Definition Clostridium difficile 630 chromosome, complete genome.
Accession NC_009089
Length 4,290,252

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The map label for this gene is comR

Identifier: 126698917

GI number: 126698917

Start: 1527283

End: 1529394

Strand: Direct

Name: comR

Synonym: CD1318

Alternate gene names: 126698917

Gene position: 1527283-1529394 (Clockwise)

Preceding gene: 126698916

Following gene: 126698918

Centisome position: 35.6

GC content: 33.29

Gene sequence:

>2112_bases
ATGTTTGAACATAAAATATTTAAAATGGATTTTGCAGGAAGAGAACTTTCTGTAGAAATAGGAAAGATTTGTGAAATGGC
TAGTGGTAGTTGTATAGTTCGATACAGTGATAGTATGGTAATGGTAAATACAACTAAATCAGCCAAACCTAGAGACGGAA
TAGACTTTTTTCCTTTAAGTGTGGATTATGAAGAAAAATTATACTCTGTAGGTAAGATACCTGGAGGTTTTTTAAAGAGA
GAAGGCAAGCCTTCAGAAAAAGCTATACTTACATCAAGATTGATAGATAGACCAATAAGACCTTTATTCCCAAAAGGATT
TAGAAATGATGTTCAGGTAGTTGCAACAGTTCTATCAGTAGACCAAGATTGTACACCAGATATAGTAGCAATGATAGGTT
CTTCAATAGCCCTTTCTATATCAGACATACCATTTAATGGACCAACAGGTTCAGTATGTGTTGGCCTTGTAGATGGTGCA
TTTGTTGTAAATCCAAACGCAGAGCAAAGAGAAAAAAGTTCAATGCATCTAGTTGTTTCAGGTACAAAGGAAGCAATAAT
GATGGTTGAAGCCGGAGCTGATGAAGTTCCAGACGAGGTAATGCTTGATGCTATTTTATTTGCTCACCAAGAAATAAAAA
AAATAGTTGAGTTTATAGAAGGTATAGTTGCAGAAGTTGGAAAAGAAAAAATGCCTGTTGAATTATACCATGCAGGAGAA
GAAATAACTCAATTGGTTCGCGAATTTGCAACTGATAAGATGAAAAAAGCAGTTCAGACTTTTGAAAAGTTAGAGAGAAT
GGAAAATATGGATAGAGTTAAAGAAGAAACTTTAGCTCACTTTGAAGAAACTTTAGAAGATTTTGAAGATTTTGTTGGAG
ATATAGAAGAAGTATTACAAGATATAATAAAAGAAGAAGTAAGAAAACTTATAGTACATGAAAATGTAAGACCAGATAAT
AGAAAACTTGAAGAAATAAGACCTATATGGTGTGAAACTGGCATGATACCTAGAGCTCATGGTTCAGCCATATTTACTAG
AGGACAAACTCAAGTACTTAATGTTGCTACTTTAGGTGCTTTAGGAGATGTTCAAAAACTAGATGGGTTAGATGAAGAAG
AAAACAAGAGATATATGCATCATTATAATTTCCCTGCATATAGTGTTGGAGAAGCTAGACCATCAAGAGGACCAGGAAGA
AGAGAAATAGGACATGGTGCTTTAGCAGAAAGAGCTTTATTACCAGTAATACCATCTCAAGAAGAATTTCCTTATGCTAT
TAGATTAGTTTCTGAAGTATTAAGTTCAAATGGTTCTACATCTCAAGCAAGTGTATGTGGCTCAACATTATCTTTACTTG
ATGCAGGTGTACCTATAAAAGATATGGTTGCAGGTATAGCAATGGGACTTATAAAGCATGATGGTAAGGTTGCAGTGCTT
TCAGATATACAAGGTATGGAAGACCATTTAGGCGATATGGACTTTAAAGTAGCTGGAACAGAGTATGGTATAACAGCAAT
ACAAATGGATATAAAAATTGATGGTATAGATAAAGAAATTCTACAACGTGCTTTAAAACAAGCTAAAGAGGGTAGAATCC
ATATACTAGGAGAGATGAGAAAAACTATATCTCAGCCAAAACCAGAACTTTCACCATATGCACCTAAGATTGTTAAAATG
CAAATAAATCCTGACAAGATAAAAGATGTAATAGGACCTGGTGGAAAGATAATAACTAAGATAATAGACGAAACTGGAGT
TAAGATAGATATTGAACAAACTGGGGAAGTATTTATATCAGGTATTGAGATTGATATGATTAAGAAAGCTCAAGAACTTA
TAAATAATATAGTAGTTGAACCAGAAGTAGGAAAAACTTATAAAGGTAAGGTAAGTAGAATAATGAACTTTGGAGCATTT
GTTGAGATACTTCCAGGAAAAGAAGGATTACTTCATATATCTCATATAGCTCATGAAAGAGTTGCCAAAGTTGAAGATGT
ATTGAATATAGGGGATGAAGTTGAAGTTAAAGTTACAGAGATTGATGAAAAAGGAAGAGTTAATTTATCAAGAAAAGTTC
TTTTACCAAAACCAGAACATAAAAATAAATAA

