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The map label for this gene is pepA [H]

Identifier: 126698897

GI number: 126698897

Start: 1505541

End: 1506992

Strand: Direct

Name: pepA [H]

Synonym: CD1300

Alternate gene names: 126698897

Gene position: 1505541-1506992 (Clockwise)

Preceding gene: 126698896

Following gene: 126698899

Centisome position: 35.09

GC content: 30.37

Gene sequence:

>1452_bases
ATGAATATAAAGTATTCTAAAGAAATATTAAAAAGTTTAGAAAATGCTATAACAGTAGTAGCTCTATTTGAGGGAGAAGA
TGTTTCTACGACATTTGATAAAATAAATATGATAAGCAGAAATTTTAATTCTAAAGAAAATAGTATAGATACTGTAACAT
TAATTGAAAATAACAATTTGGTAAATGTTTGTCTTGTTGGTTTTGGTAAGAGAGAGTTATTGAATAGAGAAAAAATTAGA
ATCATAGGTGGGAATTTGTGTAAAAAATTAAAAAATATATTGAAAAATGAAGCATATAAGAGTAGTGATGTTAATGTACT
GAATCTTAATTTAAATAGTGATGAAATAGGTTGTTTTGTAGAAGGGATATTACTTGGAAATTATAAGTTTGATAAGTATA
AGACAAAAAGTAAGGATTTTGAAAGAAAAGAAGTTGATACTATAACTATATTTACTGAAAAAGAAGTTGAGTGTCAAATA
GAAAAGGCTAAAATATTAGCTAATTCAACTATAATAGCTAGAAATCTAGTTAATGAACCATCAAACGTAATATATCCAAA
AACATTAGCAGTAGAAACAGTTAAACTTGGTGCAGAGTTTGGGTTTAATGTTGATGTTTATGAAGAAGAAAAAATAAAGG
CATTGGGAATGGATGCTTTTTTCGCTGTTTCAAGAGGTTCAATTAATAAACCAAGATTCATAGTAATGAGATACTTTGGA
GATAAAGAAAGTACAGATATATTAGGTCTAGTAGGTAAAGGATTGACTTATGATACTGGTGGATATTCTTTAAAATCAAA
TGCTTCTATGCTAGATATGAAGACAGATATGGCTGGTGCTGCGAGTGTTATAGGTGCTATGTGTGCTATATCTCAAAGTA
AATTAAAGAAAAATGTTATAGCAGTAGTGGCTGCATGTGAGAATGCTTTATCAGGAGGTTCATACAAACCTGGAGATATA
ATTAGTTCTATGGCAAAGAAAACTATTGAAGTTTTAAATACGGATGCAGAAGGTAGACTTACATTAGCTGATGCAATATA
CTACATTATAAACAATGAAAAAGTAACAAAGGTGGTTGATGTAGCTACATTAACTGGTGCTGCTTTAACATTGTTAGGTA
ATGTTGCAACTCCTATAGTAACAAATAATGATGATTTTTATTGTGAATTAGAAAAAGCTGCCACTTTATCAGGGGAAAGG
GTATGGAAGATGCCAATTTATGATGAATTTAAAGATATGATAAAAGGAGAAGAAGCAGACCTTAAAAACACTGGTGGTAA
AAATGCTGGATGTATAACAGCAGGAGCTTTTATTGGTGAATTTGTTGGGAATACTCCTTGGATACATATGGATATAGCGG
GGACAAGTACATCATCAAAATCAATTGGATACAAAGCAAAGGGGGCTACAGGAGAACCTGTTAGAACATTGTACTATTTG
GCAGAAATCTAA

Upstream 100 bases:

>100_bases
AATGGATTGCCTAGATATAGATAATAAAGATAAATTATTTACTTCTTTGGAAGAGTCTAAAAATATAATAGAACAATTAT
TTTAAAAAGGAGAATTTATT

Downstream 100 bases:

>100_bases
AAAACAATTATAAAATATAATTTATAAAGCCACGTGGATATTTTTGTAATTTAAGATTATCTATGTGGCTTTATTTTTTA
TTTAAGTAAATTATTTACTC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNIKYSKEILKSLENAITVVALFEGEDVSTTFDKINMISRNFNSKENSIDTVTLIENNNLVNVCLVGFGKRELLNREKIR
IIGGNLCKKLKNILKNEAYKSSDVNVLNLNLNSDEIGCFVEGILLGNYKFDKYKTKSKDFERKEVDTITIFTEKEVECQI
EKAKILANSTIIARNLVNEPSNVIYPKTLAVETVKLGAEFGFNVDVYEEEKIKALGMDAFFAVSRGSINKPRFIVMRYFG
DKESTDILGLVGKGLTYDTGGYSLKSNASMLDMKTDMAGAASVIGAMCAISQSKLKKNVIAVVAACENALSGGSYKPGDI
ISSMAKKTIEVLNTDAEGRLTLADAIYYIINNEKVTKVVDVATLTGAALTLLGNVATPIVTNNDDFYCELEKAATLSGER
VWKMPIYDEFKDMIKGEEADLKNTGGKNAGCITAGAFIGEFVGNTPWIHMDIAGTSTSSKSIGYKAKGATGEPVRTLYYL
AEI

Sequences:

>Translated_483_residues
MNIKYSKEILKSLENAITVVALFEGEDVSTTFDKINMISRNFNSKENSIDTVTLIENNNLVNVCLVGFGKRELLNREKIR
IIGGNLCKKLKNILKNEAYKSSDVNVLNLNLNSDEIGCFVEGILLGNYKFDKYKTKSKDFERKEVDTITIFTEKEVECQI
EKAKILANSTIIARNLVNEPSNVIYPKTLAVETVKLGAEFGFNVDVYEEEKIKALGMDAFFAVSRGSINKPRFIVMRYFG
DKESTDILGLVGKGLTYDTGGYSLKSNASMLDMKTDMAGAASVIGAMCAISQSKLKKNVIAVVAACENALSGGSYKPGDI
ISSMAKKTIEVLNTDAEGRLTLADAIYYIINNEKVTKVVDVATLTGAALTLLGNVATPIVTNNDDFYCELEKAATLSGER
VWKMPIYDEFKDMIKGEEADLKNTGGKNAGCITAGAFIGEFVGNTPWIHMDIAGTSTSSKSIGYKAKGATGEPVRTLYYL
AEI
>Mature_483_residues
MNIKYSKEILKSLENAITVVALFEGEDVSTTFDKINMISRNFNSKENSIDTVTLIENNNLVNVCLVGFGKRELLNREKIR
IIGGNLCKKLKNILKNEAYKSSDVNVLNLNLNSDEIGCFVEGILLGNYKFDKYKTKSKDFERKEVDTITIFTEKEVECQI
EKAKILANSTIIARNLVNEPSNVIYPKTLAVETVKLGAEFGFNVDVYEEEKIKALGMDAFFAVSRGSINKPRFIVMRYFG
DKESTDILGLVGKGLTYDTGGYSLKSNASMLDMKTDMAGAASVIGAMCAISQSKLKKNVIAVVAACENALSGGSYKPGDI
ISSMAKKTIEVLNTDAEGRLTLADAIYYIINNEKVTKVVDVATLTGAALTLLGNVATPIVTNNDDFYCELEKAATLSGER
VWKMPIYDEFKDMIKGEEADLKNTGGKNAGCITAGAFIGEFVGNTPWIHMDIAGTSTSSKSIGYKAKGATGEPVRTLYYL
AEI

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=436, Percent_Identity=33.4862385321101, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI47155554, Length=339, Percent_Identity=31.858407079646, Blast_Score=151, Evalue=1e-36,
Organism=Escherichia coli, GI1790710, Length=485, Percent_Identity=35.2577319587629, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI87082123, Length=313, Percent_Identity=36.4217252396166, Blast_Score=172, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17556903, Length=297, Percent_Identity=35.6902356902357, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17565172, Length=264, Percent_Identity=31.0606060606061, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24661038, Length=363, Percent_Identity=31.9559228650138, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI21355725, Length=364, Percent_Identity=32.1428571428571, Blast_Score=195, Evalue=6e-50,
Organism=Drosophila melanogaster, GI24662227, Length=418, Percent_Identity=27.511961722488, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI20129969, Length=418, Percent_Identity=28.2296650717703, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21355645, Length=434, Percent_Identity=27.8801843317972, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24662223, Length=434, Percent_Identity=27.8801843317972, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI19922386, Length=323, Percent_Identity=30.9597523219814, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI20129963, Length=370, Percent_Identity=30, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI161077148, Length=361, Percent_Identity=27.7008310249307, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI20130057, Length=361, Percent_Identity=27.7008310249307, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI21357381, Length=327, Percent_Identity=30.8868501529052, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221379063, Length=327, Percent_Identity=30.8868501529052, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI221379062, Length=327, Percent_Identity=30.8868501529052, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24646701, Length=275, Percent_Identity=29.8181818181818, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646703, Length=275, Percent_Identity=29.8181818181818, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21358201, Length=275, Percent_Identity=29.8181818181818, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52796; Mature: 52796

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKYSKEILKSLENAITVVALFEGEDVSTTFDKINMISRNFNSKENSIDTVTLIENNNL
CCCCHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCE
VNVCLVGFGKRELLNREKIRIIGGNLCKKLKNILKNEAYKSSDVNVLNLNLNSDEIGCFV
EEEEEECCCHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEE
EGILLGNYKFDKYKTKSKDFERKEVDTITIFTEKEVECQIEKAKILANSTIIARNLVNEP
EEEEECCEECCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEHHEEECCCCEEHHHHCCC
SNVIYPKTLAVETVKLGAEFGFNVDVYEEEKIKALGMDAFFAVSRGSINKPRFIVMRYFG
CCEECCCCEEEEEEEECHHCCCCEEEECCCCHHEECCCEEEEECCCCCCCCEEEEEEEEC
DKESTDILGLVGKGLTYDTGGYSLKSNASMLDMKTDMAGAASVIGAMCAISQSKLKKNVI
CCCCCCEEEECCCCCEECCCCEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AVVAACENALSGGSYKPGDIISSMAKKTIEVLNTDAEGRLTLADAIYYIINNEKVTKVVD
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCEEEEEE
VATLTGAALTLLGNVATPIVTNNDDFYCELEKAATLSGERVWKMPIYDEFKDMIKGEEAD
HHHHHHHHHHHHCCCCCCEEECCCCEEEEEEHHCCCCCCEEEECCCHHHHHHHHCCCCCC
LKNTGGKNAGCITAGAFIGEFVGNTPWIHMDIAGTSTSSKSIGYKAKGATGEPVRTLYYL
CCCCCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCCCHHHHHEEE
AEI
ECC
>Mature Secondary Structure
MNIKYSKEILKSLENAITVVALFEGEDVSTTFDKINMISRNFNSKENSIDTVTLIENNNL
CCCCHHHHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCE
VNVCLVGFGKRELLNREKIRIIGGNLCKKLKNILKNEAYKSSDVNVLNLNLNSDEIGCFV
EEEEEECCCHHHHCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCEEE
EGILLGNYKFDKYKTKSKDFERKEVDTITIFTEKEVECQIEKAKILANSTIIARNLVNEP
EEEEECCEECCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEHHEEECCCCEEHHHHCCC
SNVIYPKTLAVETVKLGAEFGFNVDVYEEEKIKALGMDAFFAVSRGSINKPRFIVMRYFG
CCEECCCCEEEEEEEECHHCCCCEEEECCCCHHEECCCEEEEECCCCCCCCEEEEEEEEC
DKESTDILGLVGKGLTYDTGGYSLKSNASMLDMKTDMAGAASVIGAMCAISQSKLKKNVI
CCCCCCEEEECCCCCEECCCCEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AVVAACENALSGGSYKPGDIISSMAKKTIEVLNTDAEGRLTLADAIYYIINNEKVTKVVD
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEECCCCEEEEEE
VATLTGAALTLLGNVATPIVTNNDDFYCELEKAATLSGERVWKMPIYDEFKDMIKGEEAD
HHHHHHHHHHHHCCCCCCEEECCCCEEEEEEHHCCCCCCEEEECCCHHHHHHHHCCCCCC
LKNTGGKNAGCITAGAFIGEFVGNTPWIHMDIAGTSTSSKSIGYKAKGATGEPVRTLYYL
CCCCCCCCCCEEEHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCCCHHHHHEEE
AEI
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]