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The map label for this gene is mutX [H]

Identifier: 126698284

GI number: 126698284

Start: 858656

End: 859132

Strand: Direct

Name: mutX [H]

Synonym: CD0705

Alternate gene names: 126698284

Gene position: 858656-859132 (Clockwise)

Preceding gene: 126698283

Following gene: 126698285

Centisome position: 20.01

GC content: 28.93

Gene sequence:

>477_bases
ATGAAACTTACAACTATTTGTTATATAGAAAAAGATGACAAGACTTTGATGTTGTACAGAAATAAAAAGAAAGATGATAT
ACATGAAGGTAAGTATGTAGGAGTTGGAGGAAAGTTTGAGCAAGGAGAGACTCCAGAAGAATGTGTAATTAGAGAAGTAA
AAGAAGAGACTGGTCTTACTCTTAAATCATTGTCATATAAAGGGTTGATAACTTTTCCAAAATTTAAAGATGAAGAAGAT
TGGTATATGTTTTTGTATTTCTCAGATGAGTTTGAAGGTGAATTATCTGAAAAAGATTTAAATGATTGTAAAGAAGGAAA
TTTAATTTGGGTTGATAATGATAAAATATTCGATTTAAATATGTGGGAAGGTGACAGGCTGTTCTTAAATTGGGCTAAGA
CTGGAAATATCTTTAGTGCAAAGATTGTATATGATAATGGGAAACTAAAAGATTATAATGTAAGTTTCTTAGATTAA

Upstream 100 bases:

>100_bases
GCAGAGCTTTCTCTTAATGCAATGAAGAATATAAGTGATATGCTTGAAAGTGCTGAAAATAATTAGTTGAGAATATAAAA
GAGAAAGCAAGGCGAGATAC

Downstream 100 bases:

>100_bases
TTAAGATATAGTTTTTAGATTAATTAAAATGTAGTTTAATGATATATTTTAAGAATATAATTTAAAGATATTACTTAAAA
ATGTAATTTAAAGTTACATC

Product: DNA repair protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MKLTTICYIEKDDKTLMLYRNKKKDDIHEGKYVGVGGKFEQGETPEECVIREVKEETGLTLKSLSYKGLITFPKFKDEED
WYMFLYFSDEFEGELSEKDLNDCKEGNLIWVDNDKIFDLNMWEGDRLFLNWAKTGNIFSAKIVYDNGKLKDYNVSFLD

Sequences:

>Translated_158_residues
MKLTTICYIEKDDKTLMLYRNKKKDDIHEGKYVGVGGKFEQGETPEECVIREVKEETGLTLKSLSYKGLITFPKFKDEED
WYMFLYFSDEFEGELSEKDLNDCKEGNLIWVDNDKIFDLNMWEGDRLFLNWAKTGNIFSAKIVYDNGKLKDYNVSFLD
>Mature_158_residues
MKLTTICYIEKDDKTLMLYRNKKKDDIHEGKYVGVGGKFEQGETPEECVIREVKEETGLTLKSLSYKGLITFPKFKDEED
WYMFLYFSDEFEGELSEKDLNDCKEGNLIWVDNDKIFDLNMWEGDRLFLNWAKTGNIFSAKIVYDNGKLKDYNVSFLD

Specific function: Involved in the DNA repair system to avoid A.T to G.C transversions. Degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003562
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: NA

Molecular weight: Translated: 18610; Mature: 18610

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTTICYIEKDDKTLMLYRNKKKDDIHEGKYVGVGGKFEQGETPEECVIREVKEETGLT
CCEEEEEEEECCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCE
LKSLSYKGLITFPKFKDEEDWYMFLYFSDEFEGELSEKDLNDCKEGNLIWVDNDKIFDLN
EEEECCCEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCEEEEEE
MWEGDRLFLNWAKTGNIFSAKIVYDNGKLKDYNVSFLD
CCCCCEEEEEEECCCCEEEEEEEEECCCEEEEEEEEEC
>Mature Secondary Structure
MKLTTICYIEKDDKTLMLYRNKKKDDIHEGKYVGVGGKFEQGETPEECVIREVKEETGLT
CCEEEEEEEECCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCE
LKSLSYKGLITFPKFKDEEDWYMFLYFSDEFEGELSEKDLNDCKEGNLIWVDNDKIFDLN
EEEECCCEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCEEEEEE
MWEGDRLFLNWAKTGNIFSAKIVYDNGKLKDYNVSFLD
CCCCCEEEEEEECCCCEEEEEEEEECCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170394; 11463916; 8163538 [H]