Upstream 100 bases:

>100_bases
ATATGTGAAGATAATTTTATATTGTTAATTTATAGTATTTTTGATAATATAGTAAATAGAGTGATATACGTGTTTTTTAA
TAAGAGGAGGACAAGCATTA

Downstream 100 bases:

>100_bases
CTTATTATATAATTAAAAGCAAAGTCTTAGGATTTTGCTTTTTTAAATACAAAAAAAGGAGATAATTTTAATATTGATAG
TTATGGATGGATTATAGTTC

Product: polynucleotide phosphorylase/polyadenylase

Products: NA

Alternate protein names: Polynucleotide phosphorylase; PNPase

Number of amino acids: Translated: 703; Mature: 703

Protein sequence:

>703_residues
MFEHKIFKMDFAGRELSVEIGKICEMASGSCIVRYSDSMVMVNTTKSAKPRDGIDFFPLSVDYEEKLYSVGKIPGGFLKR
EGKPSEKAILTSRLIDRPIRPLFPKGFRNDVQVVATVLSVDQDCTPDIVAMIGSSIALSISDIPFNGPTGSVCVGLVDGA
FVVNPNAEQREKSSMHLVVSGTKEAIMMVEAGADEVPDEVMLDAILFAHQEIKKIVEFIEGIVAEVGKEKMPVELYHAGE
EITQLVREFATDKMKKAVQTFEKLERMENMDRVKEETLAHFEETLEDFEDFVGDIEEVLQDIIKEEVRKLIVHENVRPDN
RKLEEIRPIWCETGMIPRAHGSAIFTRGQTQVLNVATLGALGDVQKLDGLDEEENKRYMHHYNFPAYSVGEARPSRGPGR
REIGHGALAERALLPVIPSQEEFPYAIRLVSEVLSSNGSTSQASVCGSTLSLLDAGVPIKDMVAGIAMGLIKHDGKVAVL
SDIQGMEDHLGDMDFKVAGTEYGITAIQMDIKIDGIDKEILQRALKQAKEGRIHILGEMRKTISQPKPELSPYAPKIVKM
QINPDKIKDVIGPGGKIITKIIDETGVKIDIEQTGEVFISGIEIDMIKKAQELINNIVVEPEVGKTYKGKVSRIMNFGAF
VEILPGKEGLLHISHIAHERVAKVEDVLNIGDEVEVKVTEIDEKGRVNLSRKVLLPKPEHKNK

Sequences:

>Translated_703_residues
MFEHKIFKMDFAGRELSVEIGKICEMASGSCIVRYSDSMVMVNTTKSAKPRDGIDFFPLSVDYEEKLYSVGKIPGGFLKR
EGKPSEKAILTSRLIDRPIRPLFPKGFRNDVQVVATVLSVDQDCTPDIVAMIGSSIALSISDIPFNGPTGSVCVGLVDGA
FVVNPNAEQREKSSMHLVVSGTKEAIMMVEAGADEVPDEVMLDAILFAHQEIKKIVEFIEGIVAEVGKEKMPVELYHAGE
EITQLVREFATDKMKKAVQTFEKLERMENMDRVKEETLAHFEETLEDFEDFVGDIEEVLQDIIKEEVRKLIVHENVRPDN
RKLEEIRPIWCETGMIPRAHGSAIFTRGQTQVLNVATLGALGDVQKLDGLDEEENKRYMHHYNFPAYSVGEARPSRGPGR
REIGHGALAERALLPVIPSQEEFPYAIRLVSEVLSSNGSTSQASVCGSTLSLLDAGVPIKDMVAGIAMGLIKHDGKVAVL
SDIQGMEDHLGDMDFKVAGTEYGITAIQMDIKIDGIDKEILQRALKQAKEGRIHILGEMRKTISQPKPELSPYAPKIVKM
QINPDKIKDVIGPGGKIITKIIDETGVKIDIEQTGEVFISGIEIDMIKKAQELINNIVVEPEVGKTYKGKVSRIMNFGAF
VEILPGKEGLLHISHIAHERVAKVEDVLNIGDEVEVKVTEIDEKGRVNLSRKVLLPKPEHKNK
>Mature_703_residues
MFEHKIFKMDFAGRELSVEIGKICEMASGSCIVRYSDSMVMVNTTKSAKPRDGIDFFPLSVDYEEKLYSVGKIPGGFLKR
EGKPSEKAILTSRLIDRPIRPLFPKGFRNDVQVVATVLSVDQDCTPDIVAMIGSSIALSISDIPFNGPTGSVCVGLVDGA
FVVNPNAEQREKSSMHLVVSGTKEAIMMVEAGADEVPDEVMLDAILFAHQEIKKIVEFIEGIVAEVGKEKMPVELYHAGE
EITQLVREFATDKMKKAVQTFEKLERMENMDRVKEETLAHFEETLEDFEDFVGDIEEVLQDIIKEEVRKLIVHENVRPDN
RKLEEIRPIWCETGMIPRAHGSAIFTRGQTQVLNVATLGALGDVQKLDGLDEEENKRYMHHYNFPAYSVGEARPSRGPGR
REIGHGALAERALLPVIPSQEEFPYAIRLVSEVLSSNGSTSQASVCGSTLSLLDAGVPIKDMVAGIAMGLIKHDGKVAVL
SDIQGMEDHLGDMDFKVAGTEYGITAIQMDIKIDGIDKEILQRALKQAKEGRIHILGEMRKTISQPKPELSPYAPKIVKM
QINPDKIKDVIGPGGKIITKIIDETGVKIDIEQTGEVFISGIEIDMIKKAQELINNIVVEPEVGKTYKGKVSRIMNFGAF
VEILPGKEGLLHISHIAHERVAKVEDVLNIGDEVEVKVTEIDEKGRVNLSRKVLLPKPEHKNK

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction

COG id: COG1185

COG function: function code J; Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain

Homologues:

Organism=Homo sapiens, GI188528628, Length=711, Percent_Identity=38.3966244725738, Blast_Score=449, Evalue=1e-126,
Organism=Escherichia coli, GI145693187, Length=695, Percent_Identity=48.2014388489209, Blast_Score=645, Evalue=0.0,
Organism=Caenorhabditis elegans, GI115534063, Length=709, Percent_Identity=33.0042313117066, Blast_Score=347, Evalue=9e-96,
Organism=Caenorhabditis elegans, GI17535281, Length=74, Percent_Identity=48.6486486486487, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI281362905, Length=707, Percent_Identity=36.3507779349364, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24651641, Length=707, Percent_Identity=36.3507779349364, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24651643, Length=707, Percent_Identity=36.3507779349364, Blast_Score=429, Evalue=1e-120,
Organism=Drosophila melanogaster, GI161079377, Length=652, Percent_Identity=36.5030674846626, Blast_Score=392, Evalue=1e-109,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1000 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 3328 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media

Swissprot (AC and ID): PNP_CLOD6 (Q18BI4)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001087814.1
- ProteinModelPortal:   Q18BI4
- STRING:   Q18BI4
- GeneID:   4914478
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD1318
- NMPDR:   fig|1496.1.peg.3414
- eggNOG:   COG1185
- HOGENOM:   HBG382411
- OMA:   YGETVVL
- ProtClustDB:   PRK11824
- GO:   GO:0005739
- HAMAP:   MF_01595
- InterPro:   IPR001247
- InterPro:   IPR015847
- InterPro:   IPR004087
- InterPro:   IPR004088
- InterPro:   IPR018111
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR012162
- InterPro:   IPR015848
- InterPro:   IPR003029
- InterPro:   IPR020568
- InterPro:   IPR022967
- Gene3D:   G3DSA:2.40.50.140
- Gene3D:   G3DSA:1.10.10.400
- PANTHER:   PTHR11252
- PIRSF:   PIRSF005499
- SMART:   SM00322
- SMART:   SM00316
- TIGRFAMs:   TIGR03591

Pfam domain/function: PF00013 KH_1; PF03726 PNPase; PF01138 RNase_PH; PF03725 RNase_PH_C; PF00575 S1; SSF46915 3_ExoRNase; SSF55666 3_ExoRNase; SSF50249 Nucleic_acid_OB; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.7.8

Molecular weight: Translated: 77835; Mature: 77835

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50084 KH_TYPE_1; PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MFEHKIFKMDFAGRELSVEIGKICEMASGSCIVRYSDSMVMVNTTKSAKPRDGIDFFPLS
CCCCEEEEEECCCCEEEEHHHHHHHHCCCCEEEEECCCEEEEECCCCCCCCCCCEEEECC
VDYEEKLYSVGKIPGGFLKREGKPSEKAILTSRLIDRPIRPLFPKGFRNDVQVVATVLSV
CCHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHC
DQDCTPDIVAMIGSSIALSISDIPFNGPTGSVCVGLVDGAFVVNPNAEQREKSSMHLVVS
CCCCCHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCEEEECCCHHHHCCCCEEEEEE
GTKEAIMMVEAGADEVPDEVMLDAILFAHQEIKKIVEFIEGIVAEVGKEKMPVELYHAGE
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCH
EITQLVREFATDKMKKAVQTFEKLERMENMDRVKEETLAHFEETLEDFEDFVGDIEEVLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIIKEEVRKLIVHENVRPDNRKLEEIRPIWCETGMIPRAHGSAIFTRGQTQVLNVATLGA
HHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHCCCCCCCCCCCEEEECCCCEEEEHHHHCC
LGDVQKLDGLDEEENKRYMHHYNFPAYSVGEARPSRGPGRREIGHGALAERALLPVIPSQ
CCCHHHHCCCCCCCCCCCCEECCCCCEECCCCCCCCCCCCHHHCCCHHHHHCCCCCCCCC
EEFPYAIRLVSEVLSSNGSTSQASVCGSTLSLLDAGVPIKDMVAGIAMGLIKHDGKVAVL
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEE
SDIQGMEDHLGDMDFKVAGTEYGITAIQMDIKIDGIDKEILQRALKQAKEGRIHILGEMR
HHCCCHHHHCCCCCEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHHCCCEEEHHHHH
KTISQPKPELSPYAPKIVKMQINPDKIKDVIGPGGKIITKIIDETGVKIDIEQTGEVFIS
HHHCCCCCCCCCCCCEEEEEEECHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCEEEE
GIEIDMIKKAQELINNIVVEPEVGKTYKGKVSRIMNFGAFVEILPGKEGLLHISHIAHER
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHH
VAKVEDVLNIGDEVEVKVTEIDEKGRVNLSRKVLLPKPEHKNK
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCCC
>Mature Secondary Structure
MFEHKIFKMDFAGRELSVEIGKICEMASGSCIVRYSDSMVMVNTTKSAKPRDGIDFFPLS
CCCCEEEEEECCCCEEEEHHHHHHHHCCCCEEEEECCCEEEEECCCCCCCCCCCEEEECC
VDYEEKLYSVGKIPGGFLKREGKPSEKAILTSRLIDRPIRPLFPKGFRNDVQVVATVLSV
CCHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHC
DQDCTPDIVAMIGSSIALSISDIPFNGPTGSVCVGLVDGAFVVNPNAEQREKSSMHLVVS
CCCCCHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEECCEEEECCCHHHHCCCCEEEEEE
GTKEAIMMVEAGADEVPDEVMLDAILFAHQEIKKIVEFIEGIVAEVGKEKMPVELYHAGE
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCH
EITQLVREFATDKMKKAVQTFEKLERMENMDRVKEETLAHFEETLEDFEDFVGDIEEVLQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIIKEEVRKLIVHENVRPDNRKLEEIRPIWCETGMIPRAHGSAIFTRGQTQVLNVATLGA
HHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHCCCCCCCCCCCEEEECCCCEEEEHHHHCC
LGDVQKLDGLDEEENKRYMHHYNFPAYSVGEARPSRGPGRREIGHGALAERALLPVIPSQ
CCCHHHHCCCCCCCCCCCCEECCCCCEECCCCCCCCCCCCHHHCCCHHHHHCCCCCCCCC
EEFPYAIRLVSEVLSSNGSTSQASVCGSTLSLLDAGVPIKDMVAGIAMGLIKHDGKVAVL
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEE
SDIQGMEDHLGDMDFKVAGTEYGITAIQMDIKIDGIDKEILQRALKQAKEGRIHILGEMR
HHCCCHHHHCCCCCEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHHCCCEEEHHHHH
KTISQPKPELSPYAPKIVKMQINPDKIKDVIGPGGKIITKIIDETGVKIDIEQTGEVFIS
HHHCCCCCCCCCCCCEEEEEEECHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCEEEE
GIEIDMIKKAQELINNIVVEPEVGKTYKGKVSRIMNFGAFVEILPGKEGLLHISHIAHER
CCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHH
VAKVEDVLNIGDEVEVKVTEIDEKGRVNLSRKVLLPKPEHKNK
HHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA