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The map label for this gene is ltrA [H]

Identifier: 126698083

GI number: 126698083

Start: 596830

End: 598659

Strand: Direct

Name: ltrA [H]

Synonym: CD0506

Alternate gene names: 126698083

Gene position: 596830-598659 (Clockwise)

Preceding gene: 126698082

Following gene: 126698084

Centisome position: 13.91

GC content: 34.32

Gene sequence:

>1830_bases
ATGACAGTCAAAGTTAGTAACAAAAAGGCACTGAGGTTCAATGAGTATTACGATACTCAGAAAATTCAAGACGAACTCTA
TCAATTATCTGCCGAAGGCAGTCATGTGTTTAGAGATTTAATGAGCTATATCACACAAGAAGAAAATATTTTATTGGCTT
ATCGAAATATCAAAAGCAATAAAGGCAGTAAAACTGCTGGAACAAATAAAAGAACGATTATTGATGTTGGTGAAGAAAAC
CCATATCAATTAGTTCAATACGTTCAAAATCGATTTAACAACTTTCAACCTCACTCCATCAGAAGAGTCGAGATTCCAAA
GCCAAATGGTAAAACCAGACCGCTAGGAATCCCAACAATTGAGGATAGATTAGTACAGCAATGCATAAAGCAGATCCTTG
AACCAATTTTGGAAGCAAAATTCCATAAGCATTCTTATGGATTTCGACCAGAAAGAAGTTCGCACCATGCCATAGCGATA
TTTCAGCAATGGACATTTAAAGGATTTCACTATGTAGTGGACATTGATATTAAGGGCTTCTTTGACAATGTAAATCATGG
AAAATTGCTTAAGCAACTCTGGACAATGAAAATTCGAGACAAGACATTTATTTCAATATTGTCGAGAATGCTTAAGGCAG
AGGTAAAAGGCATTGGAAAATCAACCAAAGGAACCCCACAAGGTGGTATTCTTTCTCCTCTTTTAGCTAATGTGGTGCTA
AACGAATTAGATTGGTGGATAGATAGTCAGTGGGACGGATTTCCAACCAAAAGAAAATACAGTAGTCTGCTGAGTAAAAC
TCAATCAATAAGAAAGTATTCAAACTTGAAAGAAATCAAAATTGTCCGTTACGCAGATGATTTCAAAATCATGTGCAAAG
ATTATCATACTGCCCAGAAAATTTTCCTCGCAACAAAACAATGGTTAAAAGTACGACTTGATTTAGACATAAGTCCTGAA
AAGTCAAAAGTAACTAATCTGAGAAAAAATTATTCTGACTTTCTAGGATTCAAGTTGAAAGTGAAAAAAGGAAAAGCAAA
CGGATATACCAATCGAAGCCGAATGTGTGATAAGGCAAAGATTAATGCGGTAGATAAACTAAAGAACAATATCAAAACAA
TCGCCGCTAATCCAACTGTAGATAATGTCAATAAGTACAACTCTGTTGTTCTAGGTTTGCATAACTATTATAAAATTGCG
ACTCTGGTCAACTTAGATTTTGTAGATATTGCTTTCACAGTAAATAAAAGTCTTGATTGTCGAACCAAAAATATTCGCAA
TAAGCACGGAACGCTAACCAGTACCTATCAAAAATTCTATAAACAATATAACTGGAAGAAACGATTCATAGCGAACATGA
TTTTATTTCCAATAGCCGGGATAAAATTTACAATGCCAAGAATCTTTCCGAAGGACTGGAATCGATATACGCCTGAAGGT
AGGCTGTTTATTCATCAAAGATTAAAGATGGATATGCATACCGTTTATTACCTGCTGGAAAATTCCAATCCGAATAAGTC
TGTAGAATTTAACGATAATCGAATCTCTCTGTTCATAGCCCAACAAGGAAAATGTCATGTTAGTGGTGAAAATTTATCAA
AAGATAATATGGAAGTTCATCACATTAAGCCGTTATCACTTGGTGGGAATGATAACTATAAGAATCTTGTGATTGTTACA
AAAGAAACACACAAATTGATTCATGCGACTAAAAGAGAAACGATAGTTCATTATTTACCTTTGGTATTAAAAAAGGAAAG
ATCATTGGAAAAGCTGAATAAATTACGTGCTTTAGCTGGGAATAGTGAAATAGAAATGAATTACTGTTGA

Upstream 100 bases:

>100_bases
GCCACTAGTCAACAGTAATTCAATCTATTTGACTGTTCATGAATTAGGTTCGGGTAAGACTAAGATAGGAAAACTTCATT
ATTACGGAAGGAACCAACTA

Downstream 100 bases:

>100_bases
TGGAACGCCGTGTGAGGGGAAACTCTCATGCACGGTGTGAAGCGGGGGAAAAGATGGAGATAACCTCAAAGTCTTACCTA
TCGCTATCTATCGGCTATGC

Product: group II intron reverse transcriptase/maturase

Products: NA

Alternate protein names: Reverse-transcriptase; RNA maturase; DNA endonuclease [H]

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MTVKVSNKKALRFNEYYDTQKIQDELYQLSAEGSHVFRDLMSYITQEENILLAYRNIKSNKGSKTAGTNKRTIIDVGEEN
PYQLVQYVQNRFNNFQPHSIRRVEIPKPNGKTRPLGIPTIEDRLVQQCIKQILEPILEAKFHKHSYGFRPERSSHHAIAI
FQQWTFKGFHYVVDIDIKGFFDNVNHGKLLKQLWTMKIRDKTFISILSRMLKAEVKGIGKSTKGTPQGGILSPLLANVVL
NELDWWIDSQWDGFPTKRKYSSLLSKTQSIRKYSNLKEIKIVRYADDFKIMCKDYHTAQKIFLATKQWLKVRLDLDISPE
KSKVTNLRKNYSDFLGFKLKVKKGKANGYTNRSRMCDKAKINAVDKLKNNIKTIAANPTVDNVNKYNSVVLGLHNYYKIA
TLVNLDFVDIAFTVNKSLDCRTKNIRNKHGTLTSTYQKFYKQYNWKKRFIANMILFPIAGIKFTMPRIFPKDWNRYTPEG
RLFIHQRLKMDMHTVYYLLENSNPNKSVEFNDNRISLFIAQQGKCHVSGENLSKDNMEVHHIKPLSLGGNDNYKNLVIVT
KETHKLIHATKRETIVHYLPLVLKKERSLEKLNKLRALAGNSEIEMNYC

Sequences:

>Translated_609_residues
MTVKVSNKKALRFNEYYDTQKIQDELYQLSAEGSHVFRDLMSYITQEENILLAYRNIKSNKGSKTAGTNKRTIIDVGEEN
PYQLVQYVQNRFNNFQPHSIRRVEIPKPNGKTRPLGIPTIEDRLVQQCIKQILEPILEAKFHKHSYGFRPERSSHHAIAI
FQQWTFKGFHYVVDIDIKGFFDNVNHGKLLKQLWTMKIRDKTFISILSRMLKAEVKGIGKSTKGTPQGGILSPLLANVVL
NELDWWIDSQWDGFPTKRKYSSLLSKTQSIRKYSNLKEIKIVRYADDFKIMCKDYHTAQKIFLATKQWLKVRLDLDISPE
KSKVTNLRKNYSDFLGFKLKVKKGKANGYTNRSRMCDKAKINAVDKLKNNIKTIAANPTVDNVNKYNSVVLGLHNYYKIA
TLVNLDFVDIAFTVNKSLDCRTKNIRNKHGTLTSTYQKFYKQYNWKKRFIANMILFPIAGIKFTMPRIFPKDWNRYTPEG
RLFIHQRLKMDMHTVYYLLENSNPNKSVEFNDNRISLFIAQQGKCHVSGENLSKDNMEVHHIKPLSLGGNDNYKNLVIVT
KETHKLIHATKRETIVHYLPLVLKKERSLEKLNKLRALAGNSEIEMNYC
>Mature_608_residues
TVKVSNKKALRFNEYYDTQKIQDELYQLSAEGSHVFRDLMSYITQEENILLAYRNIKSNKGSKTAGTNKRTIIDVGEENP
YQLVQYVQNRFNNFQPHSIRRVEIPKPNGKTRPLGIPTIEDRLVQQCIKQILEPILEAKFHKHSYGFRPERSSHHAIAIF
QQWTFKGFHYVVDIDIKGFFDNVNHGKLLKQLWTMKIRDKTFISILSRMLKAEVKGIGKSTKGTPQGGILSPLLANVVLN
ELDWWIDSQWDGFPTKRKYSSLLSKTQSIRKYSNLKEIKIVRYADDFKIMCKDYHTAQKIFLATKQWLKVRLDLDISPEK
SKVTNLRKNYSDFLGFKLKVKKGKANGYTNRSRMCDKAKINAVDKLKNNIKTIAANPTVDNVNKYNSVVLGLHNYYKIAT
LVNLDFVDIAFTVNKSLDCRTKNIRNKHGTLTSTYQKFYKQYNWKKRFIANMILFPIAGIKFTMPRIFPKDWNRYTPEGR
LFIHQRLKMDMHTVYYLLENSNPNKSVEFNDNRISLFIAQQGKCHVSGENLSKDNMEVHHIKPLSLGGNDNYKNLVIVTK
ETHKLIHATKRETIVHYLPLVLKKERSLEKLNKLRALAGNSEIEMNYC

Specific function: Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities:reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site- specific cle

COG id: COG3344

COG function: function code L; Retron-type reverse transcriptase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226520, Length=411, Percent_Identity=28.4671532846715, Blast_Score=136, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6226521, Length=326, Percent_Identity=29.4478527607362, Blast_Score=124, Evalue=6e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003615
- InterPro:   IPR002866
- InterPro:   IPR000477 [H]

Pfam domain/function: PF01348 Intron_maturas2; PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 70946; Mature: 70815

Theoretical pI: Translated: 10.41; Mature: 10.41

Prosite motif: PS50878 RT_POL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVKVSNKKALRFNEYYDTQKIQDELYQLSAEGSHVFRDLMSYITQEENILLAYRNIKSN
CEEEECCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCC
KGSKTAGTNKRTIIDVGEENPYQLVQYVQNRFNNFQPHSIRRVEIPKPNGKTRPLGIPTI
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCH
EDRLVQQCIKQILEPILEAKFHKHSYGFRPERSSHHAIAIFQQWTFKGFHYVVDIDIKGF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEEEC
FDNVNHGKLLKQLWTMKIRDKTFISILSRMLKAEVKGIGKSTKGTPQGGILSPLLANVVL
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
NELDWWIDSQWDGFPTKRKYSSLLSKTQSIRKYSNLKEIKIVRYADDFKIMCKDYHTAQK
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEHHHHHHHH
IFLATKQWLKVRLDLDISPEKSKVTNLRKNYSDFLGFKLKVKKGKANGYTNRSRMCDKAK
HHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHCCCHHH
INAVDKLKNNIKTIAANPTVDNVNKYNSVVLGLHNYYKIATLVNLDFVDIAFTVNKSLDC
CCHHHHHHCCCEEEECCCCCCCCCCCCEEEEEHHHHEEEEEEEECCEEEEEEEECCCCCC
RTKNIRNKHGTLTSTYQKFYKQYNWKKRFIANMILFPIAGIKFTMPRIFPKDWNRYTPEG
CHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCC
RLFIHQRLKMDMHTVYYLLENSNPNKSVEFNDNRISLFIAQQGKCHVSGENLSKDNMEVH
EEEEHHHHHHHHEEEEEEEECCCCCCCEEECCCEEEEEEECCCEEEECCCCCCCCCCEEE
HIKPLSLGGNDNYKNLVIVTKETHKLIHATKRETIVHYLPLVLKKERSLEKLNKLRALAG
EEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NSEIEMNYC
CCCEEEECC
>Mature Secondary Structure 
TVKVSNKKALRFNEYYDTQKIQDELYQLSAEGSHVFRDLMSYITQEENILLAYRNIKSN
EEEECCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCC
KGSKTAGTNKRTIIDVGEENPYQLVQYVQNRFNNFQPHSIRRVEIPKPNGKTRPLGIPTI
CCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCH
EDRLVQQCIKQILEPILEAKFHKHSYGFRPERSSHHAIAIFQQWTFKGFHYVVDIDIKGF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEEEEEC
FDNVNHGKLLKQLWTMKIRDKTFISILSRMLKAEVKGIGKSTKGTPQGGILSPLLANVVL
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
NELDWWIDSQWDGFPTKRKYSSLLSKTQSIRKYSNLKEIKIVRYADDFKIMCKDYHTAQK
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEEHHHHHHHH
IFLATKQWLKVRLDLDISPEKSKVTNLRKNYSDFLGFKLKVKKGKANGYTNRSRMCDKAK
HHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHCCCHHH
INAVDKLKNNIKTIAANPTVDNVNKYNSVVLGLHNYYKIATLVNLDFVDIAFTVNKSLDC
CCHHHHHHCCCEEEECCCCCCCCCCCCEEEEEHHHHEEEEEEEECCEEEEEEEECCCCCC
RTKNIRNKHGTLTSTYQKFYKQYNWKKRFIANMILFPIAGIKFTMPRIFPKDWNRYTPEG
CHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCC
RLFIHQRLKMDMHTVYYLLENSNPNKSVEFNDNRISLFIAQQGKCHVSGENLSKDNMEVH
EEEEHHHHHHHHEEEEEEEECCCCCCCEEECCCEEEEEEECCCEEEECCCCCCCCCCEEE
HIKPLSLGGNDNYKNLVIVTKETHKLIHATKRETIVHYLPLVLKKERSLEKLNKLRALAG
EEEEEECCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NSEIEMNYC
CCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655550; 11157264; 10488339; 9353259; 10413481; 11731786 [H]