATATGGAATTTAACTCGTGGAAAAGTACATGTAACAGATTACTCAAATGCATC
TAGAACAATGATGTACAATATAAATGATTTAGAATGGGATGAGGATATATTACGAGAATTGAACATACCAATAAGCATGT
TGCCATTAGTAAAACCTTCTAGCTATGTTTATGGTCATACAGATGAGCGCATGTTATCAGGAGCTAAAATACCTATTGCG
GGATGTGCTGGAGACCAACAAGCAGCATTATTTGGTCAAAATTGTGTTGAAGAAGGTACTGCAAAAAATACTTATGGAAC
GGGTTGTTTCTTGCTTATGAATACAGGCAGTAACATAGTTAAATCTAAGCATGGGTTACTTACAACAATTGCTTGGGGAG
TTGATGGAAAAGTAACATATGCATTAGAAGGAAGTATATTTATTGGAGGAGCATCTGTTCAATGGCTTAGAGATGAATTA
AAGATAATTGAATCTGCAAAAGATAGTGAAATGTATGCAAATAGGGTAGAGGATACTAATGGTGTATATGTAGTGCCAGC
ATTTACAGGTCTTGGAGCTCCATATTGGGATATGTATGCTAGGGGTTCAATTTTAGGACTTACAAGAGGAGCAAAAAAAG
AACATATAGTAAGAGCCACATTGGAATCAATTGCTTATCAGACAAAGGATGTTTTAGAAGCAATGCAAAACGATTCAAAA
TTAAAACTAAAATCATTAAAAGTTGATGGTGGAGCAAGTAATAATAATTTTTTAATGCAATTTCAATCAGATATATTAAA
TGTAGATATAGATAGACCCAAAATAGTAGAAACTACAGCTTTAGGAGCTGCTTATTTAGCAGGGTTGTCTGTTGGATTTT
ATATTGGAAGAAATGAAATTACTTCAAAGTGGTCAGTAGAAAAAGAGTTTAATCCAAATATGAGTGAAGAGAAGAGATGT
AAATTATATAAAGGATGGAAAAAAGCTGTATCGAGAGCTTTAAGCTGGGAAAAAGAAGATGAATTGGATATTTAA

Upstream 100 bases:

>100_bases
ATATTAAATTTGTATTTAAGTATGATTATTTATTGAAATATGTGATATTAAATTTTTCTTTTTAATAAATTAAATATTAT
ATGATAAGGAGAATATGGTG

Downstream 100 bases:

>100_bases
AAATTAATCAAAGTTAAATTTATTTGAATTTAAAAAGAGCTTTATGTAAAATATGAAGCTCTTTTTTTGTTGTTAATTTT
GCATTTTTATATAATCACAC

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MEKKYVMALDQGTTSSRAILFNKKGEIVKIAQKEFNQIYPKAGWVEHDPMEIWGSQSGVMREVIETAGIRPEEIASIGIT
NQRETTVVWSRYTGKPIYNAIVWQCRRTSEICDELKNKGLEESIKEKTGLLIDAYFSATKVKWILDNVEGAREKAEQGEL
LFGTIDTWLIWNLTRGKVHVTDYSNASRTMMYNINDLEWDEDILRELNIPISMLPLVKPSSYVYGHTDERMLSGAKIPIA
GCAGDQQAALFGQNCVEEGTAKNTYGTGCFLLMNTGSNIVKSKHGLLTTIAWGVDGKVTYALEGSIFIGGASVQWLRDEL
KIIESAKDSEMYANRVEDTNGVYVVPAFTGLGAPYWDMYARGSILGLTRGAKKEHIVRATLESIAYQTKDVLEAMQNDSK
LKLKSLKVDGGASNNNFLMQFQSDILNVDIDRPKIVETTALGAAYLAGLSVGFYIGRNEITSKWSVEKEFNPNMSEEKRC
KLYKGWKKAVSRALSWEKEDELDI

Sequences:

>Translated_504_residues
MEKKYVMALDQGTTSSRAILFNKKGEIVKIAQKEFNQIYPKAGWVEHDPMEIWGSQSGVMREVIETAGIRPEEIASIGIT
NQRETTVVWSRYTGKPIYNAIVWQCRRTSEICDELKNKGLEESIKEKTGLLIDAYFSATKVKWILDNVEGAREKAEQGEL
LFGTIDTWLIWNLTRGKVHVTDYSNASRTMMYNINDLEWDEDILRELNIPISMLPLVKPSSYVYGHTDERMLSGAKIPIA
GCAGDQQAALFGQNCVEEGTAKNTYGTGCFLLMNTGSNIVKSKHGLLTTIAWGVDGKVTYALEGSIFIGGASVQWLRDEL
KIIESAKDSEMYANRVEDTNGVYVVPAFTGLGAPYWDMYARGSILGLTRGAKKEHIVRATLESIAYQTKDVLEAMQNDSK
LKLKSLKVDGGASNNNFLMQFQSDILNVDIDRPKIVETTALGAAYLAGLSVGFYIGRNEITSKWSVEKEFNPNMSEEKRC
KLYKGWKKAVSRALSWEKEDELDI
>Mature_504_residues
MEKKYVMALDQGTTSSRAILFNKKGEIVKIAQKEFNQIYPKAGWVEHDPMEIWGSQSGVMREVIETAGIRPEEIASIGIT
NQRETTVVWSRYTGKPIYNAIVWQCRRTSEICDELKNKGLEESIKEKTGLLIDAYFSATKVKWILDNVEGAREKAEQGEL
LFGTIDTWLIWNLTRGKVHVTDYSNASRTMMYNINDLEWDEDILRELNIPISMLPLVKPSSYVYGHTDERMLSGAKIPIA
GCAGDQQAALFGQNCVEEGTAKNTYGTGCFLLMNTGSNIVKSKHGLLTTIAWGVDGKVTYALEGSIFIGGASVQWLRDEL
KIIESAKDSEMYANRVEDTNGVYVVPAFTGLGAPYWDMYARGSILGLTRGAKKEHIVRATLESIAYQTKDVLEAMQNDSK
LKLKSLKVDGGASNNNFLMQFQSDILNVDIDRPKIVETTALGAAYLAGLSVGFYIGRNEITSKWSVEKEFNPNMSEEKRC
KLYKGWKKAVSRALSWEKEDELDI

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=511, Percent_Identity=46.7710371819961, Blast_Score=434, Evalue=1e-122,
Organism=Homo sapiens, GI4504007, Length=511, Percent_Identity=46.7710371819961, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI41393575, Length=511, Percent_Identity=46.5753424657534, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI42794763, Length=515, Percent_Identity=46.4077669902913, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI88196792, Length=512, Percent_Identity=34.1796875, Blast_Score=332, Evalue=4e-91,
Organism=Escherichia coli, GI1790361, Length=500, Percent_Identity=65.2, Blast_Score=704, Evalue=0.0,
Organism=Escherichia coli, GI1787789, Length=475, Percent_Identity=25.6842105263158, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790005, Length=464, Percent_Identity=23.0603448275862, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1789987, Length=480, Percent_Identity=21.875, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789138, Length=315, Percent_Identity=26.984126984127, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789168, Length=493, Percent_Identity=21.9066937119675, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17535599, Length=504, Percent_Identity=43.6507936507937, Blast_Score=411, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71986140, Length=530, Percent_Identity=26.4150943396226, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71986147, Length=266, Percent_Identity=31.5789473684211, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6321755, Length=552, Percent_Identity=36.231884057971, Blast_Score=315, Evalue=1e-86,
Organism=Drosophila melanogaster, GI17864214, Length=512, Percent_Identity=44.53125, Blast_Score=425, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24654573, Length=451, Percent_Identity=45.2328159645233, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24655555, Length=503, Percent_Identity=39.5626242544732, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24655560, Length=503, Percent_Identity=39.5626242544732, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24655570, Length=503, Percent_Identity=39.5626242544732, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24655574, Length=503, Percent_Identity=39.5626242544732, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24655565, Length=503, Percent_Identity=39.5626242544732, Blast_Score=383, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19922058, Length=543, Percent_Identity=33.5174953959484, Blast_Score=291, Evalue=5e-79,
Organism=Drosophila melanogaster, GI24652871, Length=510, Percent_Identity=33.921568627451, Blast_Score=275, Evalue=7e-74,
Organism=Drosophila melanogaster, GI24656367, Length=513, Percent_Identity=28.2651072124756, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI21357867, Length=525, Percent_Identity=27.047619047619, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24656372, Length=349, Percent_Identity=29.7994269340974, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI45552909, Length=290, Percent_Identity=28.9655172413793, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 56440; Mature: 56440

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKYVMALDQGTTSSRAILFNKKGEIVKIAQKEFNQIYPKAGWVEHDPMEIWGSQSGVM
CCCCEEEEEECCCCCCEEEEEECCCCEEEHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHH
REVIETAGIRPEEIASIGITNQRETTVVWSRYTGKPIYNAIVWQCRRTSEICDELKNKGL
HHHHHHCCCCHHHHHEECCCCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHCCH
EESIKEKTGLLIDAYFSATKVKWILDNVEGAREKAEQGELLFGTIDTWLIWNLTRGKVHV
HHHHHHHCCEEEEEECCHHEEEEEHHCCHHHHHHHHCCCEEEEEECEEEEEEEECCEEEE
TDYSNASRTMMYNINDLEWDEDILRELNIPISMLPLVKPSSYVYGHTDERMLSGAKIPIA
EECCCCCCEEEEECCCCCCCHHHHHHCCCCEEEEECCCCCCEEECCCHHHHHCCCCCEEE
GCAGDQQAALFGQNCVEEGTAKNTYGTGCFLLMNTGSNIVKSKHGLLTTIAWGVDGKVTY
ECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHCCCCEEEEEEECCCCEEEE
ALEGSIFIGGASVQWLRDELKIIESAKDSEMYANRVEDTNGVYVVPAFTGLGAPYWDMYA
EEECEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHH
RGSILGLTRGAKKEHIVRATLESIAYQTKDVLEAMQNDSKLKLKSLKVDGGASNNNFLMQ
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEEE
FQSDILNVDIDRPKIVETTALGAAYLAGLSVGFYIGRNEITSKWSVEKEFNPNMSEEKRC
EECCCEEEECCCCCEEEHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCHHHHH
KLYKGWKKAVSRALSWEKEDELDI
HHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MEKKYVMALDQGTTSSRAILFNKKGEIVKIAQKEFNQIYPKAGWVEHDPMEIWGSQSGVM
CCCCEEEEEECCCCCCEEEEEECCCCEEEHHHHHHHHHCCCCCCCCCCCHHHCCCCCHHH
REVIETAGIRPEEIASIGITNQRETTVVWSRYTGKPIYNAIVWQCRRTSEICDELKNKGL
HHHHHHCCCCHHHHHEECCCCCCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHCCH
EESIKEKTGLLIDAYFSATKVKWILDNVEGAREKAEQGELLFGTIDTWLIWNLTRGKVHV
HHHHHHHCCEEEEEECCHHEEEEEHHCCHHHHHHHHCCCEEEEEECEEEEEEEECCEEEE
TDYSNASRTMMYNINDLEWDEDILRELNIPISMLPLVKPSSYVYGHTDERMLSGAKIPIA
EECCCCCCEEEEECCCCCCCHHHHHHCCCCEEEEECCCCCCEEECCCHHHHHCCCCCEEE
GCAGDQQAALFGQNCVEEGTAKNTYGTGCFLLMNTGSNIVKSKHGLLTTIAWGVDGKVTY
ECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHCCCCEEEEEEECCCCEEEE
ALEGSIFIGGASVQWLRDELKIIESAKDSEMYANRVEDTNGVYVVPAFTGLGAPYWDMYA
EEECEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHH
RGSILGLTRGAKKEHIVRATLESIAYQTKDVLEAMQNDSKLKLKSLKVDGGASNNNFLMQ
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCEEEE
FQSDILNVDIDRPKIVETTALGAAYLAGLSVGFYIGRNEITSKWSVEKEFNPNMSEEKRC
EECCCEEEECCCCCEEEHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCHHHHH
KLYKGWKKAVSRALSWEKEDELDI
HHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA